The number of traditionally excellent coastal lithologic nuclear power plants is limited.It is a trend to develop nuclear power plants on soil sites in inland areas.Therefore,the seismic safety and adaptability of non...The number of traditionally excellent coastal lithologic nuclear power plants is limited.It is a trend to develop nuclear power plants on soil sites in inland areas.Therefore,the seismic safety and adaptability of non-rock nuclear power plant(NPP)sites are the key concerns of nuclear safety researchers.Although the five site categories are clearly defined in the AP1000 design control documents,the effects of nuclear power five site conditions and soil nonlinearity on the seismic response characteristics of nuclear island buildings have not been systematically considered in previous related studies.In this study,targeting the AP1000 nuclear island structure as the research object,three-dimensional finite element models of a nuclear island structure at five types of sites(firm rock site(FR),soft rock site(SR),soft-to-medium soil site(SMS),upper bound soft-to-medium site(SMS-UB),and soft soil site(SS))are established.The partitioned analysis method of soil-structure interaction(PASSI)in the time-domain is used to investigate the effects of site hardness and nonlinearity on the acceleration,displacement,and acceleration response spectrum of the nuclear island structure under seismic excitation.The incremental equilibrium equation and explicit decoupling method are used to analyze the soil nonlinearity described by the Davidenkov model with simplified loading-reloading rules.The results show that,in the linear case,with the increase of site hardness,the peak ground acceleration(PGA)and the peak of acceleration response spectrum of the nuclear island structure increase except for the FR site,while the maximum displacement decreases.In nonlinear analysis,as the site hardness increases,the PGA,maximum displacement,and the peak of acceleration response spectrum of the nuclear island structure increase.The peak value of the acceleration response spectrum in the nonlinear case is greater than that in the linear case for FR,while smaller for SR and soil sites.The site nonlinearity reduces the peak values of the response spec展开更多
Integration of oncogenic DNA viruses into the human genome is a key step in most virusinduced carcinogenesis.Here,we constructed a virus integration site(VIS)Atlas database,an extensive collection of integration break...Integration of oncogenic DNA viruses into the human genome is a key step in most virusinduced carcinogenesis.Here,we constructed a virus integration site(VIS)Atlas database,an extensive collection of integration breakpoints for three most prevalent oncoviruses,human papillomavirus,hepatitis B virus,and Epstein-Barr virus based on the next-generation sequencing(NGS)data,literature,and experimental data.There are 63,179 breakpoints and 47,411 junctional sequences with full annotations deposited in the VIS Atlas database,comprising 47 virus genotypes and 17 disease types.The VIS Atlas database provides(1)a genome browser for NGS breakpoint quality check,visualization of VISs,and the local genomic context;(2)a novel platform to discover integration patterns;and(3)a statistics interface for a comprehensive investigation of genotypespecific integration features.Data collected in the VIS Atlas aid to provide insights into virus pathogenic mechanisms and the development of novel antitumor drugs.展开更多
基金National Natural Science Foundation of China under Grant Nos.51978337 and U2039209。
文摘The number of traditionally excellent coastal lithologic nuclear power plants is limited.It is a trend to develop nuclear power plants on soil sites in inland areas.Therefore,the seismic safety and adaptability of non-rock nuclear power plant(NPP)sites are the key concerns of nuclear safety researchers.Although the five site categories are clearly defined in the AP1000 design control documents,the effects of nuclear power five site conditions and soil nonlinearity on the seismic response characteristics of nuclear island buildings have not been systematically considered in previous related studies.In this study,targeting the AP1000 nuclear island structure as the research object,three-dimensional finite element models of a nuclear island structure at five types of sites(firm rock site(FR),soft rock site(SR),soft-to-medium soil site(SMS),upper bound soft-to-medium site(SMS-UB),and soft soil site(SS))are established.The partitioned analysis method of soil-structure interaction(PASSI)in the time-domain is used to investigate the effects of site hardness and nonlinearity on the acceleration,displacement,and acceleration response spectrum of the nuclear island structure under seismic excitation.The incremental equilibrium equation and explicit decoupling method are used to analyze the soil nonlinearity described by the Davidenkov model with simplified loading-reloading rules.The results show that,in the linear case,with the increase of site hardness,the peak ground acceleration(PGA)and the peak of acceleration response spectrum of the nuclear island structure increase except for the FR site,while the maximum displacement decreases.In nonlinear analysis,as the site hardness increases,the PGA,maximum displacement,and the peak of acceleration response spectrum of the nuclear island structure increase.The peak value of the acceleration response spectrum in the nonlinear case is greater than that in the linear case for FR,while smaller for SR and soil sites.The site nonlinearity reduces the peak values of the response spec
基金supported by the National Science and Technology Major Project of the Ministry of Science and Technology of China(Grant No.2018ZX10301402)the National Natural Science Foundation of China(Grant No.81761148025)+6 种基金the Major Projects of Guangzhou Science and Technology Bureau,China(Grant No.201704020093)the National Ten Thousands Plan for Young Top Talents,Young Pearl River Scholar,International Cooperation and Exchange Projects of the National Natural Science Foundation of China(China&Russian)(Grant No.17-54-80078)the Major Projects of Wuhan Municipal Health Commission of China(Grant No.WX19M02)the Major Projects of Hubei Provincial Health Commission of China(Grant No.WJ2019H312)the Dongguan Social Development Key Project of China(Grant No.202050715007221)the Regional Joint Fund Project of Guangdong Basic and Applied Basic Research Foundation of China(Regional Cultivation Project,Grant No.2021B1515140063)the Dongguan Social Development Key Project of China(Grant No.20221800905772).
文摘Integration of oncogenic DNA viruses into the human genome is a key step in most virusinduced carcinogenesis.Here,we constructed a virus integration site(VIS)Atlas database,an extensive collection of integration breakpoints for three most prevalent oncoviruses,human papillomavirus,hepatitis B virus,and Epstein-Barr virus based on the next-generation sequencing(NGS)data,literature,and experimental data.There are 63,179 breakpoints and 47,411 junctional sequences with full annotations deposited in the VIS Atlas database,comprising 47 virus genotypes and 17 disease types.The VIS Atlas database provides(1)a genome browser for NGS breakpoint quality check,visualization of VISs,and the local genomic context;(2)a novel platform to discover integration patterns;and(3)a statistics interface for a comprehensive investigation of genotypespecific integration features.Data collected in the VIS Atlas aid to provide insights into virus pathogenic mechanisms and the development of novel antitumor drugs.
