Based on the empirical electron theory of solids and molecules (EET), the phase valence electron structure parameters of Al-22%Si alloy are calculated, and the sensitivity of the bond network of Al-Si alloy melt to te...Based on the empirical electron theory of solids and molecules (EET), the phase valence electron structure parameters of Al-22%Si alloy are calculated, and the sensitivity of the bond network of Al-Si alloy melt to temperature (energy) and the effect of the sensitivity on the morphology are studied. The results show that the Si-Si clusters with larger nA in the slightly superheated Al-Si alloy melt supply the nucleation core to the primary silicon phase in the hypereutectic Al-22%Si alloy, and strongly generate the drag-like effect for the Al-Si clusters around them; that the variation of temperature significantly affects the stability of bonds of the core so that the solidified structure is changed; that the electric pulse applied to the alloy melt can irrecoverably alter the stability of Si-Si clusters, then the modifica- tion of the solidified structure morphology of alloys is generated; that the higher the energy of the electric pulse, the less stable the Si-Si clusters, and the more significant the electric pulse modification.展开更多
The metallographic structure of LM-29 aluminum-silicon alloy modified by electric pulse treatment has been investigated and compared with those untreated.The solidification structure of LM-29 alloy has been analyzed b...The metallographic structure of LM-29 aluminum-silicon alloy modified by electric pulse treatment has been investigated and compared with those untreated.The solidification structure of LM-29 alloy has been analyzed by means of M1AP3 Quantimet image processing and analysis system,and then the solidification process has been analyzed by means of differential scanning calorimetry(DSC).The results indicate that the primary silicon phase was refined remarkably by electric pulse while the tensile strength and elongation properties increased accordingly.Electric pulse treatment can also increase the binding power between silicon clusters and alloy melt matrix,as a result,the precipitation of primary silicon phase is suppressed to meet the demand of supercooling degree for nucleating,correspondingly.The electric pulse modification has great influence on the size of silicon atomic cluster as well as its distribution in the melt,subsequently,leads to the refinement of solidification structure.展开更多
In this editorial,we comment on the article by Wang et al.This manuscript explores the potential synergistic effects of combining zanubrutinib,a novel oral inhibitor of Bruton’s tyrosine kinase,with high-dose methotr...In this editorial,we comment on the article by Wang et al.This manuscript explores the potential synergistic effects of combining zanubrutinib,a novel oral inhibitor of Bruton’s tyrosine kinase,with high-dose methotrexate(HD-MTX)as a therapeutic intervention for primary central nervous system lymphoma(PCNSL).The study involves a retrospective analysis of 19 PCNSL patients,highlighting clinicopathological characteristics,treatment outcomes,and genomic biomarkers.The results indicate the combination’s good tolerance and strong antitumor activity,with an 84.2%overall response rate.The authors emphasize the potential of zanubrutinib to modulate key genomic features of PCNSL,particularly mutations in myeloid differentiation primary response 88 and cluster of differentiation 79B.Furthermore,the study investigates the role of circulating tumor DNA in cerebrospinal fluid for disease surveillance and treatment response monitoring.In essence,the study provides valuable insights into the potential of combining zanubrutinib with HD-MTX as a frontline therapeutic regimen for PCNSL.The findings underscore the importance of exploring alternative treatment modalities and monitoring genomic and liquid biopsy markers to optimize patient outcomes.While the findings suggest promise,the study’s limitations should be considered,and further research is needed to establish the clinical relevance of this therapeutic approach for PCNSL.展开更多
Background: A number of strategies exist for the implementation of clinical practice guides (CPGs). Aim: To assess the efficacy of implementing a cardiovascular risk CPG based on an educational method involving opinio...Background: A number of strategies exist for the implementation of clinical practice guides (CPGs). Aim: To assess the efficacy of implementing a cardiovascular risk CPG based on an educational method involving opinion leaders, and the habitual method of dissemination among primary healthcare teams. Design and Setting: Controlled, blinded, community intervention trial randomised by clusters. Methods: 21 primary healthcare centres were randomly assigned to either the intervention arm (n = 11) or the control arm (n = 10). The study subjects were patients aged ≥45 years assigned to the centres. The overall impact of the intervention was measured as the difference between the increase in the proportion of patients whose medical records showed the recording of all the variables necessary to calculate cardiovascular risk in both arms. Analyses were performed with Generalized Lineal Model on an intention-to-treat basis. Results: 917 subjects were included at the beginning of the trial (437 in the intervention arm and 480 in the control arm). 826 subjects were included in the final evaluation (436 in the intervention group and 390 in the control arm). At the end of the trial, the recording of the variables necessary for the calculation of the cardiovascular risk in the intervention group had increased more than in the control group (difference between increases 7.49% (95% CI 4.62 - 10.35)) after adjusting for confounding variables. Conclusions: Compared to the habitual method of dissemination, the implementation of this CPG using an educational method involving opinion leaders, improved the recording of the variables needed to calculate patients’ cardiovascular risk.展开更多
基金the National Natural Science Foundation of China (Grant No. 50674054) the College Key Laboratory Open Fund of Liaoning Province(Grant No. 200516203)
文摘Based on the empirical electron theory of solids and molecules (EET), the phase valence electron structure parameters of Al-22%Si alloy are calculated, and the sensitivity of the bond network of Al-Si alloy melt to temperature (energy) and the effect of the sensitivity on the morphology are studied. The results show that the Si-Si clusters with larger nA in the slightly superheated Al-Si alloy melt supply the nucleation core to the primary silicon phase in the hypereutectic Al-22%Si alloy, and strongly generate the drag-like effect for the Al-Si clusters around them; that the variation of temperature significantly affects the stability of bonds of the core so that the solidified structure is changed; that the electric pulse applied to the alloy melt can irrecoverably alter the stability of Si-Si clusters, then the modifica- tion of the solidified structure morphology of alloys is generated; that the higher the energy of the electric pulse, the less stable the Si-Si clusters, and the more significant the electric pulse modification.
