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不同波宽刺激下无抽搐电休克治疗抑郁症疗效及对心脏节律性的影响 被引量:11
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作者 李艳茹 姜玮 +2 位作者 赵希希 刘子军 任艳萍 《临床精神医学杂志》 CAS 2021年第6期482-484,共3页
目的:探讨不同波宽刺激下无抽搐电休克治疗(modified electroconvulsive therapy,MECT)对抑郁症疗效及心脏节律性的影响。方法:选取抑郁症患者120例,随机分为DGX模式组和Low 0.5模式组。给予MECT治疗6次。在治疗前、治疗3次、治疗6次后... 目的:探讨不同波宽刺激下无抽搐电休克治疗(modified electroconvulsive therapy,MECT)对抑郁症疗效及心脏节律性的影响。方法:选取抑郁症患者120例,随机分为DGX模式组和Low 0.5模式组。给予MECT治疗6次。在治疗前、治疗3次、治疗6次后用汉密尔顿抑郁量表(Hamilton Depression Rating Scale,HAMD-17)评估临床症状。记录MECT刺激时间和抽搐发作时间。监测首次MECT治疗麻醉药注射前至抽搐发作结束后10 min心电图及心律失常发生情况。结果:治疗3次后Low 0.5模式组HAMD-17减分率明显优于DGX模式组(t=2.041,P=0.044)。Low 0.5模式组与DGX模式组相比,心律失常发生率明显增高(χ^(2)=7.350,P=0.007),刺激时间明显延长(t=30.92,P<0.01),首次发作时间明显延长(t=2.098,P=0.038)。刺激时间与心律失常发生率呈正相关(r=0.212,P=0.020)。结论:Low0.5模式与DGX模式相比,治疗抑郁症起效更快,心律失常发生率更高;MECT刺激时间越长,心律失常发生率越高。 展开更多
关键词 无抽搐电休克治疗 抑郁症 波宽 心脏节律性 刺激时间
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针刺加按摩推拿治疗颞下颌关节紊乱病的临床观察 被引量:10
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作者 卜令学 陈涛 +2 位作者 陈欣 荆恒 李宁毅 《上海口腔医学》 CAS CSCD 2011年第3期292-295,共4页
目的:通过对96例颞下颌关节紊乱病患者的电针脉冲电刺激及按摩推拿治疗,探索安全、简便、有效的治疗早期颞下颌关节病的方法。方法:随机选择临床诊断为颞下颌关节紊乱病的96例患者。其中,肌筋膜痛54例,翼外肌痉挛42例。按随机原则分为... 目的:通过对96例颞下颌关节紊乱病患者的电针脉冲电刺激及按摩推拿治疗,探索安全、简便、有效的治疗早期颞下颌关节病的方法。方法:随机选择临床诊断为颞下颌关节紊乱病的96例患者。其中,肌筋膜痛54例,翼外肌痉挛42例。按随机原则分为电针脉冲电刺激组48例,按摩推拿加电针脉冲电刺激组48例,分别进行上关、下关、颊车、听宫、合谷穴位电针脉冲电刺激与按摩推拿治疗。比较观察2种疗法的治疗效果。应用SPSS11.0软件包对数据进行统计学分析。结果:按摩推拿加电针脉冲电刺激组疗效好于电针脉冲电刺激组,以早期肌筋膜痛患者疗效较好。结论:电针脉冲电刺激结合按摩推拿治疗早期颞下颌关节紊乱病具有良好疗效。 展开更多
关键词 颞下颌关节病 电针脉冲电刺激 按摩
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Transcranial pulse current stimulation improves the locomotor function in a rat model of stroke 被引量:9
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作者 Wen-Jing Wang Yan-Biao Zhong +6 位作者 Jing-Jun Zhao Meng Ren Si-Cong Zhang Ming-Shu Xu Shu-Tian Xu Ying-Jie Zhang Chun-Lei Shan 《Neural Regeneration Research》 SCIE CAS CSCD 2021年第7期1229-1234,共6页
Previous studies have shown that transcranial pulse current stimulation(tPCS) can increase cerebral neural plasticity and improve patients' locomotor function.However, the precise mechanisms underlying this effect... Previous studies have shown that transcranial pulse current stimulation(tPCS) can increase cerebral neural plasticity and improve patients' locomotor function.However, the precise mechanisms underlying this effect remain unclear.In the present study, rat models of stroke established by occlusion of the right cerebral middle artery were subjected to tPCS, 20 minutes per day for 7 successive days.tPCS significantly reduced the Bederson score, increased the foot print area of the affected limbs, and reduced the standing time of affected limbs of rats with stroke compared with that before intervention.Immunofluorescence staining and western blot assay revealed that tPCS significantly increased the expression