1 幽门螺杆菌的研究现状1.1 幽门螺杆菌的微生物学和流行病学目前发现幽门螺杆菌(Helicobacter pylori,Hp)是基因多态性较强的细菌.目前研究的重点主要是 Hp 的 cag 致病岛、vacA 基因、尿素酶 A 基因、鞭毛素 A 基因、粘附素基因及耐...1 幽门螺杆菌的研究现状1.1 幽门螺杆菌的微生物学和流行病学目前发现幽门螺杆菌(Helicobacter pylori,Hp)是基因多态性较强的细菌.目前研究的重点主要是 Hp 的 cag 致病岛、vacA 基因、尿素酶 A 基因、鞭毛素 A 基因、粘附素基因及耐药基因,以期明确 Hp 的致病性、进而达到免疫防治或减少 Hp 耐药性的产生,提高 Hp 根除疗效的目的.但尚未能根据 Hp 的基因型对临床 Hp展开更多
Pro-inflammatory cytokines are produced in the gastric mucosa by inflammatory cells activated by chronic Helicobacter pylori (H. pylori) infection. Polymorphisms of these cytokine genes are associated with individual ...Pro-inflammatory cytokines are produced in the gastric mucosa by inflammatory cells activated by chronic Helicobacter pylori (H. pylori) infection. Polymorphisms of these cytokine genes are associated with individual differences in gastric mucosal cytokine mRNA level, which result in differences in gastric mucosal inflammation, acid inhibition and gastroduodenal disease risk in response to H. pylori infection. Although polymorphisms of interleukin (IL)-1B, IL-1RN and TNF-A have been reported to relate well with gastric cancer and peptic ulcer risk, those of IL-2, IL-4, IL-6 and IL-8 genes are unclear. In combined analyses using data from previous studies, we found that the risk of gastric non-cardia cancer development was significantly associated with IL-4-168 C allele (OR: 0.81, 95% CI: 0.69-1.00) and IL-4-590 T allele carrier status (0.61, 0.53-0.73), and IL-6-174 G/G genotype (2<Abstract>Pro-inflammatory cytokines are produced in the gastric mucosa by inflammatory cells activated by chronic Helicobacter pylori (H. pylori) infection. Polymorphisms of these cytokine genes are associated with individual differences in gastric mucosal cytokine mRNA level, which result in differences in gastric mucosal inflammation, acid inhibition and gastroduodenal disease risk in response to H. pylori infection. Although polymorphisms of interleukin (IL)-1B, IL-1RN and TNF-A have been reported to relate well with gastric cancer and peptic ulcer risk, those of IL-2, IL-4, IL-6 and IL-8 genes are unclear. In combined analyses using data from previous stud- ies, we found that the risk of gastric non-cardia cancer development was significantly associated with IL-4-168 C allele (OR: 0.81, 95% CI: 0.69-1.00) and IL-4-590 T allele carrier status (0.61, 0.53-0.73), and IL-6-174 G/G genotype (2.02, 1.31-3.10). In peptic ulcer development, IL-2-330 G and IL-4-590 T allele carriers had a significantly decreased risk (0.37, 0.27-0.50 and 0.58, 0.34-0.99, respectively). Moreover, IL-2, IL-4, IL-6 and IL-8 gene genotypes prevalence differs am展开更多
目的探讨泮托拉唑治疗消化性溃疡合并上消化道出血的临床疗效。方法入选对象为2010年7月～2015年6月确诊的消化性溃疡并发上消化道出血患者360例,将360例PUCH患者采取随机数字表法随机分为对照组和观察组,每组各180例,两组患者均予补充...目的探讨泮托拉唑治疗消化性溃疡合并上消化道出血的临床疗效。方法入选对象为2010年7月～2015年6月确诊的消化性溃疡并发上消化道出血患者360例,将360例PUCH患者采取随机数字表法随机分为对照组和观察组,每组各180例,两组患者均予补充血容量、维持水电解质平衡、保护胃肠黏膜等对症治疗。治疗组加用泮托拉唑40 mg加入0.9%生理盐水250 m L中静滴,每日2次,连用3～10 d;对照组予立止血1KU加入0.9%生理盐水100 m L中静滴,每日2次。比较两组治疗后的止血效果及止血时间、住院时间。结果观察组治疗后总有效率93.3%,显著高于对照组治疗后总有效率70.0%,观察组治疗后的疗效优于对照组,差异有统计学意义（P〈0.05）。观察组患者治疗的止血时间显著短于对照组,观察组患者的住院时间也短于对照组,差异有统计学意义（P〈0.05）。结论泮托拉唑治疗消化性溃疡合并上消化道出血疗效确切,止血效果好,值得推广和应用。展开更多
