Background:Erzhu Erchen decoction(EZECD),which is based on Erchen decoction and enhanced with Atractylodes lancea and Atractylodes macrocephala,is widely used for the treatment of dampness and heat(The clinical manife...Background:Erzhu Erchen decoction(EZECD),which is based on Erchen decoction and enhanced with Atractylodes lancea and Atractylodes macrocephala,is widely used for the treatment of dampness and heat(The clinical manifestations of Western medicine include thirst,inability to drink more,diarrhea,yellow urine,red tongue,et al.)internalized disease.Nevertheless,the mechanism of EZECD on damp-heat internalized Type 2 diabetes(T2D)remains unknown.We employed data mining,pharmacology databases and experimental verification to study how EZECD treats damp-heat internalized T2D.Methods:The main compounds or genes of EZECD and damp-heat internalized T2D were obtained from the pharmacology databases.Succeeding,the overlapped targets of EZECD and damp-heat internalized T2D were performed by the Gene Ontology,kyoto encyclopedia of genes and genomes analysis.And the compound-disease targets-pathway network were constructed to obtain the hub compound.Moreover,the hub genes and core related pathways were mined with weighted gene co-expression network analysis based on Gene Expression Omnibus database,the capability of hub compound and genes was valid in AutoDock 1.5.7.Furthermore,and violin plot and gene set enrichment analysis were performed to explore the role of hub genes in damp-heat internalized T2D.Finally,the interactions of hub compound and genes were explored using Comparative Toxicogenomics Database and quantitative polymerase chain reaction.Results:First,herb-compounds-genes-disease network illustrated that the hub compound of EZECD for damp-heat internalized T2D could be quercetin.Consistently,the hub genes were CASP8,CCL2,and AHR according to weighted gene co-expression network analysis.Molecular docking showed that quercetin could bind with the hub genes.Further,gene set enrichment analysis and Gene Ontology represented that CASP8,or CCL2,is negatively involved in insulin secretion response to the TNF or lipopolysaccharide process,and AHR or CCL2 positively regulated lipid and atherosclerosis,and/or including NOD-lik展开更多
Stigma and discrimination because of epilepsy, leprosy and HIV/aids has decreased over the years, but this has not happened as regards mental illness. One aspect of the stigma issue is what has been described as self-...Stigma and discrimination because of epilepsy, leprosy and HIV/aids has decreased over the years, but this has not happened as regards mental illness. One aspect of the stigma issue is what has been described as self-stigmatization, the way the mentally ill look at themselves. The aim of this study was to illuminate the self-perception of mentally ill persons in a Swedish setting. An internationally well established questionnaire, Internalized Stigma of Mental Illness scale (ISMI) was used to investigate two samples of out-patients from northern Sweden (N = 260). Fifty two percent reported “minimum stigma”, 35% “mild” and 13% “moderate/severe” stigma. As many as 58% agreed to the statement “I am embarrassed or ashamed that I have a mental illness”. The levels of internalized stigma are rather high, but somewhat lower than reported from some other European and an Iranian study using the same methodology. In spite of several campaigns aimed at reducing the stigma and discrimination because of mental illness in Sweden, still the experience of self stigma is rather high. There is an urgent need to further developed anti-stigma strategies.展开更多
Purpose: There is extensive evidence regarding the relationship between HIV related stigma and disclosure;however, the influence of depression in this relationship is not well understood, and thus is the focus of our ...Purpose: There is extensive evidence regarding the relationship between HIV related stigma and disclosure;however, the influence of depression in this relationship is not well understood, and thus is the focus of our analysis. Methods: Baseline data from a prospective longitudinal cohort of 798 HIV patients starting ART in Kampala, Uganda were examined. A staged-approach regression analysis was used to examine variables associated with HIV disclosure to most people (general disclosure) and disclosure to primary sex partner. Internalized HIV stigma plus demographic and background covariates were first entered into the model;the binary indicator of clinical depression was added on step two, followed by the addition of the interaction of stigma and depression in step three. Separate analyses were conducted for each of the two disclosure outcomes. Results: 39% indicated that they kept their HIV status as a secret from most people, while 19% of respondents with a regular sex partner had not disclosed their HIV status to the partner. In bivariate analysis, respondents who preferred to keep their HIV status as a secret from most people had higher internalized HIV stigma (p < 0.001) and depression (p < 0.01), and were more likely to be clinically depressed (p < 0.01) compared with others in the sample. Similarly, participants who had not disclosed their HIV status to their main sex partner had higher internalized HIV stigma (p < 0.01) and depression (p < 0.05), and were more likely to be clinically depressed (p < 0.01) compared with those who had informed their partner of their HIV status. The regression analysis revealed that internalized HIV stigma was strongly negatively correlated with disclosure to primary partner, while depression was not associated. In the regression analysis for general disclosure, both stigma and depression were negatively correlated with disclosure when the interaction term was included in the model. Further analysis showed that internalized HIV stigma was more strongly associated with general 展开更多
