Five new organotin(IV) complexes of ortho-vanillin-2-hydrazinopyridine hydrazone with formula [RnSnCl4–n(VHP)] [R = Me2, n = 2 (2);R = Ph2, n = 2 (3);R= nBu2, n = 2 (4);R = nBu, n = 2 (5) and R = 1, n = 0 (6)] have b...Five new organotin(IV) complexes of ortho-vanillin-2-hydrazinopyridine hydrazone with formula [RnSnCl4–n(VHP)] [R = Me2, n = 2 (2);R = Ph2, n = 2 (3);R= nBu2, n = 2 (4);R = nBu, n = 2 (5) and R = 1, n = 0 (6)] have been synthesized by direct reaction of ortho-vanillin-2-hydrazinopyridine hydrazone [(VHP), (1)], base and organotin(IV) chloride(s) in absolute methanol. The hydrazone ligand [(VHP), (1)] and its organotin(IV) complexes (2-6) have been characterized by UV-Visible, FT-IR and 1H NMR spectral studies. Spectroscopic data suggested that in the complexes (2-4), the ligand (1) acted as a neutral bidentate ligand and is coordinated to the tin(IV) atom via the azomethine nitrogen and pyridyl nitrogen atoms, whereas the ligand (1) acted as a uninegative tridentate ligand and coordinated to the tin(IV) atom through phenolic-O, azomethine-N and pyridyl-N atoms in complexes (5-6). The toxicity of the ligand (1) and its organotin (IV) complexes (2-6) were determined against Artemia salina. Organotin(IV) complexes showed moderate activity against Artemia salina. The ligand (1) and its organotin(IV) complexes (2-6) were also tested against four types of bacteria namely Bacillus cereus, Staphylococcus aureus, Escherichia coli and Enterobacter aerogenes. All organotin(IV) complexes and the free ligand (1) showed better antibacterial activities against bacteria. Among the organotin(IV) complexes (2-6), diphenyltin(IV) complex (3) showed higher activity against the four types of bacteria.展开更多
A sediment sequence,from Fangshan in the Beijing Basin,has been sampled for paleomag-netic studies.The 1430 paleomagnetic samples possess a strong and stable magnetic remanence.A high-res-olution record of secular var...A sediment sequence,from Fangshan in the Beijing Basin,has been sampled for paleomag-netic studies.The 1430 paleomagnetic samples possess a strong and stable magnetic remanence.A high-res-olution record of secular variation in North China over the past 15 ka B.P.has been provided.Spectral anal-yses have shown that main periods of inclination,declination and relative intensity are about 1000,2000 and4000 a;800,1640 and 3300 a;and 820,1200,2200 and 3300 a;respectively.Two excursions have beendiscovered,and the correlation between the geomagnetic intensity variations and the climatic changes hasbeen discussed.展开更多
The Cosic Resonance Recognition Model (RRM) for amino acid sequences was applied to the classes of proteins displayed by four strains (Sudan, Zaire, Reston, Ivory Coast) of Ebola virus that produced either high or min...The Cosic Resonance Recognition Model (RRM) for amino acid sequences was applied to the classes of proteins displayed by four strains (Sudan, Zaire, Reston, Ivory Coast) of Ebola virus that produced either high or minimal numbers of human fatalities. The results clearly differentiated highly lethal and non-lethal strains. Solutions for the two lethal strains exhibited near ultraviolet (~230 nm) photon values while the two asymptomatic forms displayed near infrared (~1000 nm) values. Cross-correlations of spectral densities of the RRM values of the different classes of proteins associated with the genome of the viruses supported this dichotomy. The strongest coefficient occurred only between Sudan-Zaire strains but not for any of the other pairs of strains for sGP, the small glycoprotein that intercalated with the plasma cell membrane to promote insertion of viral contents into cellular space. A surprising, statistically significant cross-spectral correlation occurred between the “spike” glycoprotein component (GP1) of the virus that associated the anchoring of the virus to the mammalian cell plasma membrane and the Schumann resonance of the earth whose intensities were determined by the incidence of equatorial thunderstorms. Previous applications of the RRM to shifting photon wavelengths emitted by melanoma cells adapting to reduced ambient temperature have validated Cosic’s model and have demonstrated very narrowwave-length (about 10 nm) specificity. One possible ancillary and non-invasive treatment of people within which the fatal Ebola strains are residing would be whole body application of narrow band near-infrared light pulsed as specific physiologically-patterned sequences with sufficient radiant flux density to perfuse the entire body volume.展开更多
