Pancreatic schwannomas are rare neoplasms. Authors briefly describe a 64-year-old female patient with cystic pancreatic schwannoma mimicking other cystic tumors and review the literature. Databases for PubMed were sea...Pancreatic schwannomas are rare neoplasms. Authors briefly describe a 64-year-old female patient with cystic pancreatic schwannoma mimicking other cystic tumors and review the literature. Databases for PubMed were searched for English-language articles from 1980 to 2010 using a list of keywords, as well as references from review articles. Only 41 articles, including 47 cases, have been reported in the English literature. The mean age was 55.7 years （range 20-87 years）, with 45% of patients being male. Mean tumor size was 6.2 cm （range 1-20 cm）. Tumor location was the head （40%）, head and body （6%）, body （21%）, body and tail （15%）, tail （4%）, and uncinate process （13%）. Thirty-four percent of patients exhibited solid tumors and 60% of patients exhibited cystic tumors. Treatment included pancreati- coduodenectomy （32%）, distal pancreatectomy （21%）, enucleation （15%）, unresectable （4%）, refused opera- tion （2%） and the detail of resection was not specified in 26% of patients. No patients died of disease with a mean follow-up of 15.7 mo （range 3-65 too）, although 5 （11%） patients had a malignancy. The tumor size was significantly related to malignant tumor （13.8 ＋ 6.2 cm for malignancy vs 5.5 ＋ 4.4 cm for benign, P = 0.001） and cystic formation （7.9 ~ 5.9 cm for cystic tumor vs 3.9 ＋ 2.4 cm for solid tumor, P = 0.005）. The preoperative diagnosis of pancreatic schwannoma remains difficult. Cystic pancreatic schwannomas should be considered in the differential diagnosis of cystic neoplasms and pseudocysts. In our caset intraoperative frozen sec- tion confirmed the diagnosis of a schwannoma. Simple enudeation may be adequate, if this is possible.展开更多
Introduction: Dental pathologies during pregnancy can compromise the prognosis of pregnancy and that of the mother. We report a first-study of cases of association of pregnancy and oral pathology supported in the Depa...Introduction: Dental pathologies during pregnancy can compromise the prognosis of pregnancy and that of the mother. We report a first-study of cases of association of pregnancy and oral pathology supported in the Department of Odonto-stomatology of the National Hospital of Niamey. Objective: To report epidemiology, treatment and prognosis of dental origin cervicofacial cellulitis associated with pregnancy. Patients and Methods: This is a retrospective and prospective study over 5 years from August 1st, 2013 to July 31, 2018 involving 21 pregnant women in the Odonto-stomatology Department of the National Hospital of Niamey (HNN). Results: During the study period, 585 patients were consulted in the Odonto-stomatology Department for cervicofacial tooth cellulitis of dental origin, 21 of them were pregnant women (3.39%). The average age of the pregnant patients was 29.57 years old, extrems 25 - 29 years old. The average delay before consultation was 28.76 days. Majority patients were rural inhabitants The pathology happened in the third trimester of pregnancy (52.39%), second