of microtubule-associated protein-2 and growth-associated protein-43 around the ischemic penumbra.This finding suggests that tPCS can improve the locomotor function of rats with stroke by regulating the expression of microtubule-associated protein-2 and growth-associated protein-43 around the ischemic penumbra.These findings may provide a new method for the clinical treatment of poststroke motor dysfunction and a theoretical basis for clinical application of tPCS.The study was approved by the Animal Use and Management Committee of Shanghai University of Traditional Chinese Medicine of China(approval No.PZSHUTCM190315003) on February 22, 2019. 展开更多
关键词 motor function neural plasticity non-invasive brain stimulation protection REPAIR STROKE transcranial pulse current stimulation
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高压脉冲射流酸化解堵技术的研究与应用 被引量:8
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作者 刘明峰 杨永超 +2 位作者 宿亚仙 包俊峰 杨真 《油气采收率技术》 CSCD 2000年第3期52-54,共3页
高压脉冲射流酸化解堵是用于低渗透油田增产增注的新技术。该工艺可根据地层堵塞情况及程度 ,选择酸液种类、酸液浓度、射流脉冲频率、处理时间和处理层位。该文从水动力学和酸化机理的角度 ,对高压脉冲射流酸化解堵的基本原理、工艺技... 高压脉冲射流酸化解堵是用于低渗透油田增产增注的新技术。该工艺可根据地层堵塞情况及程度 ,选择酸液种类、酸液浓度、射流脉冲频率、处理时间和处理层位。该文从水动力学和酸化机理的角度 ,对高压脉冲射流酸化解堵的基本原理、工艺技术及有关的计算方法加以论述 ,实际井例证明该技术解堵的增产效果显著。 展开更多
关键词 脉冲射液 酸化 解堵 增产效果 油田 地层损害
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用双向脉冲作选择性神经刺激的研究 被引量:9
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作者 沈强 邰常峰 蒋大宗 《中国生物医学工程学报》 EI CAS CSCD 北大核心 1999年第1期35-43,共9页
双向脉冲选择性刺激是避免神经纤维电化学损伤、使肌肉平稳收缩、降低疲劳的有效电刺激模式。本文提出了单电极、双电极和三电极三种双向刺激模式,利用计算机模型仿真有效地实现了选择性刺激,并且利用蟾蜍的离体坐骨神经干在动物实验... 双向脉冲选择性刺激是避免神经纤维电化学损伤、使肌肉平稳收缩、降低疲劳的有效电刺激模式。本文提出了单电极、双电极和三电极三种双向刺激模式,利用计算机模型仿真有效地实现了选择性刺激,并且利用蟾蜍的离体坐骨神经干在动物实验上验证了这几种方法的可行性。 展开更多
关键词 双向脉冲 选择性刺激 神经纤维 坐骨神经干
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利用双向方波脉冲刺激实现神经纤维选择性兴奋的双电极方法 被引量:6
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作者 沈强 刘雪良 +1 位作者 蒋大宗 邰常峰 《中国生物医学工程学报》 CAS CSCD 北大核心 2001年第6期533-540,共8页
双向选择性刺激是避免神经纤维电化学损伤、使肌肉平稳收缩、降低疲劳的有效电刺激模式。本文提出了一种利用双电极双向脉冲刺激实现选择性兴奋的新方法。利用计算机模型仿真有效地实现了选择性刺激 ,利用蟾蜍的离体坐骨神经干在动物实... 双向选择性刺激是避免神经纤维电化学损伤、使肌肉平稳收缩、降低疲劳的有效电刺激模式。本文提出了一种利用双电极双向脉冲刺激实现选择性兴奋的新方法。利用计算机模型仿真有效地实现了选择性刺激 ,利用蟾蜍的离体坐骨神经干在动物实验上验证了该方法的可行性 ,并且用“激励函数”的概念从理论上成功地给予了解释。 展开更多
关键词 双向脉冲 选择性刺激 激励函数 神经纤维
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Long-pulse gastric electrical stimulation protects interstitial cells of Cajal in diabetic rats via IGF-1 signaling pathway 被引量:5
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作者 Hai Li Yan Chen +1 位作者 Shi Liu Xiao-Hua Hou 《World Journal of Gastroenterology》 SCIE CAS 2016年第23期5353-5363,共11页
