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立体定向置管引流术治疗重型脑干出血 被引量:15
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作者 李凤强 张兴春 +1 位作者 于守波 赵英志 《吉林医学》 CAS 2002年第5期272-274,共3页
目的 :探讨立体定向置管引流术治疗重型脑干出血的效果。方法 :总结立体定向于血肿内、侧脑室置管引流治疗重型脑干出血 12例经验 ,并对手术方法、手术适应证、术后处理做初步讨论。结果 :全部病例立体定向手术均获成功 ,术后存活 8例 ... 目的 :探讨立体定向置管引流术治疗重型脑干出血的效果。方法 :总结立体定向于血肿内、侧脑室置管引流治疗重型脑干出血 12例经验 ,并对手术方法、手术适应证、术后处理做初步讨论。结果 :全部病例立体定向手术均获成功 ,术后存活 8例 (存活率 6 6 %) ,无手术死亡及并发症。结论 :立体定向置管引流手术对脑干出血是一种微创、安全、有效的治疗方法。可降低重型脑干出血的死亡率和重残率。 展开更多
关键词 立体定向 引流术 脑干出血 治疗
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无框架立体定向下抽吸清除重度原发性脑干出血疗效初步分析 被引量:2
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作者 盛文国 龙连圣 +7 位作者 谢虎 姜礼鹏 李夏良 吴钟华 王伟 施顺孝 沈立 何兰兰 《临床神经外科杂志》 2023年第3期336-339,共4页
目的探讨神经外科手术机器人立体定向治疗重度原发性性脑干出血(PBH)的临床效果。方法回顾性分析2020年11月—2021年4月湖州市南太湖医院经神经外科机器人立体定向下抽吸清除血肿的10例重度原发性脑干出血患者,分析脑干血肿分型与愈后... 目的探讨神经外科手术机器人立体定向治疗重度原发性性脑干出血(PBH)的临床效果。方法回顾性分析2020年11月—2021年4月湖州市南太湖医院经神经外科机器人立体定向下抽吸清除血肿的10例重度原发性脑干出血患者,分析脑干血肿分型与愈后的相关性。结果术中无死亡病例,为期3个月的随访,存活6例,术后并发症死亡1例,放弃治疗死亡3例;根据改良Rankin评分,术后90 d内3分1例,4分3例,5分2例,死亡4例。结论手术机器人无框架立体定向穿刺清除引流重度脑干出血是有效的,明显降低死亡率,0型及1型血肿清除术后患者90 d内死亡率及改良Rankin评分均优于2型及3型血肿,基于立体定向为基础的脑干血肿分型,有利于术前评估治疗效果。 展开更多
关键词 立体定向 脑干出血 手术机器人
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Robot-assisted treatment of secondary epilepsy caused by parasitic infection:a case report
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作者 Juan Luo Xin Chen +1 位作者 Sixun Yu Haifeng Shu 《Acta Epileptologica》 2024年第2期143-150,共8页
Background Cerebral sparganosis represents the most severe manifestation of sparganosis,with a relatively low global incidence.For cases of secondary epileptic seizures caused by sparganosis infection in the functiona... Background Cerebral sparganosis represents the most severe manifestation of sparganosis,with a relatively low global incidence.For cases of secondary epileptic seizures caused by sparganosis infection in the functional areas of the brain,what advanced neurosurgical techniques should be employed to precisely identify and excise the epi-leptic lesions in the deep functional areas of the brain,aiming to achieve maximal removal while minimising the risk of neurological deficits?This remains a current challenge for epilepsy surgeons.Case presentation A 24-year-old Chinese male was admitted to our hospital,presenting with a history of left limb twitching persisting for over a year.His main clinical symptoms presented twitching and numbness of his left limb without loss of consciousness.Under the premise of inappropriate anti-seizure treatment,recurrent epilepsy attacked persist.The patient’s diagnosis was considered as“space-occupying lesions in the several lobes of brain,secondary epilepsy”after comprehensive assessment and discussion.And experts considered that the patient’s space-occupying lesions in the right frontal and parietal lobes were highly suspected to be infected by parasites.This report delved into the application of