The growth in biomedical data resources has raised potential privacy concerns and risks of genetic information leakage. For instance, exome sequencing aids clinical decisions by comparing data through web services, bu...The growth in biomedical data resources has raised potential privacy concerns and risks of genetic information leakage. For instance, exome sequencing aids clinical decisions by comparing data through web services, but it requires significant trust between users and providers. To alleviate privacy concerns, the most commonly used strategy is to anonymize sensitive data. Unfortunately, studies have shown that anonymization is insufficient to protect against reidentification attacks. Recently, privacy-preserving technologies have been applied to preserve application utility while protecting the privacy of biomedical data. We present the PICOTEES framework, a privacy-preserving online service of phenotype exploration for genetic-diagnostic variants (https://birthdefectlab.cn:3000/). PICOTEES enables privacy-preserving queries of the phenotype spectrum for a single variant by utilizing trusted execution environment technology, which can protect the privacy of the user's query information, backend models, and data, as well as the final results. We demonstrate the utility and performance of PICOTEES by exploring a bioinformatics dataset. The dataset is from a cohort containing 20,909 genetic testing patients with 3,152,508 variants from the Children's Hospital of Fudan University in China, dominated by the Chinese Han population (>99.9%). Our query results yield a large number of unreported diagnostic variants and previously reported pathogenicity.展开更多
The importance and necessity of implementing the balance system of farmland requisition and compensation are reasoned.The changing path of the balance system of farmland requisition-compensation is overviewed.In addit...The importance and necessity of implementing the balance system of farmland requisition and compensation are reasoned.The changing path of the balance system of farmland requisition-compensation is overviewed.In addition,the problems exist in the implementation of the balance system of farmland requisition-compensation are analyzed as well,covering the increasing demands on land in the process of economic development;the serious phenomenon of wasting land in urban construction;part of farmlands should be revoked from the perspective of ecological construction and environmental protection,which lead to the shortage of reserved farmland and it is hard to implement the balance system of farmland requisition-compensation;the problems of "occupying more but compensating less,occupying good land but compensating bad land" are universal;the development and reclamation of farmlands have taken certain threats to ecological environment;the differences of various regions have not been taken into consideration in implementing the balance system of farmland requisition-compensation.Some notes on the developing trend of farmlands requisition-compensation balance system are put forward.The farmlands should be occupied after being compensated first,so as to ensure the dynamic balance of the total amount of farmlands;the government should encourage the improvement of farmland with mediocre and low output,so as to enhance its production capability;the potential of urban and rural construction land use should be fully developed and the occupation of farmland should be reduced as few as possible;various aspects should be cooperated to increase the possibility of requisition-compensation among different regions.展开更多
基金funded by the Shanghai Hospital Development Center(SHDC2020CR6028-002 to W.Zhou)National Key R&D Program of China(2020YFC2006402 to Y.Lu)+7 种基金National Key R&D Program of China(2022ZD0116003 to X.Dong)the Science and Technology Commission of Shanghai(22002400700 to S.Wu)Shanghai Municipal Science and Technology Major Project(20Z11900600 to W.Zhou)National Key Research and Development Program(2018YFC0116903 to W.Zhou)Major Research Projects for Young and Middle-aged People of Fujian Province(2021ZQNZD017 to Y.Lu)supported by Key Lab Information Network Security,Ministry of Public Security(to H.Zheng and S.Wang)“Pioneer”and”Leading Goose”R&D Program of Zhejiang(No.2022C01126 to Q.Sun and S.Wang)National Key R&D Program of China(2021YFC2500802 and 2021YFC2500806 to H.Zheng and S.Wang).
文摘The growth in biomedical data resources has raised potential privacy concerns and risks of genetic information leakage. For instance, exome sequencing aids clinical decisions by comparing data through web services, but it requires significant trust between users and providers. To alleviate privacy concerns, the most commonly used strategy is to anonymize sensitive data. Unfortunately, studies have shown that anonymization is insufficient to protect against reidentification attacks. Recently, privacy-preserving technologies have been applied to preserve application utility while protecting the privacy of biomedical data. We present the PICOTEES framework, a privacy-preserving online service of phenotype exploration for genetic-diagnostic variants (https://birthdefectlab.cn:3000/). PICOTEES enables privacy-preserving queries of the phenotype spectrum for a single variant by utilizing trusted execution environment technology, which can protect the privacy of the user's query information, backend models, and data, as well as the final results. We demonstrate the utility and performance of PICOTEES by exploring a bioinformatics dataset. The dataset is from a cohort containing 20,909 genetic testing patients with 3,152,508 variants from the Children's Hospital of Fudan University in China, dominated by the Chinese Han population (>99.9%). Our query results yield a large number of unreported diagnostic variants and previously reported pathogenicity.
文摘The importance and necessity of implementing the balance system of farmland requisition and compensation are reasoned.The changing path of the balance system of farmland requisition-compensation is overviewed.In addition,the problems exist in the implementation of the balance system of farmland requisition-compensation are analyzed as well,covering the increasing demands on land in the process of economic development;the serious phenomenon of wasting land in urban construction;part of farmlands should be revoked from the perspective of ecological construction and environmental protection,which lead to the shortage of reserved farmland and it is hard to implement the balance system of farmland requisition-compensation;the problems of "occupying more but compensating less,occupying good land but compensating bad land" are universal;the development and reclamation of farmlands have taken certain threats to ecological environment;the differences of various regions have not been taken into consideration in implementing the balance system of farmland requisition-compensation.Some notes on the developing trend of farmlands requisition-compensation balance system are put forward.The farmlands should be occupied after being compensated first,so as to ensure the dynamic balance of the total amount of farmlands;the government should encourage the improvement of farmland with mediocre and low output,so as to enhance its production capability;the potential of urban and rural construction land use should be fully developed and the occupation of farmland should be reduced as few as possible;various aspects should be cooperated to increase the possibility of requisition-compensation among different regions.
