目的研究卒中后认知障碍早期康复治疗对患者康复效果的影响。方法整群选取2013年1—12月该院收治的88例确诊并开始治疗的脑卒中患者,分为观察和对照两组,每组44例。对照组患者进行规范、系统的康复治疗与指导,观察组在对照组治疗的基础...目的研究卒中后认知障碍早期康复治疗对患者康复效果的影响。方法整群选取2013年1—12月该院收治的88例确诊并开始治疗的脑卒中患者,分为观察和对照两组,每组44例。对照组患者进行规范、系统的康复治疗与指导,观察组在对照组治疗的基础上再进行专门认知康复训练,并使用简易智能状态检查(mini-mental state examination,MMSE)量表、运动功能和ADL能力评分:分别采用Fugl-Meyer分级及改良Barthel指数评分对患者进行效果比较。结果康复治疗3个月后观察组患者的MMSE评分为(25.9±1.71)分、Fugl-Meyer评分(56.92±1.86)分、Barthel评分(68.13±3.64)分;对照组患者的MMSE评分为(21.68±1.7)分、Fugl-Meyer评分(41.22±1.47)分、Barthel评分(51.56±1.97)分,差异有统计学意义(P<0.05),观察组患者康复效果优于对照组。结论早期康复治疗对脑卒中患者的认知功能障碍有明显的改善作用。值得临床应用。展开更多
BACKGROUND： At present, there are many studies on the rehabilitation therapy of stroke patients with hemiplegia, but there is deficiency of corresponding standardized rehabilitation program. OBJECTIVE： To explore th...BACKGROUND： At present, there are many studies on the rehabilitation therapy of stroke patients with hemiplegia, but there is deficiency of corresponding standardized rehabilitation program. OBJECTIVE： To explore the effects of standardized tertiary rehabilitation on the activities of daily living in stroke patients with hemiplegia within 6 months after attack. DESIGN： A clinical observation. SETTING： Department of Rehabilitation Medicine, Huashan Hospital of Fudan University. PARTICIPANTS： Eighty-two outpatients and inpatients with acute stroke were selected from the Department of Neurology, Shanghai Huashan Hosptial from January 1999 to June 2003, including 49 males and 33 females, 40 - 80 years of age, with a mean age of （65 ±11） years old. Inclusive criteria： According to the diagnostic standards for cerebrovascular diseases set by Fourth National Academic Meeting for Cerebrovascular Disease in 1995, the patients were diagnosed as new attack of cerebral infarction or cerebral hemorrhage, and confirmed by CT or MRI to be initial patients; They should be accorded with the following conditions, including within 1 week after stabilization of life signs, Glasgow coma score 〉 8 points, 40 - 80 years of age, with disturbance of limb function. Informed consents were obtained from all the patients or their relatives. Exclusive criteria： Patients were excluded due to active liver disease, liver and kidney malfunction, congestive heart failure, malignant tumor, history of dementia, failure in respiratory function, tetraplegia; cerebral infarction or cerebral hemorrhage for more than 3 weeks; unable to be followed up due to in other cities and provinces; psychiatric history; deafness and muteness. According to the will of the patients or their relatives, the patients who accepted the standardized rehabilitation program were enrolled as the treatment group （n =42）, and the others as the control group （n =40）. Approval was obtained from the ethical committee of the hospital. METHODS： All the 展开更多
Coronavirus disease 2019(COVID-19),which was outbreak in December 2019 Wuhan,China,has spread to more than 100 countries.In addition to respiratory symptoms,COVID-19 can also cause some digestive symptoms such as naus...Coronavirus disease 2019(COVID-19),which was outbreak in December 2019 Wuhan,China,has spread to more than 100 countries.In addition to respiratory symptoms,COVID-19 can also cause some digestive symptoms such as nausea and diarrhea.As a variety of respiratory diseases which are associated with a dysbiosis in both airway microbiota and the intestinal microbiota,COVID-19 may cause digestive symptoms through a constant cross-talk between the system which is known as the Gut_Lung Axis.Additionally,lymphopenia and hypercytokinemia were also common in COVID-19 patients which suggest that COVID-19 could compromise the immune system.Given the fact that gut microbiota not only could maintain immune homeostasis and immune responses at local mucosal surfaces,but also has distal protective effects and protect against respiratory virus.FMT is an effective way to enhance immunity and would be a potential therapy for individuals with viral infection.However,currently no direct clinical evidence proved that modulation of gut microbiota has the therapeutic role in treatment of COVID-19,from the perspective of microbiota and immunity after viral infection,we speculate that targeting gut microbiota might be a new therapeutic option or at least adjuvant therapeutic choice.In this Personal View,we describe the five aspects:COVID-19 and compromised immunity system,Microbiota,immune system and viral infection,FMT,immunity and virus infection,potential application of FMT in the treatment of COVID-19.展开更多
目的探讨早期康复治疗对脊髓损伤患者生存质量(Quality of life,QOL)的影响。方法选择脊髓损伤患者86例,按康复治疗介入的时间分为早期康复组(3个月内就诊)46例和对照组(3个月后就诊)40例,两组均接受常规康复治疗,并对每组患者在入组时...目的探讨早期康复治疗对脊髓损伤患者生存质量(Quality of life,QOL)的影响。方法选择脊髓损伤患者86例,按康复治疗介入的时间分为早期康复组(3个月内就诊)46例和对照组(3个月后就诊)40例,两组均接受常规康复治疗,并对每组患者在入组时和6个月后利用生存质量评定量表(WHOQOL-BREF)中文版对其QOL进行评定。结果与治疗前比较,早期康复组和对照组患者在治疗后的QOL评分均有显著提高(分别提高21.39±6.57;12.53±6.88,P<0.05),但治疗后,早期康复组的QOL评分(78.55±8.32)高于对照组(69.98±14.06),且差异有统计学意义(P<0.05)。结论早期康复治疗可以提高脊髓损伤患者的生存质量。展开更多
