We propose and experimentally demonstrate an adaptive multiple-input multiple-output（MIMO） mode switching scheme for an indoor visible light communication system combined with orthogonal frequency division multiplex...We propose and experimentally demonstrate an adaptive multiple-input multiple-output（MIMO） mode switching scheme for an indoor visible light communication system combined with orthogonal frequency division multiplexing modulation.Only requiring 1 bit feedback from the receiver,the MIMO mode at the transmitter switches between spatial multiplexing and transmit diversity adapting to the channel correlation.In such a way,we can take advantage of both spatial multiplexing and transmit diversity,where the spatial multiplexing benefits for its multiplexing gain in the low channel correlation environment,and the transmit diversity is robust to high channel correlation.Experimental results validate the performance improvement over the pure spatial multiplexing or transmit diversity system.With the increasing of the channel correlation,the measured bit error rates of the proposed system are below the 7% pre-forward error correction（pre-FEC） limit of 3.8 × 10-（-3）when the transmitted data rate is 50 Mb/s,and below the 20% pre-FEC threshold of 5.0 × 10-（-2） when the transmitted data rate is raised up to 100 Mb/s.展开更多
In the process of tumor proliferation and metastasis,tumor cells encounter hypoxia,low glucose,acidosis,and other stressful environments.These conditions prompt tumor cells to generate endoplasmic reticulum stress(ERS...In the process of tumor proliferation and metastasis,tumor cells encounter hypoxia,low glucose,acidosis,and other stressful environments.These conditions prompt tumor cells to generate endoplasmic reticulum stress(ERS).As a signal mechanism that mitigates ERS in eukaryotic cells,the unfolded protein response(UPR)pathway can activate cells and tissues,regulating pathological activities in various cells,and maintaining ER homeostasis.It forms the most crucial adaptive and defensive mechanism for cells.However,under the continuous influence of chemotherapy drugs,the quantity of unfolded proteins and erroneous proteins produced by tumor cells significantly increases,surpassing the normal regulatory range of UPR.Consequently,ERS fails to function properly,fostering tumor cell proliferation and the development of drug resistance.This review delves into the study of three UPR pathways(PERK,IRE1,and ATF6),elucidating the mechanisms of drug resistance and research progress in the signal transduction pathway of UPR related to cancers.It provides a profound understanding of the role and relationship between UPR and anti-tumor drugs,offering a new direction for effective clinical treatment.展开更多
Objective To explore the effect of acupuncture on the endoplasmic reticulum stress IRE l-CHOP signal pathway and the expression levels of related apoptosis genes in pancreatic tissue of rats with STZ-induced diabetes ...Objective To explore the effect of acupuncture on the endoplasmic reticulum stress IRE l-CHOP signal pathway and the expression levels of related apoptosis genes in pancreatic tissue of rats with STZ-induced diabetes mellitus. Methods Eighty SD rats were selected, among which, 10 were fed with normal diet and taken as blank control group （＂blank group＂ for short）, the other 70 rats were fed with high fat and high glucose food and injected with small dosage of STZ intraperitoneally, and 30 models were established successfully. The models were randomly divided into acupuncture treatment group （~＇acupuncture group＂ for short）, model control group （＂model group＂ for short） and western medicine group （metformin） with 10 rats in each group. After treatment for 4 weeks, RBG, and the expression levels of CHOP, IRE 2, Bax, Bcl-2 protein and mRNA in pancreatic tissue of rats were determined. Result Compared with the conditions before treatment, RBG reduced obviously in the acupuncture group and western medicine group （P〈0.05）, and there was no statistical difference in RBG in the model group and blank group （P〉0.05）; the expression levels of CHOP, IRE 1 and Bax proteins in pancreatic tissue of rats in the model group were significantly higher than those in the blank group （P〈0.05）, the expression results in the acupuncture group and western medicine group were significantly lower than those in model group （P〈0.05）; the expression levels of CHOP, IRE 1 and Bax mRNAs in pancreatic tissue of rats in the model group were significantly higher than those in the blank group （P〈0.01）, the expression results in the acupuncture group and western medicine group were significantly lower than those in the model group （P〈0.01）; the expression level of Bcl-2 protein in the model group was significantly lower than that in the blank group （P〈0.05）, the expression results in the acupuncture group and western medicine group were significantly higher than that in the model 展开更多
A new group-contribution method involving specific gravity as a parameter is proposed for predicting criticaltemperature.Being appliable to all kinds of organic compounds,it gives an average percent deviation of 0.88%...A new group-contribution method involving specific gravity as a parameter is proposed for predicting criticaltemperature.Being appliable to all kinds of organic compounds,it gives an average percent deviation of 0.88%for 93 compounds and is particularly useful to those substances for which the normal boiling points are stillunknown.展开更多
