A comprehensive but simple-to-use software package called DPS （Data Pro- cessing System） has been developed to execute a range of standard numerical analyses and operations used in experimental design, statistics an...A comprehensive but simple-to-use software package called DPS （Data Pro- cessing System） has been developed to execute a range of standard numerical analyses and operations used in experimental design, statistics and data mining. This program runs on standard Windows computers. Many of the functions are specific to entomological and other biological research and are not found in standard statistical sottware. This paper presents applications of DPS to experimental design, statistical analysis and data mining in entomology.展开更多
临床指南在医患临床决策和卫生政策制定时起着重要作用。在指南制定过程中由于方法学和制定策略的不足,导致指南的质量良莠不齐,因此,对指南进行研究和评价具有重要意义。2003年发表的第1版《临床指南研究与评价系统》(Appraisal of Gui...临床指南在医患临床决策和卫生政策制定时起着重要作用。在指南制定过程中由于方法学和制定策略的不足,导致指南的质量良莠不齐,因此,对指南进行研究和评价具有重要意义。2003年发表的第1版《临床指南研究与评价系统》(Appraisal of Guidelines for Researchand Evaluation,AGREE)对指南的质量保证和成功实施产生了重要作用,目前已得到广泛支持和认同。2009年,AGREE国际协作组织对2003版AGREE修正后制定出新的AGREE即AGREEⅡ。目前,AGREEⅡ已取代2003版AGREE,但国内尚没有AGREEⅡ的相关介绍。本文作者对AGREEⅡ作一介绍,以期其利于指南的研究和评价。展开更多
Chinese medicine(CM) is usually prescribed as CM formula to treat disease. The lack of effective research approach makes it difficult to elucidate the molecular mechanisms of CM formula owing to its complicated chemic...Chinese medicine(CM) is usually prescribed as CM formula to treat disease. The lack of effective research approach makes it difficult to elucidate the molecular mechanisms of CM formula owing to its complicated chemical compounds. Network pharmacology is increasingly applied in CM formula research in recent years, which is identified suitable for the study of CM formula. In this review, we summarized the methodology of network pharmacology, including network construction, network analysis and network verification. The aim of constructing a network is to achieve the interaction between the bioactive compounds and targets and the interaction between various targets, and then find out and validate the key nodes via network analysis and network verification. Besides, we reviewed the application in CM formula research, mainly including targets discovery, bioactive compounds screening, toxicity evaluation, mechanism research and quality control research. Finally, we proposed prospective in the future and limitations of network pharmacology, expecting to provide new strategy and thinking on study for CM formula.展开更多
文摘A comprehensive but simple-to-use software package called DPS （Data Pro- cessing System） has been developed to execute a range of standard numerical analyses and operations used in experimental design, statistics and data mining. This program runs on standard Windows computers. Many of the functions are specific to entomological and other biological research and are not found in standard statistical sottware. This paper presents applications of DPS to experimental design, statistical analysis and data mining in entomology.
文摘临床指南在医患临床决策和卫生政策制定时起着重要作用。在指南制定过程中由于方法学和制定策略的不足,导致指南的质量良莠不齐,因此,对指南进行研究和评价具有重要意义。2003年发表的第1版《临床指南研究与评价系统》(Appraisal of Guidelines for Researchand Evaluation,AGREE)对指南的质量保证和成功实施产生了重要作用,目前已得到广泛支持和认同。2009年,AGREE国际协作组织对2003版AGREE修正后制定出新的AGREE即AGREEⅡ。目前,AGREEⅡ已取代2003版AGREE,但国内尚没有AGREEⅡ的相关介绍。本文作者对AGREEⅡ作一介绍,以期其利于指南的研究和评价。
基金Supported by the National Natural Science Foundation of China(No.81530102)Guangdong Provincial Science and Technology Agency Special Funds(No.2017B050504005)Guangzhou City Science and Technology Agency Special Funds(No.201803010069)
文摘Chinese medicine(CM) is usually prescribed as CM formula to treat disease. The lack of effective research approach makes it difficult to elucidate the molecular mechanisms of CM formula owing to its complicated chemical compounds. Network pharmacology is increasingly applied in CM formula research in recent years, which is identified suitable for the study of CM formula. In this review, we summarized the methodology of network pharmacology, including network construction, network analysis and network verification. The aim of constructing a network is to achieve the interaction between the bioactive compounds and targets and the interaction between various targets, and then find out and validate the key nodes via network analysis and network verification. Besides, we reviewed the application in CM formula research, mainly including targets discovery, bioactive compounds screening, toxicity evaluation, mechanism research and quality control research. Finally, we proposed prospective in the future and limitations of network pharmacology, expecting to provide new strategy and thinking on study for CM formula.