neurosurgery robot-assisted frameless stereotaxic technology and intraopera-tive stereotactic electroencephalography(SEEG)monitoring technology to accurately locate and optimize removal of parasite-related epileptic lesions situated in functional areas of the brain.As a result,the patient had achieved seizure freedom,leaving no symptoms of neurological deficit.Conclusions With the highly integrated development of imaging technology,mechanical technology,computer control technology,and artificial intelligence,surgical robots are poised to play a larger role across various neurosur-gical specialties in the future.Considering benefits for patients and the promising application of this technology,its utilization holds significant value. 展开更多
关键词 Cerebral sparganosis Secondary epilepsy ROBOT Frameless stereotaxic technology
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靶点穿刺法在幕上脑出血微创穿刺置管引流术中的应用研究
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作者 戴志强 罗为 +6 位作者 谢佳芯 李杰 张鑫 刘羽阳 帅康 杨凌 封亚平 《中华神经外科疾病研究杂志》 CAS 2024年第4期21-26,共6页
目的探索靶点穿刺法在幕上脑出血微创穿刺置管引流术中穿刺的精准性和有效性。方法收集2020年1月1日至2024年5月31日在本研究作者所在医院接受微创穿刺治疗的患者,根据手术记录信息收集靶点穿刺法手术组患者52例和传统穿刺法手术组患者4... 目的探索靶点穿刺法在幕上脑出血微创穿刺置管引流术中穿刺的精准性和有效性。方法收集2020年1月1日至2024年5月31日在本研究作者所在医院接受微创穿刺治疗的患者,根据手术记录信息收集靶点穿刺法手术组患者52例和传统穿刺法手术组患者46例,评价穿刺准确性和血肿引流效果,通过格拉斯哥量表(Glasgow coma scale,GCS)、改良的脑出血分级量表(intracerebral hemorrhage grading scale,ICH-GS)、脑出血功能转归评分量表(intracerebral hemorrhage function outcome scale,ICH-FOS)评分评估临床效果及患者预后。结果靶点穿刺法手术组置管与血肿中心距离更短、残余血肿量更少、ICH-GS评分提高(P<0.05),GCS和ICH-FOS评分虽有改善,但无统计学意义(P>0.05)。结论靶点穿刺法定位精准,引流效果良好,简单易于掌握,适用于非标准颅脑CT扫描的血肿定位穿刺且没有专用定位工具的医院。 展开更多
关键词 脑出血 立体定位 微创穿刺 置管引流术
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手术机器人辅助穿刺抽吸与内镜辅助下清除治疗基底节区中小型高血压性血肿临床效果分析 被引量:5
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作者 盛文国 王聪 +11 位作者 龙连圣 谢虎 王伟 李夏良 吴钟华 施顺孝 方文杰 莫成平 姜礼鹏 关义豪 沈立 于晓敏 《实用医学杂志》 CAS 北大核心 2022年第23期2996-3001,共6页
目的探讨手术机器人辅助立体定向穿刺抽吸与内镜辅助下清除基底节区高血压性中小型血肿的临床疗效。方法回顾性分析2019年4月至2021年11月湖州学院附属南太湖医院收治的118例基底节区高血压性中小型血肿(25~55 mL)患者的临床资料,根据... 目的探讨手术机器人辅助立体定向穿刺抽吸与内镜辅助下清除基底节区高血压性中小型血肿的临床疗效。方法回顾性分析2019年4月至2021年11月湖州学院附属南太湖医院收治的118例基底节区高血压性中小型血肿(25~55 mL)患者的临床资料,根据治疗方法分为手术机器人辅助立体定向穿刺抽吸组(研究组)、内镜下血肿清除组(对照组),比较两组患者入院的一般临床资料及住院期间并发症发生率、住院时间及出院时偏瘫侧下肢肌力恢复情况。结果两组患者的一般资料差异无统计学意义(P>0.05)。两组患者住院期间再出血、应激性溃疡肺部感染、颅内感染发生率、深静脉血栓发生率差异无统计学意义(P>0.05);住院时间研究组短于对照组(17.32±4.59)d vs.(26.350±4.93)d),差异有统计学意义(P<0.05);随访6个月时偏瘫侧下肢肌力Ⅳ~Ⅴ级占比研究组高于对照组,差异有统计学意义(P<0.05)。结论手术机器人辅助立体定向穿刺抽吸脑内血肿创伤小,可以缩短患者的住院时间,改善此类患者的预后,提高此类患者的生活质量,值得临床推广。 展开更多
关键词 脑出血 高血压 手术机器人 立体定向 预后
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Cre-recombinase systems for induction of neuronspecific knockout models:a guide for biomedical researchers 被引量:1
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作者 Tetiana Shcholok Eftekhar Eftekharpour 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第2期273-279,共7页