文摘1 幽门螺杆菌的研究现状1.1 幽门螺杆菌的微生物学和流行病学目前发现幽门螺杆菌(Helicobacter pylori,Hp)是基因多态性较强的细菌.目前研究的重点主要是 Hp 的 cag 致病岛、vacA 基因、尿素酶 A 基因、鞭毛素 A 基因、粘附素基因及耐药基因,以期明确 Hp 的致病性、进而达到免疫防治或减少 Hp 耐药性的产生,提高 Hp 根除疗效的目的.但尚未能根据 Hp 的基因型对临床 Hp
文摘Pro-inflammatory cytokines are produced in the gastric mucosa by inflammatory cells activated by chronic Helicobacter pylori (H. pylori) infection. Polymorphisms of these cytokine genes are associated with individual differences in gastric mucosal cytokine mRNA level, which result in differences in gastric mucosal inflammation, acid inhibition and gastroduodenal disease risk in response to H. pylori infection. Although polymorphisms of interleukin (IL)-1B, IL-1RN and TNF-A have been reported to relate well with gastric cancer and peptic ulcer risk, those of IL-2, IL-4, IL-6 and IL-8 genes are unclear. In combined analyses using data from previous studies, we found that the risk of gastric non-cardia cancer development was significantly associated with IL-4-168 C allele (OR: 0.81, 95% CI: 0.69-1.00) and IL-4-590 T allele carrier status (0.61, 0.53-0.73), and IL-6-174 G/G genotype (2<Abstract>Pro-inflammatory cytokines are produced in the gastric mucosa by inflammatory cells activated by chronic Helicobacter pylori (H. pylori) infection. Polymorphisms of these cytokine genes are associated with individual differences in gastric mucosal cytokine mRNA level, which result in differences in gastric mucosal inflammation, acid inhibition and gastroduodenal disease risk in response to H. pylori infection. Although polymorphisms of interleukin (IL)-1B, IL-1RN and TNF-A have been reported to relate well with gastric cancer and peptic ulcer risk, those of IL-2, IL-4, IL-6 and IL-8 genes are unclear. In combined analyses using data from previous stud- ies, we found that the risk of gastric non-cardia cancer development was significantly associated with IL-4-168 C allele (OR: 0.81, 95% CI: 0.69-1.00) and IL-4-590 T allele carrier status (0.61, 0.53-0.73), and IL-6-174 G/G genotype (2.02, 1.31-3.10). In peptic ulcer development, IL-2-330 G and IL-4-590 T allele carriers had a significantly decreased risk (0.37, 0.27-0.50 and 0.58, 0.34-0.99, respectively). Moreover, IL-2, IL-4, IL-6 and IL-8 gene genotypes prevalence differs am
文摘目的探讨泮托拉唑治疗消化性溃疡合并上消化道出血的临床疗效。方法入选对象为2010年7月～2015年6月确诊的消化性溃疡并发上消化道出血患者360例,将360例PUCH患者采取随机数字表法随机分为对照组和观察组,每组各180例,两组患者均予补充血容量、维持水电解质平衡、保护胃肠黏膜等对症治疗。治疗组加用泮托拉唑40 mg加入0.9%生理盐水250 m L中静滴,每日2次,连用3～10 d;对照组予立止血1KU加入0.9%生理盐水100 m L中静滴,每日2次。比较两组治疗后的止血效果及止血时间、住院时间。结果观察组治疗后总有效率93.3%,显著高于对照组治疗后总有效率70.0%,观察组治疗后的疗效优于对照组,差异有统计学意义（P〈0.05）。观察组患者治疗的止血时间显著短于对照组,观察组患者的住院时间也短于对照组,差异有统计学意义（P〈0.05）。结论泮托拉唑治疗消化性溃疡合并上消化道出血疗效确切,止血效果好,值得推广和应用。
