Alzheimer’s disease(AD),a neurodegenerative disorder,has been determined as an outcome of genetic as well as behavioral conditions.The complete understanding of its generation and progress is yet to be understood.How...Alzheimer’s disease(AD),a neurodegenerative disorder,has been determined as an outcome of genetic as well as behavioral conditions.The complete understanding of its generation and progress is yet to be understood.However,there has been a significant progress in the diagnosis and identification of the associated risk factors of AD.Several of the risk factors were found connected with cholesterol.Scientists are mainly focusing on the reduction of amyloid β and stabilization of tau protein towards the development of its drugs.To modulate amyloid β,the key components of cholesterol metabolism have been attractive targets and the enzymes involved in the phosphorylation of tau have been tried to stabilize tau protein.This review article briefly highlights the symptoms,risk factors,and drug targets of AD.展开更多
文摘Alzheimer’s disease(AD),a neurodegenerative disorder,has been determined as an outcome of genetic as well as behavioral conditions.The complete understanding of its generation and progress is yet to be understood.However,there has been a significant progress in the diagnosis and identification of the associated risk factors of AD.Several of the risk factors were found connected with cholesterol.Scientists are mainly focusing on the reduction of amyloid β and stabilization of tau protein towards the development of its drugs.To modulate amyloid β,the key components of cholesterol metabolism have been attractive targets and the enzymes involved in the phosphorylation of tau have been tried to stabilize tau protein.This review article briefly highlights the symptoms,risk factors,and drug targets of AD.
