Synchrotron radiation(SR) X-ray has significant potential for medical applications. However, the mechanisms underlying the effects of SR X-ray on biological tissues remain unclear. Because increasing evidence has indi...Synchrotron radiation(SR) X-ray has significant potential for medical applications. However, the mechanisms underlying the effects of SR X-ray on biological tissues remain unclear. Because increasing evidence has indicated critical roles of cluster of differentiation 38(CD38) in various cellular functions and cell survival, in this study we used rodent testes as a model to determine the effects of SR X-ray irradiation on the CD38 level of the testes. We found that SR X-ray irradiation led to a significant increase in the CD38 level of rodent testes one day after the irradiation. In contrast, the SR X-ray irradiation did not produce a significant increase in the CD38 level of the testes from the rats that were administered with the antioxidant N-acetyl cysteine, thus suggesting that oxidative stress plays a significant role in the SR X-ray irradiation-induced increase in the CD38 levels. Our study has also provided evidence suggesting that poly(ADP-ribose) polymerase(PARP) activity is not involved in the SR X-ray irradiation-produced effect on the CD38 levels. Collectively, this study has provided first in vivo evidence indicating that CD38 levels can be increased by ionizing radiation, in which oxidative stress plays an important role. Because oxidative stress occurs in ionizing radiation as well as such diseases as cerebral ischemia and Parkinson's disease, oxidative stress may produce pathological effects by inducing increased CD38 levels.展开更多
Three dimensional (3D) microscopic distributions of dolomite and calcite in a limestone sample have been analyzed with a data-constrained modeling (DCM) technique using synchrotron radiation-based multi-energy X-ray c...Three dimensional (3D) microscopic distributions of dolomite and calcite in a limestone sample have been analyzed with a data-constrained modeling (DCM) technique using synchrotron radiation-based multi-energy X-ray computed tomography (CT) data as constraints. In order to optimize the experimental parameters, X-ray CT simulations and DCM analysis of a numerical phantom consisting of calcite (CaCO3) and dolomite (CaMg(CO3)2) have been used to investigate the effects on the predicted results in relation to noise, X-ray energy and sample-to-detector distance (SDD). The simulation results indicate that the optimal X-ray energies are 25 and 35 keVs, and the SDD is 10 mm. The high resolution 3D distributions of mineral phases of a natural limestone have been obtained. The results are useful for quantitative understanding of mineral, porosity, and physical property distributions in relation to oil and gas reservoirs hosted in carbonate rocks, which account for more than half of the world’s conventional hydrocarbon resources. The case studied is also instructive for the applicability of the DCM methods for other types of composite materials with modest atomic number contrasts between the mineral phases.展开更多
A small fluctuation of the photon beam position will affect the intensity and polarization characteristics of synchrotron radiation （SR） when it enters an endstation through the related beamline. In this paper, by c...A small fluctuation of the photon beam position will affect the intensity and polarization characteristics of synchrotron radiation （SR） when it enters an endstation through the related beamline. In this paper, by changing the electron orbit equilibrium position in the vertical direction, we have measured the corresponding changes in the absorption strength of the SR with a gold mesh in different chopper aperture positions. It is found that for three aperture positions, the absorption intensity of the gold mesh shows a good Gaussian distribution as the photon beam position moves, while the ratio of the SR intensity passing through the upper and lower apertures shows a monotonous variation. This suggests a new method for estimating the circular polarization degree of SR originating from the bending magnet based on our current measurement.展开更多
