The purpose of this study was to investigate the actual management of mucinous cystic neoplasm (MCN) of the pancreas. A systematic review was performed in December 2009 by consulting PubMed MEDLINE for publications an...The purpose of this study was to investigate the actual management of mucinous cystic neoplasm (MCN) of the pancreas. A systematic review was performed in December 2009 by consulting PubMed MEDLINE for publications and matching the "pancreatic mucinous cystic neoplasm", "pancreatic mucinous cystic tumour", "pancreatic mucinous cystic mass", "pancreatic cyst", and "pancreatic cystic neoplasm" to identify English language articles describing the diagnosis and treatment of the mucinous cystic neoplasm of the pancreas. In total, 16 322 references ranging from January 1969 to December 2009 were analysed and 77 articles were identified. No articles published before 1996 were selected because MCNs were not previously considered to be a completely autonomous disease. Definition, epidemiology, anatomopathological findings, clinical presentation, preoperative evaluation, treatment and prognosis were reviewed. MCNs are pancreatic mucinproducing cysts with a distinctive ovarian-type stroma localized in the body-tail of the gland and occurring in middle-aged females. The majority of MCNs are slow growing and asymptomatic. The prevalence of invasive carcinoma varies between 6% and 55%. Preoperative diagnosis depends on a combination of clinical features, tumor markers, computed tomography (CT), magnetic resonance imaging, endoscopic ultrasound with cyst fluid analysis, and positron emission tomography-CT. Surgery is indicated for all MCNs.展开更多
BACKGROUND Mucinous cystic neoplasm of the liver(MCN-L)is a cyst-forming epithelial neoplasm.The most distinguishing feature is the ovarian-type subepithelial stroma on pathological examination.CASE SUMMARY An abdomin...BACKGROUND Mucinous cystic neoplasm of the liver(MCN-L)is a cyst-forming epithelial neoplasm.The most distinguishing feature is the ovarian-type subepithelial stroma on pathological examination.CASE SUMMARY An abdominal ultrasound incidentally revealed a liver tumor in a 32-year-old woman.Physical and laboratory examination results did not reveal any abnormalities.Enhanced abdominal computed tomography(CT)revealed a cystic space measuring 7.2 cm×5.4 cm in the liver.Subsequent CT showed an increase in tumor size.Thus,we performed surgical resection of the tumor and gallbladder.Postoperative histopathological examination confirmed the diagnosis of MCN-L.At the 6-mo of follow-up,no recurrence was observed on ultrasound or CT.CONCLUSION Since preoperative diagnosis of MCN-L is difficult,active surgery is recommended and helpful for the diagnosis and treatment of MCN-L.展开更多
Mucinous cystic neoplasm(MCN)of the pancreas is an exocrine cystic tumor with a potential of harboring malignancy.The latest World Health Organization classification of tumors of digestive system designates malignant ...Mucinous cystic neoplasm(MCN)of the pancreas is an exocrine cystic tumor with a potential of harboring malignancy.The latest World Health Organization classification of tumors of digestive system designates malignant MCN as MCN with associated invasive carcinoma(MCN-AIC).Since its separation from other pancreatic cystic tumors in 1978,much progress has been made in our understanding of MCN in epidemiology,clinical and pathological features,biological behavior,as well as prognostic characteristics.This review aims to summarize the current knowledge of MCN and MCN-AIC.展开更多