Gene deletion has been a valuable tool for unraveling the mysteries of molecular biology.Early approaches included gene trapping and gene targetting to disrupt or delete a gene randomly or at a specific location,respe... Gene deletion has been a valuable tool for unraveling the mysteries of molecular biology.Early approaches included gene trapping and gene targetting to disrupt or delete a gene randomly or at a specific location,respectively.Using these technologies in mouse embryos led to the generation of mouse knocko ut models and many scientific discoveries.The efficacy and specificity of these approaches have significantly increased with the advent of new technology such as cluste red regula rly inters paced short palindromic repeats for targetted gene deletion.However,several limitations including unwanted off-target gene deletion have hindered their widespread use in the field.Crerecombinase technology has provided additional capacity for cell-specific gene deletion.In this review,we provide a summary of currently available literature on the application of this system for targetted deletion of neuronal genes.This article has been constructed to provide some background info rmation for the new trainees on the mechanism and to provide necessary information for the design,and application of the Cre-recombinase system thro ugh reviewing the most f requent promoters that are currently available for genetic manipulation of neuro ns.We additionally will provide a summary of the latest technological developments that can be used for targeting neurons.This may also serve as a general guide for the selection of appropriate models for biomedical research. 展开更多
关键词 central nervous system CEREBELLUM Cre/LoxP system Cre-recombinase transduction gene deletion gene delivery hippocampus in vivo genome editing stereotaxic injection
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锁孔血肿清除术治疗老年高血压性壳核出血临床疗效及其对炎性因子影响 被引量:5
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作者 袁淼 翟安林 +1 位作者 王帆 苟志勇 《疑难病杂志》 CAS 2018年第2期113-116,共4页
目的观察锁孔入路开颅血肿清除术治疗老年高血压性壳核出血临床疗效及其对炎性因子表达的影响。方法选择2011年1月—2017年1月四川省绵阳市404医院(川北医学院附属第二医院)神经外科手术治疗的>60岁高血压性壳核出血患者112例作为研... 目的观察锁孔入路开颅血肿清除术治疗老年高血压性壳核出血临床疗效及其对炎性因子表达的影响。方法选择2011年1月—2017年1月四川省绵阳市404医院(川北医学院附属第二医院)神经外科手术治疗的>60岁高血压性壳核出血患者112例作为研究对象,根据手术方式不同分为2组。对照组50例采用立体定向血肿穿刺引流术,观察组62例采用锁孔入路开颅血肿清除术,观察术后2组患者临床疗效、术后并发症及格拉斯哥预后评分(GOS);所有患者于术前,术后3 d、14 d采集患者静脉血标本检测炎性因子表达。结果与对照组比较,观察组术后颅内水肿持续时间明显缩短、瘫痪肢体恢复早、意识恢复快、ICU留置时间短(t=5.117、3.953、4.294、5.872,P=0.001、0.003、0.002、0.000)。术后2组患者CRP、TNF-α、IL-6表达均较术前降低(对照组F=61.030、75.686、39.125,P均=0.000;观察组F=64.684、51.150、126.189,P均=0.000),但观察组术后降低更明显(P<0.05)。观察组术后再出血及颅内、肺部、尿路感染例数均明显低于对照组(P<0.05)。术后3个月随访,观察组患者GOSⅣ级明显优于对照组(χ~2=3.972,P=0.036)。结论对于老年高血压壳核出血患者,锁孔入路血肿清除术临床疗效及预后佳,术后并发症发生率低。 展开更多
关键词 锁孔入路 开颅血肿清除术 立体定向 血肿穿刺引流术 壳核出血 C反应蛋白 格拉斯哥预后评分
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Impact of vasculature damage on the outcome of spinal cord injury:a novel collagenase-induced model may give new insights into the mechanisms involved 被引量:2