基金supported by the National Natural Science Foundation of China (No. 50674054)the Doctorate Foundation of Science and Technology Department,Liaoning Province (20081097)
文摘The metallographic structure of LM-29 aluminum-silicon alloy modified by electric pulse treatment has been investigated and compared with those untreated.The solidification structure of LM-29 alloy has been analyzed by means of M1AP3 Quantimet image processing and analysis system,and then the solidification process has been analyzed by means of differential scanning calorimetry(DSC).The results indicate that the primary silicon phase was refined remarkably by electric pulse while the tensile strength and elongation properties increased accordingly.Electric pulse treatment can also increase the binding power between silicon clusters and alloy melt matrix,as a result,the precipitation of primary silicon phase is suppressed to meet the demand of supercooling degree for nucleating,correspondingly.The electric pulse modification has great influence on the size of silicon atomic cluster as well as its distribution in the melt,subsequently,leads to the refinement of solidification structure.
文摘In this editorial,we comment on the article by Wang et al.This manuscript explores the potential synergistic effects of combining zanubrutinib,a novel oral inhibitor of Bruton’s tyrosine kinase,with high-dose methotrexate(HD-MTX)as a therapeutic intervention for primary central nervous system lymphoma(PCNSL).The study involves a retrospective analysis of 19 PCNSL patients,highlighting clinicopathological characteristics,treatment outcomes,and genomic biomarkers.The results indicate the combination’s good tolerance and strong antitumor activity,with an 84.2%overall response rate.The authors emphasize the potential of zanubrutinib to modulate key genomic features of PCNSL,particularly mutations in myeloid differentiation primary response 88 and cluster of differentiation 79B.Furthermore,the study investigates the role of circulating tumor DNA in cerebrospinal fluid for disease surveillance and treatment response monitoring.In essence,the study provides valuable insights into the potential of combining zanubrutinib with HD-MTX as a frontline therapeutic regimen for PCNSL.The findings underscore the importance of exploring alternative treatment modalities and monitoring genomic and liquid biopsy markers to optimize patient outcomes.While the findings suggest promise,the study’s limitations should be considered,and further research is needed to establish the clinical relevance of this therapeutic approach for PCNSL.
文摘Background: A number of strategies exist for the implementation of clinical practice guides (CPGs). Aim: To assess the efficacy of implementing a cardiovascular risk CPG based on an educational method involving opinion leaders, and the habitual method of dissemination among primary healthcare teams. Design and Setting: Controlled, blinded, community intervention trial randomised by clusters. Methods: 21 primary healthcare centres were randomly assigned to either the intervention arm (n = 11) or the control arm (n = 10). The study subjects were patients aged ≥45 years assigned to the centres. The overall impact of the intervention was measured as the difference between the increase in the proportion of patients whose medical records showed the recording of all the variables necessary to calculate cardiovascular risk in both arms. Analyses were performed with Generalized Lineal Model on an intention-to-treat basis. Results: 917 subjects were included at the beginning of the trial (437 in the intervention arm and 480 in the control arm). 826 subjects were included in the final evaluation (436 in the intervention group and 390 in the control arm). At the end of the trial, the recording of the variables necessary for the calculation of the cardiovascular risk in the intervention group had increased more than in the control group (difference between increases 7.49% (95% CI 4.62 - 10.35)) after adjusting for confounding variables. Conclusions: Compared to the habitual method of dissemination, the implementation of this CPG using an educational method involving opinion leaders, improved the recording of the variables needed to calculate patients’ cardiovascular risk.