AIM: To investigate the effects of different parameters of gastric electrical stimulation (GES) on interstitial cells of Cajal (ICCs) and changes in the insulin-like growth factor 1 (IGF-1) signal pathway in streptozo... AIM: To investigate the effects of different parameters of gastric electrical stimulation (GES) on interstitial cells of Cajal (ICCs) and changes in the insulin-like growth factor 1 (IGF-1) signal pathway in streptozotocin-induced diabetic rats. METHODS: Male rats were randomized into control, diabetic (DM), diabetic with sham GES (DM + SGES), diabetic with GES1 (5.5 cpm, 100 ms, 4 mA) (DM + GES1), diabetic with GES2 (5.5 cpm, 300 ms, 4 mA) (DM + GES2) and diabetic with GES3 (5.5 cpm, 550 ms, 2 mA) (DM + GES3) groups. The expression levels of c-kit, M-SCF and IGF-1 receptors were evaluated in the gastric antrum using Western blot analysis. The distribution of ICCs was observed using immunolabeling for c-kit, while smooth muscle cells and IGF-1 receptors were identified using alpha-SMA and IGF-1R antibodies. Serum level of IGF-1 was tested using enzyme-linked immunosorbent assay. RESULTS: Gastric emptying was delayed in the DM group but improved in all GES groups, especially in the GES2 group. The expression levels of c-kit, M-SCF and IGF-1R were decreased in the DM group but increased in all GES groups. More ICCs (c-kit(+)) and smooth muscle cells (alpha-SMA(+)/IGF-1R(+)) were observed in all GES groups than in the DM group. The average level of IGF-1 in the DM group was markedly decreased, but it was up-regulated in all GES groups, especially in the GES2 group. CONCLUSION: The results suggest that long-pulse GES promotes the regeneration of ICCs. The IGF-1 signaling pathway might be involved in the mechanism underlying this process, which results in improved gastric emptying. 展开更多
关键词 Long-pulse gastric electrical stimulation Interstitial cells of Cajal Gastric emptying IGF-1 pathway Diabetes mellitus Gastrointestinal motility disorders
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Alzheimer's disease with depressive symptoms: Clinical effect of intermittent theta burst stimulation repetitive transcranial magnetic stimulation 被引量:1
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作者 Xin Jin Chun-Yun Xu +2 位作者 Jin-Feng Fei Yu Fang Cong-Hao Sun 《World Journal of Psychiatry》 SCIE 2024年第8期1216-1223,共8页
BACKGROUND Alzheimer's disease(AD),characterized by the ongoing deterioration of neural function,often presents alongside depressive features and greatly affects the quality of life of individuals living with the ... BACKGROUND Alzheimer's disease(AD),characterized by the ongoing deterioration of neural function,often presents alongside depressive features and greatly affects the quality of life of individuals living with the condition.Although several treatment methods exist,their efficacy is limited.In recent years,repetitive transcranial magnetic stimulation(rTMS)utilizing the theta burst stimulation(TBS)mode,specifically the intermittent TBS(iTBS),has demonstrated promising therapeutic potential in the management of neuropsychiatric disorders.AIM To examine the therapeutic efficacy