柔性多状态开关(soft normal open points,SNOP)接入配电网可实现负荷的不间断供电,而且能改善故障期间网络的电能质量。该文首先建立SNOP的数学模型,分析在正常状态下SNOP控制方式和潮流方向,以及故障状态下与配电自动化相配合的过程...柔性多状态开关(soft normal open points,SNOP)接入配电网可实现负荷的不间断供电,而且能改善故障期间网络的电能质量。该文首先建立SNOP的数学模型,分析在正常状态下SNOP控制方式和潮流方向,以及故障状态下与配电自动化相配合的过程。然后,建立两阶段故障恢复模型,第一阶段以失负荷风险最小为目标函数,求解获得开关状态与SNOP各端口功率变化范围;不改变网络拓扑,第二阶段引入区间数描述分布式电源和负荷预测的不确定性,将鲁棒优化应用于故障恢复期间的运行状态优化,并对不满足约束的情况进行拓扑调整后重新优化。最后,以三端SNOP连接的3个IEEE33节点系统作为测试算例,分析误差,分布式电源渗透率和SNOP单端容量/线路容量对优化策略的影响。展开更多
To solve the common problem of flumes flowmeasurement accuracy without sacrificing water head, a new type of trapezoidal cutthroat flume to measure the discharge in terminal trapezoidal channels is presented.Using the...To solve the common problem of flumes flowmeasurement accuracy without sacrificing water head, a new type of trapezoidal cutthroat flume to measure the discharge in terminal trapezoidal channels is presented.Using the computational fluid dynamic method, threedimensional flow fields in trapezoidal cutthroat flumes were simulated using the RNG k-ε three-dimensional turbulence model along with the Tru VOF technique.Simulations were performed for 12 working conditions,with discharges up to 0.075 m3$s–1 to determine hydraulic performance. Experimental data for the trapezoidal cutthroat flume in terminal trapezoidal channel were also obtained to validate the simulation results. Velocity distribution of the flume obtained from simulation analyses were compared with observed results based on timeaveraged flow field and comparison yielded a solid agreement between results from the two methods, with relative error below 10%. The results indicated that the Froude number and the longitudinal average velocity increased along the convergence section and decreased in the divergent section. In the upper throat, the Froude number was less than 0.5, which meets the water measurement requirement, and the critical flow appeared near the throat section. The maximum water head loss of the trapezoidal cutthroat flume was less than 9% of the total head, compared to the rectangular cutthroat flume,and head loss of trapezoidal cutthroat flume was significantly less. Regression models developed for upstream depth versus discharge under different working conditions were satisfactory, with a relative error of less than 2.06%, which meets the common requirements of flow measurement in irrigation areas. It was concluded that trapezoidal cutthroat flumes can improve flow-measurement accuracy without sacrificing water head.展开更多
AIM To identify chromosomal copy number aberrations(CNAs) in early-stage hepatocellular carcinoma(HCC) and analyze whether they are correlated with patient prognosis.METHODS One hundred and twenty patients with early-...AIM To identify chromosomal copy number aberrations(CNAs) in early-stage hepatocellular carcinoma(HCC) and analyze whether they are correlated with patient prognosis.METHODS One hundred and twenty patients with early-stage HCC were enrolled in our study, with the collection of formalin fixed, paraffin-embedded(FFPE) specimens and clinicopathological data. Tumor areas were marked by certified pathologists on a hematoxylin and eosinstained slide, and cancer and adjacent non-cancerous tissues underwent extraction of DNA, which was analyzed with the Affymetrix Onco Scan platform to assess CNAs and loss of heterozygosity(LOH). Ten individuals with nonmalignant disease were used as the control group. Another cohort consisting of 40 patients with stage Ⅰ/Ⅱ HCC were enrolled to analyze gene expression and to correlate findings with the Onco