Background： Functional magnetic resonance imaging （fMRI） is a novel method for studying the changes of brain networks due to acupuncture treatment. In recent years, more and more studies have focused on the brain f...Background： Functional magnetic resonance imaging （fMRI） is a novel method for studying the changes of brain networks due to acupuncture treatment. In recent years, more and more studies have focused on the brain functional connectivity network of acupuncture stimulation. Objective： To offer an overview of the different influences of acupuncture on the brain functional connec- tivity network from studies using resting-state fMRI. Search strategy： The authors performed a systematic search according to PRISMA guidelines, The database PubMed was searched from January 1, 2006 to December 31, 2016 with restriction to human studies in English language. Inclusion criteria： Electronic searches were conducted in PubMed using the keywords ＂acupuncture＂ and ＂neuroimaging＂ or ＂resting-state fMRI＂ or ＂functional connectivity＂, Data extraction and analysis： Selection of included articles, data extraction and methodological quality assessments were respectively conducted by two review authors. Results： Forty-four resting-state fMRI studies were included in this systematic review according to inclu- sion criteria. Thirteen studies applied manual acupuncture vs. sham, four studies applied electro- acupuncture vs. sham, two studies also compared transcutaneous electrical acupoint stimulation vs. sham, and nine applied sham acupoint as control. Nineteen studies with a total number of 574 healthy subjects selected to perform fMRI only considered healthy adult volunteers. The brain functional connec- tivity of the patients had varying degrees of change. Compared with sham acupuncture, verum acupunc- ture could increase default mode network and sensorimotor network connectivity with pain-, affective- and memory-related brain areas. It has significantly greater connectivity of genuine acupuncture between the periaqueductal gray, anterior cingulate cortex, left posterior cingulate cortex, right anterior insula, limbic/paralimbic and precuneus compared with sham acupuncture. Some research had also shown th展开更多
Functional magnetic resonance imaging has been widely used to investigate the effects of acupuncture on neural activity. However, most functional magnetic resonance imaging studies have focused on acute changes in bra...Functional magnetic resonance imaging has been widely used to investigate the effects of acupuncture on neural activity. However, most functional magnetic resonance imaging studies have focused on acute changes in brain activation induced by acupuncture. Thus, the time course of the therapeutic effects of acupuncture remains unclear. In this study, 32 patients with amnestic mild cognitive impairment were randomly divided into two groups, where they received either Tiaoshen Yizhi acupuncture or sham acupoint acupuncture. The needles were either twirled at Tiaoshen Yizhi acupoints, including Sishencong（EX-HN1）, Yintang（EX-HN3）, Neiguan（PC6）, Taixi（KI3）, Fenglong（ST40）, and Taichong（LR3）, or at related sham acupoints at a depth of approximately 15 mm, an angle of ± 60°, and a rate of approximately 120 times per minute. Acupuncture was conducted for 4 consecutive weeks, five times per week, on weekdays. Resting-state functional magnetic resonance imaging indicated that connections between cognition-related regions such as the insula, dorsolateral prefrontal cortex, hippocampus, thalamus, inferior parietal lobule, and anterior cingulate cortex increased after acupuncture at Tiaoshen Yizhi acupoints. The insula, dorsolateral prefrontal cortex, and hippocampus acted as central brain hubs. Patients in the Tiaoshen Yizhi group exhibited improved cognitive performance after acupuncture. In the sham acupoint acupuncture group, connections between brain regions were dispersed, and we found no differences in cognitive function following the treatment. These results indicate that acupuncture at Tiaoshen Yizhi acupoints can regulate brain networks by increasing connectivity between cognition-related regions, thereby improving cognitive function in patients with mild cognitive impairment.展开更多
Resting-state functional magnetic resonance imaging (RS-fMRI)[1,2] provides relatively high spatial and temporal resolution for mapping spontaneous brain activity non-invasively. It has been widely used in cognitive n...Resting-state functional magnetic resonance imaging (RS-fMRI)[1,2] provides relatively high spatial and temporal resolution for mapping spontaneous brain activity non-invasively. It has been widely used in cognitive neuroscience and clinical studies. A number of comprehensive software packages have been developed for RS-fMRI data analysis, among which a MATLAB package named REST (RESing-state fMRI data analysis Toolkit, released in October 2008 at http://www.restfmri.net)[3] is the earliest one dedicated to RS-fMRI analysis. REST focuses on RS-fMRI postprocessing metrics.展开更多
