为提高汽车行驶平顺性和操纵稳定性等整车动力学性能优化匹配效率,提出基于TOPSIS(Technique for ordering preferences by similarity to ideal solution,TOPSIS)方法的设计变量筛选策略。首先建立考虑下控制臂和扭转梁柔性的整车刚柔...为提高汽车行驶平顺性和操纵稳定性等整车动力学性能优化匹配效率,提出基于TOPSIS(Technique for ordering preferences by similarity to ideal solution,TOPSIS)方法的设计变量筛选策略。首先建立考虑下控制臂和扭转梁柔性的整车刚柔耦合虚拟样机模型,并通过下控制臂和扭转梁自由模态试验以及整车行驶平顺性和操纵稳定性实车道路试验验证所建整车刚柔耦合模型的正确性。采用试验设计方法研究下控制臂和扭转梁各结构参数分别对前后悬架性能的影响程度,提出基于熵权法和TOPSIS方法的结构综合贡献系数计算方法,以此为评价指标筛选出对悬架性能影响较大的结构参数作为整车性能匹配优化的设计变量,结合Kriging近似模型和NSGA-II算法(Elitist non-dominated sorting genetic algorithm,NSGA-II)对整车行驶平顺性和操纵稳定性进行多目标优化设计,获取Pareto最优解集,并确定出前后悬架系统的优化方案。研究结果表明,与优化前相比较,悬架系统优化后的整车行驶平顺性和操纵稳定性均有所提高,能够实现汽车性能的整体改善。展开更多
Amorphous solid dispersions(ASDs)are popular for enhancing the solubility and bioavailability of poorly water-soluble drugs.Various approaches have been employed to produce ASDs and novel techniques are emerging.This ...Amorphous solid dispersions(ASDs)are popular for enhancing the solubility and bioavailability of poorly water-soluble drugs.Various approaches have been employed to produce ASDs and novel techniques are emerging.This review provides an updated overview of manufacturing techniques for preparing ASDs.As physical stability is a critical quality attribute for ASD,the impact of formulation,equipment,and process variables,together with the downstream processing on physical stability of ASDs have been discussed.Selection strategies are proposed to identify suitable manufacturing methods,which may aid in the development of ASDs with satisfactory physical stability.展开更多
文摘为提高汽车行驶平顺性和操纵稳定性等整车动力学性能优化匹配效率,提出基于TOPSIS(Technique for ordering preferences by similarity to ideal solution,TOPSIS)方法的设计变量筛选策略。首先建立考虑下控制臂和扭转梁柔性的整车刚柔耦合虚拟样机模型,并通过下控制臂和扭转梁自由模态试验以及整车行驶平顺性和操纵稳定性实车道路试验验证所建整车刚柔耦合模型的正确性。采用试验设计方法研究下控制臂和扭转梁各结构参数分别对前后悬架性能的影响程度,提出基于熵权法和TOPSIS方法的结构综合贡献系数计算方法,以此为评价指标筛选出对悬架性能影响较大的结构参数作为整车性能匹配优化的设计变量,结合Kriging近似模型和NSGA-II算法(Elitist non-dominated sorting genetic algorithm,NSGA-II)对整车行驶平顺性和操纵稳定性进行多目标优化设计,获取Pareto最优解集,并确定出前后悬架系统的优化方案。研究结果表明,与优化前相比较,悬架系统优化后的整车行驶平顺性和操纵稳定性均有所提高,能够实现汽车性能的整体改善。
基金supported,in whole or in part,by the Bill&Melinda Gates Foundation[No.OPP1159809,USA]supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under Award(No.R01AI132681,USA)
文摘Amorphous solid dispersions(ASDs)are popular for enhancing the solubility and bioavailability of poorly water-soluble drugs.Various approaches have been employed to produce ASDs and novel techniques are emerging.This review provides an updated overview of manufacturing techniques for preparing ASDs.As physical stability is a critical quality attribute for ASD,the impact of formulation,equipment,and process variables,together with the downstream processing on physical stability of ASDs have been discussed.Selection strategies are proposed to identify suitable manufacturing methods,which may aid in the development of ASDs with satisfactory physical stability.
