T cell-redirecting bispecific antibodies are specifically designed to bind to tumor-associated antigens,thereby engaging with CD3 on the T cell receptor.This linkage between tumor cells and T cells actively triggers T...T cell-redirecting bispecific antibodies are specifically designed to bind to tumor-associated antigens,thereby engaging with CD3 on the T cell receptor.This linkage between tumor cells and T cells actively triggers T cell activation and initiates targeted killing of the identified tumor cells.These antibodies have emerged as one of the most promising avenues within tumor immunotherapy.However,despite success in treating hematological malignancies,significant advancements in solid tumors have yet to be explored.In this review,we aim to address the critical challenges associated with T cellredirecting bispecific antibodies and explore novel strategies to overcome these obstacles,with the ultimate goal of expanding the application of this therapy to include solid tumors.展开更多
Honeypot is a recent developed computer security concept which uses active offense to against attacks from hackers . It lures hackers to attack a seemly vulnerable fake network where they could be well observed in ord...Honeypot is a recent developed computer security concept which uses active offense to against attacks from hackers . It lures hackers to attack a seemly vulnerable fake network where they could be well observed in order to learn about the tactics and tools used by the attackers, so that we may improve the system security accordingly later. In this paper, we propose a novel approach for redirecting technique in honeypot system. First, we introduce briefly concepts of the honeypot system. Then we describe a redirection technique and an implementation algorithm. Finally, using the IDS Snort and the firewall IPTable, we set up a testing environment and give some simulations results. We also discuss some future research topics.展开更多
Background: Mesh expansion and fixation at retro-rectus plane through multiples stabs produces good results. But these stabs cause cosmetic disorders for the patients and doctors. So, we find some modification to do t...Background: Mesh expansion and fixation at retro-rectus plane through multiples stabs produces good results. But these stabs cause cosmetic disorders for the patients and doctors. So, we find some modification to do this procedure without these stabbing wounds in midline hernial repair. Patients and methods: This technique was used to fix the mesh at retro-rectus plane in 50 patients suffering from midline hernias, from January 2008 through January 2010 at Zagazig university Hospital, Egypt. Laparotomy incision was done over the hernial sac or at old incision;the contents were then released and reduced into peritoneal cavity without much subcutaneous dissection. The suitable sheet of polypropylene mesh to cover the hernial defect and any weak area was prepared and fixed at retro-rectus plane percutaneously without stabbing wounds by using redirecting suture hook. The mean period of follow up was 26 months. Results: There was no recurrence during the period of follow up. Five patients developed subcutaneous bluish discoloration at the site of some stitches, which disappear within two weeks with conservative treatment. Conclusion: Percutaneous mesh expansion and fixation at retro-rectus plane by using redirecting suture hook procedure has good results in recurrence rate and cosmetic appearance.展开更多
DNS-based server redirecting is considered the most popular means of deploying CDNs. However, with the inaeasing use of i"emol:e DNS, DNS-based CDNs face a great challenge in performance degradation. To address t...DNS-based server redirecting is considered the most popular means of deploying CDNs. However, with the inaeasing use of i"emol:e DNS, DNS-based CDNs face a great challenge in performance degradation. To address this issue, encouraging progress has been made in both industry and research communities. In this article,state-of- art solutions for the remote DNS problem are discussed at first. Next, privacy concerns about DNS-based CDNs, including client location as well as redirection privacy, are identified and a representative solution is summarized. Finally, the solution is compared to those in prior works under different measures, and a discussion on DNS-based CDN applications is provided. A model is also established to deepen the underst;anding of CDN performance. We believe that this survey will shed light on the application of DNS-based CDNs, and it is expected to provide design guidelines to CDN service providers.展开更多
While the primary role of window attachments is often to moderate glare and solar heat gains,they are also able to provide additional daylight to interior spaces.For this purpose,a variety of daylight-redirecting wind...While the primary role of window attachments is often to moderate glare and solar heat gains,they are also able to provide additional daylight to interior spaces.For this purpose,a variety of daylight-redirecting window systems have been developed over the past 150 years.Fixed reflective systems(slats/light shelves)or prismatic systems that rely on total internal reflection work well under specific solar conditions,but generally sacrifice performance over a much wider range of incident solar angles and sky conditions.Dynamic systems-typically reflective slats-are more responsive to sun angles but have not been able to achieve optimal performance for glare and daylight redirection efficiency.A previous investigation into an adjustable,reflective blind concept first conceived of in the late 1970s showed promise but was not reduced to practice due to lack of adequate simulation and analysis tools.In this paper,this concept is further developed and its energy and visual comfort performance evaluated for four mid-latitude,temperate climates using ray-tracing simulation techniques.Results indicate significant potential lighting energy savings when compared with conventional automated reflective blinds(2.1-4.9 kWh/(m^(2)·a),or 14%-42%,depending on climate and orientation)or,especially,manually-operated matte white Venetian blinds(1.4-7.9 kWh/(m^(2)·a),or 9%-54%,depending on climate and orientation),while maintaining acceptable or better visual comfort conditions throughout the interior space.展开更多
基金supported by the National Natural Science Foundation of China(Nos.32070940 and 81991491)the China Postdoctoral Science Foundation(No.2021M700115)+2 种基金the Postdoctoral Innovation Talents Support Program(No.BX20220189,China)the Science and Technology Planning Project of Fujian Province(No.2022L3080,China)the CAMS Innovation Fund for Medical Sciences(No.2019RU022,China).
