The underlying patterns of sensory perceptions towards ciothing comfort performance were investigated by ex. posing thirty - eight healthy human subjects to exercise in a cold environmental condition: 14℃ and 32％ RH...The underlying patterns of sensory perceptions towards ciothing comfort performance were investigated by ex. posing thirty - eight healthy human subjects to exercise in a cold environmental condition: 14℃ and 32％ RH. The air velocity was 0.25 m/s. Each trial lasted 80 minutes, during which two T - shirts were worn successlvely by a subject. The preferences over the T - shirts by handling were determined before the test, and ratings of sensory perception during wear were recorded every ten minutes by means of questionnaires. Nineteen sensory descrlpters were selected on the basis of previous consumer survey study. By factor analysis and variable clus. tering analysis, it was found that the 19 sensory descriptors could be grouped into three factors: Factor 1 - thermal and moisture sensations: sultry, damp, clammy, clingy, hot, cold and nonabsorbent; Factor 2 - tactile sensations: prickly, scratchy, rough, itchy and statieky; Factor 3 - pressure sensations: snug, loose, heavy, lightweight, soft and展开更多
Neurotrophins play a major role in the regulation of neuronal growth such as neurite sprouting or regeneration in response to nerve injuries. The role of nerve growth factor, neurotrophin-3, and brain-derived neurotro...Neurotrophins play a major role in the regulation of neuronal growth such as neurite sprouting or regeneration in response to nerve injuries. The role of nerve growth factor, neurotrophin-3, and brain-derived neurotrophic factor in maintaining the survival of peripheral neurons remains poorly understood. In regenerative medicine, different modalities have been investigated for the delivery of growth factors to the injured neurons, in search of a suitable system for clinical applications. This study was to investigate the influence of nerve growth factor, neurotrophin-3 and brain-derived neurotrophic factor on the growth of neurites using two in vitro models of dorsal root ganglia explants and dorsal root ganglia-derived primary cell dissociated cultures. Quantitative data showed that the total neurite length and tortuosity were differently influenced by trophic factors. Nerve growth factor and, indirectly, brain-derived neurotrophic factor stimulate the tortuous growth of sensory fibers and the formation of cell clusters. Neurotrophin-3, however, enhances neurite growth in terms of length and linearity allowing for a more organized and directed axonal elongation towards a peripheral target compared to the other growth factors. These findings could be of considerable importance for any clinical application of neurotrophic factors in peripheral nerve regeneration. Ethical approval was obtained from the Regione Piemonte Animal Ethics Committee ASLTO1(file # 864/2016-PR) on September 14, 2016.展开更多
文摘The underlying patterns of sensory perceptions towards ciothing comfort performance were investigated by ex. posing thirty - eight healthy human subjects to exercise in a cold environmental condition: 14℃ and 32％ RH. The air velocity was 0.25 m/s. Each trial lasted 80 minutes, during which two T - shirts were worn successlvely by a subject. The preferences over the T - shirts by handling were determined before the test, and ratings of sensory perception during wear were recorded every ten minutes by means of questionnaires. Nineteen sensory descrlpters were selected on the basis of previous consumer survey study. By factor analysis and variable clus. tering analysis, it was found that the 19 sensory descriptors could be grouped into three factors: Factor 1 - thermal and moisture sensations: sultry, damp, clammy, clingy, hot, cold and nonabsorbent; Factor 2 - tactile sensations: prickly, scratchy, rough, itchy and statieky; Factor 3 - pressure sensations: snug, loose, heavy, lightweight, soft and
基金supported by the research start-up and the MWU’s intramural grant(to MF)the Italian MURST-MIUR foundation(to SG and IP)
文摘Neurotrophins play a major role in the regulation of neuronal growth such as neurite sprouting or regeneration in response to nerve injuries. The role of nerve growth factor, neurotrophin-3, and brain-derived neurotrophic factor in maintaining the survival of peripheral neurons remains poorly understood. In regenerative medicine, different modalities have been investigated for the delivery of growth factors to the injured neurons, in search of a suitable system for clinical applications. This study was to investigate the influence of nerve growth factor, neurotrophin-3 and brain-derived neurotrophic factor on the growth of neurites using two in vitro models of dorsal root ganglia explants and dorsal root ganglia-derived primary cell dissociated cultures. Quantitative data showed that the total neurite length and tortuosity were differently influenced by trophic factors. Nerve growth factor and, indirectly, brain-derived neurotrophic factor stimulate the tortuous growth of sensory fibers and the formation of cell clusters. Neurotrophin-3, however, enhances neurite growth in terms of length and linearity allowing for a more organized and directed axonal elongation towards a peripheral target compared to the other growth factors. These findings could be of considerable importance for any clinical application of neurotrophic factors in peripheral nerve regeneration. Ethical approval was obtained from the Regione Piemonte Animal Ethics Committee ASLTO1(file # 864/2016-PR) on September 14, 2016.
