Helicobacter pylori (H. pylori) is one of the most common human bacterial pathogens, and infection causes a wide array of gastric disorders, including simple gastritis, peptic ulcers and gastric malignancies. Gastroin...Helicobacter pylori (H. pylori) is one of the most common human bacterial pathogens, and infection causes a wide array of gastric disorders, including simple gastritis, peptic ulcers and gastric malignancies. Gastrointestinal inflammation caused by H. pylori can influence the absorption of glucose and lipids, which are also abnormal in diabetes mellitus. Type 2 diabetes mellitus (T2DM), formerly known as non-insulin-dependent diabetes mellitus or adult-onset diabetes, is a metabolic disorder that is characterized by high levels of blood glucose resulting from insulin resistance and relative insulin deficiency. It is an emerging pandemic and is rapidly becoming a serious threat to public health. Emerging data now indicate a strong relationship between H. pylori infection and the incidence of T2DM. The mechanisms underlying the pathogenesis of diabetes are complex, involving insulin resistance, chronic inflammation, insulin secretion deficiency as a result of pancreas β-cell dysfunction, glucotoxicity, and lipotoxicity. H. pylori infection is known to be involved in the pathogenesis of insulin resistance, and the growing awareness of its role in diabetes is important for the early detection of glucose dysregulation and prevention of T2DM in high-risk communities. This review probes the possible relationship between H. pylori and diabetes according to epidemiological surveys and discusses putative mechanisms underlying this correlation.展开更多
The emergence of quantum computer will threaten the security of existing public-key cryptosystems, including the Diffie Hellman key exchange protocol, encryption scheme and etc, and it makes the study of resistant qua...The emergence of quantum computer will threaten the security of existing public-key cryptosystems, including the Diffie Hellman key exchange protocol, encryption scheme and etc, and it makes the study of resistant quantum cryptography very urgent. This motivate us to design a new key exchange protocol and eneryption scheme in this paper. Firstly, some acknowledged mathematical problems was introduced, such as ergodic matrix problem and tensor decomposition problem, the two problems have been proved to NPC hard. From the computational complexity prospective, NPC problems have been considered that there is no polynomial-time quantum algorithm to solve them. From the algebraic structures prospective, non-commutative cryptography has been considered to resist quantum. The matrix and tensor operator we adopted also satisfied with this non-commutative algebraic structures, so they can be used as candidate problems for resisting quantum from perspective of computational complexity theory and algebraic structures. Secondly, a new problem was constructed based on the introduced problems in this paper, then a key exchange protocol and a public key encryption scheme were proposed based on it. Finally the security analysis, efficiency, recommended parameters, performance evaluation and etc. were also been given. The two schemes has the following characteristics, provable security,security bits can be scalable, to achieve high efficiency, quantum resistance, and etc.展开更多
基金Supported by The National Natural Science Foundation of China,No.81060038 and No.81270479grants from Jiangxi Province Talent 555 Projectthe National Science and Technology Major Projects for"Major New Drugs Innovation and Development"of China,No.2011ZX09302-007-03
文摘Helicobacter pylori (H. pylori) is one of the most common human bacterial pathogens, and infection causes a wide array of gastric disorders, including simple gastritis, peptic ulcers and gastric malignancies. Gastrointestinal inflammation caused by H. pylori can influence the absorption of glucose and lipids, which are also abnormal in diabetes mellitus. Type 2 diabetes mellitus (T2DM), formerly known as non-insulin-dependent diabetes mellitus or adult-onset diabetes, is a metabolic disorder that is characterized by high levels of blood glucose resulting from insulin resistance and relative insulin deficiency. It is an emerging pandemic and is rapidly becoming a serious threat to public health. Emerging data now indicate a strong relationship between H. pylori infection and the incidence of T2DM. The mechanisms underlying the pathogenesis of diabetes are complex, involving insulin resistance, chronic inflammation, insulin secretion deficiency as a result of pancreas β-cell dysfunction, glucotoxicity, and lipotoxicity. H. pylori infection is known to be involved in the pathogenesis of insulin resistance, and the growing awareness of its role in diabetes is important for the early detection of glucose dysregulation and prevention of T2DM in high-risk communities. This review probes the possible relationship between H. pylori and diabetes according to epidemiological surveys and discusses putative mechanisms underlying this correlation.
基金the National Natural Science Foundation of China，the State Key Program of National Natural Science of China，the Major Research Plan of the National Natural Science Foundation of China，Major State Basic Research Development Program of China (973 Program)，the Hubei Natural Science Foundation of China
文摘The emergence of quantum computer will threaten the security of existing public-key cryptosystems, including the Diffie Hellman key exchange protocol, encryption scheme and etc, and it makes the study of resistant quantum cryptography very urgent. This motivate us to design a new key exchange protocol and eneryption scheme in this paper. Firstly, some acknowledged mathematical problems was introduced, such as ergodic matrix problem and tensor decomposition problem, the two problems have been proved to NPC hard. From the computational complexity prospective, NPC problems have been considered that there is no polynomial-time quantum algorithm to solve them. From the algebraic structures prospective, non-commutative cryptography has been considered to resist quantum. The matrix and tensor operator we adopted also satisfied with this non-commutative algebraic structures, so they can be used as candidate problems for resisting quantum from perspective of computational complexity theory and algebraic structures. Secondly, a new problem was constructed based on the introduced problems in this paper, then a key exchange protocol and a public key encryption scheme were proposed based on it. Finally the security analysis, efficiency, recommended parameters, performance evaluation and etc. were also been given. The two schemes has the following characteristics, provable security,security bits can be scalable, to achieve high efficiency, quantum resistance, and etc.
