丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)是一组能被不同的细胞外刺激物如细胞因子、神经递质、激素等激活的丝氨酸/苏氨酸蛋白激酶,可分为p38、ERK、JNK和ERK5四个亚族,分别行使不同功能。MAPK信号通路对于研究疾...丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)是一组能被不同的细胞外刺激物如细胞因子、神经递质、激素等激活的丝氨酸/苏氨酸蛋白激酶,可分为p38、ERK、JNK和ERK5四个亚族,分别行使不同功能。MAPK信号通路对于研究疾病的发病机制并采取相应的阻断方法进行疾病诊疗具有重要的应用价值。本文对中药调控MAPK信号通路在疾病治疗中的最新研究进展进行综述。展开更多
The tripartite motif-containing （TRIM） proteins represent the largest E3 ubiquitin Ugase family. The multifaceted roles of TRIM38 in innate immunity and inflammation have been intensively investigated in recent year...The tripartite motif-containing （TRIM） proteins represent the largest E3 ubiquitin Ugase family. The multifaceted roles of TRIM38 in innate immunity and inflammation have been intensively investigated in recent years. TRIM38 is essential for cytosolic RNA or DNA sensor-mediated innate immune responses to both RNA and DNA viruses, while negatively regulating TLR3/4- and TNF/IL-1β-triggered inflammatory responses. In these processes, TRIM38 acts as an E3 ubiquitin or SUMO ligase, which targets key cellular signaling components, or as an enzymatic activity-independent regulator. This review summarizes recent advances that highlight the critical roles of TRIM38 in the reeulation of Droner innate immune and inflammatorv responses.展开更多
文摘丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)是一组能被不同的细胞外刺激物如细胞因子、神经递质、激素等激活的丝氨酸/苏氨酸蛋白激酶,可分为p38、ERK、JNK和ERK5四个亚族,分别行使不同功能。MAPK信号通路对于研究疾病的发病机制并采取相应的阻断方法进行疾病诊疗具有重要的应用价值。本文对中药调控MAPK信号通路在疾病治疗中的最新研究进展进行综述。
基金We thank members of the Shu laboratory for helpful discussions. The work in the authors＇ laboratory is supported by grants from the Ministry of Science and Technology of China （2016YFA0502102, 2014CB910103）, the National Natural Science Foundation of China （3163000013, 31521091, and 91429304） and National Postdoctoral Program for Innovative Talents （BX201600116）.
文摘The tripartite motif-containing （TRIM） proteins represent the largest E3 ubiquitin Ugase family. The multifaceted roles of TRIM38 in innate immunity and inflammation have been intensively investigated in recent years. TRIM38 is essential for cytosolic RNA or DNA sensor-mediated innate immune responses to both RNA and DNA viruses, while negatively regulating TLR3/4- and TNF/IL-1β-triggered inflammatory responses. In these processes, TRIM38 acts as an E3 ubiquitin or SUMO ligase, which targets key cellular signaling components, or as an enzymatic activity-independent regulator. This review summarizes recent advances that highlight the critical roles of TRIM38 in the reeulation of Droner innate immune and inflammatorv responses.
