Alternative splicing is critical for human gene expression regulation,which plays a determined role in expanding the diversity of functional proteins.Importantly,alternative splicing is a hallmark of cancer and a pote...Alternative splicing is critical for human gene expression regulation,which plays a determined role in expanding the diversity of functional proteins.Importantly,alternative splicing is a hallmark of cancer and a potential target for cancer therapeutics.Based on the statistical data,breast cancer is one of the top leading causes of cancer-related deaths in women worldwide.Strikingly,alternative splicing is closely associated with breast cancer development.Here,we seek to provide a general review of the relationship between alternative splicing and breast cancer.We introduce the process of alternative splicing and its regulatory role in cancers.In addition,we highlight the functions of aberrant alternative splicing and mutations of splicing factors in breast cancer progression.Moreover,we discuss the role of alternative splicing in cancer drug resistance and the potential of being targets for cancer therapeutics.展开更多
基金This work was supported by the National Natural Science Foundation of China(81830088,81422038,91540110,and31471235 to Y.W.,81872247 and 31400726 to W.Z.)the Department of Science and Tech no logy of Dalian City(‘Dalia n Supports High Level Talents Innovation and Entrepreneurship Program’2016RJ02 to Y.W.).
文摘Alternative splicing is critical for human gene expression regulation,which plays a determined role in expanding the diversity of functional proteins.Importantly,alternative splicing is a hallmark of cancer and a potential target for cancer therapeutics.Based on the statistical data,breast cancer is one of the top leading causes of cancer-related deaths in women worldwide.Strikingly,alternative splicing is closely associated with breast cancer development.Here,we seek to provide a general review of the relationship between alternative splicing and breast cancer.We introduce the process of alternative splicing and its regulatory role in cancers.In addition,we highlight the functions of aberrant alternative splicing and mutations of splicing factors in breast cancer progression.Moreover,we discuss the role of alternative splicing in cancer drug resistance and the potential of being targets for cancer therapeutics.
