目的对国人经第1第2骶椎骶髂(sacral alar-iliac,SAI)螺钉固定钉道各参数进行CT测量,比较S1AI和S2AI螺钉钉道解剖参数差异。方法随机选取2015年4-10月本院影像归档和通信系统中60例骨骼发育成熟且骨盆正常国人的三维计算机断层扫描(3DCT...目的对国人经第1第2骶椎骶髂(sacral alar-iliac,SAI)螺钉固定钉道各参数进行CT测量,比较S1AI和S2AI螺钉钉道解剖参数差异。方法随机选取2015年4-10月本院影像归档和通信系统中60例骨骼发育成熟且骨盆正常国人的三维计算机断层扫描(3DCT)重建数据进行分析。S1和S2骶髂骨螺钉钉道参数中最大长度和宽度的轨迹通过旋转并截取三维骨盆获得。对长度和角度参数进行评估和比较。结果 S1AI置钉较S2AI置钉尾向倾角大,男性平均增加约26°,女性平均增加约24°[男性S1(57.25±4.37)°vs S2(31.02±7.43)°,女性S1(58.61±5.11)°vs S2(34.16±6.02)°;P<0.05];外倾稍小,男性、女性皆平均减少2°[男性S1(38.14±3.10)°vs S2(40.25±2.84)°,女性S1(37.24±2.96°)vs S2(39.25±2.64°);P<0.05];最长钉道长度:男性S1(119.46±3.77)mm vs S2(120.04±6.52)mm(P=0.551),女性S1(108.21±5.24)mm vs S2(109.47±4.63)mm(P=0.434);骶骨内钉道长度:男性S1(43.12±4.63)mm vs S2(35.75±5.03)mm(P<0.05),女性S1(39.73±5.85)mm vs S2(32.16±5.28)mm(P<0.05);髂骨内宽度:男性S1(22.05±4.91)mm vs S2(21.49±3.22)mm(P=0.672),女性S1(16.93±2.12)mm vs S2(15.35±2.71)mm(P=0.366);骨皮质距离:男性S1(9.42±2.41)mm vs S2(9.01±2.33)mm(P=0.352),女性S1(5.92±1.48)mm vs S2(6.34±1.26)mm(P=0.837)。S1AI与S2AI的入钉点比较,距皮肤距离、距中线距离、距髂后上棘距离均有统计学差异。结论国人成人骨盆存在最佳骶髂骨螺钉置钉钉道时,S1AI及S2AI螺钉均具有可行性。S1AI螺钉较S2AI螺钉置钉角度尾向倾角男性平均增加约26°,女性平均增加约24°,外倾稍小,男性女性皆平均减少2°,最长置钉长度基本相同,S1AI的入钉点距皮肤和髂后上棘更深,距中线稍远。临床操作中应注意S1和S2骶髂骨螺钉置钉角度、钉道长度及入钉点的差异。展开更多
BACKGROUND Spastic pelvic floor syndrome(SPFS)is a refractory pelvic floor disease characterized by abnormal(uncoordinated)contractions of the external anal sphincter and puborectalis muscle during defecation,resultin...BACKGROUND Spastic pelvic floor syndrome(SPFS)is a refractory pelvic floor disease characterized by abnormal(uncoordinated)contractions of the external anal sphincter and puborectalis muscle during defecation,resulting in rectal emptation and obstructive constipation.The clinical manifestations of SPFS are mainly characterized by difficult defecation,often accompanied by a sense of anal blockage and drooping.Manual defecation is usually needed during defecation.From physical examination,it is commonly observed that the patient's anal muscle tension is high,and it is difficult or even impossible to enter with his fingers.AIM To investigate the characteristics of anorectal pressure and botulinum toxin A injection combined with biofeedback in treating pelvic floor muscle spasm syndrome.METHODS Retrospective analysis of 50 patients diagnosed with pelvic floor spasm syndrome.All patients underwent pelvic floor surface electromyography assessment,anorectal dynamics examination,botulinum toxin type A injection 100 U intramuscular injection,and two cycles of biofeedback therapy.RESULTS After the botulinum toxin A injection combined with two cycles of biofeedback therapy,the patient's postoperative resting and systolic blood pressure were significantly lower than before surgery(P<0.05).Moreover,the electromyography index of the patients in the resting stage and post-resting stages was significantly lower than before surgery(P<0.05).CONCLUSION Botulinum toxin A injection combined with biofeedback can significantly reduce pelvic floor muscle tension in treating pelvic floor muscle spasm syndrome.Anorectal manometry is an effective method to evaluate the efficacy of treatment objectively.However,randomized controlled trials are needed.展开更多
