期刊文献+
共找到2篇文章
< 1 >
每页显示 20 50 100
Complex positive selection pressures drive the evolution of HIV-1 with different co-receptor tropisms 被引量:5
1
作者 ZHANG ChiYu DING Na +1 位作者 CHEN KePing YANG RongGe 《Science China(Life Sciences)》 SCIE CAS 2010年第10期1204-1214,共11页
HIV-1 co-receptor tropism is central for understanding the transmission and pathogenesis of HIV-1 infection. We performed a genome-wide comparison between the adaptive evolution of R5 and X4 variants from HIV-1 subtyp... HIV-1 co-receptor tropism is central for understanding the transmission and pathogenesis of HIV-1 infection. We performed a genome-wide comparison between the adaptive evolution of R5 and X4 variants from HIV-1 subtypes B and C. The results showed that R5 and X4 variants experienced differential evolutionary patterns and different HIV-1 genes encountered various positive selection pressures, suggesting that complex selection pressures are driving HIV-1 evolution. Compared with other hypervariable regions of Gp120, significantly more positively selected sites were detected in the V3 region of subtype B X4 variants, V2 region of subtype B R5 variants, and V1 and V4 regions of subtype C X4 variants, indicating an association of positive selection with co-receptor recognition/binding. Intriguingly, a significantly higher proportion (33.3% and 55.6%, P【0.05) of positively selected sites were identified in the C3 region than other conserved regions of Gp120 in all the analyzed HIV-1 variants, indicating that the C3 region might be more important to HIV-1 adaptation than previously thought. Approximately half of the positively selected sites identified in the env gene were identical between R5 and X4 variants. There were three common positively selected sites (96, 113 and 281) identified in Gp41 of all X4 and R5 variants from subtypes B and C. These sites might not only suggest a functional importance in viral survival and adaptation, but also imply a potential cross-immunogenicity between HIV-1 R5 and X4 variants, which has important implications for AIDS vaccine development. 展开更多
关键词 HIV-1 co-receptor tropism adaptive evolution positively selected site R5 and X4 GP120 EPITOPES
原文传递
丙型肝炎病毒5个基因的正选择位点研究 被引量:2
2
作者 王真真 丁娜 +1 位作者 刘俊 徐庆刚 《生物学杂志》 CAS CSCD 2012年第6期23-28,共6页
按照时间和亚型筛选丙型肝炎病毒5个主要基因(E1、E2、NS3、NS5A和NS5B)的正选择位点,并分析其变化规律。研究结果表明这些基因在总体上均受到纯化选择压力(平均ω<1),且大小依次是E2<E1<NS5A<NS5B<NS3;进一步的分子进... 按照时间和亚型筛选丙型肝炎病毒5个主要基因(E1、E2、NS3、NS5A和NS5B)的正选择位点,并分析其变化规律。研究结果表明这些基因在总体上均受到纯化选择压力(平均ω<1),且大小依次是E2<E1<NS5A<NS5B<NS3;进一步的分子进化分析鉴定出多个正选择位点,且随着时间的变化,每个基因的正选择位点并非恒定,数目不断增加,位置不断更替;同一基因三个亚型间的正选择位点也不尽相同,1a亚型的正选择位点数目最多,1b亚型次之,3a亚型最少,这些结果使得对HCV的进化规律有了进一步的理解。 展开更多
关键词 丙型肝炎病毒 时间 亚型 正选择位点
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部