The emphasis on the simplification of cognitive and motor tasks by recent results of morphological computation has rendered possible the construction of appropriate“mimetic bodies”able to render accompanied computat...The emphasis on the simplification of cognitive and motor tasks by recent results of morphological computation has rendered possible the construction of appropriate“mimetic bodies”able to render accompanied computations simpler,according to a general appeal to the“simplexity”of animal embodied cognition.A new activity of what we can call“distributed computation”holds the promise of originating a new generation of robots with better adaptability and restricted number of required control parameters.The framework of distributed computation helps us see them in a more naturalized and prudent perspective,avoiding ontological or metaphysical considerations.Despite these progresses,there are still problems regarding the epistemological limitations of computational modeling remain to be solved.展开更多
Viral-mediated gene transfer of thymidine kinase ofherpes simplex virus (HSV-tk) has been used to confercytotoxic sensitivity to ganciclovir (GCV) in a variety oftnmor cells. HSV-tk converts GCV into a phosphorylatedc...Viral-mediated gene transfer of thymidine kinase ofherpes simplex virus (HSV-tk) has been used to confercytotoxic sensitivity to ganciclovir (GCV) in a variety oftnmor cells. HSV-tk converts GCV into a phosphorylatedcompound which is toxic for dividing cells by blockingDNA synthesis. Our previous study has shown展开更多
Herpes simplex virus （HSV）, a member of the Herpesviridae family, is a significant human pathogen that results in mucocutaneous lesions in the oral cavity or genital infections. Acyclovir （ACV） and related nucleos...Herpes simplex virus （HSV）, a member of the Herpesviridae family, is a significant human pathogen that results in mucocutaneous lesions in the oral cavity or genital infections. Acyclovir （ACV） and related nucleoside analogues can successfully treat HSV infections, but the emergence of drug resistance to ACV has created a barrier for the treatment of HSV infections, especially in immunocompromised patients. There is an urgent need to explore new and effective tactics to circumvent drug resistance to HSV. This review summarises the current strategies in the development of new targets （the DNA helicase/primase （H/P） complex）, new types of molecules （nature products） and new antiviral mechanisms （lethal mutagenesis of Janus-type nucleosides） to fight the drug resistance of HSV.展开更多
文摘The emphasis on the simplification of cognitive and motor tasks by recent results of morphological computation has rendered possible the construction of appropriate“mimetic bodies”able to render accompanied computations simpler,according to a general appeal to the“simplexity”of animal embodied cognition.A new activity of what we can call“distributed computation”holds the promise of originating a new generation of robots with better adaptability and restricted number of required control parameters.The framework of distributed computation helps us see them in a more naturalized and prudent perspective,avoiding ontological or metaphysical considerations.Despite these progresses,there are still problems regarding the epistemological limitations of computational modeling remain to be solved.
文摘Viral-mediated gene transfer of thymidine kinase ofherpes simplex virus (HSV-tk) has been used to confercytotoxic sensitivity to ganciclovir (GCV) in a variety oftnmor cells. HSV-tk converts GCV into a phosphorylatedcompound which is toxic for dividing cells by blockingDNA synthesis. Our previous study has shown
基金the National Natural Science Foundations of China(document no.:81321002,81500860,81300888)a grant from 111 Project of Ministry of Education,China,for fi nancial support
文摘Herpes simplex virus （HSV）, a member of the Herpesviridae family, is a significant human pathogen that results in mucocutaneous lesions in the oral cavity or genital infections. Acyclovir （ACV） and related nucleoside analogues can successfully treat HSV infections, but the emergence of drug resistance to ACV has created a barrier for the treatment of HSV infections, especially in immunocompromised patients. There is an urgent need to explore new and effective tactics to circumvent drug resistance to HSV. This review summarises the current strategies in the development of new targets （the DNA helicase/primase （H/P） complex）, new types of molecules （nature products） and new antiviral mechanisms （lethal mutagenesis of Janus-type nucleosides） to fight the drug resistance of HSV.
