Rubber plantation is the major land use type in Southeast Asia. Monitoring the spa- tial-temporal pattern of rubber plantation is significant for regional land resource development, eco-environmental protection, and m...Rubber plantation is the major land use type in Southeast Asia. Monitoring the spa- tial-temporal pattern of rubber plantation is significant for regional land resource development, eco-environmental protection, and maintaining border security. With remote sensing tech- nologies, we analyzed the rubber distribution pattern and spatial-temporal dynamic; with GIS and a newly proposed index of Planted Intensity （PI）, we further quantified the impacts and limits of topographical factors on rubber plantation in the border region of China, Laos and Myanmar （BRCLM） between 1980 and 2010. The results showed that： （1） As the dominant land use type in this border region, the acreage of rubber plantation was 6014 km2 in 2010, accounting for 8.17% of the total area. Viewing from the rubber plantation structure, the ratio of mature- （〉10 year） and young rubber plantation （〈 10 year） was 5：7. （2） From 1980 to 2010, rubber plantation expanded significantly in BRCLM, from 705 km2 to 6014 km2, nearly nine times. The distribution characteristics of rubber plantation varied from concentrated toward dispersed, from border inside to outside, and expanded further in all directions with Jinghong City as the center. （3） Restricted by the topographical factors, more than 4/5 proportion of rubber plantation concentrated in the appropriate elevation gradients between 600 and 1000 m, rarely occurred in elevations beyond 1200 m in BRCLM. Nearly 2/3 of rubber plantation concentrated on slopes of 8^-25~, rarely distributed on slopes above 35~. Rubber plantation was primarily distributed in south and east aspects, relatively few in north and west aspects. Rubber planted intensity displayed the similar distribution trend. （4） Comparative studies of rubber plantation in different countries showed that there was a remarkable increase in area at higher elevations and steeper slopes in China, while there were large appropriate topog- raphical gradients for rubber plantation in Laos and Myanmar which benefited 展开更多
采用液相色谱-四极杆/轨道阱高分辨质谱（Q-Exactive）技术,建立了火锅底料、食品调味料、烤肉、凉皮中吗啡、可待因、蒂巴因、罂粟碱、那可丁5种生物碱的确证方法。样品在稀盐酸溶液中超声提取,经三氯甲烷除脂,离子交换固相萃取柱净化...采用液相色谱-四极杆/轨道阱高分辨质谱（Q-Exactive）技术,建立了火锅底料、食品调味料、烤肉、凉皮中吗啡、可待因、蒂巴因、罂粟碱、那可丁5种生物碱的确证方法。样品在稀盐酸溶液中超声提取,经三氯甲烷除脂,离子交换固相萃取柱净化,氨化甲醇-乙酸乙酯洗脱,Accucore a Q色谱柱分离,电喷雾模式下通过静电场轨道阱全扫描得到5种生物碱的准分子离子峰,同时设定阈值自动触发二级质谱进行定性确证,同位素内标法定量,实现了食品中罂粟壳主要特征成份的筛查,同时对5种生物碱的特征子离子裂解方式进行研究。在最佳实验条件下,5种生物碱的质谱扫描质量精度误差小于5 ppm。吗啡的定量下限（LOQ）为2.0μg/kg,可待因为0.2μg/kg,罂粟碱、蒂巴因和那可丁为0.1μg/kg。分析物浓度与对应峰面积呈良好的线性关系（r2〉0.999）,方法回收率为63.4%~112.8%,相对标准偏差（RSD）为5.5%~13.6%。将该方法应用于多种实际样品分析,其定量结果准确,定性可靠。展开更多
This paper analyzed forest land use change in Trans-Boundary Laos-China Biodiversity Conservation Area which is called Namha National Biodiversity Conservation Areas （Namha NBCAs）, with 1992 and 2002 TM （ETM）. Bas...This paper analyzed forest land use change in Trans-Boundary Laos-China Biodiversity Conservation Area which is called Namha National Biodiversity Conservation Areas （Namha NBCAs）, with 1992 and 2002 TM （ETM）. Based on GIS and statistical methods, the intensity, state index of land use change and transfer matrix were used to study spatio-temporal land use change in the region. The results showed that the area of forest land decreased greatly, also the area of bamboo and grassland decreased. The other way round, the area of unstocked forest, slash and burn and rice paddy land increased. As a whole, the intensity of forest land change was higher, but others were lower. From the transfer matrix, most of the forest land changed into unstocked forest and urban area, some to slash and burn The grassland and bamboo were mainly transferred to forest and unstocked forest. The unstocked forest land mostly came from forest land and grassland. It was showed there were three main causes of the land use change namely： opium poppy cultivation, rubber plantation and also ecotourism activities and finally some policies were developed in order to address the land use change in the study areas.展开更多