trimester (33.33%), in first (14.29%). This pathology was observed among disadvantaged socioeconomic class as housewives (85.71%) and uneducated women (61.90%). The lake of oral hygien was the main cause of cellulitis. We noted a history of periodontal disease (52.38%), fever upper 38°C (61.90%), trismus (85.71%,) dysphonia (42.86%), odynophagia (23.81%), dysphagia (42.86%), dyspnea (33.33%), and cervicofacial swelling (100%.) The treatment was medico-surgical. The prognosis depended on the precocious treatment with 76.19% cured. But unfortunately 4 cases died (19.05%), still for birth (52.38%) and 9.52% abortion. Conclusion: Association dental origin cervicofacial展开更多
目的研究蛋白磷酸酶2A癌性抑制因子(cancerous inhibitor of protein phosphatase 2A,CIP2A)在膀胱尿路上皮癌组织中的表达及其与临床病理特征的关系,探讨其成为膀胱尿路上皮癌预后指标的可行性。方法应用RT-PCR和Western blot检测CIP2A...目的研究蛋白磷酸酶2A癌性抑制因子(cancerous inhibitor of protein phosphatase 2A,CIP2A)在膀胱尿路上皮癌组织中的表达及其与临床病理特征的关系,探讨其成为膀胱尿路上皮癌预后指标的可行性。方法应用RT-PCR和Western blot检测CIP2A mRNA和蛋白在25例膀胱尿路上皮癌和对应癌旁组织中的表达情况;应用组织芯片技术和免疫组织化学方法,检测CIP2A在117例膀胱尿路上皮癌和30例癌旁组织中的表达情况,分析CIP2A与膀胱尿路上皮癌患者临床病理特征及预后之间的关系。结果CIP2A mRNA和蛋白在25例配对膀胱尿路上皮癌组织中的表达水平明显高于癌旁组织。免疫组织化学检测发现,膀胱尿路上皮癌组织中CIP2A蛋白的阳性表达率为76.9%(90/117),明显高于癌旁组织的6.7%(2/30),差异有统计学意义(P<0.001)。CIP2A表达与肿瘤病理分级(P<0.001)、临床分期(P<0.001)、肿瘤大小(P=0.002)和淋巴结转移(P=0.046)有关,但与年龄、性别及肿瘤数目无关(P>0.05)。Kaplan-Meier单因素分析显示,CIP2A蛋白高表达是总体生存率和无复发生存率的影响因素(P<0.001)。Cox多因素风险比例模型显示,与总生存率相关的独立预后因素为临床分期、肿瘤病理分级和CIP2A表达,与无复发生存率相关的独立预后因素亦为临床分期、肿瘤病理分级和CIP2A表达。结论CIP2A蛋白在膀胱尿路上皮癌组织中高表达,可能与膀胱尿路上皮癌的进展有关,其表达状态是膀胱尿路上皮癌患者独立预后因素。展开更多
文摘Pancreatic schwannomas are rare neoplasms. Authors briefly describe a 64-year-old female patient with cystic pancreatic schwannoma mimicking other cystic tumors and review the literature. Databases for PubMed were searched for English-language articles from 1980 to 2010 using a list of keywords, as well as references from review articles. Only 41 articles, including 47 cases, have been reported in the English literature. The mean age was 55.7 years （range 20-87 years）, with 45% of patients being male. Mean tumor size was 6.2 cm （range 1-20 cm）. Tumor location was the head （40%）, head and body （6%）, body （21%）, body and tail （15%）, tail （4%）, and uncinate process （13%）. Thirty-four percent of patients exhibited solid tumors and 60% of patients exhibited cystic tumors. Treatment included pancreati- coduodenectomy （32%）, distal pancreatectomy （21%）, enucleation （15%）, unresectable （4%）, refused opera- tion （2%） and the detail of resection was not specified in 26% of patients. No patients died of disease with a mean follow-up of 15.7 mo （range 3-65 too）, although 5 （11%） patients had a malignancy. The tumor size was significantly related to malignant tumor （13.8 ＋ 6.2 cm for malignancy vs 5.5 ＋ 4.4 cm for benign, P = 0.001） and cystic formation （7.9 ~ 5.9 cm for cystic tumor vs 3.9 ＋ 2.4 cm for solid tumor, P = 0.005）. The preoperative diagnosis of pancreatic schwannoma remains difficult. Cystic pancreatic schwannomas should be considered in the differential diagnosis of cystic neoplasms and pseudocysts. In our caset intraoperative frozen sec- tion confirmed the diagnosis of a schwannoma. Simple enudeation may be adequate, if this is possible.