Objective： To investigate the modulatory effect of acupuncture treatment on the resting-state functional connectivity of brain regions in migraine without aura （MWoA） patients. Methods： Twelve MWoA patients were t...Objective： To investigate the modulatory effect of acupuncture treatment on the resting-state functional connectivity of brain regions in migraine without aura （MWoA） patients. Methods： Twelve MWoA patients were treated with standard acupuncture treatment for 4 weeks. All MWoA patients received resting-state functional magnetic resonance imaging （fMRI） scanning before and after acupuncture treatment. Another 12 normal subjects matched in age and gender were recruited to serve as healthy controls. The changes of resting- state functional connectivity in MWoA patients before and after the acupuncture treatment and those with the healthy controls were compared. Results： Before acupuncture treatment, the MWoA patients had significantly decreased functional connectivity in certain brain regions within the frontal and temporal lobe when compared with the healthy controls. After acupuncture treatment, brain regions showing decreased functional connectivity revealed significant reduction in MWoA patients compared with before acupuncture treatment. Conclusions： Acupuncture treatment could increase the functional connectivity of brain regions in the intrinsic decreased brain networks in MWoA patients. The results provided further insights into the interpretation of neural mechanisms of acupuncture treatment for migraine.展开更多
目的运用静息状态功能磁共振成像（functional magnetic resonanceimaging，fMRI）研究首发青少年抑郁症患者静息状态下脑功能活动异常。方法21例（男12例，女9例）首发青少年抑郁症患者组和18例（男10例，女8例）正常对照组在静息状态...目的运用静息状态功能磁共振成像（functional magnetic resonanceimaging，fMRI）研究首发青少年抑郁症患者静息状态下脑功能活动异常。方法21例（男12例，女9例）首发青少年抑郁症患者组和18例（男10例，女8例）正常对照组在静息状态下进行功能磁共振扫描，观察局部一致性（regionalhomogeneity，ReHo）值的变化。结果患者组右颞下回（MINI坐标：66，-24，-20）、左上前扣带皮层（-27，47，-6）、左额极区（-24，59，14）、左上后扣带皮层（-1，-16，35）、左下后扣带皮层（-2，-38，32）、左楔前叶（-1，-48，65）的ReHo值较对照组高；右侧颞中回（45，-34，32）的ReHo值较正常对照组低（P〈0．05）。结论首发青少年抑郁症患者脑部存在广泛的ReHo异常，这些脑区的自发神经活动异常可能是青少年抑郁症潜在的神经病理基础。展开更多
Various resting-state fMRI(R-fMRI) measures have been developed to characterize intrinsic brain activity. While each of these measures has gained a growing presence in the literature, questions remain regarding the co...Various resting-state fMRI(R-fMRI) measures have been developed to characterize intrinsic brain activity. While each of these measures has gained a growing presence in the literature, questions remain regarding the common and unique aspects these indices capture. The present work provided a comprehensive examination of inter-individual variation and intra-individual temporal variation for commonly used measures, including fractional amplitude of low frequency fluctuations, regional homogeneity,voxel-mirrored homotopic connectivity, network centrality and global signal correlation. Regardless of whether examining intra-individual or inter-individual variation, we found that these definitionally distinct R-fMRI indices tend to exhibit a relatively high degree of covariation, which doesn't exist in phase randomized surrogate data. As a measure of intrinsic brain function, concordance for R-fMRI indices was negatively correlated with age across individuals(i.e., concordance among functional indices decreased with age). To understand the functional significance of concordance, we noted that higher concordance was generally associated with higher strengths of R-fMRI indices, regardless of whether looking through the lens of inter-individual(i.e., high vs. low concordance participants) or intra-individual(i.e., high vs.low concordance states identified via temporal dynamic analyses) differences. We also noted a linear increase in functional concordance together with the R-fMRI indices through the scan, which may suggest a decrease in arousal. The current study demonstrated an enriched picture regarding the relationship among the R-fMRI indices, as well as provided new insights in examining dynamic states within and between individuals.展开更多
基金supported by the National Natural Science Foundation of China(No.81473784)University Science Research Project of Anhui Province of China(No.KJ2017A298)+1 种基金the Key Project of the Youth Elite Support Plan in Universities of Anhui Province of China(No.gxyq ZD2016134)Construction Project of Scientific Research Innovation Platform of Anhui Province of China(No.2015TD033)
