Several parameters for predicting survival in patients with colorectal cancer have been identified, including the performance status, age, gender and tumor-nodemetastasis(TNM) stage. Although the TNM stage is importan...Several parameters for predicting survival in patients with colorectal cancer have been identified, including the performance status, age, gender and tumor-nodemetastasis(TNM) stage. Although the TNM stage is important and useful for predicting the prognosis and determining the appropriate treatment, it is well known that the survival time varies widely, even in patients with the same stage of disease. Therefore, the identification of new parameters capable of more precisely predicting patient survival is needed to help select the optimal treatment, especially in patients in the advanced stage of disease. Although the TNM stage reflects the tumor characteristics, cancer progression and survival are not determined solely based on the local characteristics of the tumor, but also the host systemic immune/inflammatory response. Therefore, using a combination of parameters that reflect both tumor characteristics and the host systemic inflammatory status is thought to be important for accurately predicting patient survival.展开更多
Objective: To analyze data available in the literature regarding a possible prognostic value of the platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) in prostate cancer (PCa) patients stratif...Objective: To analyze data available in the literature regarding a possible prognostic value of the platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) in prostate cancer (PCa) patients stratified in non-metastatic and metastatic diseases.Methods: A literature search process was performed following the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. In our meta-analysis, the pooled event rate estimated and the pooled hazard ratio were calculated using a random effect model.Results: Forty-two articles were selected for our analysis. The pooled risk difference for non-organ confined PCa between high and low NLR cases was 0.06 (95% confidence interval [CI]: −0.03-0.15) and between high and low PLR cases increased to 0.30 (95% CI: 0.16-0.43). In non-metastatic PCa cases, the pooled hazard ratio for overall mortality between high and low NLR was 1.33 (95% CI: 0.78-1.88) and between high and low PLR was 1.47 (95% CI: 0.91-2.03), whereas in metastatic PCa cases, between high and low NLR was 1.79 (95% CI: 1.44-2.13) and between high and low PLR was 1.05 (95% CI: 0.87-1.24).Conclusion: The prognostic values of NLR and PLR in terms of PCa characteristics and responses after treatment show a high level of heterogeneity of results among studies. These two ratios can represent the inflammatory and immunity status of the patient related to several conditions. A higher predictive value is related to a high NLR in terms of risk for overall mortality in metastatic PCa cases under systemic treatments.展开更多
目的探讨急性期双相障碍患者炎症指标及非酶类抗氧化物与其临床症状严重程度的关系。方法选取80例急性期双相障碍患者(双相障碍组)和80例健康体检者(健康对照组)作为研究对象,检测两组被试者中性粒细胞计数与淋巴细胞计数的比值(neutrop...目的探讨急性期双相障碍患者炎症指标及非酶类抗氧化物与其临床症状严重程度的关系。方法选取80例急性期双相障碍患者(双相障碍组)和80例健康体检者(健康对照组)作为研究对象,检测两组被试者中性粒细胞计数与淋巴细胞计数的比值(neutrophil to lymphocyteratio,NLR)、血小板计数与淋巴细胞计数的比值(platelet to lymphocyteratio,PLR)、单核细胞计数与淋巴细胞计数的比值(monocyte to lymphocyte ratio,MLR)及血胆红素、白蛋白、尿酸水平;采用汉密尔顿抑郁量表(Hamilton depression scale,HAMD)和杨氏躁狂量表(Young mania rating scale,YMRS)评估两组被试者的抑郁症状及躁狂症状;分析HAMD、YMRS量表评分与各指标之间的关系。结果与健康对照组比较,双相障碍组血尿酸、MLR升高,白蛋白水平降低(P均<0.05)。HAMD和YMRS量表评分与白蛋白呈负相关(r=-0.410、-0.462,P均<0.05),与MLR呈正相关(r=0.353、0.455,P均<0.05)。血尿酸水平与YMRS量表评分呈正相关(r=0.346,P<0.05)。结论炎症指标MLR和非酶类抗氧化物白蛋白、血尿酸水平有助于急性期双相障碍的临床评估。展开更多
文摘Several parameters for predicting survival in patients with colorectal cancer have been identified, including the performance status, age, gender and tumor-nodemetastasis(TNM) stage. Although the TNM stage is important and useful for predicting the prognosis and determining the appropriate treatment, it is well known that the survival time varies widely, even in patients with the same stage of disease. Therefore, the identification of new parameters capable of more precisely predicting patient survival is needed to help select the optimal treatment, especially in patients in the advanced stage of disease. Although the TNM stage reflects the tumor characteristics, cancer progression and survival are not determined solely based on the local characteristics of the tumor, but also the host systemic immune/inflammatory response. Therefore, using a combination of parameters that reflect both tumor characteristics and the host systemic inflammatory status is thought to be important for accurately predicting patient survival.
文摘Objective: To analyze data available in the literature regarding a possible prognostic value of the platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) in prostate cancer (PCa) patients stratified in non-metastatic and metastatic diseases.Methods: A literature search process was performed following the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. In our meta-analysis, the pooled event rate estimated and the pooled hazard ratio were calculated using a random effect model.Results: Forty-two articles were selected for our analysis. The pooled risk difference for non-organ confined PCa between high and low NLR cases was 0.06 (95% confidence interval [CI]: −0.03-0.15) and between high and low PLR cases increased to 0.30 (95% CI: 0.16-0.43). In non-metastatic PCa cases, the pooled hazard ratio for overall mortality between high and low NLR was 1.33 (95% CI: 0.78-1.88) and between high and low PLR was 1.47 (95% CI: 0.91-2.03), whereas in metastatic PCa cases, between high and low NLR was 1.79 (95% CI: 1.44-2.13) and between high and low PLR was 1.05 (95% CI: 0.87-1.24).Conclusion: The prognostic values of NLR and PLR in terms of PCa characteristics and responses after treatment show a high level of heterogeneity of results among studies. These two ratios can represent the inflammatory and immunity status of the patient related to several conditions. A higher predictive value is related to a high NLR in terms of risk for overall mortality in metastatic PCa cases under systemic treatments.
文摘目的探讨急性期双相障碍患者炎症指标及非酶类抗氧化物与其临床症状严重程度的关系。方法选取80例急性期双相障碍患者(双相障碍组)和80例健康体检者(健康对照组)作为研究对象,检测两组被试者中性粒细胞计数与淋巴细胞计数的比值(neutrophil to lymphocyteratio,NLR)、血小板计数与淋巴细胞计数的比值(platelet to lymphocyteratio,PLR)、单核细胞计数与淋巴细胞计数的比值(monocyte to lymphocyte ratio,MLR)及血胆红素、白蛋白、尿酸水平;采用汉密尔顿抑郁量表(Hamilton depression scale,HAMD)和杨氏躁狂量表(Young mania rating scale,YMRS)评估两组被试者的抑郁症状及躁狂症状;分析HAMD、YMRS量表评分与各指标之间的关系。结果与健康对照组比较,双相障碍组血尿酸、MLR升高,白蛋白水平降低(P均<0.05)。HAMD和YMRS量表评分与白蛋白呈负相关(r=-0.410、-0.462,P均<0.05),与MLR呈正相关(r=0.353、0.455,P均<0.05)。血尿酸水平与YMRS量表评分呈正相关(r=0.346,P<0.05)。结论炎症指标MLR和非酶类抗氧化物白蛋白、血尿酸水平有助于急性期双相障碍的临床评估。