文摘T cell-redirecting bispecific antibodies are specifically designed to bind to tumor-associated antigens,thereby engaging with CD3 on the T cell receptor.This linkage between tumor cells and T cells actively triggers T cell activation and initiates targeted killing of the identified tumor cells.These antibodies have emerged as one of the most promising avenues within tumor immunotherapy.However,despite success in treating hematological malignancies,significant advancements in solid tumors have yet to be explored.In this review,we aim to address the critical challenges associated with T cellredirecting bispecific antibodies and explore novel strategies to overcome these obstacles,with the ultimate goal of expanding the application of this therapy to include solid tumors.
基金This workis supported by Natural Science Foundation of Jiangsu Province (BK2004218 ,BK2003106) Pandeng Project of Nanjing Universities of Postsand Telecommunications.
文摘Honeypot is a recent developed computer security concept which uses active offense to against attacks from hackers . It lures hackers to attack a seemly vulnerable fake network where they could be well observed in order to learn about the tactics and tools used by the attackers, so that we may improve the system security accordingly later. In this paper, we propose a novel approach for redirecting technique in honeypot system. First, we introduce briefly concepts of the honeypot system. Then we describe a redirection technique and an implementation algorithm. Finally, using the IDS Snort and the firewall IPTable, we set up a testing environment and give some simulations results. We also discuss some future research topics.
文摘Background: Mesh expansion and fixation at retro-rectus plane through multiples stabs produces good results. But these stabs cause cosmetic disorders for the patients and doctors. So, we find some modification to do this procedure without these stabbing wounds in midline hernial repair. Patients and methods: This technique was used to fix the mesh at retro-rectus plane in 50 patients suffering from midline hernias, from January 2008 through January 2010 at Zagazig university Hospital, Egypt. Laparotomy incision was done over the hernial sac or at old incision;the contents were then released and reduced into peritoneal cavity without much subcutaneous dissection. The suitable sheet of polypropylene mesh to cover the hernial defect and any weak area was prepared and fixed at retro-rectus plane percutaneously without stabbing wounds by using redirecting suture hook. The mean period of follow up was 26 months. Results: There was no recurrence during the period of follow up. Five patients developed subcutaneous bluish discoloration at the site of some stitches, which disappear within two weeks with conservative treatment. Conclusion: Percutaneous mesh expansion and fixation at retro-rectus plane by using redirecting suture hook procedure has good results in recurrence rate and cosmetic appearance.
文摘DNS-based server redirecting is considered the most popular means of deploying CDNs. However, with the inaeasing use of i"emol:e DNS, DNS-based CDNs face a great challenge in performance degradation. To address this issue, encouraging progress has been made in both industry and research communities. In this article,state-of- art solutions for the remote DNS problem are discussed at first. Next, privacy concerns about DNS-based CDNs, including client location as well as redirection privacy, are identified and a representative solution is summarized. Finally, the solution is compared to those in prior works under different measures, and a discussion on DNS-based CDN applications is provided. A model is also established to deepen the underst;anding of CDN performance. We believe that this survey will shed light on the application of DNS-based CDNs, and it is expected to provide design guidelines to CDN service providers.
基金supported by the California Energy Commission through its Electric Program Investment Charge(EPIC)Program on behalf of the citizens of California and by the Assistant Secretary for Energy Efficiency and Renewable Energy of the U.S.Department of Energy under Contract No.DE-AC02-05CH11231.
文摘While the primary role of window attachments is often to moderate glare and solar heat gains,they are also able to provide additional daylight to interior spaces.For this purpose,a variety of daylight-redirecting window systems have been developed over the past 150 years.Fixed reflective systems(slats/light shelves)or prismatic systems that rely on total internal reflection work well under specific solar conditions,but generally sacrifice performance over a much wider range of incident solar angles and sky conditions.Dynamic systems-typically reflective slats-are more responsive to sun angles but have not been able to achieve optimal performance for glare and daylight redirection efficiency.A previous investigation into an adjustable,reflective blind concept first conceived of in the late 1970s showed promise but was not reduced to practice due to lack of adequate simulation and analysis tools.In this paper,this concept is further developed and its energy and visual comfort performance evaluated for four mid-latitude,temperate climates using ray-tracing simulation techniques.Results indicate significant potential lighting energy savings when compared with conventional automated reflective blinds(2.1-4.9 kWh/(m^(2)·a),or 14%-42%,depending on climate and orientation)or,especially,manually-operated matte white Venetian blinds(1.4-7.9 kWh/(m^(2)·a),or 9%-54%,depending on climate and orientation),while maintaining acceptable or better visual comfort conditions throughout the interior space.
