Three novel transition metal complexes [ML2（phen）]＇H20 （M= Mn, Co, Zn; HL= C10H702NSe, 2-phenyl-4-selenazole carboxylic acid, phen= 1,10-phenanthroline） 1-3 were synthesized and characterized by elemental analysi...Three novel transition metal complexes [ML2（phen）]＇H20 （M= Mn, Co, Zn; HL= C10H702NSe, 2-phenyl-4-selenazole carboxylic acid, phen= 1,10-phenanthroline） 1-3 were synthesized and characterized by elemental analysis, IR spectra. Their crystal structures were deterimined by single-crystal X-ray diffraction method. The antibacterial activities of the complexes against five species of bacteria, Escherichia coli （E. coli）, Staphylococcus epidermidis （S. epidermidis）, Staphylococcus aureus （S. au- reus）, Acinetobacter baumanii （A. baumanii） and Streptococcus viridans （S. viridans）, were tested respectively. The anticancer activities of the complexes against human pancreatic cancer line PANC-28 and human hepatocarcinoma line HuH7 were also studied. The interactions between the complexes and DNA were studied by ethidium bromide （EB） fluorescent probe.展开更多
Sodium fluoride was found to be a simple, mild and efficient catalyst for the synthesis of 2,4- disuhstituted 1,3-thiazoles and selenazoles utilizing phenacyl bromides/3-（2-bromoacetyl）-2H-chro- men-2-one and thiour...Sodium fluoride was found to be a simple, mild and efficient catalyst for the synthesis of 2,4- disuhstituted 1,3-thiazoles and selenazoles utilizing phenacyl bromides/3-（2-bromoacetyl）-2H-chro- men-2-one and thioureaJphenylthiourea/selenourea in aqueous methanol at ambient temperature. Analytically pure products are formed within 1-3 rain in excellent yields.展开更多
基金financially supported by Natural Science Foundation of Zhejiang Province (Y4080256)
文摘Three novel transition metal complexes [ML2（phen）]＇H20 （M= Mn, Co, Zn; HL= C10H702NSe, 2-phenyl-4-selenazole carboxylic acid, phen= 1,10-phenanthroline） 1-3 were synthesized and characterized by elemental analysis, IR spectra. Their crystal structures were deterimined by single-crystal X-ray diffraction method. The antibacterial activities of the complexes against five species of bacteria, Escherichia coli （E. coli）, Staphylococcus epidermidis （S. epidermidis）, Staphylococcus aureus （S. au- reus）, Acinetobacter baumanii （A. baumanii） and Streptococcus viridans （S. viridans）, were tested respectively. The anticancer activities of the complexes against human pancreatic cancer line PANC-28 and human hepatocarcinoma line HuH7 were also studied. The interactions between the complexes and DNA were studied by ethidium bromide （EB） fluorescent probe.
基金the Ministry of Human Resource Development for their support
文摘Sodium fluoride was found to be a simple, mild and efficient catalyst for the synthesis of 2,4- disuhstituted 1,3-thiazoles and selenazoles utilizing phenacyl bromides/3-（2-bromoacetyl）-2H-chro- men-2-one and thioureaJphenylthiourea/selenourea in aqueous methanol at ambient temperature. Analytically pure products are formed within 1-3 rain in excellent yields.
