Objectives： To investigate the safety and efficacy of Yangxinkang Tablets （养心康片） in patients with chronic heart failure （CHF） and syndrome of qi and yin deficiency, blood stasis, and water retention. Methods...Objectives： To investigate the safety and efficacy of Yangxinkang Tablets （养心康片） in patients with chronic heart failure （CHF） and syndrome of qi and yin deficiency, blood stasis, and water retention. Methods： In a double-blinded, randomized, placebo-controlled, multicenter clinical trail, 228 patients with CHF New York Heart Association （NYHA） class Ⅱ or Ⅲ in stage C were assigned by randomized block method to two groups in a 1：1 ratio to undergo either conventional Western treatment or conventional treatment plus Yangxinkang Tablets for 4 weeks. The outcome measure were effect of cardiac function, Chinese medicine （CM） syndromes, scores of symptoms, signs, and quality of life measured by Minnesota Living with heart failure questionnaire （MLHFQ） before and after the treatment. Results： Totally 112 patients were analyzed in the treatment group and 109 in the control group. They were comparable in NYHA functional class, basic parameters and primary diseases before treatment. Cardiac function and CM syndromes were greatly ameliorated in both groups after treatment. Total effective rates of cardiac function and CM syndrome in the treatment group were significantly higher than those in the control group （P〈0.05）. Total symptom score and sign score in the treatment group decreased significantly after treatment （P〈0.01）, which were significantly lower than those in the control group （P〈0.05）. There were statistically significant differences in post-treatment scores of gasp, cough with phlegm, pulmonary rales and jugular vein engorgement between the two groups （P〈0.05 or P〈0.01）. Three MLHFQ scores decreased significantly in both groups after treatment （P〈0.01）. Post-treatment total scale score and physical subscale score in the treatment group and the reduction of them showed statistically significant differences （P〈0.05） as compared with the control group. There was no significant difference between the two groups in emotional subscale score 展开更多
BACKGROUND Prior studies indicate that doing breathing exercises improves physical performance and quality of life (QoL) in heart failure patients. However, these effects remain unclear and contradictory. AIM To deter...BACKGROUND Prior studies indicate that doing breathing exercises improves physical performance and quality of life (QoL) in heart failure patients. However, these effects remain unclear and contradictory. AIM To determine the effects of machine-assisted and non-machine-assisted respiratory training on physical performance and QoL in heart failure patients. METHODS This was a systematic review and network meta-analysis study. A literature search of electronic databases was conducted for randomized controlled trials (RCTs) on heart failure. Respiratory training interventions were grouped as seven categories: IMT_Pn (inspiratory muscle training without pressure or < 10% maximal inspiratory pressure, MIP), IMT_Pl (inspiratory muscle training with low pressure, 10%-15% MIP), IMT_Pm (inspiratory muscle training with medium pressure, 30%-40% MIP), IMT_Ph (inspiratory muscle training with high pressure, 60% MIP or MIP plus aerobics), Aerobics (aerobic exercise or weight training), Qi_Ex (tai chi, yoga, and breathing exercise), and none. The four outcomes were heart rate, peak oxygen uptake (VO2 peak), 6-min walking distance test (6MWT), and Minnesota Living with Heart Failure QoL. The random-effects model, side-splitting model, and the surface under the cumulative ranking curve (SUCRA) were used to test and analyze the data. RESULTS A total of 1499 subjects from 31 RCT studies were included. IMT_Ph had the highest effect sizes for VO2 peak and 6MWT, IMT_Pm highest for QoL, and Qi_Ex highest for heart rate. Aerobics had the second highest for VO2 peak, Qi_Ex second highest for 6MWT, and IMT_Ph second highest for heart rate and QoL.CONCLUSION This study supports that high- and medium-intensity machine-assisted training improves exercise capacity and QoL in hospital-based heart failure patients. After hospital discharge, non-machine-assisted training continuously improves cardiac function.展开更多
