Both external and endogenous electrical fields widely exist in the environment of cortical neurons. The effects of a weak alternating current （AC） field on a neural network model with synaptic plasticity are studied...Both external and endogenous electrical fields widely exist in the environment of cortical neurons. The effects of a weak alternating current （AC） field on a neural network model with synaptic plasticity are studied. It is found that self-sustained rhythmic firing patterns, which are closely correlated with the cognitive functions, are significantly modified due to the self-organizing of the network in the weak AC field. The activities of the neural networks are affected by the synaptic connection strength, the exterrtal stimuli, and so on. In the presence of learning rules, the synaptic connections can be modulated by the external stimuli, which will further enhance the sensitivity of the network to the external signal. The properties of the external AC stimuli can serve as control parameters in modulating the evolution of the neural network.展开更多
目的研究A型肉毒杆菌毒素(botulinum toxin,BTX-A)对青年磨牙患者的临床治疗效果。方法选取2020年9月至2022年3月浙江树人大学树兰国际医学院附属树兰(杭州)医院接诊的42例夜磨牙症患者,采用随机数字表法分为对照组(n=21)和试验组(n=21...目的研究A型肉毒杆菌毒素(botulinum toxin,BTX-A)对青年磨牙患者的临床治疗效果。方法选取2020年9月至2022年3月浙江树人大学树兰国际医学院附属树兰(杭州)医院接诊的42例夜磨牙症患者,采用随机数字表法分为对照组(n=21)和试验组(n=21)。治疗前对两组进行多导睡眠监测和疼痛视觉模拟评分(visual analog scale,VAS)评估,试验组咬肌区注射BTX-A,对照组咬肌区注射生理盐水,注射4周后再次进行多导睡眠监测和疼痛评估,比较两组治疗前后多导睡眠监测参数、咀嚼肌节律性运动(rhythmic masticatory muscle activity,RMMA)事件参数、疼痛水平和不良反应情况。结果注射4周后,两组多导睡眠监测参数比较,差异均无统计学意义(P>0.05)。试验组患者咀嚼肌节律性运动发作期间咬肌肌电爆发的峰值幅度(peak amplitude of electromyography burst in the masseter muscle during rhythmic masticatory muscle activity,RMMA.MA)及咬肌最大自主收缩时咬肌肌电爆发的峰值幅度(peak amplitude of electromyography burst in the masseter muscle during maximal voluntary clenching,MVC.MA)均低于对照组,差异均有统计学意义(P<0.05)。两组VAS均低于注射前且试验组低于对照组,差异均有统计学意义(P<0.05)。两组均未报告吞咽困难或咀嚼不良事件。结论A型肉毒杆菌毒素注射不能减少夜磨牙的发生,但其通过降低咬肌的强度能缓解夜磨牙症的牙齿磨损和咬肌酸痛,但长期效果仍需进一步观察。展开更多
目的：探讨孕期酒精暴露对子代新生大鼠延髓脑片基本节律性呼吸放电（rhythmic respiratory discharge activity, RRDA）的作用。方法制作包含面神经后核内侧区（the medial region of the nucleus retrofacialis, mNRF）并保留舌下神...目的：探讨孕期酒精暴露对子代新生大鼠延髓脑片基本节律性呼吸放电（rhythmic respiratory discharge activity, RRDA）的作用。方法制作包含面神经后核内侧区（the medial region of the nucleus retrofacialis, mNRF）并保留舌下神经根的新生大鼠离体延髓脑片标本，给予灌流改良的Kreb＇s液（modified Kreb＇s solution, MKS），使用吸附电极记录延髓脑片腹侧面舌下神经根RRDA，分析RRDA的变化。实验分为5组：对照组、4%酒精暴露组、6%酒精暴露组、8%酒精暴露组和10%酒精暴露组，研究孕期不同浓度酒精暴露对RRDA的作用。结果对照组、4%酒精暴露组、6%酒精暴露组、8%酒精暴露组各组组内RRDA在50 min内吸气时程（TI）、呼吸频率（RF）、放电积分幅度（IA）无统计学差异，10%酒精暴露组RRDA节律不规整；与对照组相比，4%-10%酒精暴露组的RRDA随酒精浓度增加逐渐降低，TI缩短、RF下降、IA减弱。结论孕期酒精暴露抑制子代新生大鼠延髓脑片舌下神经根RRDA，这可能是孕期酒精暴露抑制子代呼吸功能的基础。展开更多
基金Project supported by the National Natural Science Foundation of China (Grant Nos. 61072012, 60901035, 50907044, and 61172009)
文摘Both external and endogenous electrical fields widely exist in the environment of cortical neurons. The effects of a weak alternating current （AC） field on a neural network model with synaptic plasticity are studied. It is found that self-sustained rhythmic firing patterns, which are closely correlated with the cognitive functions, are significantly modified due to the self-organizing of the network in the weak AC field. The activities of the neural networks are affected by the synaptic connection strength, the exterrtal stimuli, and so on. In the presence of learning rules, the synaptic connections can be modulated by the external stimuli, which will further enhance the sensitivity of the network to the external signal. The properties of the external AC stimuli can serve as control parameters in modulating the evolution of the neural network.
文摘目的研究A型肉毒杆菌毒素(botulinum toxin,BTX-A)对青年磨牙患者的临床治疗效果。方法选取2020年9月至2022年3月浙江树人大学树兰国际医学院附属树兰(杭州)医院接诊的42例夜磨牙症患者,采用随机数字表法分为对照组(n=21)和试验组(n=21)。治疗前对两组进行多导睡眠监测和疼痛视觉模拟评分(visual analog scale,VAS)评估,试验组咬肌区注射BTX-A,对照组咬肌区注射生理盐水,注射4周后再次进行多导睡眠监测和疼痛评估,比较两组治疗前后多导睡眠监测参数、咀嚼肌节律性运动(rhythmic masticatory muscle activity,RMMA)事件参数、疼痛水平和不良反应情况。结果注射4周后,两组多导睡眠监测参数比较,差异均无统计学意义(P>0.05)。试验组患者咀嚼肌节律性运动发作期间咬肌肌电爆发的峰值幅度(peak amplitude of electromyography burst in the masseter muscle during rhythmic masticatory muscle activity,RMMA.MA)及咬肌最大自主收缩时咬肌肌电爆发的峰值幅度(peak amplitude of electromyography burst in the masseter muscle during maximal voluntary clenching,MVC.MA)均低于对照组,差异均有统计学意义(P<0.05)。两组VAS均低于注射前且试验组低于对照组,差异均有统计学意义(P<0.05)。两组均未报告吞咽困难或咀嚼不良事件。结论A型肉毒杆菌毒素注射不能减少夜磨牙的发生,但其通过降低咬肌的强度能缓解夜磨牙症的牙齿磨损和咬肌酸痛,但长期效果仍需进一步观察。