Scan data.RESULTS Copy number amplifications occurred at chromosomes 1 q21.1-q44 and 8 q12.3-24.3 and deletions were found at 4 q13.1-q35.2, 8 p 23.2-21.1, 16 q23.3-24.3, and 17 p13.3-12, while LOH commonly occurred at 1 p32.3, 3 p21.31, 8 p23.2-21.1, 16 q22.1-24.3, and 17 p 13.3-11 in early-stage HCC. Using Cox regression analysis, we also found that a higher percentage of genome change(≥ 60%) was an independent factor for worse prognosis in early-stage HCC(P = 0.031). Among the 875 genes in the Onco Scan Gene Chip, six were independent predictors of worse disease-free survival, of which three were amplified(MYC, ELAC2, and SYK) and three were deleted(GAK, MECOM, and WRN). Further, patients with HCC who exhibited ≥ 3 CNAs involving these six genes have worse outcomes compared to those who had < 3 CNAs(P < 0.001). Similarly, Asian patients with stage I HCC from The Cancer Genome Atlas harboring CNAs with these genes were also predicted to have poorer outcomes.CONCLUSION Patients with early-stage HCC and increased genome change or CNAs involving MYC, ELAC2, SYK, GAK, MECOM, or WRN are at risk for poorer outcome after resection.展开更多
In this paper, we propose a two strain epidemic model with single host population. It is assumed that strain one can mutate into strain two. Also latent-stage progression age and mutation are incorporated into the mod...In this paper, we propose a two strain epidemic model with single host population. It is assumed that strain one can mutate into strain two. Also latent-stage progression age and mutation are incorporated into the model. Stability of equilibria （including the disease free equilibrium, dominant equilibria and the coexistence equilibrium） is investigated and it is found that they are locally stable under suitable and biological feasible constraints. Results indicate that the competition exclusion and coexistence of the two strains are possible depending on the mutation. Numerical simulations are also performed to illustrate these results.展开更多
The change in the maize moisture content during different growth stages is an important indicator to evaluate the growth status of maize.In particular,the moisture content during the grain-filling stage reflects the g...The change in the maize moisture content during different growth stages is an important indicator to evaluate the growth status of maize.In particular,the moisture content during the grain-filling stage reflects the grain quality and maturity and it can also be used as an important indicator for breeding and seed selection.At present,the drying method is usually used to calculate the moisture content and the dehydration rate at the grain-filling stage,however,it requires large sample size and long test time.In order to monitor the change in the moisture content at the maize grain-filling stage using small sample set,the Bootstrap re-sampling strategy-sample set partitioning based on joint x-y distances-partial least squares(Bootstrap-SPXY-PLS)moisture content monitoring model and near-infrared spectroscopy for small sample sizes of 10,20,and 50 were used.To improve the prediction accuracy of the model,the optimal number of factors of the model was determined and the comprehensive evaluation thresholds RVP(coefficient of determination(R^(2)),the root mean square error of cross-validation(RMSECV)and the root mean square error of prediction(RMSEP))was proposed for sub-model screening.The model exhibited a good performance for predicting the moisture content of the maize grain at the filling stage for small sample set.For the sample sizes of 20 and 50,the R^(2) values were greater than 0.99.The average deviations of the predicted and reference values of the model were 0.1078%,0.057%,and 0.0918%,respectively.Therefore,the model was effective for monitoring the moisture content at the grain-filling stage for a small sample size.The method is also suitable for the quantitative analysis of different concentrations using near-infrared spectroscopy and small sample size.展开更多
