目的:研究乌梅丸联合蒙脱石散治疗腹泻型肠易激综合征的临床疗效。方法:87例符合纳入标准的腹泻型肠易激综合征患者随机分为观察组和对照组,观察组患者给予乌梅丸联合蒙脱石散治疗,对照组患者给予蒙脱石散治疗,评价治疗后疗效,随访6个月...目的:研究乌梅丸联合蒙脱石散治疗腹泻型肠易激综合征的临床疗效。方法:87例符合纳入标准的腹泻型肠易激综合征患者随机分为观察组和对照组,观察组患者给予乌梅丸联合蒙脱石散治疗,对照组患者给予蒙脱石散治疗,评价治疗后疗效,随访6个月,比较分析治疗前后症候积分,复发例数及5-HT水平。结果:观察组总有效率显著高于对照组(93.02%vs 70.45%;χ~2=8.874,P=0.031<0.05);治疗前,两组症候积分无显著性差异(P>0.05);治疗结束后及治疗后6个月,观察组回盲部5-HT水平和症候积分显著低于对照组(P<0.05);观察组复发例数显著低于对照组(4 vs 13,χ~2=4.765,P=0.0290<0.05)。结论:乌梅丸联合蒙脱石散能显著改善腹泻型肠易激综合征症状,降低5-HT水平,预后不易复发。展开更多
Objective To explore the mechanism of Pi(Spleen)-deficiency-induced functional diarrhea(FD)model rats treated by Shenling Baizhu Powder(参苓白术散,SBP).Methods Thirty male Sprague-Dawley rats were randomly divided int...Objective To explore the mechanism of Pi(Spleen)-deficiency-induced functional diarrhea(FD)model rats treated by Shenling Baizhu Powder(参苓白术散,SBP).Methods Thirty male Sprague-Dawley rats were randomly divided into 5 groups including control,model,low-,medium-,and high-dose SBP groups(SBPLDG,SBPMDG,SBPHDG),6 rats in each group,respectively.Pi-deficiency-induced FD rats model was developed through Radix et Rhizoma Rhei gavage for 7 days.After modeling,the rats were treated with 3 doses of SBP[0.93,1.86,and 3.72 g/(kg·d)],and the rats in the control and model groups were given pure water for 7 days.The diarrhea index was calculated.On the 7th and 14th days,the traveled distance of rat was measured by the open field test.Serum D-xylose content was determined by the phloroglucinol method and interleukin(IL)-10 and IL-17 levels were measured using an enzyme-linked immunosorbent assay kit.The content of Treg cells was determined by flow cytometry.Results Compared with the control group,the diarrhea index and IL-17 level in the model group were significantly higher and the total exercise distance and D-xylose content significantly decreased(P>0.05).The expression of IL-10 in the SBPHDG group was significantly up-regulated,and serum D-xylose level and Treg cells increased significantly compared with the model group(P>0.05).Conclusion High-dose SBP exhibited ameliorating effects against Pi-deficiency induced FD,which might be attributed to its modulations on intestinal absorption function as well as adaptive immunity in mesenteric lymph nodes of rat.展开更多
Nanosized BaCe_(0.95)Y_(0.05)O_(3-δ) powders with the homogeneous composition were synthesized by a new combustion process based on the Pechini method. A polymeric precursor sol was formed by use of citric acid and e...Nanosized BaCe_(0.95)Y_(0.05)O_(3-δ) powders with the homogeneous composition were synthesized by a new combustion process based on the Pechini method. A polymeric precursor sol was formed by use of citric acid and ethylene glycol as the chelating agents of metal ions. The perovskite-type BaCe_(0.95)Y_(0.05)O_(3-δ) powders with uniform shape and smaller than 40 nm in sized were obtained through the combustion of the polymeric precursor sol at the existence of nitric acid and ammonium hydroxide. It was found the particle size could be controlled by modulating the quantities of nitric acid and ammonium hydroxide, the quantities of the residue, carbonate ions were also affected by the quantities of the citric acid and ethylene glycol.展开更多
The suspension characteristics of ultrafine powder slurry in the stirred vessel were simulated by using computational fluid dynamics.The results show that the Rushton disk turbine impeller is more conducive to maintai...The suspension characteristics of ultrafine powder slurry in the stirred vessel were simulated by using computational fluid dynamics.The results show that the Rushton disk turbine impeller is more conducive to maintaining suspended homogeneity and circulation of slurry compared with the pitch blade turbine pumping up impeller and the pitch blade turbine pumping down impeller.And the increase in stirring speed enhances turbulent fluctuation and anisotropic velocity of the fluid at the cost of more power consumption,which improves dispersibility and suspensibility of the particles.Meanwhile,the change of impeller clearance has a weak influence on the flow pattern,and the impeller clearance of 0.32T(T is the diameter of the bottom of the reactor)can achieve better dispersivity and suspensibility of the particles with lower power consumption and larger axial velocity.The experiments of surface coating modification of ultrafine titanium dioxide(TiO2)were carried out under the same conditions for those of the simulation system.The surface film morphology and photocatalytic properties of the modified TiO2 were analyzed,and the obtained data are well consistent with the simulation results.展开更多