This study investigated the abnormal expression of ATP synthase β-subunit（ATPsyn-β） in pancreas islets of rat model of polycystic ovary syndrome（PCOS） with type 2 diabetes mellitus（T2DM）,and the secretion func...This study investigated the abnormal expression of ATP synthase β-subunit（ATPsyn-β） in pancreas islets of rat model of polycystic ovary syndrome（PCOS） with type 2 diabetes mellitus（T2DM）,and the secretion function changes after up-regulation of ATP5 b.Sixty female SD rats were divided into three groups randomly and equally.The rat model of PCOS with T2 DM was established by free access to the high-carbohydrate/high-fat diet,subcutaneous injections of DHEA,and a single injection of streptozotocin.The pancreas was removed for the detection of the ATPsyn-β expression by immunohistochemical staining,Western blotting and reverse transcription-PCR（RT-PCR）.The pancreas islets of the rats were cultured,isolated with collagenase Ⅴ and purified by gradient centrifugation,and the insulin secretion after treatment with different glucose concentrations was tested.Lentivirus ATP5 b was successfully constructed with the vector of GV208 and transfected into the pancreas islets for the over-expression of ATPsyn-β.The insulin secretion and intracellular ATP content were determined after transfection of the PCOS-T2 DM pancreas islets with Lenti-ATP5 b.The results showed that the expression of ATPsyn-β protein and m RNA was significantly decreased in the pancreas of PCOS-T2 DM rats.The ATP content in the pancreas islets was greatly increased and the insulin secretion was improved after the up-regulation of ATPsyn-β in the pancreas islets transfected with lenti-ATP5 b.These results indicated that for PCOS,the ATPsyn-β might be one of the key factors for the attack of T2 DM.展开更多
目的探讨肾混合性上皮和间质肿瘤(mixed epithelial and stromal tumor of the kidney,MESTK)临床病理特征。方法收集5例MESTK的临床资料及随访结果,采用HE染色及免疫组织化学染色,观察组织学特征及免疫组织化学特点,并复习相关文献。结...目的探讨肾混合性上皮和间质肿瘤(mixed epithelial and stromal tumor of the kidney,MESTK)临床病理特征。方法收集5例MESTK的临床资料及随访结果,采用HE染色及免疫组织化学染色,观察组织学特征及免疫组织化学特点,并复习相关文献。结果5例均为女性,年龄44~62岁,平均51.2岁。临床表现主要为腰背部疼痛及血尿,影像学检查提示肾脏囊实性占位。病理大体表现为肾脏界线清楚的囊实性肿瘤,多位于肾中极;组织学特征:肿瘤由上皮和间质成分混合构成,上皮排列成小管、微囊、大囊、乳头等结构,间质由梭形细胞组成,疏密不一,可见卵巢样间质、间质水肿及慢性炎症细胞浸润,上皮及间质细胞均未见明显异型性。免疫组织化学:上皮细胞表达广谱细胞角蛋白(CK_(pan))、CK7、PAX-8、P504S,间质细胞大多表达结蛋白(desmin)、平滑肌肌动蛋白(SMA)、雌激素受体(ER)、孕激素受体(PR)、CD10,Ki-67增殖指数低。结论MESTK是一种罕见的良性肾脏肿瘤,好发于围绝经期女性,影像学检查常误诊为囊性肾癌,有独特的病理组织学和免疫组织化学表现,肿物完整切除后,预后良好。展开更多
目的探讨戈舍瑞林联合腹腔镜治疗卵巢型子宫内膜异位症的临床价值。方法选择2018年4月—2019年10月医院收治的卵巢型子宫内膜异位症患者80例,按照随机数字表法分为两组,各40例。对照组在全身麻醉下实施腹腔镜手术干预,观察组则于对照组...目的探讨戈舍瑞林联合腹腔镜治疗卵巢型子宫内膜异位症的临床价值。方法选择2018年4月—2019年10月医院收治的卵巢型子宫内膜异位症患者80例,按照随机数字表法分为两组,各40例。对照组在全身麻醉下实施腹腔镜手术干预,观察组则于对照组基础上给予戈舍瑞林,比较两组干预前后抗苗勒管激素水平,比较两组干预前后卵巢超声指标,分析随访期间疼痛NRS评分变化情况,随访1年,比较两组受孕情况。结果干预1年后,两组抗苗勒管激素水平均显著高于干预前(P<0.05),且观察组抗苗勒管激素水平高于对照组(P<0.05),干预1年后,观察组卵巢超声指标中排卵期窦卵泡数(average antral follicle count,AFC)水平高于对照组(P<0.05),卵巢基质动脉搏动指数(pulsatility i n dex,PI)和卵巢动脉阻力指数(resistance index,RI)均显著小于对照组(P<0.05),干预3个月后和干预1年后,观察组疼痛NRS评分低于对照组(P<0.05),观察组自然受孕比例显著高于对照组(P<0.05)。结论针对卵巢型子宫内膜异位症,应用戈舍瑞林联合腹腔镜治疗,能有效的调节卵巢功能,缓解疼痛症状,提高自然妊娠几率。展开更多