The DDA-Ⅱ process aimed at manufacture of diesel fuel meeting the Euro-Ⅳ emission standard from inferior diesel feedstock has been developed and tested in pilot scale. This technology adopts non-noble metal catalyst...The DDA-Ⅱ process aimed at manufacture of diesel fuel meeting the Euro-Ⅳ emission standard from inferior diesel feedstock has been developed and tested in pilot scale. This technology adopts non-noble metal catalysts and a highly integrated two-stage process scheme featuring low investment and operating cost and convenience in operation. Under an appropriate process regime the DDA-Ⅱ technology can process FCC LCO, a blend of straight-run diesel and FCC LCO, or the SR diesel to yield the diesel product streams meeting the Euro-Ⅳ or even higher emission standards.展开更多
文摘柔性多状态开关(soft normal open points,SNOP)接入配电网可实现负荷的不间断供电,而且能改善故障期间网络的电能质量。该文首先建立SNOP的数学模型,分析在正常状态下SNOP控制方式和潮流方向,以及故障状态下与配电自动化相配合的过程。然后,建立两阶段故障恢复模型,第一阶段以失负荷风险最小为目标函数,求解获得开关状态与SNOP各端口功率变化范围;不改变网络拓扑,第二阶段引入区间数描述分布式电源和负荷预测的不确定性,将鲁棒优化应用于故障恢复期间的运行状态优化,并对不满足约束的情况进行拓扑调整后重新优化。最后,以三端SNOP连接的3个IEEE33节点系统作为测试算例,分析误差,分布式电源渗透率和SNOP单端容量/线路容量对优化策略的影响。
基金the financial support given by the Special Fund for Agro-scientific Research in the Public Interest of China (201503125)the National Key Research and Development Program of China
文摘To solve the common problem of flumes flowmeasurement accuracy without sacrificing water head, a new type of trapezoidal cutthroat flume to measure the discharge in terminal trapezoidal channels is presented.Using the computational fluid dynamic method, threedimensional flow fields in trapezoidal cutthroat flumes were simulated using the RNG k-ε three-dimensional turbulence model along with the Tru VOF technique.Simulations were performed for 12 working conditions,with discharges up to 0.075 m3$s–1 to determine hydraulic performance. Experimental data for the trapezoidal cutthroat flume in terminal trapezoidal channel were also obtained to validate the simulation results. Velocity distribution of the flume obtained from simulation analyses were compared with observed results based on timeaveraged flow field and comparison yielded a solid agreement between results from the two methods, with relative error below 10%. The results indicated that the Froude number and the longitudinal average velocity increased along the convergence section and decreased in the divergent section. In the upper throat, the Froude number was less than 0.5, which meets the water measurement requirement, and the critical flow appeared near the throat section. The maximum water head loss of the trapezoidal cutthroat flume was less than 9% of the total head, compared to the rectangular cutthroat flume,and head loss of trapezoidal cutthroat flume was significantly less. Regression models developed for upstream depth versus discharge under different working conditions were satisfactory, with a relative error of less than 2.06%, which meets the common requirements of flow measurement in irrigation areas. It was concluded that trapezoidal cutthroat flumes can improve flow-measurement accuracy without sacrificing water head.