文摘Five new organotin(IV) complexes of ortho-vanillin-2-hydrazinopyridine hydrazone with formula [RnSnCl4–n(VHP)] [R = Me2, n = 2 (2);R = Ph2, n = 2 (3);R= nBu2, n = 2 (4);R = nBu, n = 2 (5) and R = 1, n = 0 (6)] have been synthesized by direct reaction of ortho-vanillin-2-hydrazinopyridine hydrazone [(VHP), (1)], base and organotin(IV) chloride(s) in absolute methanol. The hydrazone ligand [(VHP), (1)] and its organotin(IV) complexes (2-6) have been characterized by UV-Visible, FT-IR and 1H NMR spectral studies. Spectroscopic data suggested that in the complexes (2-4), the ligand (1) acted as a neutral bidentate ligand and is coordinated to the tin(IV) atom via the azomethine nitrogen and pyridyl nitrogen atoms, whereas the ligand (1) acted as a uninegative tridentate ligand and coordinated to the tin(IV) atom through phenolic-O, azomethine-N and pyridyl-N atoms in complexes (5-6). The toxicity of the ligand (1) and its organotin (IV) complexes (2-6) were determined against Artemia salina. Organotin(IV) complexes showed moderate activity against Artemia salina. The ligand (1) and its organotin(IV) complexes (2-6) were also tested against four types of bacteria namely Bacillus cereus, Staphylococcus aureus, Escherichia coli and Enterobacter aerogenes. All organotin(IV) complexes and the free ligand (1) showed better antibacterial activities against bacteria. Among the organotin(IV) complexes (2-6), diphenyltin(IV) complex (3) showed higher activity against the four types of bacteria.
基金the Xi'an Laboratory of Loess and Quaternary Geology,Academia Sinica.
文摘A sediment sequence,from Fangshan in the Beijing Basin,has been sampled for paleomag-netic studies.The 1430 paleomagnetic samples possess a strong and stable magnetic remanence.A high-res-olution record of secular variation in North China over the past 15 ka B.P.has been provided.Spectral anal-yses have shown that main periods of inclination,declination and relative intensity are about 1000,2000 and4000 a;800,1640 and 3300 a;and 820,1200,2200 and 3300 a;respectively.Two excursions have beendiscovered,and the correlation between the geomagnetic intensity variations and the climatic changes hasbeen discussed.
文摘The Cosic Resonance Recognition Model (RRM) for amino acid sequences was applied to the classes of proteins displayed by four strains (Sudan, Zaire, Reston, Ivory Coast) of Ebola virus that produced either high or minimal numbers of human fatalities. The results clearly differentiated highly lethal and non-lethal strains. Solutions for the two lethal strains exhibited near ultraviolet (~230 nm) photon values while the two asymptomatic forms displayed near infrared (~1000 nm) values. Cross-correlations of spectral densities of the RRM values of the different classes of proteins associated with the genome of the viruses supported this dichotomy. The strongest coefficient occurred only between Sudan-Zaire strains but not for any of the other pairs of strains for sGP, the small glycoprotein that intercalated with the plasma cell membrane to promote insertion of viral contents into cellular space. A surprising, statistically significant cross-spectral correlation occurred between the “spike” glycoprotein component (GP1) of the virus that associated the anchoring of the virus to the mammalian cell plasma membrane and the Schumann resonance of the earth whose intensities were determined by the incidence of equatorial thunderstorms. Previous applications of the RRM to shifting photon wavelengths emitted by melanoma cells adapting to reduced ambient temperature have validated Cosic’s model and have demonstrated very narrowwave-length (about 10 nm) specificity. One possible ancillary and non-invasive treatment of people within which the fatal Ebola strains are residing would be whole body application of narrow band near-infrared light pulsed as specific physiologically-patterned sequences with sufficient radiant flux density to perfuse the entire body volume.