of iTBS mode of rTMS for treating depressive symptoms in patients with AD.METHODS This retrospective study enrolled 105 individuals diagnosed with AD with depressive symptoms at Huzhou Third Municipal Hospital,affiliated with Huzhou University,between January 2020 and December 2023.Participants received standard pharmacological interventions and were categorized into control(n=53)and observation(n=52)groups based on treatment protocols.The observation group received iTBS mode of rTMS,while the control group received pseudo-stimulation.A comparative analysis evaluated psychological well-being,adverse events,and therapeutic at initiation of hospitalization(T0)and 15 days post-treatment(T1).RESULTS At T1,both groups exhibited a marked reduction in self-rating depression scale and Hamilton depression scale scores compared to T0.Furthermore,the observa-tion group showed a more pronounced decrease than the control group.By T1,the Mini-mental state examination scores for both groups had increased markedly from their initial T0 assessments.Importantly,the increase was particularly more substantial in the observation group than in the control group.Fourteen patients in the control group had ineffective treatment effects,while five patients in the observation group experienced the same.Additionally,the observation group experienced a substantially reduced incidence of ineffective treatment as compared to the control group(both P<0.05);there were no recor 展开更多
关键词 Alzheimer's disease Non-persistentθshort array fast pulse mode DEPRESSION Clinical efficacy DEMENTIA Repetitive transcranial magnetic stimulation
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多级脉冲气体加载压裂裂缝扩展及增产效果分析 被引量:5
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作者 蒲春生 孙志宇 王香增 《大庆石油地质与开发》 CAS CSCD 北大核心 2007年第6期99-101,106,共4页
多级脉冲气体加载压裂松弛岩层地应力、压裂地层的过程中,通过引入加权函数,应用弹性力学、断裂力学理论建立了多裂缝条件下裂缝起裂扩展模型,并采用与时间相关的爆生气体压力分布方程,模拟了爆生气体驱动下缝长、缝宽的变化过程,分析... 多级脉冲气体加载压裂松弛岩层地应力、压裂地层的过程中,通过引入加权函数,应用弹性力学、断裂力学理论建立了多裂缝条件下裂缝起裂扩展模型,并采用与时间相关的爆生气体压力分布方程,模拟了爆生气体驱动下缝长、缝宽的变化过程,分析了不同裂缝参数对产能和表皮系数的影响。结果表明,裂缝起裂后向前延伸直到止裂,止裂后裂缝会发生一定程度的闭合;不同的裂缝条数会产生不同的最终缝长;多极脉冲气体加载压裂能够显著增加油井产量,降低储层表皮系数,裂缝的长度对油井产量的增加起决定作用,在压裂弹能量一定的情况下应该设计增加裂缝长度,减少裂缝条数。实现了对多级脉冲气体加载压裂的优化与控制。 展开更多
关键词 多级脉冲 气体压裂 裂缝扩展 增产效果
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多模式音频脉冲信号光电穴位刺激对高血压大鼠血液流变性及血压的影响 被引量:5
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作者 龚琬玲 黄时俊 +2 位作者 司歌 张凯燕 陈仲本 《生物医学工程学杂志》 EI CAS CSCD 北大核心 2012年第3期415-419,共5页
本文主要研究多模式音频脉冲信号光、电穴位刺激对自发性高血压大鼠血液流变性及血压的影响,以探索延缓血压升高的方法。雄性自发性高血压大鼠40只随机分为A组(对照组)、B组(电刺激"足三里"穴)、C组(脉冲激光照射耳尖穴)、D组... 本文主要研究多模式音频脉冲信号光、电穴位刺激对自发性高血压大鼠血液流变性及血压的影响,以探索延缓血压升高的方法。雄性自发性高血压大鼠40只随机分为A组(对照组)、B组(电刺激"足三里"穴)、C组(脉冲激光照射耳尖穴)、D组(耳尖穴行激光照射兼对"足三里"行电刺激),每组10只。每天激光照射时间为45min,电刺激时间为30min,连续治疗10d,比较大鼠血液流变学参数及血压的变化情况。结果显示:C、D组全血黏度、血浆黏度及红细胞变形指数较对照组均有改善,D组全血黏度及血浆黏度值最小;B、D组血压在治疗后有不同程度的降低,D组血压下降幅度较明显,A、C组血压有不同程度的上升,但C组上升幅度明显小于A组。综上,脉冲式的光、电刺激信号同时作用于自发性高血压大鼠的不同穴位,对改善血液流变特性及非药物辅助治疗高血压有较为明显的治疗效果。 展开更多