According to the analysis, there are still many problems in our foreign language teaching. To improve students' English acquisition, foreign language teaching should follow the law of SLA based on the function of ...According to the analysis, there are still many problems in our foreign language teaching. To improve students' English acquisition, foreign language teaching should follow the law of SLA based on the function of internalized grammar.展开更多
Externalized approach and Internalized approach are two approaches to the study of languages. Understanding the features of two approaches is indispensable to discuss and analyze the acquisition of second language. An...Externalized approach and Internalized approach are two approaches to the study of languages. Understanding the features of two approaches is indispensable to discuss and analyze the acquisition of second language. And universal grammar which is closely related to the two approaches plays an important role in the acquisition of second language. Three accesses to universal grammar in L2 learning are explicitly described to state the second language is acquired.展开更多
It has been shown that early experiences of maltreatment can stably influence an individual’s internal and externalaggressive behavior in adulthood. And on what mechanisms do this stability arise? From the perspectiv...It has been shown that early experiences of maltreatment can stably influence an individual’s internal and externalaggressive behavior in adulthood. And on what mechanisms do this stability arise? From the perspective of personalitysolidification theory, this study sample of 1951 primary and secondary school students was used toexplore the relationship between child maltreatment, Big Five personality and internalized and externalizedaggression, as well as the different mechanisms of differentiation of personality components in child maltreatmenton two different natures of aggression, using four scales: The Childhood Trauma Questionnaire (CTQ), RevisedNEO Personality Inventory (NEO-PI-R), None-suicidal Self-Injury Scale and Aggression Questionnaire. The findingssuggest that (1) neuroticism plays the same mediating mechanism in the effect of child maltreatment on thepersistence of internalized and externalized aggression;and (2) conscientiousness plays a different mechanism ineffect of child maltreatment on both internalized and externalized aggression. Therefore, child maltreatmentshould be discouraged and the development of a sound personality should be guided, thus reducing future aggressivebehavior and promoting child development and social harmony.展开更多
In his minimalist design of the Faculty of Language, Chomsky contends with a process of mapping I-language to E-language, and in passing, a process of re-internalizing E-language to I-language. This paper attempts to ...In his minimalist design of the Faculty of Language, Chomsky contends with a process of mapping I-language to E-language, and in passing, a process of re-internalizing E-language to I-language. This paper attempts to address the question of how and in what ways E-language contributes to the inner working and re-shaping of I-language by mainly referring to Pirah?, English and Chinese for illustrative exemplification.展开更多
Objectives: Stigma and discrimination because of mental illness is still prevalent even in high-income countries where a lot of emphasis has been given to anti-stigma activities and measures to reduce the marginalizat...Objectives: Stigma and discrimination because of mental illness is still prevalent even in high-income countries where a lot of emphasis has been given to anti-stigma activities and measures to reduce the marginalization of these persons. One aspect of the stigma issue is the self-stigmatization that persons suffering from mental illness are experiencing. In this study two different societies have been compared as regards internalized stigma of mental illness. Methods: A widely used questionnaire was used by the Internalized Stigma of Mental Illness scale (ISMI). One sample of psychiatric patients from Sweden (N = 163) and from Iran (N = 138) is compared. Results: The Swedish sample generally reports lower levels of experienced stigma except for items covering selfblame and feelings of alienation. Conclusions: There are reasons to consider the aspect of self-stigmatization when working with mentally ill persons even in high income countries with well developed mental health services.展开更多
基金supported by a grant from Hubei Key Laboratory of Diabetes and Angiopathy Program of Hubei University of Science and Technology(2020XZ10)Project of Education Commission of Hubei Province(B2022192).