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作者 Patrick Losey Daniel C.Anthony 《Neural Regeneration Research》 SCIE CAS CSCD 2014年第20期1783-1786,共4页
The deleterious effect of vasculature damage on the outcome of spinal cord injury has long been recognized, and numerous clinical studies have shown that the presence of hemorrhage into the spinal cord is directly ass... The deleterious effect of vasculature damage on the outcome of spinal cord injury has long been recognized, and numerous clinical studies have shown that the presence of hemorrhage into the spinal cord is directly associated with a poorer neurological outcome. Vascular damage leads to de- creased blood flow to the cord and the release of potentially toxic blood-borne components. Here we consider the mechanisms that may be contributing to hemorrhage-induced damage and discuss the utility of a new model of spinal cord hemorrhage, which was urgently required as most of our current understanding has been extrapolated from intracerebral hemorrhage studies. 展开更多
关键词 spinal cord injury VASCULATURE hemorrhage animal model COLLAGENASE stereotaxic microinjection
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脑深部电刺激参数调整和随访治疗帕金森病震颤及强直的疗效研究 被引量:4
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作者 管小亭 初君盛 +1 位作者 栾国明 张碧君 《现代康复》 CSCD 2001年第6期33-33,35,共2页
目的观察脑深部电刺激(DBS)治疗帕金森病(PD)术后症状改善,并应用电流脉冲发生器(IPG)进行参数调整以达最佳临床效果。方法2例PD患者进行了手术,采用立体定向系统,以微电极引导将刺激电极植入相应靶点,例1选择丘脑腹中间核(Vim),例... 目的观察脑深部电刺激(DBS)治疗帕金森病(PD)术后症状改善,并应用电流脉冲发生器(IPG)进行参数调整以达最佳临床效果。方法2例PD患者进行了手术,采用立体定向系统,以微电极引导将刺激电极植入相应靶点,例1选择丘脑腹中间核(Vim),例2选择丘脑底核(STN)为靶点。结果术后各种参数相对稳定,在反复启动和关闭IGP前后,差别明显。结论DBS治疗PD安全有效,副作用可逆,,IGP参数调整和随访是DBS手术是否成功的重要部分。 展开更多
关键词 脑深部电刺激 帕金森病 立体定向手术 微电极
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乳腺微小病灶立体定位切除活检的临床应用 被引量:4
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作者 尹红 陈杏初 《临床与病理杂志》 CAS 2014年第5期534-536,共3页
目的:探讨乳腺微小病灶经B超、钼靶定位切除活检的临床应用价值。方法:分别对55例、40例临床触诊阴性的乳腺微小病灶进行B超、钼靶定位切除活检。结果:发现乳腺纤维腺瘤35例(36.84%),乳腺增生29例(30.53%),乳管内乳头状瘤7例(7.37%),慢... 目的:探讨乳腺微小病灶经B超、钼靶定位切除活检的临床应用价值。方法:分别对55例、40例临床触诊阴性的乳腺微小病灶进行B超、钼靶定位切除活检。结果:发现乳腺纤维腺瘤35例(36.84%),乳腺增生29例(30.53%),乳管内乳头状瘤7例(7.37%),慢性乳腺炎5例(5.26%),轻度不典型增生4例,中度不典型增生2例,乳腺癌19例(20.00%),其中0期乳腺癌4例,I期乳腺癌5例,II乳腺癌10例。结论:利用B超及钼靶X线引导下金属导丝定位切除乳腺微小病灶病检具有重要的临床应用价值。 展开更多
关键词 乳腺微小病灶 立体定位 乳腺B超 乳腺钼靶
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A newly developed open-end intracranial hematoma drainage tube 被引量:1
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作者 Chao He Nongnaphat Wanussakul +2 位作者 Dong Yang Tianya Wu Ming Zhao 《Translational Neuroscience and Clinics》 2016年第2期150-152,共3页