目的探讨优质护理干预在慢性肾衰竭腹膜透析患者护理中的应用效果。方法选取2018年2月~2019年6月沈阳市第四人民医院收治的74例慢性肾衰竭腹膜透析患者作为研究对象,按随机投掷法分为参照组(37例)和研究组(37例)。参照组采用常规护理方...目的探讨优质护理干预在慢性肾衰竭腹膜透析患者护理中的应用效果。方法选取2018年2月~2019年6月沈阳市第四人民医院收治的74例慢性肾衰竭腹膜透析患者作为研究对象,按随机投掷法分为参照组(37例)和研究组(37例)。参照组采用常规护理方法,研究组采用优质护理干预方法,比较两组护理前后肾功能指标[血肌酐(SCr)、血尿素氮(BUN)、24 h尿蛋白定量(24 h Pro)]、并发症发生率及护理满意度。结果两组患者护理前的SCr、BUN、24 h Pro水平比较,差异无统计学意义(P>0.05);研究组护理后SCr、BUN、24 h Pro水平均低于参照组,差异有统计学意义(P<0.05);研究组的护理总满意度高于参照组,差异有统计学意义(P<0.05);研究组并发症总发生率低于参照组,差异有统计学意义(P<0.05)。结论优质护理干预在慢性肾衰竭腹膜透析患者中的应用效果显著,可改善患者肾功能指标并降低并发症发生率,提升患者护理满意度。展开更多
Objective：To explore the dose-effect relationship of Astragalus granule（AG） on improving the quality of life（QOL） of the patients with chronic heart failure（CHF）.Methods：Ninety CHF patients of Fei（肺）-qi def...Objective：To explore the dose-effect relationship of Astragalus granule（AG） on improving the quality of life（QOL） of the patients with chronic heart failure（CHF）.Methods：Ninety CHF patients of Fei（肺）-qi deficiency and/or Xin（心）-Shen（肾） yang-deficiency syndromes were equally randomized divided with a random number table into three groups;they received the high（7.5 g）,moderate（4.5 g）,and low dosage（2.25 g） of AG orally taken twice a day,respectively,and 4 mg of perindopril tablet once a day for 30 successive days.The heart function grade,patients＇ left ventricular ejection fraction（LVEF） and walking distance in 6 min（6mWD） were measured before and after treatment,and the patients＇ QOL was scored by the Minnesota Questionnaire for QOL evaluation in the patients with CHF at the same time.Results：The heart function grades of all the three groups after treatment were improved compared with those before treatment,but the improvements in high-dose group and moderate dose group were better than that in the low dose group（P0.05）.LVEFs were increased significantly in all the three groups,but the improvements in the high-dose group（59.42%±7.50%） and moderate dose group（61.98%±6.82%） were better than that in the low dose group（51.45%±6.80%,P0.01）; the 6mWDs in the all groups were also significantly increased（P0.01）,up to 419.80136.23 m,387.15134.13 m, and 317.69±39.97 m,respectively;and Minnesota scores in them were lowered to 29.59±4.69 scores,35.74±5.89 scores,and 42.78±6.06 scores,respectively;comparisons in aspects on 6mWD and Minnesota score showed that the effectiveness with high dose is the most effective,moderate dose as the second,and low dose as the lowest（P0.01）.Conclusions：AG was sufficient to display an optimal effect on improving heart contraction at the moderate dose.In aspects of improving the QOL of CHF patients,the effectiveness of AG showed a dosedependent trend.It should be applied discriminatively depending on the展开更多
基金Supported by Guangzhou Municipal Science and Technology Bureau Key Technology Research and Development of Pharmaceutical Preparations and Industrial Demonstration projects of China(No.2008A1-E4101)
文摘Objectives： To investigate the safety and efficacy of Yangxinkang Tablets （养心康片） in patients with chronic heart failure （CHF） and syndrome of qi and yin deficiency, blood stasis, and water retention. Methods： In a double-blinded, randomized, placebo-controlled, multicenter clinical trail, 228 patients with CHF New York Heart Association （NYHA） class Ⅱ or Ⅲ in stage C were assigned by randomized block method to two groups in a 1：1 ratio to undergo either conventional Western treatment or conventional treatment plus Yangxinkang Tablets for 4 weeks. The outcome measure were effect of cardiac function, Chinese medicine （CM） syndromes, scores of symptoms, signs, and quality of life measured by Minnesota Living with heart failure questionnaire （MLHFQ） before and after the treatment. Results： Totally 112 patients were analyzed in the treatment group and 109 in the control group. They were comparable in NYHA functional class, basic parameters and primary diseases before treatment. Cardiac function and CM syndromes were greatly ameliorated in both groups after treatment. Total effective rates of cardiac function and CM syndrome in the treatment group were significantly higher than those in the control group （P〈0.05）. Total symptom score and sign score in the treatment group decreased significantly after treatment （P〈0.01）, which were significantly lower than those in the control group （P〈0.05）. There were statistically significant differences in post-treatment scores of gasp, cough with phlegm, pulmonary rales and jugular vein engorgement between the two groups （P〈0.05 or P〈0.01）. Three MLHFQ scores decreased significantly in both groups after treatment （P〈0.01）. Post-treatment total scale score and physical subscale score in the treatment group and the reduction of them showed statistically significant differences （P〈0.05） as compared with the control group. There was no significant difference between the two groups in emotional subscale score