文摘目的:研究乌梅丸联合蒙脱石散治疗腹泻型肠易激综合征的临床疗效。方法:87例符合纳入标准的腹泻型肠易激综合征患者随机分为观察组和对照组,观察组患者给予乌梅丸联合蒙脱石散治疗,对照组患者给予蒙脱石散治疗,评价治疗后疗效,随访6个月,比较分析治疗前后症候积分,复发例数及5-HT水平。结果:观察组总有效率显著高于对照组(93.02%vs 70.45%;χ~2=8.874,P=0.031<0.05);治疗前,两组症候积分无显著性差异(P>0.05);治疗结束后及治疗后6个月,观察组回盲部5-HT水平和症候积分显著低于对照组(P<0.05);观察组复发例数显著低于对照组(4 vs 13,χ~2=4.765,P=0.0290<0.05)。结论:乌梅丸联合蒙脱石散能显著改善腹泻型肠易激综合征症状,降低5-HT水平,预后不易复发。
基金the National Natural Science Foundation of China(No.81703956,81830114,81774164)。
文摘Objective To explore the mechanism of Pi(Spleen)-deficiency-induced functional diarrhea(FD)model rats treated by Shenling Baizhu Powder(参苓白术散,SBP).Methods Thirty male Sprague-Dawley rats were randomly divided into 5 groups including control,model,low-,medium-,and high-dose SBP groups(SBPLDG,SBPMDG,SBPHDG),6 rats in each group,respectively.Pi-deficiency-induced FD rats model was developed through Radix et Rhizoma Rhei gavage for 7 days.After modeling,the rats were treated with 3 doses of SBP[0.93,1.86,and 3.72 g/(kg·d)],and the rats in the control and model groups were given pure water for 7 days.The diarrhea index was calculated.On the 7th and 14th days,the traveled distance of rat was measured by the open field test.Serum D-xylose content was determined by the phloroglucinol method and interleukin(IL)-10 and IL-17 levels were measured using an enzyme-linked immunosorbent assay kit.The content of Treg cells was determined by flow cytometry.Results Compared with the control group,the diarrhea index and IL-17 level in the model group were significantly higher and the total exercise distance and D-xylose content significantly decreased(P>0.05).The expression of IL-10 in the SBPHDG group was significantly up-regulated,and serum D-xylose level and Treg cells increased significantly compared with the model group(P>0.05).Conclusion High-dose SBP exhibited ameliorating effects against Pi-deficiency induced FD,which might be attributed to its modulations on intestinal absorption function as well as adaptive immunity in mesenteric lymph nodes of rat.
文摘Nanosized BaCe_(0.95)Y_(0.05)O_(3-δ) powders with the homogeneous composition were synthesized by a new combustion process based on the Pechini method. A polymeric precursor sol was formed by use of citric acid and ethylene glycol as the chelating agents of metal ions. The perovskite-type BaCe_(0.95)Y_(0.05)O_(3-δ) powders with uniform shape and smaller than 40 nm in sized were obtained through the combustion of the polymeric precursor sol at the existence of nitric acid and ammonium hydroxide. It was found the particle size could be controlled by modulating the quantities of nitric acid and ammonium hydroxide, the quantities of the residue, carbonate ions were also affected by the quantities of the citric acid and ethylene glycol.
基金financially supported by the National Natural Science Foundation of China(Nos.21838003,91834301 and 21878092)the Shanghai Scientific and Technological Innovation Project(No.18JC1410600)+2 种基金the Social Development Program of Shanghai(Nos.17DZ1200900 and 18DZ2252400)the Innovation Program of Shanghai Municipal Education Commissionthe Fundamental Research Funds for the Central Universities(No.222201718002)。
文摘The suspension characteristics of ultrafine powder slurry in the stirred vessel were simulated by using computational fluid dynamics.The results show that the Rushton disk turbine impeller is more conducive to maintaining suspended homogeneity and circulation of slurry compared with the pitch blade turbine pumping up impeller and the pitch blade turbine pumping down impeller.And the increase in stirring speed enhances turbulent fluctuation and anisotropic velocity of the fluid at the cost of more power consumption,which improves dispersibility and suspensibility of the particles.Meanwhile,the change of impeller clearance has a weak influence on the flow pattern,and the impeller clearance of 0.32T(T is the diameter of the bottom of the reactor)can achieve better dispersivity and suspensibility of the particles with lower power consumption and larger axial velocity.The experiments of surface coating modification of ultrafine titanium dioxide(TiO2)were carried out under the same conditions for those of the simulation system.The surface film morphology and photocatalytic properties of the modified TiO2 were analyzed,and the obtained data are well consistent with the simulation results.
