Phosphorus is one of the macronutrients essential for plant growth and development. Many soils around the world are deficient in phosphate （Pi） which is the form of phosphorus that plants can absorb and utilize. To ...Phosphorus is one of the macronutrients essential for plant growth and development. Many soils around the world are deficient in phosphate （Pi） which is the form of phosphorus that plants can absorb and utilize. To cope with the stress of Pi starvation, plants have evolved many elaborate strategies to enhance the acquisition and utilization of Pi from the environment. These strategies include morphological, biochemical and physiological responses which ultimately enable plants to better survive under low Pi conditions. Though these adaptive responses have been well described because of their ecological and agricultural importance, our studies on the molecular mechanisms underlying these responses are still in their infancy. In the last decade, significant progresses have been made towards the identification of the molecular components which are involved in the control of plant responses to Pi starvation. In this article, we first provide an overview of some major responses of plants to Pi starvation, then summarize what we have known so far about the signaling components involved in these responses, as well as the roles of sugar and phytohormones.展开更多
促分裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)是细胞浆内一类高度保守的丝氨酸蛋白激酶,其介导的信号转导通路在机体的炎性反应中发挥重大作用.他与炎症性肠病(inflammatory bowel diseases,IBD关系密切,不仅参与IBD...促分裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)是细胞浆内一类高度保守的丝氨酸蛋白激酶,其介导的信号转导通路在机体的炎性反应中发挥重大作用.他与炎症性肠病(inflammatory bowel diseases,IBD关系密切,不仅参与IBD炎性介质的调节,还参与调控IBD发病发展相关基因.本文综述了MAPK信号通路在IBD发病机制中的作用,旨在为IBD的诊治研究提供新的思路.展开更多
脓毒症高致死率使其成为人类健康的重大威胁,其发病机制尚未完全明确,已知免疫失衡是其主要发病机制之一。高迁移率族蛋白B1(High Mobility Group Box1 Protein,HMGB1)是致免疫失衡的关键因子,有RAGE、TLRs和CD24等多种受体,可通过与受...脓毒症高致死率使其成为人类健康的重大威胁,其发病机制尚未完全明确,已知免疫失衡是其主要发病机制之一。高迁移率族蛋白B1(High Mobility Group Box1 Protein,HMGB1)是致免疫失衡的关键因子,有RAGE、TLRs和CD24等多种受体,可通过与受体结合,介导多种信号转导通路,从而发挥免疫调节功能。中药以单体和复方治疗脓毒症均取得一定进展,有待进一步结合现代医学共同应对脓毒症挑战。展开更多
文摘Phosphorus is one of the macronutrients essential for plant growth and development. Many soils around the world are deficient in phosphate （Pi） which is the form of phosphorus that plants can absorb and utilize. To cope with the stress of Pi starvation, plants have evolved many elaborate strategies to enhance the acquisition and utilization of Pi from the environment. These strategies include morphological, biochemical and physiological responses which ultimately enable plants to better survive under low Pi conditions. Though these adaptive responses have been well described because of their ecological and agricultural importance, our studies on the molecular mechanisms underlying these responses are still in their infancy. In the last decade, significant progresses have been made towards the identification of the molecular components which are involved in the control of plant responses to Pi starvation. In this article, we first provide an overview of some major responses of plants to Pi starvation, then summarize what we have known so far about the signaling components involved in these responses, as well as the roles of sugar and phytohormones.
文摘促分裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)是细胞浆内一类高度保守的丝氨酸蛋白激酶,其介导的信号转导通路在机体的炎性反应中发挥重大作用.他与炎症性肠病(inflammatory bowel diseases,IBD关系密切,不仅参与IBD炎性介质的调节,还参与调控IBD发病发展相关基因.本文综述了MAPK信号通路在IBD发病机制中的作用,旨在为IBD的诊治研究提供新的思路.
文摘脓毒症高致死率使其成为人类健康的重大威胁,其发病机制尚未完全明确,已知免疫失衡是其主要发病机制之一。高迁移率族蛋白B1(High Mobility Group Box1 Protein,HMGB1)是致免疫失衡的关键因子,有RAGE、TLRs和CD24等多种受体,可通过与受体结合,介导多种信号转导通路,从而发挥免疫调节功能。中药以单体和复方治疗脓毒症均取得一定进展,有待进一步结合现代医学共同应对脓毒症挑战。
