Background: HPV infection represents an important etiologic factor for Oropharyngeal Squamous Cell Carcinoma (OPSCC). The different ethnic backgrounds could be related to different susceptibility to Human Papillomavir...Background: HPV infection represents an important etiologic factor for Oropharyngeal Squamous Cell Carcinoma (OPSCC). The different ethnic backgrounds could be related to different susceptibility to Human Papillomavirus (HPV). The aim of our study was to assess the whole of genetic ancestry in HPV status in OPSCC patients. Methods: We conducted a cross-sectional study on patients with OPSCC admitted to the Barretos Cancer Hospital, Brazil from 2014 to 2019. Of these, DNA extraction was performed on 40 patients and genetic ancestry was assessed using a specific panel of 46 informative ancestry markers. Results: We observed a predominance of European ancestry (63%), followed by African (18%), Amerindian (9%) and Asian (8%) both in the OPSCC HPV-positive and HPV-negative group. We did not find any statistically significant differences between the HPV-positive and HPV-negative OPSCC groups in relation to European (p = 0.499), African (p = 0.448), Asian (p = 0.275) or Amerindian (p = 0.836) ancestry. Conclusions: We found a predominance of European ancestry, both in the HPV-positive and HPV-negative groups. In our study, we did not find statistically significant differences between HPV-positive or HPV-negative groups in relation to ancestry.展开更多
目的比较低剂量放疗(LD-RT)与标准剂量放疗(SD-RT)治疗人乳头瘤病毒(HPV)阳性口咽癌患者的疗效及安全性。方法检索PubMed、Web of Science、Cochrane Library、EMbase、中国生物医学文献数据库、中国知网、维普、万方数据库中,2000年1月...目的比较低剂量放疗(LD-RT)与标准剂量放疗(SD-RT)治疗人乳头瘤病毒(HPV)阳性口咽癌患者的疗效及安全性。方法检索PubMed、Web of Science、Cochrane Library、EMbase、中国生物医学文献数据库、中国知网、维普、万方数据库中,2000年1月1日至2023年2月9日期间,所有对比研究低剂量与标准剂量放疗治疗HPV阳性口咽癌的文献。按照纳入与排除标准进行严格的筛选,提取资料,采用RevMan 5.4软件进行meta分析。结果最终纳入8篇文献,汇总结果表明LD-RT组患者的总生存(OS)期和无进展生存(PFS)期与SD-RT组基本一致(HR=0.83,95%CI为0.59~1.18,P=0.31;HR=0.97,95%CI为0.53~1.78,P=0.92),但经皮内镜胃造瘘管(PEG)置管率显著降低(RR=0.45,95%CI为0.28~0.72,P=0.001)。结论LD-RT可使HPV阳性口咽癌患者获得与SD-RT相当的疗效和更低的PEG置管率。展开更多
文摘Background: HPV infection represents an important etiologic factor for Oropharyngeal Squamous Cell Carcinoma (OPSCC). The different ethnic backgrounds could be related to different susceptibility to Human Papillomavirus (HPV). The aim of our study was to assess the whole of genetic ancestry in HPV status in OPSCC patients. Methods: We conducted a cross-sectional study on patients with OPSCC admitted to the Barretos Cancer Hospital, Brazil from 2014 to 2019. Of these, DNA extraction was performed on 40 patients and genetic ancestry was assessed using a specific panel of 46 informative ancestry markers. Results: We observed a predominance of European ancestry (63%), followed by African (18%), Amerindian (9%) and Asian (8%) both in the OPSCC HPV-positive and HPV-negative group. We did not find any statistically significant differences between the HPV-positive and HPV-negative OPSCC groups in relation to European (p = 0.499), African (p = 0.448), Asian (p = 0.275) or Amerindian (p = 0.836) ancestry. Conclusions: We found a predominance of European ancestry, both in the HPV-positive and HPV-negative groups. In our study, we did not find statistically significant differences between HPV-positive or HPV-negative groups in relation to ancestry.
文摘目的比较低剂量放疗(LD-RT)与标准剂量放疗(SD-RT)治疗人乳头瘤病毒(HPV)阳性口咽癌患者的疗效及安全性。方法检索PubMed、Web of Science、Cochrane Library、EMbase、中国生物医学文献数据库、中国知网、维普、万方数据库中,2000年1月1日至2023年2月9日期间,所有对比研究低剂量与标准剂量放疗治疗HPV阳性口咽癌的文献。按照纳入与排除标准进行严格的筛选,提取资料,采用RevMan 5.4软件进行meta分析。结果最终纳入8篇文献,汇总结果表明LD-RT组患者的总生存(OS)期和无进展生存(PFS)期与SD-RT组基本一致(HR=0.83,95%CI为0.59~1.18,P=0.31;HR=0.97,95%CI为0.53~1.78,P=0.92),但经皮内镜胃造瘘管(PEG)置管率显著降低(RR=0.45,95%CI为0.28~0.72,P=0.001)。结论LD-RT可使HPV阳性口咽癌患者获得与SD-RT相当的疗效和更低的PEG置管率。