文摘目的探讨钙卫蛋白（S100A8／A9）在急性心肌梗死（Acute myocardial infarction ，AMI）患者血清中的水平以及与患者近期预后的关系。方法收集2012年3月至2013年3月在本院诊治且病历资料完整的AMI患者64例，稳定型心绞痛（SAP组）30例，另选择健康体检者（NC组）30例作为对照组。收集研究对象的一般情况，血生化指标；检测各组入院时空腹血清S100A8／A9水平，出院后3个月对AM I患者进行电话随访，了解患者的近期预后。结果 AMI组的血清S100A8／A9水平明显高于 SAP组、健康对照组（ P ＜0．05）；SAP组S100A8／A9水平亦高于健康对照组（ P ＜0．05）；S100A8／A9、空腹血糖（FPG）、吸烟以及高胆固醇血症影响 AMI患者的近期预后（死亡或因心脏事件再住院）（ P ＜0．05）。结论 AMI患者血清S100A8／A9水平显著升高；血清S100A8／A9与AMI患者的近期预后相关。
文摘Introduction: Dental pathologies during pregnancy can compromise the prognosis of pregnancy and that of the mother. We report a first-study of cases of association of pregnancy and oral pathology supported in the Department of Odonto-stomatology of the National Hospital of Niamey. Objective: To report epidemiology, treatment and prognosis of dental origin cervicofacial cellulitis associated with pregnancy. Patients and Methods: This is a retrospective and prospective study over 5 years from August 1st, 2013 to July 31, 2018 involving 21 pregnant women in the Odonto-stomatology Department of the National Hospital of Niamey (HNN). Results: During the study period, 585 patients were consulted in the Odonto-stomatology Department for cervicofacial tooth cellulitis of dental origin, 21 of them were pregnant women (3.39%). The average age of the pregnant patients was 29.57 years old, extrems 25 - 29 years old. The average delay before consultation was 28.76 days. Majority patients were rural inhabitants The pathology happened in the third trimester of pregnancy (52.39%), second trimester (33.33%), in first (14.29%). This pathology was observed among disadvantaged socioeconomic class as housewives (85.71%) and uneducated women (61.90%). The lake of oral hygien was the main cause of cellulitis. We noted a history of periodontal disease (52.38%), fever upper 38°C (61.90%), trismus (85.71%,) dysphonia (42.86%), odynophagia (23.81%), dysphagia (42.86%), dyspnea (33.33%), and cervicofacial swelling (100%.) The treatment was medico-surgical. The prognosis depended on the precocious treatment with 76.19% cured. But unfortunately 4 cases died (19.05%), still for birth (52.38%) and 9.52% abortion. Conclusion: Association dental origin cervicofacial
文摘目的研究蛋白磷酸酶2A癌性抑制因子(cancerous inhibitor of protein phosphatase 2A,CIP2A)在膀胱尿路上皮癌组织中的表达及其与临床病理特征的关系,探讨其成为膀胱尿路上皮癌预后指标的可行性。方法应用RT-PCR和Western blot检测CIP2A mRNA和蛋白在25例膀胱尿路上皮癌和对应癌旁组织中的表达情况;应用组织芯片技术和免疫组织化学方法,检测CIP2A在117例膀胱尿路上皮癌和30例癌旁组织中的表达情况,分析CIP2A与膀胱尿路上皮癌患者临床病理特征及预后之间的关系。结果CIP2A mRNA和蛋白在25例配对膀胱尿路上皮癌组织中的表达水平明显高于癌旁组织。免疫组织化学检测发现,膀胱尿路上皮癌组织中CIP2A蛋白的阳性表达率为76.9%(90/117),明显高于癌旁组织的6.7%(2/30),差异有统计学意义(P<0.001)。CIP2A表达与肿瘤病理分级(P<0.001)、临床分期(P<0.001)、肿瘤大小(P=0.002)和淋巴结转移(P=0.046)有关,但与年龄、性别及肿瘤数目无关(P>0.05)。Kaplan-Meier单因素分析显示,CIP2A蛋白高表达是总体生存率和无复发生存率的影响因素(P<0.001)。Cox多因素风险比例模型显示,与总生存率相关的独立预后因素为临床分期、肿瘤病理分级和CIP2A表达,与无复发生存率相关的独立预后因素亦为临床分期、肿瘤病理分级和CIP2A表达。结论CIP2A蛋白在膀胱尿路上皮癌组织中高表达,可能与膀胱尿路上皮癌的进展有关,其表达状态是膀胱尿路上皮癌患者独立预后因素。
