The appearance of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variant Omicron(B.1.1.529)has caused panic responses around the world because of its high transmission rate and number of mutations.This rev...The appearance of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variant Omicron(B.1.1.529)has caused panic responses around the world because of its high transmission rate and number of mutations.This review summarizes the highly mutated regions,the essential infectivity,transmission,vaccine breakthrough and antibody resistance of the Omicron variant of SARSCoV-2.The Omicron is highly transmissible and is spreading faster than any previous variant,but may cause less severe symptoms than previous variants.The Omicron is able to escape the immune system’s defenses and coronavirus disease 2019 vaccines are less effective against the Omicron variant.Early careful preventive steps including vaccination will always be key for the suppression of the Omicron variant.展开更多
The rapid accumulation of mutations in the SARS-CoV-2 Omicron variant that enabled its outbreak raises questions as to whether its proximal origin occurred in humans or another mammalian host. Here, we identified 45 p...The rapid accumulation of mutations in the SARS-CoV-2 Omicron variant that enabled its outbreak raises questions as to whether its proximal origin occurred in humans or another mammalian host. Here, we identified 45 point mutations that Omicron acquired since divergence from the B.1.1 lineage. We found that the Omicron spike protein sequence was subjected to stronger positive selection than that of any reported SARS-CoV-2 variants known to evolve persistently in human hosts, suggesting a possibility of hostjumping. The molecular spectrum of mutations(i.e., the relative frequency of the 12 types of base substitutions) acquired by the progenitor of Omicron was significantly different from the spectrum for viruses that evolved in human patients but resembled the spectra associated with virus evolution in a mouse cellular environment. Furthermore, mutations in the Omicron spike protein significantly overlapped with SARS-CoV-2 mutations known to promote adaptation to mouse hosts, particularly through enhanced spike protein binding affinity for the mouse cell entry receptor. Collectively, our results suggest that the progenitor of Omicron jumped from humans to mice, rapidly accumulated mutations conducive to infecting that host,then jumped back into humans, indicating an inter-species evolutionary trajectory for the Omicron outbreak.展开更多
奥密克戎(Omicron)是近来新发现的一种新型冠状病毒肺炎新型变异病毒,迅速在全球传播,被世界卫生组织定为需要关注的变种(variant of concern),其流行病学、致病特点、临床诊断、治疗和预防仍在观察与总结中,儿童感染后的诊疗报道更少...奥密克戎(Omicron)是近来新发现的一种新型冠状病毒肺炎新型变异病毒,迅速在全球传播,被世界卫生组织定为需要关注的变种(variant of concern),其流行病学、致病特点、临床诊断、治疗和预防仍在观察与总结中,儿童感染后的诊疗报道更少。该文就奥密克戎感染对儿童的影响、预防、诊断和治疗进行介绍。展开更多
自新型冠状病毒肺炎(COVID-19)爆发以来,新冠病毒在传播的过程中发生了进化和变异,已经形成了多个变异株,目前有5种“关切变异株(variant of concern,VOC)”,分别是阿尔法(Alpha)、贝塔(Beta)、伽马(Gamma)、德尔塔(Delta)和奥密克戎(Om...自新型冠状病毒肺炎(COVID-19)爆发以来,新冠病毒在传播的过程中发生了进化和变异,已经形成了多个变异株,目前有5种“关切变异株(variant of concern,VOC)”,分别是阿尔法(Alpha)、贝塔(Beta)、伽马(Gamma)、德尔塔(Delta)和奥密克戎(Omicron)。2021年11月9日,南非首次从病例样本中检测到1种新冠病毒变异株(B.1.1.529),11月26日,世界卫生组织将其命名为奥密克戎(Omicron)变异株,目前奥密克戎变异株已经成为了全球主要流行株。Omicron由几个亚型组成,包括BA.1、BA.2和BA.3,Omicron变异株的亚型具有不同的突变位点、传播力,本文将对奥密克戎变异株各亚型的特点和免疫逃逸的机制做一简要综述。展开更多
文摘The appearance of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variant Omicron(B.1.1.529)has caused panic responses around the world because of its high transmission rate and number of mutations.This review summarizes the highly mutated regions,the essential infectivity,transmission,vaccine breakthrough and antibody resistance of the Omicron variant of SARSCoV-2.The Omicron is highly transmissible and is spreading faster than any previous variant,but may cause less severe symptoms than previous variants.The Omicron is able to escape the immune system’s defenses and coronavirus disease 2019 vaccines are less effective against the Omicron variant.Early careful preventive steps including vaccination will always be key for the suppression of the Omicron variant.
基金supported by grants from the National Natural Science Foundation of China(31922014)。
文摘The rapid accumulation of mutations in the SARS-CoV-2 Omicron variant that enabled its outbreak raises questions as to whether its proximal origin occurred in humans or another mammalian host. Here, we identified 45 point mutations that Omicron acquired since divergence from the B.1.1 lineage. We found that the Omicron spike protein sequence was subjected to stronger positive selection than that of any reported SARS-CoV-2 variants known to evolve persistently in human hosts, suggesting a possibility of hostjumping. The molecular spectrum of mutations(i.e., the relative frequency of the 12 types of base substitutions) acquired by the progenitor of Omicron was significantly different from the spectrum for viruses that evolved in human patients but resembled the spectra associated with virus evolution in a mouse cellular environment. Furthermore, mutations in the Omicron spike protein significantly overlapped with SARS-CoV-2 mutations known to promote adaptation to mouse hosts, particularly through enhanced spike protein binding affinity for the mouse cell entry receptor. Collectively, our results suggest that the progenitor of Omicron jumped from humans to mice, rapidly accumulated mutations conducive to infecting that host,then jumped back into humans, indicating an inter-species evolutionary trajectory for the Omicron outbreak.
文摘奥密克戎(Omicron)是近来新发现的一种新型冠状病毒肺炎新型变异病毒,迅速在全球传播,被世界卫生组织定为需要关注的变种(variant of concern),其流行病学、致病特点、临床诊断、治疗和预防仍在观察与总结中,儿童感染后的诊疗报道更少。该文就奥密克戎感染对儿童的影响、预防、诊断和治疗进行介绍。
文摘自新型冠状病毒肺炎(COVID-19)爆发以来,新冠病毒在传播的过程中发生了进化和变异,已经形成了多个变异株,目前有5种“关切变异株(variant of concern,VOC)”,分别是阿尔法(Alpha)、贝塔(Beta)、伽马(Gamma)、德尔塔(Delta)和奥密克戎(Omicron)。2021年11月9日,南非首次从病例样本中检测到1种新冠病毒变异株(B.1.1.529),11月26日,世界卫生组织将其命名为奥密克戎(Omicron)变异株,目前奥密克戎变异株已经成为了全球主要流行株。Omicron由几个亚型组成,包括BA.1、BA.2和BA.3,Omicron变异株的亚型具有不同的突变位点、传播力,本文将对奥密克戎变异株各亚型的特点和免疫逃逸的机制做一简要综述。
