Schisandra chinensis,a widely used Chinese herbal medicine,was considered as central nervous system(CNS)drug for years.Both ethanol extracts(EES)and water extracts(WES)of it were applied clinically.Unfortunately,the d...Schisandra chinensis,a widely used Chinese herbal medicine,was considered as central nervous system(CNS)drug for years.Both ethanol extracts(EES)and water extracts(WES)of it were applied clinically.Unfortunately,the difference of their efficacy and even effective material foundation of S.chinensis remains obscure.In this study,to explore the active constituents of S.chinensis,we compared pharmacodynamics and chemical profiles in vitrolin vivo of EES/WES for the first time using multiple chemical analysis,pharmacological and data processing approaches.It was proved that there was no significant difference in the anti-depressive effects between WES and EES.However,the contents of most components in vitro and in plasma were higher in EES than those in WES,which was unconvincing for their similar efficacy.Therefore,we further explored components of S.chinensis targeted onto brain and the results showed that 5 lignans were identified with definite absorptivity respectively both in EES and WES caused by the limitation of blood-brain barrier.Moreover,bioinformatic analysis predicted their anti-depressive action.Above all,the systematic strategy screened 5 brain-targeted effective substances of S.chinensis and it was suggested that exploring the components into nidi would promote the studies on herbs effective material basis.展开更多
The environment structure of natural nidi and epidemic areas of hemorrhagic fever with renal syndrome (HFRS) possesses characteristics of topography, hydrology, climate, soil, vegetation, and animals. The natural nidi...The environment structure of natural nidi and epidemic areas of hemorrhagic fever with renal syndrome (HFRS) possesses characteristics of topography, hydrology, climate, soil, vegetation, and animals. The natural nidi and epidemic areas of HFRS are distributed mainly in plain and hilly regions under 500 meters above the sea level; in plentiful-water zones and transitional zones; in temperate zone and subtropical zone of the eastern monsoon region; in the abundant-aluminum soil region and the sial soil region; in the eastern China damp forest region (agricultural districts and northeast forest districts); in the eastern Asia dampness-prefering animal geographic region. Apodemus agrarius and Rattus norvegicus are the thriving animal population, predominant species or common species as well as the main reservoir hosts and sources of infection in the natural nidi and epidemic areas of HFRS.展开更多
基金financially supported by the National Natural Science Foundation of China(U1508220)Liaoning DistinguishedProfessor Project for Qing Li(2017,China)Shenyang Pharmaceutical University Innovative Research Team.
文摘Schisandra chinensis,a widely used Chinese herbal medicine,was considered as central nervous system(CNS)drug for years.Both ethanol extracts(EES)and water extracts(WES)of it were applied clinically.Unfortunately,the difference of their efficacy and even effective material foundation of S.chinensis remains obscure.In this study,to explore the active constituents of S.chinensis,we compared pharmacodynamics and chemical profiles in vitrolin vivo of EES/WES for the first time using multiple chemical analysis,pharmacological and data processing approaches.It was proved that there was no significant difference in the anti-depressive effects between WES and EES.However,the contents of most components in vitro and in plasma were higher in EES than those in WES,which was unconvincing for their similar efficacy.Therefore,we further explored components of S.chinensis targeted onto brain and the results showed that 5 lignans were identified with definite absorptivity respectively both in EES and WES caused by the limitation of blood-brain barrier.Moreover,bioinformatic analysis predicted their anti-depressive action.Above all,the systematic strategy screened 5 brain-targeted effective substances of S.chinensis and it was suggested that exploring the components into nidi would promote the studies on herbs effective material basis.
文摘The environment structure of natural nidi and epidemic areas of hemorrhagic fever with renal syndrome (HFRS) possesses characteristics of topography, hydrology, climate, soil, vegetation, and animals. The natural nidi and epidemic areas of HFRS are distributed mainly in plain and hilly regions under 500 meters above the sea level; in plentiful-water zones and transitional zones; in temperate zone and subtropical zone of the eastern monsoon region; in the abundant-aluminum soil region and the sial soil region; in the eastern China damp forest region (agricultural districts and northeast forest districts); in the eastern Asia dampness-prefering animal geographic region. Apodemus agrarius and Rattus norvegicus are the thriving animal population, predominant species or common species as well as the main reservoir hosts and sources of infection in the natural nidi and epidemic areas of HFRS.
