An organic compound exhibiting simultaneously reversible switch between its emission colors and luminescence mechanisms,possessing high contrast from deep blue normal fluorescence(NF) to yellow thermally activated del...An organic compound exhibiting simultaneously reversible switch between its emission colors and luminescence mechanisms,possessing high contrast from deep blue normal fluorescence(NF) to yellow thermally activated delayed fluorescence(TADF),is reported. Based on these two complementary colors, white-light emission combining NF and TADF from a single compound can be achieved in various states. Experimental results and density functional theory calculations indicate that the controllable conformational distribution under thermal and mechanical activation is the mechanism responsible for the reversible switching behavior.展开更多
To report early imaging assessment of ablated area post electrochemotherapy (ECT) in patients with locally advanced pancreatic cancer (LAPC). METHODSECT was performed in 19 LAPC patients enrolled in an approved ongoin...To report early imaging assessment of ablated area post electrochemotherapy (ECT) in patients with locally advanced pancreatic cancer (LAPC). METHODSECT was performed in 19 LAPC patients enrolled in an approved ongoing clinical phase I/II study. Before and after ECT, 18 patients underwent computed tomography (CT) scan, 11 patients underwent morphological and functional magnetic resonance (MR) scan (dynamic contrast enhanced-MRI) calculating wash-in slope (WIS) and wash-out slope (WOS); diffusion weighted imaging calculating pseudo-diffusivity (Dp), perfusion fraction (fp) and tissue diffusivity (Dt); 10 patients underwent positron emission tomography (PET). Response evaluation criteria in solid tumour (RECIST) on MR and CT were used to assess tumour therapy response. Choi on CT, PET response criteria in solid tumors (PERCIST) on PET and functional parameters on MR were used to evaluate treatment response. RESULTSFor each patient no significant reduction was measurable by CT and MR using RECIST. According Choi criteria a partial response was obtained in 18/18 (100.0%) patients. According PERCIST criteria 6/10 (60.0%) patients showed a partial response, 3/10 (30.0%) stable disease and 1/10 (10.0%) progression disease. Moreover, using functional MR parameters, a significant reduction of viable tumour after ECT can be observed. According ΔWIS and ΔWOS 9/11 (81.8%) patients exhibited a partial response and 2/11 (18.2%) stable disease; 8/11 (72.7%) patients were considered in partial response by ΔDp evaluation and 3/11 (27.3%) in stable disease; according ΔDt 7/11 (63.6%) patients showed a partial response, 1/11 (9.1%) showed progression of disease and 3/11 (27.3%) were stable. Perfusion fraction fp showed a significant reduction after ECT only in four patients. No significant difference was observed after ECT in signal intensity of T1-weighted images and T2-weighted images, and in equilibrium-phase of contrast study, according to χ<sup>2</sup> test was observed. A good correlation was reported between ΔHounsfi展开更多
Purpose–The purpose of this paper is to introduce new implementations for parallel processing applications using bijective systolic networks and their corresponding carbon-based field emission controlled switching.Th...Purpose–The purpose of this paper is to introduce new implementations for parallel processing applications using bijective systolic networks and their corresponding carbon-based field emission controlled switching.The developed implementations are performed in the reversible domain to perform the required bijective parallel computing,where the implementations for parallel computations that utilize the presented field-emission controlled switching and their corresponding many-valued(m-ary)extensions for the use in nano systolic networks are introduced.The second part of the paper introduces the implementation of systolic computing using two-to-one controlled switching via carbon-based field emission that were presented in the first part of the paper,and the computational extension to the general case of many-valued(m-ary)systolic networks utilizing many-to-one carbon-based field emission is also introduced.Design/methodology/approach–The introduced systolic systems utilize recent findings in field emission and nano applications to implement the functionality of the basic bijective systolic network.This includes many-valued systolic computing via field-emission techniques using carbon-based nanotubes and nanotips.The realization of bijective logic circuits in current and emerging technologies can be very important for various reasons.The reduction of power consumption is a major requirement for the circuit design in future technologies,and thus,the new nano systolic circuits can play an important role in the design of circuits that consume minimal power for future applications such as in low-power signal processing.In addition,the implemented bijective systems can be utilized to implement massive parallel processing and thus obtaining very high processing performance,where the implementation will also utilize the significant size reduction within the nano domain.The extensions of implementations to field emission-based many-valued systolic networks using the introduced bijective nano systolic architectures are 展开更多