Oripavine is the major alkaloid of Papaver orientale. It is an important intermediate in the biosynthesis of morphine alkaloids. Recently, new Papaver somniferum strains have been developed which accumulate thebaine a...Oripavine is the major alkaloid of Papaver orientale. It is an important intermediate in the biosynthesis of morphine alkaloids. Recently, new Papaver somniferum strains have been developed which accumulate thebaine and oripavine, but not morphine and codeine. Therefore, the chemistry of oripavine has been studied intensively to synthesize opioid pharmaceuticals such as oxymorphone, naloxone and buprenorphine.展开更多
Response surface methodology(RSM) was used to determine the optimum conditions of the methanolysis of crude poppy seed oil using Na OCH3 as catalyst. The experiments were run according to five levels, four variable ce...Response surface methodology(RSM) was used to determine the optimum conditions of the methanolysis of crude poppy seed oil using Na OCH3 as catalyst. The experiments were run according to five levels, four variable central composite rotatable design(CCRD) using RSM. The reaction variables, i.e., molar ratio of methanol/oil(3:1–9:1), catalyst concentration(0.5 wt%–1.25 wt% Na OCH3), reaction temperature(25–65 °C), and reaction time(20–90 min) were studied. We demonstrated that the molar ratio of methanol/oil, catalyst concentration,and reaction temperature were the significant parameters affecting the yield of poppy seed oil methyl esters(PSOMEs). The optimum transesterification reaction conditions, established using the RSM, which offered a89.35% PSOME yield, were found to be 7.5:1 molar ratio of methanol/oil, 0.75% catalyst concentration, 45 °C reaction temperature, and 90 min reaction time. The proposed process provided an average biodiesel yield of more than 85%. A linear correlation was constructed between the observed and predicted values of the yield.The gas chromatography(GC) analyses have shown that PSOMEs contain linoleic-, oleic-, palmitic-, and stearic-acids as main fatty acids. The FTIR spectrum of the PSOMEs was also analyzed to confirm the completion of the transesterification reaction. The fuel properties of the PSOMEs were discussed in light of biodiesel standards(ASTM D 6751 and EN 14214).展开更多
Chinese patent medicines（CPMs） are widely used across China, and they are differently administrated from chemical drugs. For traditional reasons, CPMs may contain opium-derived compounds, such as morphine, which may...Chinese patent medicines（CPMs） are widely used across China, and they are differently administrated from chemical drugs. For traditional reasons, CPMs may contain opium-derived compounds, such as morphine, which may pose the issues of drug abuse and addiction. In the present study, we aimed to evaluate the present risk of morphine-containing CPMs in causing drug abuse and addiction, based on a questionnaire-based approach and from a medicinal administrative perspective. We chose 76 CPMs containing morphine from government document and set them as the study group, and 10 chemical drugs containing morphine were set as the control group. Because there is no ready-made method, we created an evaluation sheet consisting of five questions to evaluate each drug and generate a risk-value score. Crosstabs analysis using SPSS 15.0 was conducted to obtain the influencing factors. We found that the study group obtained a mean score of 2.04 for the risk value, which was five times of that of the control group. Specifically, no maximum limit of morphine or codeine was set in product quality standards for more than four-fifth of the drugs. Moreover, 46.0% of package inserts failed to show any warning about addiction or prohibition over the long-term use of the drugs. The number of ingredients, as well as the functions of the drugs, was found to correlate with the risk value. Our findings suggested that CPMs were more risky in causing drug abuse and addiction than chemical drugs. Approaches, such as i） controlling the number of ingredients, ii） setting up maximum limit of morphine or codeine in quality standard, iii） providing more information on the package insert of drugs and iv） monitoring the drug containing both morphine and ephedrine, will be effective in reducing the risk of drug abuse and addiction.展开更多