文摘The purpose of this study was to investigate the actual management of mucinous cystic neoplasm (MCN) of the pancreas. A systematic review was performed in December 2009 by consulting PubMed MEDLINE for publications and matching the "pancreatic mucinous cystic neoplasm", "pancreatic mucinous cystic tumour", "pancreatic mucinous cystic mass", "pancreatic cyst", and "pancreatic cystic neoplasm" to identify English language articles describing the diagnosis and treatment of the mucinous cystic neoplasm of the pancreas. In total, 16 322 references ranging from January 1969 to December 2009 were analysed and 77 articles were identified. No articles published before 1996 were selected because MCNs were not previously considered to be a completely autonomous disease. Definition, epidemiology, anatomopathological findings, clinical presentation, preoperative evaluation, treatment and prognosis were reviewed. MCNs are pancreatic mucinproducing cysts with a distinctive ovarian-type stroma localized in the body-tail of the gland and occurring in middle-aged females. The majority of MCNs are slow growing and asymptomatic. The prevalence of invasive carcinoma varies between 6% and 55%. Preoperative diagnosis depends on a combination of clinical features, tumor markers, computed tomography (CT), magnetic resonance imaging, endoscopic ultrasound with cyst fluid analysis, and positron emission tomography-CT. Surgery is indicated for all MCNs.
基金Hebei Province Medical Science Research Key Project Plan,No.20160318.
文摘BACKGROUND Mucinous cystic neoplasm of the liver(MCN-L)is a cyst-forming epithelial neoplasm.The most distinguishing feature is the ovarian-type subepithelial stroma on pathological examination.CASE SUMMARY An abdominal ultrasound incidentally revealed a liver tumor in a 32-year-old woman.Physical and laboratory examination results did not reveal any abnormalities.Enhanced abdominal computed tomography(CT)revealed a cystic space measuring 7.2 cm×5.4 cm in the liver.Subsequent CT showed an increase in tumor size.Thus,we performed surgical resection of the tumor and gallbladder.Postoperative histopathological examination confirmed the diagnosis of MCN-L.At the 6-mo of follow-up,no recurrence was observed on ultrasound or CT.CONCLUSION Since preoperative diagnosis of MCN-L is difficult,active surgery is recommended and helpful for the diagnosis and treatment of MCN-L.
文摘Mucinous cystic neoplasm(MCN)of the pancreas is an exocrine cystic tumor with a potential of harboring malignancy.The latest World Health Organization classification of tumors of digestive system designates malignant MCN as MCN with associated invasive carcinoma(MCN-AIC).Since its separation from other pancreatic cystic tumors in 1978,much progress has been made in our understanding of MCN in epidemiology,clinical and pathological features,biological behavior,as well as prognostic characteristics.This review aims to summarize the current knowledge of MCN and MCN-AIC.
