Cattle encephalon glycoside and ignotin(CEGI)injection is a compound preparation formed by a combination of muscle extract from hea lthy rabbits and brain gangliosides from cattle,and it is generally used as a neuropr...Cattle encephalon glycoside and ignotin(CEGI)injection is a compound preparation formed by a combination of muscle extract from hea lthy rabbits and brain gangliosides from cattle,and it is generally used as a neuroprotectant in the treatment of central and peripheral nerve injuries.However,there is still a need for high-level clinical evidence from large samples to support the use of CEGI.We therefore carried out a prospective,multicenter,randomized,double-blind,parallel-group,placebo-controlled study in which we recruited 319 patients with acute cerebral infarction from 16 centers in China from October 2013 to May 2016.The patients were randomized at a 3:1 ratio into CEGI(n=239;155 male,84 female;61.2±9.2 years old)and placebo(n=80;46 male,34 female;63.2±8.28 years old)groups.All patients were given standard care once daily for 14 days,including a 200 mg aspirin enteric-coated tablet and 20 mg atorvastatin calcium,both taken orally,and intravenous infusion of 250–500 mL 0.9%sodium chloride containing 40 mg sodium tanshinone IIA sulfonate.Based on conventional treatment,patients in the CEGI and placebo groups were given 12 mL CEGI or 12 mL sterile water,respectively,in an intravenous drip of 250 mL 0.9%sodium chloride(2 mL/min)once daily for 14 days.According to baseline National Institutes of Health Stroke Scale scores,patients in the two groups were divided into mild and moderate subgroups.Based on the modified Rankin Scale results,the rate of patients with good outcomes in the CEGI group was higher than that in the placebo group,and the rate of disability in the CEGI group was lower than that in the placebo group on day 90 after treatment.In the CEGI group,neurological deficits were decreased on days 14 and 90 after treatment,as measured by the National Institutes of Health Stroke Scale and the Barthel Index.Subgroup analysis revealed that CEGI led to more significant improvements in moderate stroke patients.No drug-related adverse events occurred in the CEGI or placebo groups.In conclusion,CEGI may be a 展开更多
基于电力客户的历史数据,采用客户的基本属性、用电行为、缴费行为、客户信用、行业前景信息等多个维度确定模型所需指标体系。通过指标的相关系数矩阵及信息值(information value,IV)筛选出最终进入模型的指标变量,同时采用最优分组的...基于电力客户的历史数据,采用客户的基本属性、用电行为、缴费行为、客户信用、行业前景信息等多个维度确定模型所需指标体系。通过指标的相关系数矩阵及信息值(information value,IV)筛选出最终进入模型的指标变量,同时采用最优分组的方法对变量进行分组,并进行证据权重转化(weight of evidence,WOE)。基于处理后的数据,运用逻辑回归算法构建用电客户电费风险预测模型,并依据得到的模型结果量化输出变量标准评分卡表,从而将客户划分为高风险、中风险和低风险用户,为不同的用户采取差异化的营销措施提供依据。展开更多
目的观察吸入不同浓度七氟醚联合丙泊酚麻醉对罗库溴铵药效学的影响。方法选择2014年11月—2015年2月在我院行择期腹部手术患者67例,按随机数字表法分为3组:丙泊酚联合呼气末0.5最低肺泡有效浓度(MAC)七氟醚组(Ⅰ组,24例);丙泊酚联合0.7...目的观察吸入不同浓度七氟醚联合丙泊酚麻醉对罗库溴铵药效学的影响。方法选择2014年11月—2015年2月在我院行择期腹部手术患者67例,按随机数字表法分为3组:丙泊酚联合呼气末0.5最低肺泡有效浓度(MAC)七氟醚组(Ⅰ组,24例);丙泊酚联合0.75 MAC七氟醚组(Ⅱ组,20例);丙泊酚联合1 MAC七氟醚组(Ⅲ组,23例)。3组患者采用咪达唑仑0.05 mg/kg、舒芬太尼0.3μg/kg、依托咪酯0.3 mg/kg诱导麻醉,闭环肌松输注系统(CLMRIS)输注2倍95%有效剂量(ED95)的罗库溴铵(0.6 mg/kg),并采用T1模式进行肌松监测。记录罗库溴铵平均使用剂量、恢复指数以及丙泊酚和瑞芬太尼的平均使用剂量。结果Ⅰ~Ⅲ组罗库溴铵平均使用剂量依次降低[(9.71±2.38 vs 7.50±0.98 vs 6.90±1.14)μg·kg^(-1)·min^(-1),F=18.562,P<0.05],3组间恢复指数差异无统计学意义[(8.92±2.62 vs 8.95±2.58 vs 10.30±3.65)min,F=1.577,P>0.05],同时Ⅲ组丙泊酚和瑞芬太尼的平均使用剂量较Ⅰ组、Ⅱ组降低(P<0.05)。结论高浓度的七氟醚可增强罗库溴铵的肌松作用,同时可减少丙泊酚和瑞芬太尼使用量。展开更多