基金National Natural Science Foundation of China, No.41271117 Strategy of Science and Technology Planning Project of Institute of Geographic Sciences and Natural Resources Research, CAS, No.2012SJ008
文摘Rubber plantation is the major land use type in Southeast Asia. Monitoring the spa- tial-temporal pattern of rubber plantation is significant for regional land resource development, eco-environmental protection, and maintaining border security. With remote sensing tech- nologies, we analyzed the rubber distribution pattern and spatial-temporal dynamic; with GIS and a newly proposed index of Planted Intensity （PI）, we further quantified the impacts and limits of topographical factors on rubber plantation in the border region of China, Laos and Myanmar （BRCLM） between 1980 and 2010. The results showed that： （1） As the dominant land use type in this border region, the acreage of rubber plantation was 6014 km2 in 2010, accounting for 8.17% of the total area. Viewing from the rubber plantation structure, the ratio of mature- （〉10 year） and young rubber plantation （〈 10 year） was 5：7. （2） From 1980 to 2010, rubber plantation expanded significantly in BRCLM, from 705 km2 to 6014 km2, nearly nine times. The distribution characteristics of rubber plantation varied from concentrated toward dispersed, from border inside to outside, and expanded further in all directions with Jinghong City as the center. （3） Restricted by the topographical factors, more than 4/5 proportion of rubber plantation concentrated in the appropriate elevation gradients between 600 and 1000 m, rarely occurred in elevations beyond 1200 m in BRCLM. Nearly 2/3 of rubber plantation concentrated on slopes of 8^-25~, rarely distributed on slopes above 35~. Rubber plantation was primarily distributed in south and east aspects, relatively few in north and west aspects. Rubber planted intensity displayed the similar distribution trend. （4） Comparative studies of rubber plantation in different countries showed that there was a remarkable increase in area at higher elevations and steeper slopes in China, while there were large appropriate topog- raphical gradients for rubber plantation in Laos and Myanmar which benefited
文摘采用液相色谱-四极杆/轨道阱高分辨质谱（Q-Exactive）技术,建立了火锅底料、食品调味料、烤肉、凉皮中吗啡、可待因、蒂巴因、罂粟碱、那可丁5种生物碱的确证方法。样品在稀盐酸溶液中超声提取,经三氯甲烷除脂,离子交换固相萃取柱净化,氨化甲醇-乙酸乙酯洗脱,Accucore a Q色谱柱分离,电喷雾模式下通过静电场轨道阱全扫描得到5种生物碱的准分子离子峰,同时设定阈值自动触发二级质谱进行定性确证,同位素内标法定量,实现了食品中罂粟壳主要特征成份的筛查,同时对5种生物碱的特征子离子裂解方式进行研究。在最佳实验条件下,5种生物碱的质谱扫描质量精度误差小于5 ppm。吗啡的定量下限（LOQ）为2.0μg/kg,可待因为0.2μg/kg,罂粟碱、蒂巴因和那可丁为0.1μg/kg。分析物浓度与对应峰面积呈良好的线性关系（r2〉0.999）,方法回收率为63.4%~112.8%,相对标准偏差（RSD）为5.5%~13.6%。将该方法应用于多种实际样品分析,其定量结果准确,定性可靠。
文摘This paper analyzed forest land use change in Trans-Boundary Laos-China Biodiversity Conservation Area which is called Namha National Biodiversity Conservation Areas （Namha NBCAs）, with 1992 and 2002 TM （ETM）. Based on GIS and statistical methods, the intensity, state index of land use change and transfer matrix were used to study spatio-temporal land use change in the region. The results showed that the area of forest land decreased greatly, also the area of bamboo and grassland decreased. The other way round, the area of unstocked forest, slash and burn and rice paddy land increased. As a whole, the intensity of forest land change was higher, but others were lower. From the transfer matrix, most of the forest land changed into unstocked forest and urban area, some to slash and burn The grassland and bamboo were mainly transferred to forest and unstocked forest. The unstocked forest land mostly came from forest land and grassland. It was showed there were three main causes of the land use change namely： opium poppy cultivation, rubber plantation and also ecotourism activities and finally some policies were developed in order to address the land use change in the study areas.