A new chemically mutagenic mutant of Synechococcus PCC7942 named high-CO2 re-quiring mutant, which could grow at 4% CO2 but could not grow at air levels of CO2, was isolated. Com-parative studies on some physiological...A new chemically mutagenic mutant of Synechococcus PCC7942 named high-CO2 re-quiring mutant, which could grow at 4% CO2 but could not grow at air levels of CO2, was isolated. Com-parative studies on some physiological aspects of the mutant and high-cO2 growing cells (growing at 4%CO2 ) were conducted. The result showed that the mutant had lower growing rate, about 1/40th photosyn-thetic affinity to inorganic carbon, 25% lower carbonic anhydrase (CA) activity, lower quenching rate ofchlorophyll fluoresence, and about 1/2 alkalinization rate of the medium. The CA activity responses ofthe two types of cells to different concentrations of CO2 were determined. Upon the addition of inorganiccarbon (Ci), the rate of active Ci uptake described by the rate of chlorophyll fluorescence quenching ofthe mutant was obviously lower compared with that of the high-CO2 growing cells; the size of the internalinorganic carbon pool size determined by the extent of fluorescence quenching Of the mutant was alsosmaller.展开更多
5’-bromodeoxycytidine (BrdU)-resistance is a marker widely used in animal somatic cell genetics. The BrdU-resistance is the retardation of BrdU incorporation into DNA, which prevents the cell from phosphorating the t...5’-bromodeoxycytidine (BrdU)-resistance is a marker widely used in animal somatic cell genetics. The BrdU-resistance is the retardation of BrdU incorporation into DNA, which prevents the cell from phosphorating the thymidine or BrdU. BrdU-restance can be manifested by the change of osmolarity of cytoplasmic membrane or other unkown causes. It has been reported that even BrdU-resistant cells requiring展开更多
Objective To study the role of inositol requiring enzyme 1(IRE1)-mediated endoplasmic reticulum stress on hepatocyte apoptosis of experimental fulminant hepatic failure(FHF). Methods Thirty male depuratory
As the aging population continues to increase worldwide,a proportionally increasing number of elderly patients will be undergoing surgical procedures requiring anesthesia care.It has been estimated that approximately ...As the aging population continues to increase worldwide,a proportionally increasing number of elderly patients will be undergoing surgical procedures requiring anesthesia care.It has been estimated that approximately one of every three surgical procedures are performed on a patient who is 65 years of age or older.展开更多
Among the disease of the urinary tract in dogs and cats,the most common diseases requiring surgery are urinary bladder and urethra.In this article,the principles of diagnosis,strategy of treatments and basic technique...Among the disease of the urinary tract in dogs and cats,the most common diseases requiring surgery are urinary bladder and urethra.In this article,the principles of diagnosis,strategy of treatments and basic techniques for these diseases are discussed.1 Urinary bladder In dogs,most common bladder diseases are cystitis,cystic calculi,cystic trauma due to car accident and bladder cancer.The patients often show abnormal urination such as incontinence,pollakiuria and stranguria.Turbid urine or he-展开更多
The plasma membrane of the cell wall of Halobacterium contains a purple membrane which is a novel light energy transducing membrane. On absorbing light energy, protons are translocated across the membrane and thereby ...The plasma membrane of the cell wall of Halobacterium contains a purple membrane which is a novel light energy transducing membrane. On absorbing light energy, protons are translocated across the membrane and thereby a proton gradient is generated. The energy stored as proton gradient may be used by the cell for ATP synthesis or other biological energy-requiring functions.展开更多
A sign pattern(matrix)is a matrix whose entries are the symbols+,-and 0.Foran n×n sign pattern matrix A,the sign pattern class of A,denoted by Q(A),is the set ofall n×n real matrices whose entries have signs...A sign pattern(matrix)is a matrix whose entries are the symbols+,-and 0.Foran n×n sign pattern matrix A,the sign pattern class of A,denoted by Q(A),is the set ofall n×n real matrices whose entries have signs indicated by the corresponding entries of A.We say that a sign pattern matrix A requires a matrix property P if every real matrix in Q(A)has the property P.A matrix with all distinct eigenvalues has many nice展开更多
On August 10th, 2009 the Ministry of PublicSecurity, the Ministry of Commerce, theGeneral Administration of Customs, the StateAdministration for Industry & Commerce, theState Administration of Work Safety and theS...On August 10th, 2009 the Ministry of PublicSecurity, the Ministry of Commerce, theGeneral Administration of Customs, the StateAdministration for Industry & Commerce, theState Administration of Work Safety and theState Food and Drug Administration jointlypromulgated a regulation, requiring the展开更多