X-ray magnetic circular dichroism （XMCD） has become an important and powerful tool because it allows the study of material properties in combination with elemental specificity, chemical state specificity, and magnet...X-ray magnetic circular dichroism （XMCD） has become an important and powerful tool because it allows the study of material properties in combination with elemental specificity, chemical state specificity, and magnetic specificity. A new soft X-ray magnetic circular dichroism apparatus has been developed at the Beijing Synchrotron Radiation Facility （BSRF）. The apparatus combines three experimental conditions： an ultra-high-vacuum environ- ment, moderate magnetic fields and in-situ sample preparation to measure the absorption signal. We designed a C-type dipole electromagnet that provides magnetic fields up to 0.5 T in parallel （or anti-parallel） direction rela- tive to the incoming X-ray beam. The performances of the electromagnet are measured and the results show good agreement with the simulation ones. Following film grown in situ by evaporation methods, XMCD measurements are performed. Combined polarization corrections, the magnetic moments of the Fe and Co films determined by sum rules are consistent with other theoretical predictions and experimental measurements.展开更多
Bao Zheng, styled Xi-ren, a native of Luzhou County (Now Hefei, Anhui Province), was born in the second year of Xiangping (the title of Emperor Zhenzong’s reign, A. D. 999 North Song Dynasty) and died in the 7th year...Bao Zheng, styled Xi-ren, a native of Luzhou County (Now Hefei, Anhui Province), was born in the second year of Xiangping (the title of Emperor Zhenzong’s reign, A. D. 999 North Song Dynasty) and died in the 7th year of Jiayou (the title of Emperor Renzong’s reign, A. D. 1062) at the age of 64. In his childhood and youth he was diligent in pursuing his studies. When he was 29 years old, he became a successful candidate in the highest emperial examination and hereafter took official career for more than展开更多
同步辐射光束位置稳定性对光束强度至关重要,直接会影响到实验数据的质量,因此需要在实验过程中对光束位置进行实时监测.在同步辐射光束线上一般会使用双丝型的光束位置监测器(beam position monitor,BPM)扫描光束,获得光束的截面分布,...同步辐射光束位置稳定性对光束强度至关重要,直接会影响到实验数据的质量,因此需要在实验过程中对光束位置进行实时监测.在同步辐射光束线上一般会使用双丝型的光束位置监测器(beam position monitor,BPM)扫描光束,获得光束的截面分布,同时在固定位置的双丝会对光束位置进行静态的实时监测.但是这种监测方式对于入射光束分布有特殊的要求,当光束较大地偏离原有位置时会对双丝BPM造成损伤的危险.北京同步辐射1W2B生物大分子实验站通过采用双丝型BPM实时动态跟踪监测方式,有效地解决了常规监测方式带来的光束分布和光敏丝损伤问题,为实验光束的稳定性研究提供了基础.展开更多
基金the National Basic Research Program (973) of China(No.2010CB834306)the National Natural Science Foundation of China(No.81171098)
文摘Synchrotron radiation(SR) X-ray has significant potential for medical applications. However, the mechanisms underlying the effects of SR X-ray on biological tissues remain unclear. Because increasing evidence has indicated critical roles of cluster of differentiation 38(CD38) in various cellular functions and cell survival, in this study we used rodent testes as a model to determine the effects of SR X-ray irradiation on the CD38 level of the testes. We found that SR X-ray irradiation led to a significant increase in the CD38 level of rodent testes one day after the irradiation. In contrast, the SR X-ray irradiation did not produce a significant increase in the CD38 level of the testes from the rats that were administered with the antioxidant N-acetyl cysteine, thus suggesting that oxidative stress plays a significant role in the SR X-ray irradiation-induced increase in the CD38 levels. Our study has also provided evidence suggesting that poly(ADP-ribose) polymerase(PARP) activity is not involved in the SR X-ray irradiation-produced effect on the CD38 levels. Collectively, this study has provided first in vivo evidence indicating that CD38 levels can be increased by ionizing radiation, in which oxidative stress plays an important role. Because oxidative stress occurs in ionizing radiation as well as such diseases as cerebral ischemia and Parkinson's disease, oxidative stress may produce pathological effects by inducing increased CD38 levels.
