目的分析江苏省镇江市男男同性性行为人群(men who have sex with men,MSM)中人类免疫缺陷病毒(human immunodeficiency virus,HIV)重复检测比例及影响因素,为进一步促进MSM HIV定期检测提供政策依据。方法2019—2021年,本研究通过社交...目的分析江苏省镇江市男男同性性行为人群(men who have sex with men,MSM)中人类免疫缺陷病毒(human immunodeficiency virus,HIV)重复检测比例及影响因素,为进一步促进MSM HIV定期检测提供政策依据。方法2019—2021年,本研究通过社交软件Blued平台“快乐检”招募MSM,采用横断面调查问卷收集一般人口学信息、HIV检测史、性行为特征等相关信息,采用logistic回归分析影响HIV重复检测的因素。结果本研究纳入MSM 1307例,HIV重复检测857例(65.57%)。多因素logistic回归分析显示,低年龄(0~<25岁,OR=1.72,95%CI:1.04~2.85),月收入低于5000元(0~<3000元:OR=2.00,95%CI:1.36~2.95;3000~<5000元:OR=1.47,95%CI:1.09~1.98),知晓性伴HIV感染状况(OR=1.58,95%CI:1.19~2.09),罹患性病(OR=5.42,95%CI:1.62~18.11),饮酒后发生肛交或口交性行为(OR=1.58,95%CI:1.14~2.20),最近1次检测方式为自我检测(OR=1.85,95%CI:1.23~2.79)和HIV抗体检测阴性(OR=2.25,95%CI:1.29~3.91)人群更容易进行HIV重复检测。结论镇江市MSM HIV重复检测率仍需进一步提高,应加大HIV自我检测的推广,同时加强MSM高危性行为干预,切实降低MSM HIV感染风险。展开更多
A face serum composed of a combination of biologically active compounds was evaluated for safety and efficacy <em>in vitro</em>, in a repeat insult patch test and in a human clinical efficacy trial. The se...A face serum composed of a combination of biologically active compounds was evaluated for safety and efficacy <em>in vitro</em>, in a repeat insult patch test and in a human clinical efficacy trial. The serum inhibited tyrosinase activity modestly, decreased collagenase activity and exhibited notable free radical scavenging activity <em>in vitro</em>. It is gentle to the skin, as the serum did not irritate the skin or produce symptoms of allergic contact dermatitis in the 55 healthy adults that participated in the repeat insult patch test. In the efficacy trial, daily application of the face serum for 30 days significantly increased skin hydration, with all 35 volunteers experiencing improvement. Substantial improvements in skin elasticity, roughness (fine lines and wrinkles), and brightness also occurred during the trial. Dermatological examination also revealed a trend for reduced comedone count with use of the serum. Self-assessment responses revealed that all volunteers experienced improvements in multiple skin quality parameters and that participant perceptions are consistent with the results of the instrumental analyses. These findings indicated that the measured improvements in skin quality are not only statistically significant but are also clinically relevant as they were great enough for users of the face serum to feel and recognize.展开更多
文摘目的分析江苏省镇江市男男同性性行为人群(men who have sex with men,MSM)中人类免疫缺陷病毒(human immunodeficiency virus,HIV)重复检测比例及影响因素,为进一步促进MSM HIV定期检测提供政策依据。方法2019—2021年,本研究通过社交软件Blued平台“快乐检”招募MSM,采用横断面调查问卷收集一般人口学信息、HIV检测史、性行为特征等相关信息,采用logistic回归分析影响HIV重复检测的因素。结果本研究纳入MSM 1307例,HIV重复检测857例(65.57%)。多因素logistic回归分析显示,低年龄(0~<25岁,OR=1.72,95%CI:1.04~2.85),月收入低于5000元(0~<3000元:OR=2.00,95%CI:1.36~2.95;3000~<5000元:OR=1.47,95%CI:1.09~1.98),知晓性伴HIV感染状况(OR=1.58,95%CI:1.19~2.09),罹患性病(OR=5.42,95%CI:1.62~18.11),饮酒后发生肛交或口交性行为(OR=1.58,95%CI:1.14~2.20),最近1次检测方式为自我检测(OR=1.85,95%CI:1.23~2.79)和HIV抗体检测阴性(OR=2.25,95%CI:1.29~3.91)人群更容易进行HIV重复检测。结论镇江市MSM HIV重复检测率仍需进一步提高,应加大HIV自我检测的推广,同时加强MSM高危性行为干预,切实降低MSM HIV感染风险。
文摘A face serum composed of a combination of biologically active compounds was evaluated for safety and efficacy <em>in vitro</em>, in a repeat insult patch test and in a human clinical efficacy trial. The serum inhibited tyrosinase activity modestly, decreased collagenase activity and exhibited notable free radical scavenging activity <em>in vitro</em>. It is gentle to the skin, as the serum did not irritate the skin or produce symptoms of allergic contact dermatitis in the 55 healthy adults that participated in the repeat insult patch test. In the efficacy trial, daily application of the face serum for 30 days significantly increased skin hydration, with all 35 volunteers experiencing improvement. Substantial improvements in skin elasticity, roughness (fine lines and wrinkles), and brightness also occurred during the trial. Dermatological examination also revealed a trend for reduced comedone count with use of the serum. Self-assessment responses revealed that all volunteers experienced improvements in multiple skin quality parameters and that participant perceptions are consistent with the results of the instrumental analyses. These findings indicated that the measured improvements in skin quality are not only statistically significant but are also clinically relevant as they were great enough for users of the face serum to feel and recognize.