关键词 脉冲激光 激光照射 电刺激 血液流变性 高血压
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Improving control effects of absence seizures using single-pulse alternately resetting stimulation (SARS) of corticothalamic circuit 被引量:5
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作者 Denggui FAN Yanhong ZHENG +1 位作者 Zecheng YANG Qingyun WANG 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2020年第9期1287-1302,共16页
Presently,we develop a simplified corticothalamic(SCT)model and propose a single-pulse alternately resetting stimulation(SARS)with sequentially applying anodic(A,“+”)or cathodic(C,“−”)phase pulses to the thalamic ... Presently,we develop a simplified corticothalamic(SCT)model and propose a single-pulse alternately resetting stimulation(SARS)with sequentially applying anodic(A,“+”)or cathodic(C,“−”)phase pulses to the thalamic reticular(RE)nuclei,thalamus-cortex(TC)relay nuclei,and cortical excitatory(EX)neurons,respectively.Abatement effects of ACC-SARS of RE,TC,and EX for the 2 Hz-4 Hz spike and wave discharges(SWD)of absence seizures are then concerned.The m∶n on-off ACC-SARS protocol is shown to effectively reduce the SWD with the least current consumption.In particular,when its frequency is out of the 2 Hz-4 Hz SWD dominant rhythm,the desired seizure abatements can be obtained,which can be further improved by our proposed directional steering(DS)stimulation.The dynamical explanations for the SARS induced seizure abatements are lastly given by calculating the averaged mean firing rate(AMFR)of neurons and triggering averaged mean firing rates(TAMFRs)of 2 Hz-4 Hz SWD. 展开更多
关键词 epileptic absence seizure spike and wave discharge(SWD) single-pulse alternately resetting stimulation(SARS) mean field model averaged mean firing rate(AMFR) seizure control
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Activation of Anti-tumor Immune Response by Ablation of HCC with Nanosecond Pulsed Electric Field 被引量:4
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作者 Xiaobo Xu Yiling Chen +2 位作者 Ruiqing Zhang Xudong Miao Xinhua Che 《Journal of Clinical and Translational Hepatology》 SCIE 2018年第1期85-88,共4页
Locoregional therapy is playing an increasingly important role in the non-surgical management of hepatocellular carcinoma(HCC).The novel technique of non-thermal electric ablation by nanosecond pulsed electric field h... Locoregional therapy is playing an increasingly important role in the non-surgical management of hepatocellular carcinoma(HCC).The novel technique of non-thermal electric ablation by nanosecond pulsed electric field has been recognized as a potential locoregional methodology for indicated HCC.This manuscript explores the most recent studies to indicate its unique anti-tumor immune response.The possible immune mechanism,termed as nano-pulse stimulation,was also analyzed. 展开更多