文摘Background： Functional magnetic resonance imaging （fMRI） is a novel method for studying the changes of brain networks due to acupuncture treatment. In recent years, more and more studies have focused on the brain functional connectivity network of acupuncture stimulation. Objective： To offer an overview of the different influences of acupuncture on the brain functional connec- tivity network from studies using resting-state fMRI. Search strategy： The authors performed a systematic search according to PRISMA guidelines, The database PubMed was searched from January 1, 2006 to December 31, 2016 with restriction to human studies in English language. Inclusion criteria： Electronic searches were conducted in PubMed using the keywords ＂acupuncture＂ and ＂neuroimaging＂ or ＂resting-state fMRI＂ or ＂functional connectivity＂, Data extraction and analysis： Selection of included articles, data extraction and methodological quality assessments were respectively conducted by two review authors. Results： Forty-four resting-state fMRI studies were included in this systematic review according to inclu- sion criteria. Thirteen studies applied manual acupuncture vs. sham, four studies applied electro- acupuncture vs. sham, two studies also compared transcutaneous electrical acupoint stimulation vs. sham, and nine applied sham acupoint as control. Nineteen studies with a total number of 574 healthy subjects selected to perform fMRI only considered healthy adult volunteers. The brain functional connec- tivity of the patients had varying degrees of change. Compared with sham acupuncture, verum acupunc- ture could increase default mode network and sensorimotor network connectivity with pain-, affective- and memory-related brain areas. It has significantly greater connectivity of genuine acupuncture between the periaqueductal gray, anterior cingulate cortex, left posterior cingulate cortex, right anterior insula, limbic/paralimbic and precuneus compared with sham acupuncture. Some research had also shown th
基金supported by the National Natural Science Foundation of China,No.81173354a grant from the Science and Technology Plan Project of Guangdong Province of China,No.2013B021800099a grant from the Science and Technology Plan Project of Shenzhen City of China,No.JCYJ20150402152005642
文摘Functional magnetic resonance imaging has been widely used to investigate the effects of acupuncture on neural activity. However, most functional magnetic resonance imaging studies have focused on acute changes in brain activation induced by acupuncture. Thus, the time course of the therapeutic effects of acupuncture remains unclear. In this study, 32 patients with amnestic mild cognitive impairment were randomly divided into two groups, where they received either Tiaoshen Yizhi acupuncture or sham acupoint acupuncture. The needles were either twirled at Tiaoshen Yizhi acupoints, including Sishencong（EX-HN1）, Yintang（EX-HN3）, Neiguan（PC6）, Taixi（KI3）, Fenglong（ST40）, and Taichong（LR3）, or at related sham acupoints at a depth of approximately 15 mm, an angle of ± 60°, and a rate of approximately 120 times per minute. Acupuncture was conducted for 4 consecutive weeks, five times per week, on weekdays. Resting-state functional magnetic resonance imaging indicated that connections between cognition-related regions such as the insula, dorsolateral prefrontal cortex, hippocampus, thalamus, inferior parietal lobule, and anterior cingulate cortex increased after acupuncture at Tiaoshen Yizhi acupoints. The insula, dorsolateral prefrontal cortex, and hippocampus acted as central brain hubs. Patients in the Tiaoshen Yizhi group exhibited improved cognitive performance after acupuncture. In the sham acupoint acupuncture group, connections between brain regions were dispersed, and we found no differences in cognitive function following the treatment. These results indicate that acupuncture at Tiaoshen Yizhi acupoints can regulate brain networks by increasing connectivity between cognition-related regions, thereby improving cognitive function in patients with mild cognitive impairment.
基金supported by Department of Science and Technology, Zhejiang Province (2015C03037)the National Natural Science Foundation of China (81520108016, 81661148045, 61671198, 81671774, 81701776, 81471653)
文摘Resting-state functional magnetic resonance imaging (RS-fMRI)[1,2] provides relatively high spatial and temporal resolution for mapping spontaneous brain activity non-invasively. It has been widely used in cognitive neuroscience and clinical studies. A number of comprehensive software packages have been developed for RS-fMRI data analysis, among which a MATLAB package named REST (RESing-state fMRI data analysis Toolkit, released in October 2008 at http://www.restfmri.net)[3] is the earliest one dedicated to RS-fMRI analysis. REST focuses on RS-fMRI postprocessing metrics.