Objective: To design a new open-end intracranial hematoma drainage tube for clinical application. Methods: The newly developed device consists of two parts: the plunger and barrel.On one side, the barrel is bullet sha... Objective: To design a new open-end intracranial hematoma drainage tube for clinical application. Methods: The newly developed device consists of two parts: the plunger and barrel.On one side, the barrel is bullet shaped with an opening tip. The plunger is located in the middle cavity of the tube barrel and extended out at the open-end. It was designed for strengthening the tube barrel and for convenience in performing the drainage procedure. It can be used by inserting the drainage tube into the lesion and pulling out the plunger, whereby blood will forcefully rise up inside the barrel, providing a satisfactory outcome. It is made for effusion drainage purposes. During the procedure, the drainage tip is placed at the deepest part of the intracranial hematoma to completely drain the blood. Moreover, the plunger fits tightly in the tube, preventing leakage during the operation. With the use of the device, brain can be separated. In addition, the device can help reduce the risk of cerebral damage because of the small operating area. The barrel sidewall has matching opening holes bilaterally and equally for exchanging substances between the inner and outer parts.The overlapping ratio in each horizontal pair is around 1/3–1/2. Each pair on the opposite side will form a different pressure. Thus, the opening holes will not easily get blocked with blood clot. Results: Blood and accumulated liquid from the deepest part of the intracranial hematoma can be directly drawn through the drainage tube without damaging a large area. The tube does not get blocked easily and allows for complete removal of the hematoma. Conclusions: The device is asuitable instrument for clinical application. 展开更多
关键词 open-end drainage tube BULLET shape barrel PLUNGER stereotaxic drainage matching holes on each side
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增强现实技术辅助定位引流术与立体定向引流术治疗老年幕上脑出血对比研究 被引量:3
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作者 库洪彬 张颜礼 +3 位作者 高海晓 张卫民 孙鑫晔 库洪安 《中国神经精神疾病杂志》 CAS CSCD 北大核心 2020年第12期716-720,共5页
目的对比利用智能手机增强现实(augmented reality,AR)技术进行幕上脑出血引流术与传统立体定向引流术的手术时间与效果。方法回顾性收集我院2018年2月至2020年2月我院老年幕上脑出血(出血量30~60 mL)引流手术治疗166例。其中研究组92例... 目的对比利用智能手机增强现实(augmented reality,AR)技术进行幕上脑出血引流术与传统立体定向引流术的手术时间与效果。方法回顾性收集我院2018年2月至2020年2月我院老年幕上脑出血(出血量30~60 mL)引流手术治疗166例。其中研究组92例,为利用智能手机简化AR技术辅助立体定位血肿引流手术患者。对照组74例,为传统立体定向血肿引流手术患者。对比研究组与对照组患者手术时间、引流管位置准确率、血肿清除率、术后改良Rankin评分(modified Rankin scale,mRS)的差异,评价利用简化AR技术辅助定位引流术在幕上脑出血治疗中的应用价值。结果研究组手术时间(42.5±7.7)min,对照组(109.4±7.3)min,两组比较差异有统计学意义(P<0.05)。研究组和对照组置管准确率(94.6%vs.97.3%)、血肿清除率(87.3%±8.3%vs.89.5%±9.1%)8、术后4周mRS(2.3±1.2 vs.2.2±1.3)、术后90 d随访Barthel(Barthel index,BI)明显改善率(76.1%vs.68.9%),两组比较差异无统计学意义(P>0.05)。结论利用智能手机简化AR技术辅助定位引流术治疗幕上脑出血,可明显缩短手术时间,无需专业设备、操作简便,并可取得与传统立体定向手术相同的疗效。 展开更多
关键词 幕上脑出血 增强现实 立体定位 血肿引流术 智能手机
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Lipopolysaccharide mouse models for Parkinson's disease research:a critical appraisal 被引量:2
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作者 Isaac Deng Larisa Bobrovskaya 《Neural Regeneration Research》 SCIE CAS CSCD 2022年第11期2413-2417,共5页
