目的：研究参附注射液联合痰热清注射液益气温阳、化痰解毒改善老年Ⅳ期表皮生长因子受体（EGFR）野生型非小细胞肺癌患者经多西他赛化疗后的减毒增效作用。方法：符合条件的64例患者分为对照组（采用多西他赛单药化疗方案）和治疗组（...目的：研究参附注射液联合痰热清注射液益气温阳、化痰解毒改善老年Ⅳ期表皮生长因子受体（EGFR）野生型非小细胞肺癌患者经多西他赛化疗后的减毒增效作用。方法：符合条件的64例患者分为对照组（采用多西他赛单药化疗方案）和治疗组（在对照组基础上加用益气温阳化痰解毒的中医方案）,各32例。两组患者均在每周期d1静脉滴注多西他赛注射液75 mg·m^-2,治疗组在此基础上,加用中医方案（益气温阳、化痰解毒）,即参附注射液60~80 m L加入5%葡糖糖注射液250 m L中静脉滴注,1次/d（qd）,痰热清注射液20~30 m L加入5%葡糖糖注射液250 m L中静脉滴注,qd,治疗10 d。每21 d为1个周期,治疗2周期后分别对两组患者进行中医证候,免疫功能,Ⅲ~Ⅳ度骨髓抑制及安全性评价。结果：治疗后,治疗组乏力少气、咯血、咳嗽、咳痰、胸痛、胸闷等中医证候改善情况优于对照组（P〈0.05）。治疗组治疗后外周血CD3^＋,CD4^＋,白细胞介素（IL）-27高于对照组（P〈0.05）,CD8^＋,细胞毒性T淋巴细胞相关抗原-4（s CTLA-4）水平低于对照组（P〈0.05）。与对照组治疗后相比,治疗组的Ⅲ/Ⅳ度血液学毒性降低（P〈0.05）。结论：益气温阳、化痰解毒的参附注射液联合痰热清注射液能改善晚期老年非小细胞肺癌的中医证候,增加化疗后患者的免疫功能,减轻血液学毒性,安全性高,具有减毒增效的作用,值得临床推广应用。展开更多
Through expounding the theory of phlegm-turbidity and the development of epilepsy,this paper presents the new theoretical basis for the treatment of epilepsy.The authors calculate that phlegm and turbidity are differe...Through expounding the theory of phlegm-turbidity and the development of epilepsy,this paper presents the new theoretical basis for the treatment of epilepsy.The authors calculate that phlegm and turbidity are different in the formation and pathogenic effects.Therefore,it is necessary to expound the formation of the phlegm and turbidity.It is also necessary to explain the pathogenesis of the phlegm and turbidity in the epilepsy.Phlegm is caused by the invasion of external evil,emotional disorders,or Qi deficiency and decline,resulting in Qi and blood disorder in the body;the accumulation of phlegm and heat for a long time will lead to the accumulation of turbidity;further with the failure of Qi and fluid circulation,it will lead to brain damage and epileptic seizures.Therefore,the treatment needs to distinguish the severity of phlegm and turbidity,based on which,use different herbs for the treatment of epilepsy.展开更多
文摘目的：研究参附注射液联合痰热清注射液益气温阳、化痰解毒改善老年Ⅳ期表皮生长因子受体（EGFR）野生型非小细胞肺癌患者经多西他赛化疗后的减毒增效作用。方法：符合条件的64例患者分为对照组（采用多西他赛单药化疗方案）和治疗组（在对照组基础上加用益气温阳化痰解毒的中医方案）,各32例。两组患者均在每周期d1静脉滴注多西他赛注射液75 mg·m^-2,治疗组在此基础上,加用中医方案（益气温阳、化痰解毒）,即参附注射液60~80 m L加入5%葡糖糖注射液250 m L中静脉滴注,1次/d（qd）,痰热清注射液20~30 m L加入5%葡糖糖注射液250 m L中静脉滴注,qd,治疗10 d。每21 d为1个周期,治疗2周期后分别对两组患者进行中医证候,免疫功能,Ⅲ~Ⅳ度骨髓抑制及安全性评价。结果：治疗后,治疗组乏力少气、咯血、咳嗽、咳痰、胸痛、胸闷等中医证候改善情况优于对照组（P〈0.05）。治疗组治疗后外周血CD3^＋,CD4^＋,白细胞介素（IL）-27高于对照组（P〈0.05）,CD8^＋,细胞毒性T淋巴细胞相关抗原-4（s CTLA-4）水平低于对照组（P〈0.05）。与对照组治疗后相比,治疗组的Ⅲ/Ⅳ度血液学毒性降低（P〈0.05）。结论：益气温阳、化痰解毒的参附注射液联合痰热清注射液能改善晚期老年非小细胞肺癌的中医证候,增加化疗后患者的免疫功能,减轻血液学毒性,安全性高,具有减毒增效的作用,值得临床推广应用。
文摘Through expounding the theory of phlegm-turbidity and the development of epilepsy,this paper presents the new theoretical basis for the treatment of epilepsy.The authors calculate that phlegm and turbidity are different in the formation and pathogenic effects.Therefore,it is necessary to expound the formation of the phlegm and turbidity.It is also necessary to explain the pathogenesis of the phlegm and turbidity in the epilepsy.Phlegm is caused by the invasion of external evil,emotional disorders,or Qi deficiency and decline,resulting in Qi and blood disorder in the body;the accumulation of phlegm and heat for a long time will lead to the accumulation of turbidity;further with the failure of Qi and fluid circulation,it will lead to brain damage and epileptic seizures.Therefore,the treatment needs to distinguish the severity of phlegm and turbidity,based on which,use different herbs for the treatment of epilepsy.