AIM To investigate the association of urinary chemokines with the treatment response in chronic prostatitis/chronic pelvic pain syndrome(CP/CPPS) patients.METHODS Between 2007-2011,18 out of 21 male CP/CPPS patients m...AIM To investigate the association of urinary chemokines with the treatment response in chronic prostatitis/chronic pelvic pain syndrome(CP/CPPS) patients.METHODS Between 2007-2011,18 out of 21 male CP/CPPS patients met the exclusion/inclusion criteria of the 16 wk longitudinal study on twice daily oral treatment with Phosphodiesterase 4 inhibitor called Apremilast for 12 wk. Symptom scores and urine specimen were collected at baseline and every visit at 4 wk interval from CP/CPPS patients who completed at least 8 wk of drug treatment. Urine collected at each visit was frozen and then analyzed together after thawing for chemokines and growth factors using MILLIPLEX? MAP immunoassay. Cross sectional association of Chronic Prostatitis Symptom Index(CPSI) and visual analog scale(VAS) with chemokine levels in urine collected at baseline was assessed in 18 CP/CPPS patients relative to 10 asymptomatic male subjects. Longitudinal association between urine chemokine levels and symptom scores was assessed in 8 treatmentadherent CP/CPPS patients at baseline and at 4,8,12 and 16 wk.RESULTS Urine chemokines levels of CXCL-1(GRO-a),CXCL-8(IL-8),CXCL-10(IP-10) and CCL5(RANTES) in CP/CPPS patients at baseline were significantly elevated relative to asymptomatic subjects,whereas levels of s IL-1RA in CP/CPPS were significantly lower compared to controls(P <0.05). Quantitatively,urine levels of CXCL-10 were higher than other chemokines in CP/CPPS,but its fold change of5 relative to controls was lower than the 20 fold change noted for CXCL-8. The mean age of enrolled patients who completed at least 8 wk of treatment(n = 8) was 46.5± 9.4 years and analysis found that elevation of CXCL-8and CCL5 increased the odds for higher score of CPSI by54% and 25%,respectively(F test,P = 0.00007). Urine levels of CCL2(MCP-1) and CXCL-10 together explained approximately 85% of variance in longitudinal data on multivariate analysis. Bivariate analysis of 5 patients who fully complied and completed the assigned dose regimen,showed strong linear c展开更多
文摘目的对国人经第1第2骶椎骶髂(sacral alar-iliac,SAI)螺钉固定钉道各参数进行CT测量,比较S1AI和S2AI螺钉钉道解剖参数差异。方法随机选取2015年4-10月本院影像归档和通信系统中60例骨骼发育成熟且骨盆正常国人的三维计算机断层扫描(3DCT)重建数据进行分析。S1和S2骶髂骨螺钉钉道参数中最大长度和宽度的轨迹通过旋转并截取三维骨盆获得。对长度和角度参数进行评估和比较。结果 S1AI置钉较S2AI置钉尾向倾角大,男性平均增加约26°,女性平均增加约24°[男性S1(57.25±4.37)°vs S2(31.02±7.43)°,女性S1(58.61±5.11)°vs S2(34.16±6.02)°;P<0.05];外倾稍小,男性、女性皆平均减少2°[男性S1(38.14±3.10)°vs S2(40.25±2.84)°,女性S1(37.24±2.96°)vs S2(39.25±2.64°);P<0.05];最长钉道长度:男性S1(119.46±3.77)mm vs S2(120.04±6.52)mm(P=0.551),女性S1(108.21±5.24)mm vs S2(109.47±4.63)mm(P=0.434);骶骨内钉道长度:男性S1(43.12±4.63)mm vs S2(35.75±5.03)mm(P<0.05),女性S1(39.73±5.85)mm vs S2(32.16±5.28)mm(P<0.05);髂骨内宽度:男性S1(22.05±4.91)mm vs S2(21.49±3.22)mm(P=0.672),女性S1(16.93±2.12)mm vs S2(15.35±2.71)mm(P=0.366);骨皮质距离:男性S1(9.42±2.41)mm vs S2(9.01±2.33)mm(P=0.352),女性S1(5.92±1.48)mm vs S2(6.34±1.26)mm(P=0.837)。S1AI与S2AI的入钉点比较,距皮肤距离、距中线距离、距髂后上棘距离均有统计学差异。结论国人成人骨盆存在最佳骶髂骨螺钉置钉钉道时,S1AI及S2AI螺钉均具有可行性。S1AI螺钉较S2AI螺钉置钉角度尾向倾角男性平均增加约26°,女性平均增加约24°,外倾稍小,男性女性皆平均减少2°,最长置钉长度基本相同,S1AI的入钉点距皮肤和髂后上棘更深,距中线稍远。临床操作中应注意S1和S2骶髂骨螺钉置钉角度、钉道长度及入钉点的差异。