Parkinson's disease,the most common movement disorder,has a strong neuroinflammatory aspect.This is evident by increased pro-inflammatory cytokines in the serum,and the presence of activated microglial cells,and i... Parkinson's disease,the most common movement disorder,has a strong neuroinflammatory aspect.This is evident by increased pro-inflammatory cytokines in the serum,and the presence of activated microglial cells,and inflammatory cytokines in the substantia nigra of post-mortem brains as well as cerebrospinal fluid of Parkinson's disease patients.The central and peripheral neuroinflammatory aspects of Parkinson's disease can be investigated in vivo via administration of the inflammagen lipopolysaccharide,a component of the cell wall of gram-negative bacteria.In this mini-review,we will critically evaluate different routes of lipopolysaccharide administration(including intranasal systemic and ste reotasic),their relevance to clinical Parkinson's disease as well as the recent findings in lipopolysaccharide mouse models.We will also share our own expe riences with systemic and intrastriatal lipopolysaccharide models in C57BL/6 mice and will discuss the usefulness of lipopolysaccharide mouse models for future research in the field. 展开更多
关键词 C57BL/6 mice intranasal models lipopolysaccharide models NEUROINFLAMMATION Parkinson's disease stereotaxic models substantia nigra systemic models
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Constructing the rodent stereotaxic brain atlas:a survey 被引量:2
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作者 Zhao Feng Anan Li +1 位作者 Hui Gong Qingming Luo 《Science China(Life Sciences)》 SCIE CAS CSCD 2022年第1期93-106,共14页
The stereotaxic brain atlas is a fundamental reference tool commonly used in the field of neuroscience.Here we provide a brief history of brain atlas development and clarify three key conceptual elements of stereotaxi... The stereotaxic brain atlas is a fundamental reference tool commonly used in the field of neuroscience.Here we provide a brief history of brain atlas development and clarify three key conceptual elements of stereotaxic brain atlasing:brain image,atlas,and stereotaxis.We also refine four technical indices for evaluating the construction of atlases:the quality of staining and labeling,the granularity of delineation,spatial resolution,and the precision of spatial location and orientation.Additionally,we discuss state-of-the-art technologies and their trends in the fields of image acquisition,stereotaxic coordinate construction,image processing,anatomical structure recognition,and publishing:the procedures of brain atlas illustration.We believe that the use of single-cell resolution and micron-level location precision will become a future trend in the study of the stereotaxic brain atlas,which will greatly benefit the development of neuroscience. 展开更多
关键词 brain atlas stereotaxic CYTOARCHITECTURE brainsmatics
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脑实质内小占位病灶的手术治疗 被引量:3