文摘Oripavine is the major alkaloid of Papaver orientale. It is an important intermediate in the biosynthesis of morphine alkaloids. Recently, new Papaver somniferum strains have been developed which accumulate thebaine and oripavine, but not morphine and codeine. Therefore, the chemistry of oripavine has been studied intensively to synthesize opioid pharmaceuticals such as oxymorphone, naloxone and buprenorphine.
基金the Deanship of Scientific Research at King Saud University for its funding of this research through the research group project RGP-VPP-048
文摘Response surface methodology(RSM) was used to determine the optimum conditions of the methanolysis of crude poppy seed oil using Na OCH3 as catalyst. The experiments were run according to five levels, four variable central composite rotatable design(CCRD) using RSM. The reaction variables, i.e., molar ratio of methanol/oil(3:1–9:1), catalyst concentration(0.5 wt%–1.25 wt% Na OCH3), reaction temperature(25–65 °C), and reaction time(20–90 min) were studied. We demonstrated that the molar ratio of methanol/oil, catalyst concentration,and reaction temperature were the significant parameters affecting the yield of poppy seed oil methyl esters(PSOMEs). The optimum transesterification reaction conditions, established using the RSM, which offered a89.35% PSOME yield, were found to be 7.5:1 molar ratio of methanol/oil, 0.75% catalyst concentration, 45 °C reaction temperature, and 90 min reaction time. The proposed process provided an average biodiesel yield of more than 85%. A linear correlation was constructed between the observed and predicted values of the yield.The gas chromatography(GC) analyses have shown that PSOMEs contain linoleic-, oleic-, palmitic-, and stearic-acids as main fatty acids. The FTIR spectrum of the PSOMEs was also analyzed to confirm the completion of the transesterification reaction. The fuel properties of the PSOMEs were discussed in light of biodiesel standards(ASTM D 6751 and EN 14214).
基金Funding Grants from University of Macao Research Grants(MYRG2015-00160-ICMS-QRCM and MYRG2014-00069-ICMS-QRCM)
文摘Chinese patent medicines（CPMs） are widely used across China, and they are differently administrated from chemical drugs. For traditional reasons, CPMs may contain opium-derived compounds, such as morphine, which may pose the issues of drug abuse and addiction. In the present study, we aimed to evaluate the present risk of morphine-containing CPMs in causing drug abuse and addiction, based on a questionnaire-based approach and from a medicinal administrative perspective. We chose 76 CPMs containing morphine from government document and set them as the study group, and 10 chemical drugs containing morphine were set as the control group. Because there is no ready-made method, we created an evaluation sheet consisting of five questions to evaluate each drug and generate a risk-value score. Crosstabs analysis using SPSS 15.0 was conducted to obtain the influencing factors. We found that the study group obtained a mean score of 2.04 for the risk value, which was five times of that of the control group. Specifically, no maximum limit of morphine or codeine was set in product quality standards for more than four-fifth of the drugs. Moreover, 46.0% of package inserts failed to show any warning about addiction or prohibition over the long-term use of the drugs. The number of ingredients, as well as the functions of the drugs, was found to correlate with the risk value. Our findings suggested that CPMs were more risky in causing drug abuse and addiction than chemical drugs. Approaches, such as i） controlling the number of ingredients, ii） setting up maximum limit of morphine or codeine in quality standard, iii） providing more information on the package insert of drugs and iv） monitoring the drug containing both morphine and ephedrine, will be effective in reducing the risk of drug abuse and addiction.