关键词 Locoregional therapy Hepatocellular carcinoma(HCC) Nanosecond pulsed electric field(nsPEF) Nano-pulse stimulation(NPS)
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深度探讨铅酸蓄电池的工作原理及维护技术 被引量:4
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作者 崔建国 宁永香 《山西电子技术》 2018年第6期73-76,共4页
针对目前铅酸蓄电池使用量巨大同时淘汰量巨大的情况,其造成的环境污染特别严重,首先通过深层次探讨蓄电池的工作原理,指出其被淘汰或失效的根本原因:硫化。进而设计两种修复或延缓铅酸蓄电池硫化的方案:其一设计一种软化剂配方,从物理... 针对目前铅酸蓄电池使用量巨大同时淘汰量巨大的情况,其造成的环境污染特别严重,首先通过深层次探讨蓄电池的工作原理,指出其被淘汰或失效的根本原因:硫化。进而设计两种修复或延缓铅酸蓄电池硫化的方案:其一设计一种软化剂配方,从物理方面清洗极板从而消除硫酸铅结晶;其二设计一种简易的电瓶修复仪电路,采用较强的电脉冲信号连续地清除电池极板上的结晶硫化物,并有效地防止新的结晶硫化物产生,使蓄电池极板始终呈全新和高效工作状态,恢复和保证蓄电池稳定的容量输出。最后提供一种免维护蓄电池加液的方法。 展开更多
关键词 极板 硫酸铅 硫化 软化剂 脉冲 刺激
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体表脉冲电刺激对昆明小鼠心电活动的影响 被引量:2
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作者 李永林 张辉 +4 位作者 史若飞 汤小曼 解力 黄吕 张晓刚 《中国组织工程研究》 CAS CSCD 2014年第27期4318-4323,共6页
背景:使用不同强度、频率及时间的电刺激作用于人体,可能产生各种不同的病理生理反应。目的:观察体表脉冲电刺激对小鼠心律及心率的影响。方法:将30只昆明小鼠随机分为3组,每组10只,用BL-420F型生物机能实验系统提供刺激电源,对3组昆明... 背景:使用不同强度、频率及时间的电刺激作用于人体,可能产生各种不同的病理生理反应。目的:观察体表脉冲电刺激对小鼠心律及心率的影响。方法:将30只昆明小鼠随机分为3组,每组10只,用BL-420F型生物机能实验系统提供刺激电源,对3组昆明小鼠分别予以不同电压、不同时间、不同频率的体表电刺激,然后观察Ⅱ导联心电图、小鼠得全身反应与局部变化。结果与结论:≤10 V的电刺激对小鼠心率无明显影响,并且未出现心律失常;电压≥15 V时,电刺激可使小鼠心率减慢,停止30 min后心率恢复正常;电压≥35 V时,小鼠出现心率减慢和心律失常,并且停止刺激后心率不能恢复正常;电压>75 V后,小鼠出现室颤。电压为10 V时,脉冲电刺激时间和频率变化对小鼠心电活动影响不显著。说明脉冲电刺激对小鼠心电活动的影响主要由所用电压高低不同引起,电压≤10 V时对小鼠心电活动无影响;脉冲电刺激时间与电场频率对小鼠心电活动影响不明显。 展开更多
关键词 实验动物 组织构建 脉冲电刺激 修复重建 移植 Ⅱ导联心电图 心率 心律失常
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QUANTITATIVE ANALYSIS ON CHANGES OF HEPATIC HEMODYNAMICS AFTER TRANSCUTANEOUS ELECTRIC PULSE STIMULATION OF LOCAL POINTS BY USING COLOR DOPPLER ULTRASOUND DIAGNOSTIC APPARATUS
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作者 张均倡 王岭 +2 位作者 李红 李峻 张云 《World Journal of Acupuncture-Moxibustion》 2006年第3期3-7,共5页
Objective: To evaluate the effect of transcutaneous electric pulse stimulation (TEPS) on hepatic blood flow and parenchymal microcirculation in patients with fatty liver. Methods: A total of 31 fatty liver volunteer p... Objective: To evaluate the effect of transcutaneous electric pulse stimulation (TEPS) on hepatic blood flow and parenchymal microcirculation in patients with fatty liver. Methods: A total of 31 fatty liver volunteer patients were observed in this study. Changes of color Doppler energy (CDE) images before and after TEPS of local points nearby the liver were recorded by using color Doppler ultrasound diagnostic apparatus (ACUSON 128XP/10C). Sum of color pixel area (SCPA), average of color value (ACV) and SCPA×ACV (integral) of the hepatic flow images were analyzed by an image processing system, single blind method and paired t-test. Programmed TEPS (0.5- 150 Hz / 2 000 Hz , 10- 25 V ) was applied to the right Qimen (期门 LR 14)-Jingmen (京门 GB 25), Fuai (腹哀 SP 16)-Ganshu (肝俞 BL 18) respectively for 15 min. Results: Compared with basic values of pretreatment, SCPA, ACV and SCPA×ACV increased significantly (t=2.71, P<0.02; t=3.42, P<0.01; and t=8.15, P<0.001) after TEPS, meaning improvement of hepatic blood flow supply. Conclusion: TEPS of acupoints near the liver can improve hepatic blood flow and hepatic parenchymal microcirculation in patients with fatty liver. 展开更多