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作者 陈文凯 李迎山 +5 位作者 王安生 毕可礼 韩建林 李武学 常树林 江平 《中国神经精神疾病杂志》 CAS CSCD 北大核心 1995年第5期277-278,共2页
报告手术治疗脑内小占位病灶45例,其中经颅骨钻孔CT立体定向下摘除病灶19例,而3例是以显微手术完成的。在CT立体定向下用显微手术摘除脑实质内小占位病灶具有定位准确,更易保护脑组织及血管,使术后患者脑组织功能保持或优... 报告手术治疗脑内小占位病灶45例,其中经颅骨钻孔CT立体定向下摘除病灶19例,而3例是以显微手术完成的。在CT立体定向下用显微手术摘除脑实质内小占位病灶具有定位准确,更易保护脑组织及血管,使术后患者脑组织功能保持或优于术前水平。 展开更多
关键词 脑实质占位病灶 占位病灶 神经外科手术 CT
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Analysis of Therapeutic Effect of X-knife on Intracranial Tumors in 44 Cases
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作者 张海江 麦洁文 +5 位作者 梁艺湖 张瑞澜 温尊北 陈宗友 林启富 曾业辉 《中国组织工程研究》 CAS CSCD 2001年第10期152-153,共2页
Objective to investigate therapeutic methods and effect of X-knife for on intracranial diseases. Method Recent effect of 44 pqtients with cranial diseases by X-knife was observed. Radiological follow-up was perform... Objective to investigate therapeutic methods and effect of X-knife for on intracranial diseases. Method Recent effect of 44 pqtients with cranial diseases by X-knife was observed. Radiological follow-up was performed on 40 cases with mean 5.65 months of follow-up time. Result 92.5%of tumors were controlled locally, stability and recovery rate was 90.0%.The local control of metastatic tumors of brain was higher,but most patients with metastatic tumors died of primary lesion.New metastatic lesions appeared in patients without panencephalic radiotherapy in 1~5months .Tumors of pineal region were sensitive to X-knife.Conclusion X-knife has a definite effect on intracranial diseases .For patients with tumors of pineal region complicated by serious hydrocephalus,shunting should be conducted before X-knife treatment.For patients with mild or morderate hydrocephalus,X-knife chould be utilized only under correct interventions such as dehydration.The local control rate of intracranial metastatic tumors was high,but survival time postoperation depended on panencephalic radiotherapy or control of primafry lision. For tumors with diameter >3cm,pituitary tumors,brains stem tumors and tumors in cerebellopontine angle region repeated X -knife were suggested,which could improve cure rate and decrease complications. 展开更多
关键词 X-knife INTRACRANIAL diseases stereotaxic RADIOLOGY and NEUROSURGERY
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Development of Digital Stereotaxic Instrument for Pigeons(Columba Livia) 被引量:1
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作者 Xinyu Liu Yanna Ping +2 位作者 Dongyun Wang Hang Xie Li Shi 《Journal of Bionic Engineering》 SCIE EI CSCD 2022年第4期1003-1013,共11页