文摘This study investigated the abnormal expression of ATP synthase β-subunit（ATPsyn-β） in pancreas islets of rat model of polycystic ovary syndrome（PCOS） with type 2 diabetes mellitus（T2DM）,and the secretion function changes after up-regulation of ATP5 b.Sixty female SD rats were divided into three groups randomly and equally.The rat model of PCOS with T2 DM was established by free access to the high-carbohydrate/high-fat diet,subcutaneous injections of DHEA,and a single injection of streptozotocin.The pancreas was removed for the detection of the ATPsyn-β expression by immunohistochemical staining,Western blotting and reverse transcription-PCR（RT-PCR）.The pancreas islets of the rats were cultured,isolated with collagenase Ⅴ and purified by gradient centrifugation,and the insulin secretion after treatment with different glucose concentrations was tested.Lentivirus ATP5 b was successfully constructed with the vector of GV208 and transfected into the pancreas islets for the over-expression of ATPsyn-β.The insulin secretion and intracellular ATP content were determined after transfection of the PCOS-T2 DM pancreas islets with Lenti-ATP5 b.The results showed that the expression of ATPsyn-β protein and m RNA was significantly decreased in the pancreas of PCOS-T2 DM rats.The ATP content in the pancreas islets was greatly increased and the insulin secretion was improved after the up-regulation of ATPsyn-β in the pancreas islets transfected with lenti-ATP5 b.These results indicated that for PCOS,the ATPsyn-β might be one of the key factors for the attack of T2 DM.
文摘目的探讨肾混合性上皮和间质肿瘤(mixed epithelial and stromal tumor of the kidney,MESTK)临床病理特征。方法收集5例MESTK的临床资料及随访结果,采用HE染色及免疫组织化学染色,观察组织学特征及免疫组织化学特点,并复习相关文献。结果5例均为女性,年龄44~62岁,平均51.2岁。临床表现主要为腰背部疼痛及血尿,影像学检查提示肾脏囊实性占位。病理大体表现为肾脏界线清楚的囊实性肿瘤,多位于肾中极;组织学特征:肿瘤由上皮和间质成分混合构成,上皮排列成小管、微囊、大囊、乳头等结构,间质由梭形细胞组成,疏密不一,可见卵巢样间质、间质水肿及慢性炎症细胞浸润,上皮及间质细胞均未见明显异型性。免疫组织化学:上皮细胞表达广谱细胞角蛋白(CK_(pan))、CK7、PAX-8、P504S,间质细胞大多表达结蛋白(desmin)、平滑肌肌动蛋白(SMA)、雌激素受体(ER)、孕激素受体(PR)、CD10,Ki-67增殖指数低。结论MESTK是一种罕见的良性肾脏肿瘤,好发于围绝经期女性,影像学检查常误诊为囊性肾癌,有独特的病理组织学和免疫组织化学表现,肿物完整切除后,预后良好。
文摘目的探讨戈舍瑞林联合腹腔镜治疗卵巢型子宫内膜异位症的临床价值。方法选择2018年4月—2019年10月医院收治的卵巢型子宫内膜异位症患者80例,按照随机数字表法分为两组,各40例。对照组在全身麻醉下实施腹腔镜手术干预,观察组则于对照组基础上给予戈舍瑞林,比较两组干预前后抗苗勒管激素水平,比较两组干预前后卵巢超声指标,分析随访期间疼痛NRS评分变化情况,随访1年,比较两组受孕情况。结果干预1年后,两组抗苗勒管激素水平均显著高于干预前(P<0.05),且观察组抗苗勒管激素水平高于对照组(P<0.05),干预1年后,观察组卵巢超声指标中排卵期窦卵泡数(average antral follicle count,AFC)水平高于对照组(P<0.05),卵巢基质动脉搏动指数(pulsatility i n dex,PI)和卵巢动脉阻力指数(resistance index,RI)均显著小于对照组(P<0.05),干预3个月后和干预1年后,观察组疼痛NRS评分低于对照组(P<0.05),观察组自然受孕比例显著高于对照组(P<0.05)。结论针对卵巢型子宫内膜异位症,应用戈舍瑞林联合腹腔镜治疗,能有效的调节卵巢功能,缓解疼痛症状,提高自然妊娠几率。