关键词 Fatty liver Transcutaneous electric pulse stimulation Color Doppler energy Hepatic hemodynamics
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高能多脉冲超正压射孔技术 被引量:1
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作者 张杰 薛中天 +1 位作者 廖红伟 张新庆 《断块油气田》 CAS 2003年第5期82-83,共2页
高能多脉冲超正压射孔技术是一项利用高能燃料的燃烧在目的层产生压力的超正压射孔或增产新技术。主要介绍了该技术的基本原理和装置的结构设计 ,并给出了该技术在国内一些油田的应用实例。实例说明 ,该技术是一项非常好的完井或增产新... 高能多脉冲超正压射孔技术是一项利用高能燃料的燃烧在目的层产生压力的超正压射孔或增产新技术。主要介绍了该技术的基本原理和装置的结构设计 ,并给出了该技术在国内一些油田的应用实例。实例说明 ,该技术是一项非常好的完井或增产新技术。 展开更多
关键词 多脉冲 超正压射孔 增产技术 射孔效率 水力压裂
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Effect of low-frequency pulse percutaneous electric stimulation on peripheral nerve injuries at different sites 被引量:1
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作者 Jinwu Wang Liye Chen +4 位作者 Qi Li Weifeng Ni Min Zhang Shangchun Guo Bingfang Zeng 《Neural Regeneration Research》 SCIE CAS CSCD 2006年第3期253-255,共3页
BACKGROUND: The postoperative recovery of nerve function in patients with peripheral nerve injury is always an important problem to solve after treatment. The electric stimulation induced electromagnetic field can no... BACKGROUND: The postoperative recovery of nerve function in patients with peripheral nerve injury is always an important problem to solve after treatment. The electric stimulation induced electromagnetic field can nourish nerve, postpone muscular atrophy, and help the postoperative neuromuscular function. OBJECTIVE: To observe the effects of low-frequency pulse percutaneous electric stimulation on the functional recovery of postoperative patients with peripheral nerve injury, and quantitatively evaluate the results of electromyogram (EMG) examination before and after treatment. DESIGN : A retrospective case analysis SETTING: The Sixth People's Hospital affiliated to Shanghai Jiaotong University PARTICIPANTS: Nineteen postoperative inpatients with peripheral nerve injury were selected from the De- partment of Orthopaedics, the Sixth People's Hospital affiliated to Shanghai Jiaotong University from June 2005 to January 2006, including 13 males and 6 females aged 24-62 years with an average of 36 years old. There were 3 cases of brachial plexus nerve injury, 3 of median nerve injury, 7 of radial nerve injury, 3 of ul- nar nerve injury and 3 of common peroneal nerve injury, and all the patients received probing nerve fiber restoration. Their main preoperative manifestations were dennervation, pain in limbs, motor and sensory