Purpose-The purpose of this paper is to introduce new implementations for parallel processing applications using bijective systolic networks and the corresponding carbon-based field emission controlled switching.The d...Purpose-The purpose of this paper is to introduce new implementations for parallel processing applications using bijective systolic networks and the corresponding carbon-based field emission controlled switching.The developed implementations are performed in the reversible domain to perform the required bijective parallel computing,where the implementations for parallel computations that utilize the presented field-emission controlled switching and their corresponding m-ary(many-valued)extensions for the use in nano systolic networks are introduced.The first part of the paper presents important fundamentals with regards to systolic computing and carbon-based field emission that will be utilized in the implementations within the second part of the paper.Design/methodology/approach-The introduced systolic systems utilize recent findings in field emission and nano applications to implement the functionality of the basic bijective systolic network.This includes many-valued systolic computing via field emission techniques using carbon-based nanotubes and nanotips.The realization of bijective logic circuits in current and emerging technologies can be very important for various reasons.The reduction of power consumption is a major requirement for the circuit design in future technologies,and thus,the new nano systolic circuits can play an important role in the design of circuits that consume minimal power for future applications such as in low-power signal processing.In addition,the implemented bijective systems can be utilized to implement massive parallel processing and thus obtaining very high processing performance,where the implementation will also utilize the significant size reduction within the nano domain.The extensions of implementations to field emission-based many-valued systolic networks using the introduced bijective nano systolic architectures are also presented.Findings-Novel bijective systolic architectures using nano-based field emission implementations are introduced in this paper,and the implementati展开更多
The authors report clinical correlations of single photon emission computerized tomography (SPECT) findings in reversible posterior leukoencephalopathy (RPL). These are observations that have not received wide attenti...The authors report clinical correlations of single photon emission computerized tomography (SPECT) findings in reversible posterior leukoencephalopathy (RPL). These are observations that have not received wide attention in literature. A 31-year-old hypertensive gentleman, on discontinuing antihypertensive medications, presented with vomiting, headache, focal motor to bilateral tonic-clonic seizures, altered sensorium, right gaze palsy and right hemiparesis. Accelerated hypertension was noted and he improved well with antihypertensive and anticonvulsant therapy. While cranial magnetic resonance imaging (MRI) revealed extensive bilateral lesions, SPECT imaging revealed perfusion defects involving bilateral basal ganglia, left parieto-occipital, right cerebellar and right occipital regions, which corresponded with clinical deficits on examination. While MRI is the standard of care for the evaluation of RPL, this case suggests that SPECT abnormalities may be better localized to the pathogenic lesions. Furthermore, this may begin to explain the pathophysiology of injury in RPL.展开更多
基金supported by the National Key R&D Program of China (2016YFB0401004)the National Natural Science Foundation of China (51625301, 51573059, 91233116)+1 种基金the National Basic Research Program of China (2015CB655003)Guangdong Provincial Department of Science and Technology (2016B090906003, 2016TX03C175)
文摘An organic compound exhibiting simultaneously reversible switch between its emission colors and luminescence mechanisms,possessing high contrast from deep blue normal fluorescence(NF) to yellow thermally activated delayed fluorescence(TADF),is reported. Based on these two complementary colors, white-light emission combining NF and TADF from a single compound can be achieved in various states. Experimental results and density functional theory calculations indicate that the controllable conformational distribution under thermal and mechanical activation is the mechanism responsible for the reversible switching behavior.