文摘Cattle encephalon glycoside and ignotin(CEGI)injection is a compound preparation formed by a combination of muscle extract from hea lthy rabbits and brain gangliosides from cattle,and it is generally used as a neuroprotectant in the treatment of central and peripheral nerve injuries.However,there is still a need for high-level clinical evidence from large samples to support the use of CEGI.We therefore carried out a prospective,multicenter,randomized,double-blind,parallel-group,placebo-controlled study in which we recruited 319 patients with acute cerebral infarction from 16 centers in China from October 2013 to May 2016.The patients were randomized at a 3:1 ratio into CEGI(n=239;155 male,84 female;61.2±9.2 years old)and placebo(n=80;46 male,34 female;63.2±8.28 years old)groups.All patients were given standard care once daily for 14 days,including a 200 mg aspirin enteric-coated tablet and 20 mg atorvastatin calcium,both taken orally,and intravenous infusion of 250–500 mL 0.9%sodium chloride containing 40 mg sodium tanshinone IIA sulfonate.Based on conventional treatment,patients in the CEGI and placebo groups were given 12 mL CEGI or 12 mL sterile water,respectively,in an intravenous drip of 250 mL 0.9%sodium chloride(2 mL/min)once daily for 14 days.According to baseline National Institutes of Health Stroke Scale scores,patients in the two groups were divided into mild and moderate subgroups.Based on the modified Rankin Scale results,the rate of patients with good outcomes in the CEGI group was higher than that in the placebo group,and the rate of disability in the CEGI group was lower than that in the placebo group on day 90 after treatment.In the CEGI group,neurological deficits were decreased on days 14 and 90 after treatment,as measured by the National Institutes of Health Stroke Scale and the Barthel Index.Subgroup analysis revealed that CEGI led to more significant improvements in moderate stroke patients.No drug-related adverse events occurred in the CEGI or placebo groups.In conclusion,CEGI may be a
文摘基于电力客户的历史数据,采用客户的基本属性、用电行为、缴费行为、客户信用、行业前景信息等多个维度确定模型所需指标体系。通过指标的相关系数矩阵及信息值(information value,IV)筛选出最终进入模型的指标变量,同时采用最优分组的方法对变量进行分组,并进行证据权重转化(weight of evidence,WOE)。基于处理后的数据,运用逻辑回归算法构建用电客户电费风险预测模型,并依据得到的模型结果量化输出变量标准评分卡表,从而将客户划分为高风险、中风险和低风险用户,为不同的用户采取差异化的营销措施提供依据。
文摘目的观察吸入不同浓度七氟醚联合丙泊酚麻醉对罗库溴铵药效学的影响。方法选择2014年11月—2015年2月在我院行择期腹部手术患者67例,按随机数字表法分为3组:丙泊酚联合呼气末0.5最低肺泡有效浓度(MAC)七氟醚组(Ⅰ组,24例);丙泊酚联合0.75 MAC七氟醚组(Ⅱ组,20例);丙泊酚联合1 MAC七氟醚组(Ⅲ组,23例)。3组患者采用咪达唑仑0.05 mg/kg、舒芬太尼0.3μg/kg、依托咪酯0.3 mg/kg诱导麻醉,闭环肌松输注系统(CLMRIS)输注2倍95%有效剂量(ED95)的罗库溴铵(0.6 mg/kg),并采用T1模式进行肌松监测。记录罗库溴铵平均使用剂量、恢复指数以及丙泊酚和瑞芬太尼的平均使用剂量。结果Ⅰ~Ⅲ组罗库溴铵平均使用剂量依次降低[(9.71±2.38 vs 7.50±0.98 vs 6.90±1.14)μg·kg^(-1)·min^(-1),F=18.562,P<0.05],3组间恢复指数差异无统计学意义[(8.92±2.62 vs 8.95±2.58 vs 10.30±3.65)min,F=1.577,P>0.05],同时Ⅲ组丙泊酚和瑞芬太尼的平均使用剂量较Ⅰ组、Ⅱ组降低(P<0.05)。结论高浓度的七氟醚可增强罗库溴铵的肌松作用,同时可减少丙泊酚和瑞芬太尼使用量。
文摘遥感技术可以快速、准确地监测森林火灾火烧迹地的植被遥感参数变化,分析植被对火灾的响应与恢复特征,为防灾减灾决策提供科学依据。本文首先基于森林火灾前后的Landsat5 TM数据,利用差分归一化燃烧指数(the Differential Normalized Burn Ratio,d NBR)来提取2009年澳大利亚维多利亚州火烧迹地的范围,计算过火区面积及火烧强度;其次基于时间序列的全球地表特征参量(Global Land Surface Satellite,GLASS)产品中的叶面积指数(Leaf Area Index,LAI)、吸收光合有效辐射比例(Fraction of Absorbed Photosynthetically Active Radiation,FAPAR)数据,利用距平分析法对比不同火烧强度过火区植被与未过火区植被受森林火灾的影响状况与植被恢复特征。结果表明,森林火灾发生后,LAI、FAPAR值迅速降低,火烧强度越大,LAI、FAPAR下降程度越大,高火烧强度过火区的LAI、FAPAR最大降幅分别为中火烧强度、低火烧强度过火区的1.2、1.3倍;随时间推移,LAI、FAPAR值逐渐上升,在2-3年内恢复至未过火区水平。LAI、FAPAR恢复至未过火区平均水平的时间与森林火灾规模、火烧强度密切相关:维多利亚州森林火灾过火区域中大过火斑块、高火烧强度林地的植被遥感参数恢复时间相比小过火斑块、低火烧强度林地滞后1-2年。植被遥感参数LAI、FAPAR能很好地反映过火区植被的受损状况及恢复过程。