文摘Background:Erzhu Erchen decoction(EZECD),which is based on Erchen decoction and enhanced with Atractylodes lancea and Atractylodes macrocephala,is widely used for the treatment of dampness and heat(The clinical manifestations of Western medicine include thirst,inability to drink more,diarrhea,yellow urine,red tongue,et al.)internalized disease.Nevertheless,the mechanism of EZECD on damp-heat internalized Type 2 diabetes(T2D)remains unknown.We employed data mining,pharmacology databases and experimental verification to study how EZECD treats damp-heat internalized T2D.Methods:The main compounds or genes of EZECD and damp-heat internalized T2D were obtained from the pharmacology databases.Succeeding,the overlapped targets of EZECD and damp-heat internalized T2D were performed by the Gene Ontology,kyoto encyclopedia of genes and genomes analysis.And the compound-disease targets-pathway network were constructed to obtain the hub compound.Moreover,the hub genes and core related pathways were mined with weighted gene co-expression network analysis based on Gene Expression Omnibus database,the capability of hub compound and genes was valid in AutoDock 1.5.7.Furthermore,and violin plot and gene set enrichment analysis were performed to explore the role of hub genes in damp-heat internalized T2D.Finally,the interactions of hub compound and genes were explored using Comparative Toxicogenomics Database and quantitative polymerase chain reaction.Results:First,herb-compounds-genes-disease network illustrated that the hub compound of EZECD for damp-heat internalized T2D could be quercetin.Consistently,the hub genes were CASP8,CCL2,and AHR according to weighted gene co-expression network analysis.Molecular docking showed that quercetin could bind with the hub genes.Further,gene set enrichment analysis and Gene Ontology represented that CASP8,or CCL2,is negatively involved in insulin secretion response to the TNF or lipopolysaccharide process,and AHR or CCL2 positively regulated lipid and atherosclerosis,and/or including NOD-lik
文摘Stigma and discrimination because of epilepsy, leprosy and HIV/aids has decreased over the years, but this has not happened as regards mental illness. One aspect of the stigma issue is what has been described as self-stigmatization, the way the mentally ill look at themselves. The aim of this study was to illuminate the self-perception of mentally ill persons in a Swedish setting. An internationally well established questionnaire, Internalized Stigma of Mental Illness scale (ISMI) was used to investigate two samples of out-patients from northern Sweden (N = 260). Fifty two percent reported “minimum stigma”, 35% “mild” and 13% “moderate/severe” stigma. As many as 58% agreed to the statement “I am embarrassed or ashamed that I have a mental illness”. The levels of internalized stigma are rather high, but somewhat lower than reported from some other European and an Iranian study using the same methodology. In spite of several campaigns aimed at reducing the stigma and discrimination because of mental illness in Sweden, still the experience of self stigma is rather high. There is an urgent need to further developed anti-stigma strategies.