Pigs are important animal models in veterinary and medical research and have been widely used in experiments requiring surgical anesthesia[1,2].The aim of this study was to assess cardiac,hemodynamic and respiratory r...Pigs are important animal models in veterinary and medical research and have been widely used in experiments requiring surgical anesthesia[1,2].The aim of this study was to assess cardiac,hemodynamic and respiratory responses during propofol-sevoflurane intravenous and inhalant combined approach after premedication with ShumianningⅡand evaluate the quality of anesthesia and recovery in minipigs.1 Materials and展开更多
基金supported by the National Natural Science Foundation of China under Grant No.61501296
文摘We propose and experimentally demonstrate an adaptive multiple-input multiple-output（MIMO） mode switching scheme for an indoor visible light communication system combined with orthogonal frequency division multiplexing modulation.Only requiring 1 bit feedback from the receiver,the MIMO mode at the transmitter switches between spatial multiplexing and transmit diversity adapting to the channel correlation.In such a way,we can take advantage of both spatial multiplexing and transmit diversity,where the spatial multiplexing benefits for its multiplexing gain in the low channel correlation environment,and the transmit diversity is robust to high channel correlation.Experimental results validate the performance improvement over the pure spatial multiplexing or transmit diversity system.With the increasing of the channel correlation,the measured bit error rates of the proposed system are below the 7% pre-forward error correction（pre-FEC） limit of 3.8 × 10-（-3）when the transmitted data rate is 50 Mb/s,and below the 20% pre-FEC threshold of 5.0 × 10-（-2） when the transmitted data rate is raised up to 100 Mb/s.
文摘In the process of tumor proliferation and metastasis,tumor cells encounter hypoxia,low glucose,acidosis,and other stressful environments.These conditions prompt tumor cells to generate endoplasmic reticulum stress(ERS).As a signal mechanism that mitigates ERS in eukaryotic cells,the unfolded protein response(UPR)pathway can activate cells and tissues,regulating pathological activities in various cells,and maintaining ER homeostasis.It forms the most crucial adaptive and defensive mechanism for cells.However,under the continuous influence of chemotherapy drugs,the quantity of unfolded proteins and erroneous proteins produced by tumor cells significantly increases,surpassing the normal regulatory range of UPR.Consequently,ERS fails to function properly,fostering tumor cell proliferation and the development of drug resistance.This review delves into the study of three UPR pathways(PERK,IRE1,and ATF6),elucidating the mechanisms of drug resistance and research progress in the signal transduction pathway of UPR related to cancers.It provides a profound understanding of the role and relationship between UPR and anti-tumor drugs,offering a new direction for effective clinical treatment.
基金Supported by National Natural Science Foundation for Youth of China:81202769Construction project"Innovation team of acupuncture theory,technology and application"of the platform for research and innovation in colleges and universitiesin Anhui:2015 TD 033
文摘Objective To explore the effect of acupuncture on the endoplasmic reticulum stress IRE l-CHOP signal pathway and the expression levels of related apoptosis genes in pancreatic tissue of rats with STZ-induced diabetes mellitus. Methods Eighty SD rats were selected, among which, 10 were fed with normal diet and taken as blank control group （＂blank group＂ for short）, the other 70 rats were fed with high fat and high glucose food and injected with small dosage of STZ intraperitoneally, and 30 models were established successfully. The models were randomly divided into acupuncture treatment group （~＇acupuncture group＂ for short）, model control group （＂model group＂ for short） and western medicine group （metformin） with 10 rats in each group. After treatment for 4 weeks, RBG, and the expression levels of CHOP, IRE 2, Bax, Bcl-2 protein and mRNA in pancreatic tissue of rats were determined. Result Compared with the conditions before treatment, RBG reduced obviously in the acupuncture group and western medicine group （P〈0.05）, and there was no statistical difference in RBG in the model group and blank group （P〉0.05）; the expression levels of CHOP, IRE 1 and Bax proteins in pancreatic tissue of rats in the model group were significantly higher than those in the blank group （P〈0.05）, the expression results in the acupuncture group and western medicine group were significantly lower than those in model group （P〈0.05）; the expression levels of CHOP, IRE 1 and Bax mRNAs in pancreatic tissue of rats in the model group were significantly higher than those in the blank group （P〈0.01）, the expression results in the acupuncture group and western medicine group were significantly lower than those in the model group （P〈0.01）; the expression level of Bcl-2 protein in the model group was significantly lower than that in the blank group （P〈0.05）, the expression results in the acupuncture group and western medicine group were significantly higher than that in the model
基金The Project Supported by National Natural Science Foundation of China and Computer Chemistry Laboratory of Chinese Academy of Sciences.