disturbances. All the 19 patients were informed with the therapeutic program and items for evaluation. METHODS: ① Low-frequency pulse percutaneous electric stimulation apparatus: The patients were given electric stimulation with the TERESA cantata instrument (TERESA-0, Shanghai Teresa Health Technology, Co., Ltd.). The patients were stimulated with symmetric square waves of 1-111 Hz, and the intensity was 1.2-5.0 mA, and it was gradually adjusted according to the recovered conditions of neural regeneration following the principle that the intensity was strong enough and the patients felt no obvious upset. They were treated for 4- 24 weeks, 10-30 minutes for each time, 展开更多
关键词 Effect of low-frequency pulse percutaneous electric stimulation on peripheral nerve injuries at different sites
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裸燕麦麸皮提取物和低频脉冲刺激干预PFD大鼠对ArfGAP3通路的影响
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作者 李碧慧 王悦棠 +3 位作者 刘完美 时欢 徐赛群 何娴婕 《生物化工》 CAS 2023年第3期80-82,共3页
目的:分析裸燕麦麸皮提取物和低频脉冲刺激分别干预盆底功能障碍(PFD)大鼠对ADP核糖基化因子GTP结合蛋白3(ArfGAP3)信号通路的影响。方法:将30只大鼠随机均分为模型组、药物干预组、物理干预组,比较各组干预后病灶局部组织中ArfGAP3、... 目的:分析裸燕麦麸皮提取物和低频脉冲刺激分别干预盆底功能障碍(PFD)大鼠对ADP核糖基化因子GTP结合蛋白3(ArfGAP3)信号通路的影响。方法:将30只大鼠随机均分为模型组、药物干预组、物理干预组,比较各组干预后病灶局部组织中ArfGAP3、透明质酸(HA)、层粘连蛋白(LN)、Ⅳ型胶原蛋白(Ⅳ-C)含量的统计学差异。用回归模型分析HA、LN、Ⅳ-C和ArfGAP3的综合关联。结果:药物干预组和模型组、物理干预组和模型组、物理干预组和药物干预组两两比较,各指标差异均有统计意义(P<0.05)。各指标对ArfGAP3蛋白影响程度依次为LN蛋白、HA蛋白、Ⅳ-C蛋白。结论:低频脉冲刺激和裸燕麦麸皮提取物虽然均能对PFD大鼠病灶局部ArfGAP3通路产生激活作用,但低频脉冲刺激物理治疗方式能更为快捷且显著的降低LN蛋白表达,增加HA、Ⅳ-C蛋白表达,可能对病灶局部肌功能恢复有更好促进作用。 展开更多
关键词 低频 脉冲刺激 裸燕麦麸皮 盆底功能障碍 ArfGAP3信号通路
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高能多脉冲超平衡射孔技术及其应用 被引量:1
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作者 张杰 廖红伟 +1 位作者 薛中天 张新庆 《天然气工业》 EI CAS CSCD 北大核心 2003年第z1期86-88,11,共3页
高能多脉冲超平衡射孔技术利用高能燃料的燃烧 ,在目的层产生 1.2~ 1.5倍于地层破裂压力的高压后开始射孔 ,随后压力补给弹燃烧补给压力 ,对射孔孔眼进行冲刷和延伸、并产生不受地应力控制的裂缝的射孔或增产新技术。文章介绍了该技术... 高能多脉冲超平衡射孔技术利用高能燃料的燃烧 ,在目的层产生 1.2~ 1.5倍于地层破裂压力的高压后开始射孔 ,随后压力补给弹燃烧补给压力 ,对射孔孔眼进行冲刷和延伸、并产生不受地应力控制的裂缝的射孔或增产新技术。文章介绍了该技术的基本原理和装置的结构设计 ,并给出了该技术在中原油田一些气田的应用实例。应用表明 ,该技术具有氮气加压式超平衡射孔的优点 :简便、成本低、增产明显 ,2 0口井平均增产 3.5倍。 展开更多
关键词 多脉冲 超平衡射孔 增产技术 天然气 应用
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脉冲激励下轴突产生兴奋后抑制现象的去极化阻滞机制的理论仿真研究
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作者 韩文娟 陈梦娇 +2 位作者 杨明浩 古华光 任维 《生物物理学报》 CAS CSCD 北大核心 2010年第6期497-504,共8页
轴突重复兴奋后表现的兴奋后抑制是机制尚未明了的一种重要的生理现象。在Hodgkin-Huxley方程基础上,引入Na+-K+泵流,并考虑轴突膜内、髓鞘间隙限制区和轴突膜外离子浓度,以及Na+、K+平衡电位的能斯特方程,建立了轴突的电活动模型。低... 轴突重复兴奋后表现的兴奋后抑制是机制尚未明了的一种重要的生理现象。在Hodgkin-Huxley方程基础上,引入Na+-K+泵流,并考虑轴突膜内、髓鞘间隙限制区和轴突膜外离子浓度,以及Na+、K+平衡电位的能斯特方程,建立了轴突的电活动模型。低频脉冲激励下,模型产生与刺激脉冲一一对应的动作电位;中等频率脉冲激励下,模型产生兴奋后抑制现象。随着脉冲频率的增加,兴奋后抑制现象出现的频次也增加。在不同刺激强度下,产生兴奋后抑制现象的脉冲频率范围不同。依据数值模拟结果,分析了兴奋后抑制现象的动态过程,以及不同阶段的不同离子机制。揭示了兴奋后抑制是一种去极化阻滞现象,与髓鞘间隙限制区K+、胞内Na+累积和Na+-K+泵的活动密切相关。 展开更多
关键词 兴奋后抑制 去极化阻滞 脉冲刺激 Na+-K+泵 神经放电
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