文摘Purpose: There is extensive evidence regarding the relationship between HIV related stigma and disclosure;however, the influence of depression in this relationship is not well understood, and thus is the focus of our analysis. Methods: Baseline data from a prospective longitudinal cohort of 798 HIV patients starting ART in Kampala, Uganda were examined. A staged-approach regression analysis was used to examine variables associated with HIV disclosure to most people (general disclosure) and disclosure to primary sex partner. Internalized HIV stigma plus demographic and background covariates were first entered into the model;the binary indicator of clinical depression was added on step two, followed by the addition of the interaction of stigma and depression in step three. Separate analyses were conducted for each of the two disclosure outcomes. Results: 39% indicated that they kept their HIV status as a secret from most people, while 19% of respondents with a regular sex partner had not disclosed their HIV status to the partner. In bivariate analysis, respondents who preferred to keep their HIV status as a secret from most people had higher internalized HIV stigma (p < 0.001) and depression (p < 0.01), and were more likely to be clinically depressed (p < 0.01) compared with others in the sample. Similarly, participants who had not disclosed their HIV status to their main sex partner had higher internalized HIV stigma (p < 0.01) and depression (p < 0.05), and were more likely to be clinically depressed (p < 0.01) compared with those who had informed their partner of their HIV status. The regression analysis revealed that internalized HIV stigma was strongly negatively correlated with disclosure to primary partner, while depression was not associated. In the regression analysis for general disclosure, both stigma and depression were negatively correlated with disclosure when the interaction term was included in the model. Further analysis showed that internalized HIV stigma was more strongly associated with general
文摘According to the analysis, there are still many problems in our foreign language teaching. To improve students' English acquisition, foreign language teaching should follow the law of SLA based on the function of internalized grammar.
文摘Externalized approach and Internalized approach are two approaches to the study of languages. Understanding the features of two approaches is indispensable to discuss and analyze the acquisition of second language. And universal grammar which is closely related to the two approaches plays an important role in the acquisition of second language. Three accesses to universal grammar in L2 learning are explicitly described to state the second language is acquired.
基金Program of Philosophy and Social Science Foundation of Hunan Province(18YBA324).
文摘It has been shown that early experiences of maltreatment can stably influence an individual’s internal and externalaggressive behavior in adulthood. And on what mechanisms do this stability arise? From the perspective of personalitysolidification theory, this study sample of 1951 primary and secondary school students was used toexplore the relationship between child maltreatment, Big Five personality and internalized and externalizedaggression, as well as the different mechanisms of differentiation of personality components in child maltreatmenton two different natures of aggression, using four scales: The Childhood Trauma Questionnaire (CTQ), RevisedNEO Personality Inventory (NEO-PI-R), None-suicidal Self-Injury Scale and Aggression Questionnaire. The findingssuggest that (1) neuroticism plays the same mediating mechanism in the effect of child maltreatment on thepersistence of internalized and externalized aggression;and (2) conscientiousness plays a different mechanism ineffect of child maltreatment on both internalized and externalized aggression. Therefore, child maltreatmentshould be discouraged and the development of a sound personality should be guided, thus reducing future aggressivebehavior and promoting child development and social harmony.
文摘In his minimalist design of the Faculty of Language, Chomsky contends with a process of mapping I-language to E-language, and in passing, a process of re-internalizing E-language to I-language. This paper attempts to address the question of how and in what ways E-language contributes to the inner working and re-shaping of I-language by mainly referring to Pirah?, English and Chinese for illustrative exemplification.
文摘Objectives: Stigma and discrimination because of mental illness is still prevalent even in high-income countries where a lot of emphasis has been given to anti-stigma activities and measures to reduce the marginalization of these persons. One aspect of the stigma issue is the self-stigmatization that persons suffering from mental illness are experiencing. In this study two different societies have been compared as regards internalized stigma of mental illness. Methods: A widely used questionnaire was used by the Internalized Stigma of Mental Illness scale (ISMI). One sample of psychiatric patients from Sweden (N = 163) and from Iran (N = 138) is compared. Results: The Swedish sample generally reports lower levels of experienced stigma except for items covering selfblame and feelings of alienation. Conclusions: There are reasons to consider the aspect of self-stigmatization when working with mentally ill persons even in high income countries with well developed mental health services.