Stereotaxic instrument is an indispensable tool for numerous types of neuroscience studies and is routinely performed in neuroscience laboratories as part of a variety of experimental procedures.Due to the development... Stereotaxic instrument is an indispensable tool for numerous types of neuroscience studies and is routinely performed in neuroscience laboratories as part of a variety of experimental procedures.Due to the development of robotics and automation,the stereotaxic instrument for rodents has made great progress,while it is relatively backward and scarce for birds.A digital stereotaxic instrument for pigeons(Columba livia),a classic animal model for learning,memory and cognition,was developed in this study.Its performance was verified from three aspects including stereotaxic accuracy,stereotaxic stability and stereotaxic reproducibility.The developed stereotaxic instrument has the following characteristics:(1)a digital positioning system was used,which is characterized by high stereotaxic accuracy;(2)a novel head-fixation system was developed to increase the adaptability of head-fixation;(3)a four-point fixation method was suggested,improving the stability of head-fixation;(4)the stereotaxic instrument has strong versatility,which can be suitable for a wide variety of birds.Moreover,the proposed stereotaxic instrument has better positioning accuracy and stability,which will promote the study of neural mechanisms for pigeons. 展开更多
关键词 PIGEONS stereotaxic instrument Digital positioning system Head fixation system REPRODUCIBILITY
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脑出血后出血病灶的CT三维重建模型 被引量:2
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作者 佟德华 郭守刚 +6 位作者 唐洲平 湛彦强 陈娣 张苏明 何锐波 许理 赵英俊 《中华神经外科杂志》 CSCD 北大核心 2009年第1期65-67,共3页
目的为计算机辅助立体定向设备的研发设计的,可以依据CT扫描数据进行三维重建并模拟临床腩出血操作过程的颅骨模型。方法以融解的石蜡灌铸内置有假想病灶的颅骨标本制为颅骨模型,采集CT扫描后的序列DICOM数据,通过自编软件平台进行3... 目的为计算机辅助立体定向设备的研发设计的,可以依据CT扫描数据进行三维重建并模拟临床腩出血操作过程的颅骨模型。方法以融解的石蜡灌铸内置有假想病灶的颅骨标本制为颅骨模型,采集CT扫描后的序列DICOM数据,通过自编软件平台进行3D重建、手术规划,由计算机辅助立体定向设备对该模型进行模拟微创穿刺。结果完成蜡灌铸的脑出血颅骨模型,且该模型在CT扫描和之后的3D重建中可清晰显示和区别标记物、骨骼、石蜡、假想病灶。结论蜡铸脑出血颅骨模型方法简单、可反复建模,能较理想地评估计算机辅助立体定向设备原型机的系统性能。 展开更多
关键词 颅骨 脑出血 模型 计算机辅助 立体定向 三维
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纹状体边缘区与学习记忆功能关系的实验研究 被引量:1
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作者 郑兆聪 王如密 舒斯云 《立体定向和功能性神经外科杂志》 2002年第1期17-19,共3页
目的 探讨纹状体边缘区与学习记忆功能的关系 ;方法 采用立体定向技术将神经毒剂海人藻酸(KA)注射破坏纹状体边缘区神经细胞体 ,并在注射前后用Y型迷宫测试大鼠的学习和记忆功能 ;结果 双侧纹状体边缘区受到破坏的大鼠学习和记忆功... 目的 探讨纹状体边缘区与学习记忆功能的关系 ;方法 采用立体定向技术将神经毒剂海人藻酸(KA)注射破坏纹状体边缘区神经细胞体 ,并在注射前后用Y型迷宫测试大鼠的学习和记忆功能 ;结果 双侧纹状体边缘区受到破坏的大鼠学习和记忆功能明显减退 (P <0 0 1) ,且与传统认为的记忆中枢NBM破坏后的结果无显著差异 (P >0 0 5 ) ;结论 纹状体边缘区与大鼠的空间辨别作业的学习记忆密切相关 。 展开更多
关键词 纹状体 立体定向 边缘区 学习 记忆 大鼠 实验
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影像导向立体定向开颅切除颅内小病灶病变 被引量:1
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作者 李玉斌 冯继 +6 位作者 刘兰祥 周益民 王占秋 杨大为 李宝龙 张海垠 杨丽敏 《中国实用神经疾病杂志》 2009年第19期12-14,共3页
目的探讨影像导向立体定向开颅切除颅内小病灶病变的手术方法和临床应用。方法结合CT/MRI,在立体定向仪及手术计划系统指导下,对19例直径0.8~3.5cm的颅内病变进行显微手术切除。结果所有病灶均定位精确,一次手术切除,无死亡病... 目的探讨影像导向立体定向开颅切除颅内小病灶病变的手术方法和临床应用。方法结合CT/MRI,在立体定向仪及手术计划系统指导下,对19例直径0.8~3.5cm的颅内病变进行显微手术切除。结果所有病灶均定位精确,一次手术切除,无死亡病例。病变性质:胶质瘤9例,转移瘤3例,脑囊虫3例,脑脓肿2例,海绵状血管瘤2例。结论影像导向立体定向开颅切除颅内小病灶病变是一种定位精确、侵袭性小、安全有效的手术方法。 展开更多
关键词 立体定向 开颅切除术 颅内病灶
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