文摘Three dimensional (3D) microscopic distributions of dolomite and calcite in a limestone sample have been analyzed with a data-constrained modeling (DCM) technique using synchrotron radiation-based multi-energy X-ray computed tomography (CT) data as constraints. In order to optimize the experimental parameters, X-ray CT simulations and DCM analysis of a numerical phantom consisting of calcite (CaCO3) and dolomite (CaMg(CO3)2) have been used to investigate the effects on the predicted results in relation to noise, X-ray energy and sample-to-detector distance (SDD). The simulation results indicate that the optimal X-ray energies are 25 and 35 keVs, and the SDD is 10 mm. The high resolution 3D distributions of mineral phases of a natural limestone have been obtained. The results are useful for quantitative understanding of mineral, porosity, and physical property distributions in relation to oil and gas reservoirs hosted in carbonate rocks, which account for more than half of the world’s conventional hydrocarbon resources. The case studied is also instructive for the applicability of the DCM methods for other types of composite materials with modest atomic number contrasts between the mineral phases.
基金Supported by National Natural Science Foundation of China(21271007,10274073)Post-doctoral Research Start-up Funding of Anhui University of Architecture(K02553)
文摘A small fluctuation of the photon beam position will affect the intensity and polarization characteristics of synchrotron radiation （SR） when it enters an endstation through the related beamline. In this paper, by changing the electron orbit equilibrium position in the vertical direction, we have measured the corresponding changes in the absorption strength of the SR with a gold mesh in different chopper aperture positions. It is found that for three aperture positions, the absorption intensity of the gold mesh shows a good Gaussian distribution as the photon beam position moves, while the ratio of the SR intensity passing through the upper and lower apertures shows a monotonous variation. This suggests a new method for estimating the circular polarization degree of SR originating from the bending magnet based on our current measurement.
基金Supported by National Natural Science Foundation of China(61204008)
文摘X-ray magnetic circular dichroism （XMCD） has become an important and powerful tool because it allows the study of material properties in combination with elemental specificity, chemical state specificity, and magnetic specificity. A new soft X-ray magnetic circular dichroism apparatus has been developed at the Beijing Synchrotron Radiation Facility （BSRF）. The apparatus combines three experimental conditions： an ultra-high-vacuum environ- ment, moderate magnetic fields and in-situ sample preparation to measure the absorption signal. We designed a C-type dipole electromagnet that provides magnetic fields up to 0.5 T in parallel （or anti-parallel） direction rela- tive to the incoming X-ray beam. The performances of the electromagnet are measured and the results show good agreement with the simulation ones. Following film grown in situ by evaporation methods, XMCD measurements are performed. Combined polarization corrections, the magnetic moments of the Fe and Co films determined by sum rules are consistent with other theoretical predictions and experimental measurements.
基金Project supported by the National Natural Science Foundation of China and 8.5 Major Project Foundation of Academia Sinica.
文摘Bao Zheng, styled Xi-ren, a native of Luzhou County (Now Hefei, Anhui Province), was born in the second year of Xiangping (the title of Emperor Zhenzong’s reign, A. D. 999 North Song Dynasty) and died in the 7th year of Jiayou (the title of Emperor Renzong’s reign, A. D. 1062) at the age of 64. In his childhood and youth he was diligent in pursuing his studies. When he was 29 years old, he became a successful candidate in the highest emperial examination and hereafter took official career for more than
文摘同步辐射光束位置稳定性对光束强度至关重要,直接会影响到实验数据的质量,因此需要在实验过程中对光束位置进行实时监测.在同步辐射光束线上一般会使用双丝型的光束位置监测器(beam position monitor,BPM)扫描光束,获得光束的截面分布,同时在固定位置的双丝会对光束位置进行静态的实时监测.但是这种监测方式对于入射光束分布有特殊的要求,当光束较大地偏离原有位置时会对双丝BPM造成损伤的危险.北京同步辐射1W2B生物大分子实验站通过采用双丝型BPM实时动态跟踪监测方式,有效地解决了常规监测方式带来的光束分布和光敏丝损伤问题,为实验光束的稳定性研究提供了基础.