文摘BACKGROUND Spastic pelvic floor syndrome(SPFS)is a refractory pelvic floor disease characterized by abnormal(uncoordinated)contractions of the external anal sphincter and puborectalis muscle during defecation,resulting in rectal emptation and obstructive constipation.The clinical manifestations of SPFS are mainly characterized by difficult defecation,often accompanied by a sense of anal blockage and drooping.Manual defecation is usually needed during defecation.From physical examination,it is commonly observed that the patient's anal muscle tension is high,and it is difficult or even impossible to enter with his fingers.AIM To investigate the characteristics of anorectal pressure and botulinum toxin A injection combined with biofeedback in treating pelvic floor muscle spasm syndrome.METHODS Retrospective analysis of 50 patients diagnosed with pelvic floor spasm syndrome.All patients underwent pelvic floor surface electromyography assessment,anorectal dynamics examination,botulinum toxin type A injection 100 U intramuscular injection,and two cycles of biofeedback therapy.RESULTS After the botulinum toxin A injection combined with two cycles of biofeedback therapy,the patient's postoperative resting and systolic blood pressure were significantly lower than before surgery(P<0.05).Moreover,the electromyography index of the patients in the resting stage and post-resting stages was significantly lower than before surgery(P<0.05).CONCLUSION Botulinum toxin A injection combined with biofeedback can significantly reduce pelvic floor muscle tension in treating pelvic floor muscle spasm syndrome.Anorectal manometry is an effective method to evaluate the efficacy of treatment objectively.However,randomized controlled trials are needed.
文摘AIM To investigate the association of urinary chemokines with the treatment response in chronic prostatitis/chronic pelvic pain syndrome(CP/CPPS) patients.METHODS Between 2007-2011,18 out of 21 male CP/CPPS patients met the exclusion/inclusion criteria of the 16 wk longitudinal study on twice daily oral treatment with Phosphodiesterase 4 inhibitor called Apremilast for 12 wk. Symptom scores and urine specimen were collected at baseline and every visit at 4 wk interval from CP/CPPS patients who completed at least 8 wk of drug treatment. Urine collected at each visit was frozen and then analyzed together after thawing for chemokines and growth factors using MILLIPLEX? MAP immunoassay. Cross sectional association of Chronic Prostatitis Symptom Index(CPSI) and visual analog scale(VAS) with chemokine levels in urine collected at baseline was assessed in 18 CP/CPPS patients relative to 10 asymptomatic male subjects. Longitudinal association between urine chemokine levels and symptom scores was assessed in 8 treatmentadherent CP/CPPS patients at baseline and at 4,8,12 and 16 wk.RESULTS Urine chemokines levels of CXCL-1(GRO-a),CXCL-8(IL-8),CXCL-10(IP-10) and CCL5(RANTES) in CP/CPPS patients at baseline were significantly elevated relative to asymptomatic subjects,whereas levels of s IL-1RA in CP/CPPS were significantly lower compared to controls(P <0.05). Quantitatively,urine levels of CXCL-10 were higher than other chemokines in CP/CPPS,but its fold change of5 relative to controls was lower than the 20 fold change noted for CXCL-8. The mean age of enrolled patients who completed at least 8 wk of treatment(n = 8) was 46.5± 9.4 years and analysis found that elevation of CXCL-8and CCL5 increased the odds for higher score of CPSI by54% and 25%,respectively(F test,P = 0.00007). Urine levels of CCL2(MCP-1) and CXCL-10 together explained approximately 85% of variance in longitudinal data on multivariate analysis. Bivariate analysis of 5 patients who fully complied and completed the assigned dose regimen,showed strong linear c
