The relationship between the severity of dengue infection and allergy is still obscure. We conducted an electronic search across 12 databases for relevant articles reporting allergic symptoms, dengue infection, and de...The relationship between the severity of dengue infection and allergy is still obscure. We conducted an electronic search across 12 databases for relevant articles reporting allergic symptoms, dengue infection, and dengue classification. These studies were categorized according to dengue severity and allergy symptoms, and a meta-analysis was performed by pooling the studies in each category. Among the included 57 articles, pruritus was the most common allergic sign followed by non-specified allergy and asthma(28.6%, 13%, and 6.5%, respectively). Despite the reported significant association of dengue with pruritus and total Ig E level(P \ 0.05), in comparison with non-dengue cases and healthy controls, there was no association between the different severe dengue group with pruritus, skin allergy, food allergy or asthma. However,removing the largest study revealed a significant association between asthma with dengue hemorrhagic fever(DHF) rather than dengue fever(DF). In comparison with DF, DHF was associated with Ig E positivity. Furthermore, specific-Ig E level was higher in secondary DF rather than primary DF. There was a possible association between allergy symptoms and dengue severity progression. Further studies are needed to clarify this association.展开更多
目的：探析急诊抢救重症哮喘，联合小剂量肾上腺素治疗的疗效。方法随机选取92例重症哮喘患者，男48例，女44例，平均年龄（36．9±2．3）岁，根据患者急诊抢救使用的治疗方法，以随机数字法均分为观察组、对照组。急诊入院后对照...目的：探析急诊抢救重症哮喘，联合小剂量肾上腺素治疗的疗效。方法随机选取92例重症哮喘患者，男48例，女44例，平均年龄（36．9±2．3）岁，根据患者急诊抢救使用的治疗方法，以随机数字法均分为观察组、对照组。急诊入院后对照组患者给予常规急诊抢救方案（氨茶碱联合甲强龙）。观察组采用联合小剂量肾上腺素治疗，累计肾上腺素总量不超过1 mg。观察并记录两组患者治疗前与、治疗期间、治疗成功后的血氧饱和度、心率、呼吸等临床症状体征变化及改善情况。结果（1）①治疗前至30 min 末，对照组、观察组的呼吸频率（RR）、心率（HR）、症状评分均呈显著下降趋势，血氧饱和度（SaO2）均呈显著上升趋势（对照组 P ＜0．05；观察组 P ＜0．05）；②治疗30 min 末各观察指标组间比较：RR、HR、症状评分，观察组显著低于对照组；观察组 SaO2显著高于对照组 P ＜0．01。（2）①治疗10～30 min 末，两组患者治疗总有效率呈上升趋势，对照组 P＝0．001；观察组 P ＝0．007；组间比较30 min 末观察组总有效率显著高于对照组 P ＜0．05；②治疗有效率与 RR、HR、症状评分、SaO2相关系数，观察组分别为：－0．952、－0．934、－0．996、0．997，P ＜0．001；对照组分别为：－0．959、0．865、0．896、－0．986，P ＜0．001。结论在急诊抢救重症哮喘患者的治疗中，联合小剂量肾上腺素效果较常规氨茶碱联合甲强龙治疗方法，起效快且更能发挥良好的止咳、解痉、舒张平滑肌、降低毛细管通透性等治疗效果，对 SaO2的改善更能起到正性积极作用，相关药物不良反应低，且能耐受，安全性较好，值得推广。展开更多
文摘The relationship between the severity of dengue infection and allergy is still obscure. We conducted an electronic search across 12 databases for relevant articles reporting allergic symptoms, dengue infection, and dengue classification. These studies were categorized according to dengue severity and allergy symptoms, and a meta-analysis was performed by pooling the studies in each category. Among the included 57 articles, pruritus was the most common allergic sign followed by non-specified allergy and asthma(28.6%, 13%, and 6.5%, respectively). Despite the reported significant association of dengue with pruritus and total Ig E level(P \ 0.05), in comparison with non-dengue cases and healthy controls, there was no association between the different severe dengue group with pruritus, skin allergy, food allergy or asthma. However,removing the largest study revealed a significant association between asthma with dengue hemorrhagic fever(DHF) rather than dengue fever(DF). In comparison with DF, DHF was associated with Ig E positivity. Furthermore, specific-Ig E level was higher in secondary DF rather than primary DF. There was a possible association between allergy symptoms and dengue severity progression. Further studies are needed to clarify this association.
文摘目的：探析急诊抢救重症哮喘，联合小剂量肾上腺素治疗的疗效。方法随机选取92例重症哮喘患者，男48例，女44例，平均年龄（36．9±2．3）岁，根据患者急诊抢救使用的治疗方法，以随机数字法均分为观察组、对照组。急诊入院后对照组患者给予常规急诊抢救方案（氨茶碱联合甲强龙）。观察组采用联合小剂量肾上腺素治疗，累计肾上腺素总量不超过1 mg。观察并记录两组患者治疗前与、治疗期间、治疗成功后的血氧饱和度、心率、呼吸等临床症状体征变化及改善情况。结果（1）①治疗前至30 min 末，对照组、观察组的呼吸频率（RR）、心率（HR）、症状评分均呈显著下降趋势，血氧饱和度（SaO2）均呈显著上升趋势（对照组 P ＜0．05；观察组 P ＜0．05）；②治疗30 min 末各观察指标组间比较：RR、HR、症状评分，观察组显著低于对照组；观察组 SaO2显著高于对照组 P ＜0．01。（2）①治疗10～30 min 末，两组患者治疗总有效率呈上升趋势，对照组 P＝0．001；观察组 P ＝0．007；组间比较30 min 末观察组总有效率显著高于对照组 P ＜0．05；②治疗有效率与 RR、HR、症状评分、SaO2相关系数，观察组分别为：－0．952、－0．934、－0．996、0．997，P ＜0．001；对照组分别为：－0．959、0．865、0．896、－0．986，P ＜0．001。结论在急诊抢救重症哮喘患者的治疗中，联合小剂量肾上腺素效果较常规氨茶碱联合甲强龙治疗方法，起效快且更能发挥良好的止咳、解痉、舒张平滑肌、降低毛细管通透性等治疗效果，对 SaO2的改善更能起到正性积极作用，相关药物不良反应低，且能耐受，安全性较好，值得推广。