文摘To report early imaging assessment of ablated area post electrochemotherapy (ECT) in patients with locally advanced pancreatic cancer (LAPC). METHODSECT was performed in 19 LAPC patients enrolled in an approved ongoing clinical phase I/II study. Before and after ECT, 18 patients underwent computed tomography (CT) scan, 11 patients underwent morphological and functional magnetic resonance (MR) scan (dynamic contrast enhanced-MRI) calculating wash-in slope (WIS) and wash-out slope (WOS); diffusion weighted imaging calculating pseudo-diffusivity (Dp), perfusion fraction (fp) and tissue diffusivity (Dt); 10 patients underwent positron emission tomography (PET). Response evaluation criteria in solid tumour (RECIST) on MR and CT were used to assess tumour therapy response. Choi on CT, PET response criteria in solid tumors (PERCIST) on PET and functional parameters on MR were used to evaluate treatment response. RESULTSFor each patient no significant reduction was measurable by CT and MR using RECIST. According Choi criteria a partial response was obtained in 18/18 (100.0%) patients. According PERCIST criteria 6/10 (60.0%) patients showed a partial response, 3/10 (30.0%) stable disease and 1/10 (10.0%) progression disease. Moreover, using functional MR parameters, a significant reduction of viable tumour after ECT can be observed. According ΔWIS and ΔWOS 9/11 (81.8%) patients exhibited a partial response and 2/11 (18.2%) stable disease; 8/11 (72.7%) patients were considered in partial response by ΔDp evaluation and 3/11 (27.3%) in stable disease; according ΔDt 7/11 (63.6%) patients showed a partial response, 1/11 (9.1%) showed progression of disease and 3/11 (27.3%) were stable. Perfusion fraction fp showed a significant reduction after ECT only in four patients. No significant difference was observed after ECT in signal intensity of T1-weighted images and T2-weighted images, and in equilibrium-phase of contrast study, according to χ<sup>2</sup> test was observed. A good correlation was reported between ΔHounsfi
文摘Purpose–The purpose of this paper is to introduce new implementations for parallel processing applications using bijective systolic networks and their corresponding carbon-based field emission controlled switching.The developed implementations are performed in the reversible domain to perform the required bijective parallel computing,where the implementations for parallel computations that utilize the presented field-emission controlled switching and their corresponding many-valued(m-ary)extensions for the use in nano systolic networks are introduced.The second part of the paper introduces the implementation of systolic computing using two-to-one controlled switching via carbon-based field emission that were presented in the first part of the paper,and the computational extension to the general case of many-valued(m-ary)systolic networks utilizing many-to-one carbon-based field emission is also introduced.Design/methodology/approach–The introduced systolic systems utilize recent findings in field emission and nano applications to implement the functionality of the basic bijective systolic network.This includes many-valued systolic computing via field-emission techniques using carbon-based nanotubes and nanotips.The realization of bijective logic circuits in current and emerging technologies can be very important for various reasons.The reduction of power consumption is a major requirement for the circuit design in future technologies,and thus,the new nano systolic circuits can play an important role in the design of circuits that consume minimal power for future applications such as in low-power signal processing.In addition,the implemented bijective systems can be utilized to implement massive parallel processing and thus obtaining very high processing performance,where the implementation will also utilize the significant size reduction within the nano domain.The extensions of implementations to field emission-based many-valued systolic networks using the introduced bijective nano systolic architectures are
基金This research was performed during sabbatical leave in 2015-2016 granted to the author from The University of Jordan and spent at Philadelphia University.
文摘Purpose-The purpose of this paper is to introduce new implementations for parallel processing applications using bijective systolic networks and the corresponding carbon-based field emission controlled switching.The developed implementations are performed in the reversible domain to perform the required bijective parallel computing,where the implementations for parallel computations that utilize the presented field-emission controlled switching and their corresponding m-ary(many-valued)extensions for the use in nano systolic networks are introduced.The first part of the paper presents important fundamentals with regards to systolic computing and carbon-based field emission that will be utilized in the implementations within the second part of the paper.Design/methodology/approach-The introduced systolic systems utilize recent findings in field emission and nano applications to implement the functionality of the basic bijective systolic network.This includes many-valued systolic computing via field emission techniques using carbon-based nanotubes and nanotips.The realization of bijective logic circuits in current and emerging technologies can be very important for various reasons.The reduction of power consumption is a major requirement for the circuit design in future technologies,and thus,the new nano systolic circuits can play an important role in the design of circuits that consume minimal power for future applications such as in low-power signal processing.In addition,the implemented bijective systems can be utilized to implement massive parallel processing and thus obtaining very high processing performance,where the implementation will also utilize the significant size reduction within the nano domain.The extensions of implementations to field emission-based many-valued systolic networks using the introduced bijective nano systolic architectures are also presented.Findings-Novel bijective systolic architectures using nano-based field emission implementations are introduced in this paper,and the implementati
文摘The authors report clinical correlations of single photon emission computerized tomography (SPECT) findings in reversible posterior leukoencephalopathy (RPL). These are observations that have not received wide attention in literature. A 31-year-old hypertensive gentleman, on discontinuing antihypertensive medications, presented with vomiting, headache, focal motor to bilateral tonic-clonic seizures, altered sensorium, right gaze palsy and right hemiparesis. Accelerated hypertension was noted and he improved well with antihypertensive and anticonvulsant therapy. While cranial magnetic resonance imaging (MRI) revealed extensive bilateral lesions, SPECT imaging revealed perfusion defects involving bilateral basal ganglia, left parieto-occipital, right cerebellar and right occipital regions, which corresponded with clinical deficits on examination. While MRI is the standard of care for the evaluation of RPL, this case suggests that SPECT abnormalities may be better localized to the pathogenic lesions. Furthermore, this may begin to explain the pathophysiology of injury in RPL.