文摘目的研究卒中后认知障碍早期康复治疗对患者康复效果的影响。方法整群选取2013年1—12月该院收治的88例确诊并开始治疗的脑卒中患者,分为观察和对照两组,每组44例。对照组患者进行规范、系统的康复治疗与指导,观察组在对照组治疗的基础上再进行专门认知康复训练,并使用简易智能状态检查(mini-mental state examination,MMSE)量表、运动功能和ADL能力评分:分别采用Fugl-Meyer分级及改良Barthel指数评分对患者进行效果比较。结果康复治疗3个月后观察组患者的MMSE评分为(25.9±1.71)分、Fugl-Meyer评分(56.92±1.86)分、Barthel评分(68.13±3.64)分;对照组患者的MMSE评分为(21.68±1.7)分、Fugl-Meyer评分(41.22±1.47)分、Barthel评分(51.56±1.97)分,差异有统计学意义(P<0.05),观察组患者康复效果优于对照组。结论早期康复治疗对脑卒中患者的认知功能障碍有明显的改善作用。值得临床应用。
基金a grant from the State Science and Technology Department of "the Tenth Five-Year Plan" Tackle Key Problem,No.2001BA703B21
文摘BACKGROUND： At present, there are many studies on the rehabilitation therapy of stroke patients with hemiplegia, but there is deficiency of corresponding standardized rehabilitation program. OBJECTIVE： To explore the effects of standardized tertiary rehabilitation on the activities of daily living in stroke patients with hemiplegia within 6 months after attack. DESIGN： A clinical observation. SETTING： Department of Rehabilitation Medicine, Huashan Hospital of Fudan University. PARTICIPANTS： Eighty-two outpatients and inpatients with acute stroke were selected from the Department of Neurology, Shanghai Huashan Hosptial from January 1999 to June 2003, including 49 males and 33 females, 40 - 80 years of age, with a mean age of （65 ±11） years old. Inclusive criteria： According to the diagnostic standards for cerebrovascular diseases set by Fourth National Academic Meeting for Cerebrovascular Disease in 1995, the patients were diagnosed as new attack of cerebral infarction or cerebral hemorrhage, and confirmed by CT or MRI to be initial patients; They should be accorded with the following conditions, including within 1 week after stabilization of life signs, Glasgow coma score 〉 8 points, 40 - 80 years of age, with disturbance of limb function. Informed consents were obtained from all the patients or their relatives. Exclusive criteria： Patients were excluded due to active liver disease, liver and kidney malfunction, congestive heart failure, malignant tumor, history of dementia, failure in respiratory function, tetraplegia; cerebral infarction or cerebral hemorrhage for more than 3 weeks; unable to be followed up due to in other cities and provinces; psychiatric history; deafness and muteness. According to the will of the patients or their relatives, the patients who accepted the standardized rehabilitation program were enrolled as the treatment group （n =42）, and the others as the control group （n =40）. Approval was obtained from the ethical committee of the hospital. METHODS： All the
基金This project was supported by National Natural Science foundation of China(81970156).We thank Bohong Dengand Fusheng Liu for assistance in preparing the manuscript.
文摘Coronavirus disease 2019(COVID-19),which was outbreak in December 2019 Wuhan,China,has spread to more than 100 countries.In addition to respiratory symptoms,COVID-19 can also cause some digestive symptoms such as nausea and diarrhea.As a variety of respiratory diseases which are associated with a dysbiosis in both airway microbiota and the intestinal microbiota,COVID-19 may cause digestive symptoms through a constant cross-talk between the system which is known as the Gut_Lung Axis.Additionally,lymphopenia and hypercytokinemia were also common in COVID-19 patients which suggest that COVID-19 could compromise the immune system.Given the fact that gut microbiota not only could maintain immune homeostasis and immune responses at local mucosal surfaces,but also has distal protective effects and protect against respiratory virus.FMT is an effective way to enhance immunity and would be a potential therapy for individuals with viral infection.However,currently no direct clinical evidence proved that modulation of gut microbiota has the therapeutic role in treatment of COVID-19,from the perspective of microbiota and immunity after viral infection,we speculate that targeting gut microbiota might be a new therapeutic option or at least adjuvant therapeutic choice.In this Personal View,we describe the five aspects:COVID-19 and compromised immunity system,Microbiota,immune system and viral infection,FMT,immunity and virus infection,potential application of FMT in the treatment of COVID-19.
文摘目的探讨早期康复治疗对脊髓损伤患者生存质量(Quality of life,QOL)的影响。方法选择脊髓损伤患者86例,按康复治疗介入的时间分为早期康复组(3个月内就诊)46例和对照组(3个月后就诊)40例,两组均接受常规康复治疗,并对每组患者在入组时和6个月后利用生存质量评定量表(WHOQOL-BREF)中文版对其QOL进行评定。结果与治疗前比较,早期康复组和对照组患者在治疗后的QOL评分均有显著提高(分别提高21.39±6.57;12.53±6.88,P<0.05),但治疗后,早期康复组的QOL评分(78.55±8.32)高于对照组(69.98±14.06),且差异有统计学意义(P<0.05)。结论早期康复治疗可以提高脊髓损伤患者的生存质量。
