In this paper,there are discussed the informational functions of the living structures,analyzing the properties of the simplest eukaryotic cell as an example of a structural unit of the living unicellular and multicel...In this paper,there are discussed the informational functions of the living structures,analyzing the properties of the simplest eukaryotic cell as an example of a structural unit of the living unicellular and multicellular systems.The initiation of this analysis starts from an older example of an imaginary mechanism,particularly that described by the Maxwell’s demon experiment,which along the history of the information development concepts accompanied the philosophic vision on the structuration of matter and of the living entities,showing that these are actually the result of the intervention of information on the matter available substrate.Particularly,it is shown that the deoxyribonucleic acid(DNA)structure is appropriate to store a large quantity of structural information,allowing the transfer of this information by transcription and translation mechanisms to proteins,which act as(re)structuration/transmission informational agents,or the generation of a new cellular daughter structure by a replication process.On the basis of the theory of information in communication channels,applicable also in biological systems,it was discussed the followed line for the evaluation of the quantity of structural information in various cells,demonstrating the evolution of organism complexity by the increase of the structural information quantity from unicellular(bacterium)to human cell.Applying a natural strategy of entropy lowering mainly by heat elimination,folding protein structuration and compartmentalization on the evolutionary scale,the living structures act as dynamic entities assuring their self-organizational structure by a permanent change of matter,energy and information with the environment in an efficient way,following a negative entropic process by internal structuration,similarly with Maxwell’s demon work.It is shown that to assure such a communication with external and internal intracellular structure,it was necessary the development of an own info-operational system of communication and decision,in which th展开更多
Age-related macular degeneration (AMD) is still an incurable blinding eye disease because of complex pathogenic mechanisms and unusual diseased regions.With the use of chemical biology tools,great progress has been ac...Age-related macular degeneration (AMD) is still an incurable blinding eye disease because of complex pathogenic mechanisms and unusual diseased regions.With the use of chemical biology tools,great progress has been achieved in improving the understanding of AMD pathogenesis.The severity of AMD is,at least in part,linked to the non-degradable lipofuscin bis-retinoids in retinal pigment epithelial (RPE).This material is thought to result from the lifelong accumulation of lysosomal residual bodies containing the end products derived from the daily phagocytosis of rod outer segments by RPE cells.Here,we present previously recognized bis-retinoids with focus on structures and biosynthetic pathways.In addition to a brief discussion on the mutual conversion relationships of bis-retinoids,future perspectives and the medical relevance of such studies on these lipofuscin constituents are also highlighted.展开更多
文摘In this paper,there are discussed the informational functions of the living structures,analyzing the properties of the simplest eukaryotic cell as an example of a structural unit of the living unicellular and multicellular systems.The initiation of this analysis starts from an older example of an imaginary mechanism,particularly that described by the Maxwell’s demon experiment,which along the history of the information development concepts accompanied the philosophic vision on the structuration of matter and of the living entities,showing that these are actually the result of the intervention of information on the matter available substrate.Particularly,it is shown that the deoxyribonucleic acid(DNA)structure is appropriate to store a large quantity of structural information,allowing the transfer of this information by transcription and translation mechanisms to proteins,which act as(re)structuration/transmission informational agents,or the generation of a new cellular daughter structure by a replication process.On the basis of the theory of information in communication channels,applicable also in biological systems,it was discussed the followed line for the evaluation of the quantity of structural information in various cells,demonstrating the evolution of organism complexity by the increase of the structural information quantity from unicellular(bacterium)to human cell.Applying a natural strategy of entropy lowering mainly by heat elimination,folding protein structuration and compartmentalization on the evolutionary scale,the living structures act as dynamic entities assuring their self-organizational structure by a permanent change of matter,energy and information with the environment in an efficient way,following a negative entropic process by internal structuration,similarly with Maxwell’s demon work.It is shown that to assure such a communication with external and internal intracellular structure,it was necessary the development of an own info-operational system of communication and decision,in which th
基金supported by the National Natural Science Foundation of China(Nos.21202146 and 81271018)the Fundamental Research Funds for the Central Universities,Chinathe Zhejiang Key Laboratory Fund of China(No.2011E10006)
文摘Age-related macular degeneration (AMD) is still an incurable blinding eye disease because of complex pathogenic mechanisms and unusual diseased regions.With the use of chemical biology tools,great progress has been achieved in improving the understanding of AMD pathogenesis.The severity of AMD is,at least in part,linked to the non-degradable lipofuscin bis-retinoids in retinal pigment epithelial (RPE).This material is thought to result from the lifelong accumulation of lysosomal residual bodies containing the end products derived from the daily phagocytosis of rod outer segments by RPE cells.Here,we present previously recognized bis-retinoids with focus on structures and biosynthetic pathways.In addition to a brief discussion on the mutual conversion relationships of bis-retinoids,future perspectives and the medical relevance of such studies on these lipofuscin constituents are also highlighted.