文摘BACKGROUND Prior studies indicate that doing breathing exercises improves physical performance and quality of life (QoL) in heart failure patients. However, these effects remain unclear and contradictory. AIM To determine the effects of machine-assisted and non-machine-assisted respiratory training on physical performance and QoL in heart failure patients. METHODS This was a systematic review and network meta-analysis study. A literature search of electronic databases was conducted for randomized controlled trials (RCTs) on heart failure. Respiratory training interventions were grouped as seven categories: IMT_Pn (inspiratory muscle training without pressure or < 10% maximal inspiratory pressure, MIP), IMT_Pl (inspiratory muscle training with low pressure, 10%-15% MIP), IMT_Pm (inspiratory muscle training with medium pressure, 30%-40% MIP), IMT_Ph (inspiratory muscle training with high pressure, 60% MIP or MIP plus aerobics), Aerobics (aerobic exercise or weight training), Qi_Ex (tai chi, yoga, and breathing exercise), and none. The four outcomes were heart rate, peak oxygen uptake (VO2 peak), 6-min walking distance test (6MWT), and Minnesota Living with Heart Failure QoL. The random-effects model, side-splitting model, and the surface under the cumulative ranking curve (SUCRA) were used to test and analyze the data. RESULTS A total of 1499 subjects from 31 RCT studies were included. IMT_Ph had the highest effect sizes for VO2 peak and 6MWT, IMT_Pm highest for QoL, and Qi_Ex highest for heart rate. Aerobics had the second highest for VO2 peak, Qi_Ex second highest for 6MWT, and IMT_Ph second highest for heart rate and QoL.CONCLUSION This study supports that high- and medium-intensity machine-assisted training improves exercise capacity and QoL in hospital-based heart failure patients. After hospital discharge, non-machine-assisted training continuously improves cardiac function.
文摘目的探讨优质护理干预在慢性肾衰竭腹膜透析患者护理中的应用效果。方法选取2018年2月~2019年6月沈阳市第四人民医院收治的74例慢性肾衰竭腹膜透析患者作为研究对象,按随机投掷法分为参照组(37例)和研究组(37例)。参照组采用常规护理方法,研究组采用优质护理干预方法,比较两组护理前后肾功能指标[血肌酐(SCr)、血尿素氮(BUN)、24 h尿蛋白定量(24 h Pro)]、并发症发生率及护理满意度。结果两组患者护理前的SCr、BUN、24 h Pro水平比较,差异无统计学意义(P>0.05);研究组护理后SCr、BUN、24 h Pro水平均低于参照组,差异有统计学意义(P<0.05);研究组的护理总满意度高于参照组,差异有统计学意义(P<0.05);研究组并发症总发生率低于参照组,差异有统计学意义(P<0.05)。结论优质护理干预在慢性肾衰竭腹膜透析患者中的应用效果显著,可改善患者肾功能指标并降低并发症发生率,提升患者护理满意度。
基金Supported by the Funds of Scientific and Technological Research on Traditional Chinese Medicine,Traditional Chinese Medicine Administration of Jiangsu Province,China(No. HL07113)
文摘Objective：To explore the dose-effect relationship of Astragalus granule（AG） on improving the quality of life（QOL） of the patients with chronic heart failure（CHF）.Methods：Ninety CHF patients of Fei（肺）-qi deficiency and/or Xin（心）-Shen（肾） yang-deficiency syndromes were equally randomized divided with a random number table into three groups;they received the high（7.5 g）,moderate（4.5 g）,and low dosage（2.25 g） of AG orally taken twice a day,respectively,and 4 mg of perindopril tablet once a day for 30 successive days.The heart function grade,patients＇ left ventricular ejection fraction（LVEF） and walking distance in 6 min（6mWD） were measured before and after treatment,and the patients＇ QOL was scored by the Minnesota Questionnaire for QOL evaluation in the patients with CHF at the same time.Results：The heart function grades of all the three groups after treatment were improved compared with those before treatment,but the improvements in high-dose group and moderate dose group were better than that in the low dose group（P0.05）.LVEFs were increased significantly in all the three groups,but the improvements in the high-dose group（59.42%±7.50%） and moderate dose group（61.98%±6.82%） were better than that in the low dose group（51.45%±6.80%,P0.01）; the 6mWDs in the all groups were also significantly increased（P0.01）,up to 419.80136.23 m,387.15134.13 m, and 317.69±39.97 m,respectively;and Minnesota scores in them were lowered to 29.59±4.69 scores,35.74±5.89 scores,and 42.78±6.06 scores,respectively;comparisons in aspects on 6mWD and Minnesota score showed that the effectiveness with high dose is the most effective,moderate dose as the second,and low dose as the lowest（P0.01）.Conclusions：AG was sufficient to display an optimal effect on improving heart contraction at the moderate dose.In aspects of improving the QOL of CHF patients,the effectiveness of AG showed a dosedependent trend.It should be applied discriminatively depending on the
