为建立一种离子色谱-质谱法检测血液中γ-羟基丁酸(GHB)、氟乙酸钠、亚硝酸钠、草甘膦和草铵膦五种水溶性毒物的方法,选用AS19阴离子色谱柱进行分离,以在线产生的50 mmol/L氢氧化钠为淋洗液等度淋洗,飞行时间质谱仪作检测器,采用电喷雾...为建立一种离子色谱-质谱法检测血液中γ-羟基丁酸(GHB)、氟乙酸钠、亚硝酸钠、草甘膦和草铵膦五种水溶性毒物的方法,选用AS19阴离子色谱柱进行分离,以在线产生的50 mmol/L氢氧化钠为淋洗液等度淋洗,飞行时间质谱仪作检测器,采用电喷雾电离源负离子模式、选择离子监测模式(Selected Ion Monitor,SIM)进行分析,外标法定量。利用离子色谱-质谱法检测五种水溶性毒物简单快速、专属性强、灵敏度高,可为司法鉴定实践提供重要的科学支撑。展开更多
Nuclear magnetic resonance (NMR) is well known for its capacity to identify thestructure of chemical compounds. But, as we know, it has not yet been used in thedetection and identification of fluorine-containing toxic...Nuclear magnetic resonance (NMR) is well known for its capacity to identify thestructure of chemical compounds. But, as we know, it has not yet been used in thedetection and identification of fluorine-containing toxicants in complicated matrixes.Here some efforts were made in this area to apply this powerful technique totoxicological analysis. Sodium fluoroacetate and fluoroacetamide are two fluorine-containing rodenticidesof high toxicity. Their determination in samples related to intoxication is展开更多
文摘为建立一种离子色谱-质谱法检测血液中γ-羟基丁酸(GHB)、氟乙酸钠、亚硝酸钠、草甘膦和草铵膦五种水溶性毒物的方法,选用AS19阴离子色谱柱进行分离,以在线产生的50 mmol/L氢氧化钠为淋洗液等度淋洗,飞行时间质谱仪作检测器,采用电喷雾电离源负离子模式、选择离子监测模式(Selected Ion Monitor,SIM)进行分析,外标法定量。利用离子色谱-质谱法检测五种水溶性毒物简单快速、专属性强、灵敏度高,可为司法鉴定实践提供重要的科学支撑。
文摘Nuclear magnetic resonance (NMR) is well known for its capacity to identify thestructure of chemical compounds. But, as we know, it has not yet been used in thedetection and identification of fluorine-containing toxicants in complicated matrixes.Here some efforts were made in this area to apply this powerful technique totoxicological analysis. Sodium fluoroacetate and fluoroacetamide are two fluorine-containing rodenticidesof high toxicity. Their determination in samples related to intoxication is
文摘目的基于液相色谱-串联质谱法,建立衍生化法测定乳粉中氟乙酸钠(1080)的新方法。方法样品经水-丙酮提取,阴离子树脂净化后,由3-硝基苯胺-EDAC衍生和HLB净化处理提取,通过BEH C18色谱柱进行分离,电喷雾负离子多反应监测模式进行检测,内标法定量。结果氟乙酸钠(1080)在1.0~100.0ng/mL浓度范围内具有良好的线性,相关系数r为0.9993,检出限(limit of detection, LOD)可达到0.3μg/kg,不同添加浓度的平均回收率在99.1%~103%之间,测定结果的相对标准偏差在2.0%~6.2%之间。结论本方法准确、灵敏度高,可用于乳粉中氟乙酸钠的快速准确测定和定量分析。