基金Supported by the Chang Gung Memorial Hospital in Taiwan,No.CMRPG 3C0951-3 and No.CMRPG 3A0671 to Yu MC,and No.CMRPD3F0011 to Tsai CN
文摘AIM To identify chromosomal copy number aberrations(CNAs) in early-stage hepatocellular carcinoma(HCC) and analyze whether they are correlated with patient prognosis.METHODS One hundred and twenty patients with early-stage HCC were enrolled in our study, with the collection of formalin fixed, paraffin-embedded(FFPE) specimens and clinicopathological data. Tumor areas were marked by certified pathologists on a hematoxylin and eosinstained slide, and cancer and adjacent non-cancerous tissues underwent extraction of DNA, which was analyzed with the Affymetrix Onco Scan platform to assess CNAs and loss of heterozygosity(LOH). Ten individuals with nonmalignant disease were used as the control group. Another cohort consisting of 40 patients with stage Ⅰ/Ⅱ HCC were enrolled to analyze gene expression and to correlate findings with the Onco Scan data.RESULTS Copy number amplifications occurred at chromosomes 1 q21.1-q44 and 8 q12.3-24.3 and deletions were found at 4 q13.1-q35.2, 8 p 23.2-21.1, 16 q23.3-24.3, and 17 p13.3-12, while LOH commonly occurred at 1 p32.3, 3 p21.31, 8 p23.2-21.1, 16 q22.1-24.3, and 17 p 13.3-11 in early-stage HCC. Using Cox regression analysis, we also found that a higher percentage of genome change(≥ 60%) was an independent factor for worse prognosis in early-stage HCC(P = 0.031). Among the 875 genes in the Onco Scan Gene Chip, six were independent predictors of worse disease-free survival, of which three were amplified(MYC, ELAC2, and SYK) and three were deleted(GAK, MECOM, and WRN). Further, patients with HCC who exhibited ≥ 3 CNAs involving these six genes have worse outcomes compared to those who had < 3 CNAs(P < 0.001). Similarly, Asian patients with stage I HCC from The Cancer Genome Atlas harboring CNAs with these genes were also predicted to have poorer outcomes.CONCLUSION Patients with early-stage HCC and increased genome change or CNAs involving MYC, ELAC2, SYK, GAK, MECOM, or WRN are at risk for poorer outcome after resection.
文摘In this paper, we propose a two strain epidemic model with single host population. It is assumed that strain one can mutate into strain two. Also latent-stage progression age and mutation are incorporated into the model. Stability of equilibria （including the disease free equilibrium, dominant equilibria and the coexistence equilibrium） is investigated and it is found that they are locally stable under suitable and biological feasible constraints. Results indicate that the competition exclusion and coexistence of the two strains are possible depending on the mutation. Numerical simulations are also performed to illustrate these results.
基金This work was financially supported by the grant from the International Cooperation and Exchange of the National Natural Science Foundation of China(No.31811540396),Chinathe National Natural Science Foundation of China(No.31701318),Chinathe Training Project of Heilongjiang Bayi Agricultural University,China(No.XZR2016-09).
文摘The change in the maize moisture content during different growth stages is an important indicator to evaluate the growth status of maize.In particular,the moisture content during the grain-filling stage reflects the grain quality and maturity and it can also be used as an important indicator for breeding and seed selection.At present,the drying method is usually used to calculate the moisture content and the dehydration rate at the grain-filling stage,however,it requires large sample size and long test time.In order to monitor the change in the moisture content at the maize grain-filling stage using small sample set,the Bootstrap re-sampling strategy-sample set partitioning based on joint x-y distances-partial least squares(Bootstrap-SPXY-PLS)moisture content monitoring model and near-infrared spectroscopy for small sample sizes of 10,20,and 50 were used.To improve the prediction accuracy of the model,the optimal number of factors of the model was determined and the comprehensive evaluation thresholds RVP(coefficient of determination(R^(2)),the root mean square error of cross-validation(RMSECV)and the root mean square error of prediction(RMSEP))was proposed for sub-model screening.The model exhibited a good performance for predicting the moisture content of the maize grain at the filling stage for small sample set.For the sample sizes of 20 and 50,the R^(2) values were greater than 0.99.The average deviations of the predicted and reference values of the model were 0.1078%,0.057%,and 0.0918%,respectively.Therefore,the model was effective for monitoring the moisture content at the grain-filling stage for a small sample size.The method is also suitable for the quantitative analysis of different concentrations using near-infrared spectroscopy and small sample size.
文摘The DDA-Ⅱ process aimed at manufacture of diesel fuel meeting the Euro-Ⅳ emission standard from inferior diesel feedstock has been developed and tested in pilot scale. This technology adopts non-noble metal catalysts and a highly integrated two-stage process scheme featuring low investment and operating cost and convenience in operation. Under an appropriate process regime the DDA-Ⅱ technology can process FCC LCO, a blend of straight-run diesel and FCC LCO, or the SR diesel to yield the diesel product streams meeting the Euro-Ⅳ or even higher emission standards.