基金Supported by the National Natural Science Foundation of China(No.81473667)Beijing Young Talent Program of Beijing Education Committee(No.YETP0823)the Research Funds of Beijing University of Chinese Medicine(No.2013-JYBZZJS-148,2014-JYBZZ-XS-142)
文摘Objective： To investigate the modulatory effect of acupuncture treatment on the resting-state functional connectivity of brain regions in migraine without aura （MWoA） patients. Methods： Twelve MWoA patients were treated with standard acupuncture treatment for 4 weeks. All MWoA patients received resting-state functional magnetic resonance imaging （fMRI） scanning before and after acupuncture treatment. Another 12 normal subjects matched in age and gender were recruited to serve as healthy controls. The changes of resting- state functional connectivity in MWoA patients before and after the acupuncture treatment and those with the healthy controls were compared. Results： Before acupuncture treatment, the MWoA patients had significantly decreased functional connectivity in certain brain regions within the frontal and temporal lobe when compared with the healthy controls. After acupuncture treatment, brain regions showing decreased functional connectivity revealed significant reduction in MWoA patients compared with before acupuncture treatment. Conclusions： Acupuncture treatment could increase the functional connectivity of brain regions in the intrinsic decreased brain networks in MWoA patients. The results provided further insights into the interpretation of neural mechanisms of acupuncture treatment for migraine.
文摘目的运用静息状态功能磁共振成像（functional magnetic resonanceimaging，fMRI）研究首发青少年抑郁症患者静息状态下脑功能活动异常。方法21例（男12例，女9例）首发青少年抑郁症患者组和18例（男10例，女8例）正常对照组在静息状态下进行功能磁共振扫描，观察局部一致性（regionalhomogeneity，ReHo）值的变化。结果患者组右颞下回（MINI坐标：66，-24，-20）、左上前扣带皮层（-27，47，-6）、左额极区（-24，59，14）、左上后扣带皮层（-1，-16，35）、左下后扣带皮层（-2，-38，32）、左楔前叶（-1，-48，65）的ReHo值较对照组高；右侧颞中回（45，-34，32）的ReHo值较正常对照组低（P〈0．05）。结论首发青少年抑郁症患者脑部存在广泛的ReHo异常，这些脑区的自发神经活动异常可能是青少年抑郁症潜在的神经病理基础。
基金supported by the National Key R&D Program of China (2017YFC1309902 to CGY)National Basic Research Program (2015CB351702 to XNZ)+4 种基金the Natural Science Foundation of China (81671774 and 81630031 to CGY, 81471740, 81220108014 to XNZ)the Hundred Talents Program of the Chinese Academy of Sciences (Y5CX072006 to CGY)Beijing Municipal Science & Technology Commission (Z161100000216152 to CGY)the National Institutes of Health (U01MH099059 to MPM)the Child Mind Institute (1FDN2012-1 to MPM)
文摘Various resting-state fMRI(R-fMRI) measures have been developed to characterize intrinsic brain activity. While each of these measures has gained a growing presence in the literature, questions remain regarding the common and unique aspects these indices capture. The present work provided a comprehensive examination of inter-individual variation and intra-individual temporal variation for commonly used measures, including fractional amplitude of low frequency fluctuations, regional homogeneity,voxel-mirrored homotopic connectivity, network centrality and global signal correlation. Regardless of whether examining intra-individual or inter-individual variation, we found that these definitionally distinct R-fMRI indices tend to exhibit a relatively high degree of covariation, which doesn't exist in phase randomized surrogate data. As a measure of intrinsic brain function, concordance for R-fMRI indices was negatively correlated with age across individuals(i.e., concordance among functional indices decreased with age). To understand the functional significance of concordance, we noted that higher concordance was generally associated with higher strengths of R-fMRI indices, regardless of whether looking through the lens of inter-individual(i.e., high vs. low concordance participants) or intra-individual(i.e., high vs.low concordance states identified via temporal dynamic analyses) differences. We also noted a linear increase in functional concordance together with the R-fMRI indices through the scan, which may suggest a decrease in arousal. The current study demonstrated an enriched picture regarding the relationship among the R-fMRI indices, as well as provided new insights in examining dynamic states within and between individuals.