文摘A new group-contribution method involving specific gravity as a parameter is proposed for predicting criticaltemperature.Being appliable to all kinds of organic compounds,it gives an average percent deviation of 0.88%for 93 compounds and is particularly useful to those substances for which the normal boiling points are stillunknown.
文摘A new chemically mutagenic mutant of Synechococcus PCC7942 named high-CO2 re-quiring mutant, which could grow at 4% CO2 but could not grow at air levels of CO2, was isolated. Com-parative studies on some physiological aspects of the mutant and high-cO2 growing cells (growing at 4%CO2 ) were conducted. The result showed that the mutant had lower growing rate, about 1/40th photosyn-thetic affinity to inorganic carbon, 25% lower carbonic anhydrase (CA) activity, lower quenching rate ofchlorophyll fluoresence, and about 1/2 alkalinization rate of the medium. The CA activity responses ofthe two types of cells to different concentrations of CO2 were determined. Upon the addition of inorganiccarbon (Ci), the rate of active Ci uptake described by the rate of chlorophyll fluorescence quenching ofthe mutant was obviously lower compared with that of the high-CO2 growing cells; the size of the internalinorganic carbon pool size determined by the extent of fluorescence quenching Of the mutant was alsosmaller.
文摘5’-bromodeoxycytidine (BrdU)-resistance is a marker widely used in animal somatic cell genetics. The BrdU-resistance is the retardation of BrdU incorporation into DNA, which prevents the cell from phosphorating the thymidine or BrdU. BrdU-restance can be manifested by the change of osmolarity of cytoplasmic membrane or other unkown causes. It has been reported that even BrdU-resistant cells requiring
文摘Objective To study the role of inositol requiring enzyme 1(IRE1)-mediated endoplasmic reticulum stress on hepatocyte apoptosis of experimental fulminant hepatic failure(FHF). Methods Thirty male depuratory
基金supported by the University of California Davis Health Department of Anesthesiology and Pain MedicineNIH grant UL1 TR001860 of the University of California Davis Health
文摘As the aging population continues to increase worldwide,a proportionally increasing number of elderly patients will be undergoing surgical procedures requiring anesthesia care.It has been estimated that approximately one of every three surgical procedures are performed on a patient who is 65 years of age or older.
文摘Among the disease of the urinary tract in dogs and cats,the most common diseases requiring surgery are urinary bladder and urethra.In this article,the principles of diagnosis,strategy of treatments and basic techniques for these diseases are discussed.1 Urinary bladder In dogs,most common bladder diseases are cystitis,cystic calculi,cystic trauma due to car accident and bladder cancer.The patients often show abnormal urination such as incontinence,pollakiuria and stranguria.Turbid urine or he-
文摘The plasma membrane of the cell wall of Halobacterium contains a purple membrane which is a novel light energy transducing membrane. On absorbing light energy, protons are translocated across the membrane and thereby a proton gradient is generated. The energy stored as proton gradient may be used by the cell for ATP synthesis or other biological energy-requiring functions.
文摘A sign pattern(matrix)is a matrix whose entries are the symbols+,-and 0.Foran n×n sign pattern matrix A,the sign pattern class of A,denoted by Q(A),is the set ofall n×n real matrices whose entries have signs indicated by the corresponding entries of A.We say that a sign pattern matrix A requires a matrix property P if every real matrix in Q(A)has the property P.A matrix with all distinct eigenvalues has many nice
文摘On August 10th, 2009 the Ministry of PublicSecurity, the Ministry of Commerce, theGeneral Administration of Customs, the StateAdministration for Industry & Commerce, theState Administration of Work Safety and theState Food and Drug Administration jointlypromulgated a regulation, requiring the
文摘Pigs are important animal models in veterinary and medical research and have been widely used in experiments requiring surgical anesthesia[1,2].The aim of this study was to assess cardiac,hemodynamic and respiratory responses during propofol-sevoflurane intravenous and inhalant combined approach after premedication with ShumianningⅡand evaluate the quality of anesthesia and recovery in minipigs.1 Materials and
