The family members of the mitogen-activated protein (MAP) kinases mediate a wide variety of cellular behaviors in response to extracellular stimuli. One of the four main sub-groups, the p38 group of MAP kinases, serve...The family members of the mitogen-activated protein (MAP) kinases mediate a wide variety of cellular behaviors in response to extracellular stimuli. One of the four main sub-groups, the p38 group of MAP kinases, serve as a nexus for signal transduction and play a vital role in numerous biological processes. In this review, we highlight the known characteristics and components of the p38 pathway along with the mechanism and consequences of p38 activation. We focus on the role of p38 as a signal transduction mediator and examine the evidence linking p38 to inflammation, cell cycle, cell death, development, cell differentiation, senescence and tumorigenesis in specific cell types. Upstream and downstream components of p38 are described and questions remaining to be answered are posed. Finally, we propose several directions for future research on p38.展开更多
Carbon neutrality requires systematic transformations of both energy and metal systems.These transformations are not isolated but rather interlinked and interdependent,such that trade-offs between different strategies...Carbon neutrality requires systematic transformations of both energy and metal systems.These transformations are not isolated but rather interlinked and interdependent,such that trade-offs between different strategies exist.Herein,we explore the critical interlinkages between energy and metal systems and further propose a circular metal-energy nexus to advance global coordinated actions towards a carbon-neutral future.展开更多
This study examines the Water-Energy-Food-Ecosystems (WEFE) nexus in Lebanese agriculture, with a focus on the shift from conventional surface irrigation techniques to advanced smart irrigation systems in the Bekaa re...This study examines the Water-Energy-Food-Ecosystems (WEFE) nexus in Lebanese agriculture, with a focus on the shift from conventional surface irrigation techniques to advanced smart irrigation systems in the Bekaa region, specifically targeting potato cultivation. The study quantitatively analyzes the interaction among water, energy, and agricultural outputs at the farm scale using the WEFE Nexus framework for scenario analysis. It evaluates variations in water productivity, environmental effects, and economic outcomes, offering a detailed view of existing practices and their sustainable improvement potential. The WEFE Nexus assessment demonstrates that smart irrigation integration significantly decreased resource usage: water consumption was reduced by 58%, diesel fuel use for irrigation dropped by 57%, and the demand for labor and fertilizers decreased by 47% and 49%, respectively. This change led to enhanced crop yields and increased resource efficiency, demonstrating the potential of smart irrigation as a transformative strategy for sustainable agriculture in Lebanon and other arid areas. Economic analysis showed that farmers could recover the costs of installing the smart irrigation system within 3 months. The findings highlight the need for further research on integrating smart irrigation with renewable energy, showing potential for sustainable agricultural development. .展开更多
Given the challenges facing most humanitarian operations worldwide, a change of approach is needed to ensure greater sustainability of humanitarian settlements right from the planning stage. Some studies attribute uns...Given the challenges facing most humanitarian operations worldwide, a change of approach is needed to ensure greater sustainability of humanitarian settlements right from the planning stage. Some studies attribute unsustainability to inadequate provision of basic resources and highlight the apparent bottlenecks that prevent access to the meaningful data needed to plan and remedy problems. Most operations have relied on an “ad hoc ism” approach, employing parallel and disconnected data processing methods, resulting in a wide range of data being collected without subsequent prioritization to optimize interconnections that could enhance performance. There have been little efforts to study the trade-offs potentially at stake. This work proposes a new framework enabling all subsystems to operate in a single system and focusing on data processing perspective. To achieve this, this paper proposes a Triple Nexus Framework as an attempt to integrate water, energy, and housing sector data derived from a specific sub-system within the overall system in the application of Model-Based Systems Engineering. Understanding the synergies between water, energy, and housing, Systems Engineering characterizes the triple nexus framework and identifies opportunities for improved decision-making in processing operational data from these sectors. Two scenarios illustrate how an integrated platform could be a gateway to access meaningful operational data in the system and a starting point for modeling integrated human settlement systems. Upon execution, the model is tested for nexus megadata processing, and the optimization simulation yielded 67% satisfactory results, demonstrating that an integrated system could improve sustainability, and that capacity building in service delivery is more than beneficial.展开更多
Understanding and predicting the impact of the global energy transition and the United Nations Sustainable Development Goals (SDGs) on global mineral demand and African supply is challenging. This study uses a resourc...Understanding and predicting the impact of the global energy transition and the United Nations Sustainable Development Goals (SDGs) on global mineral demand and African supply is challenging. This study uses a resource nexus approach to investigate and analyze the impact of this transition on energy and water demand and CO2 emissions using three annual material demand scenarios. The results indicate that African mining will consume more energy by 2050, leading to an increase in cumulative demand for energy (from 98 to 14,577 TWh) and water (from 15,013 to 223,000 million m3), as well as CO2 emissions (1318 and 19,561 Gg CO2e). In contrast, only a modest increase in energy demand (207 TWh) will be required by 2050 to achieve the SDGs. Therefore, the African mining industry should reduce its energy consumption and invest more in the renewable energy sector to support the global energy transition.展开更多
文摘The family members of the mitogen-activated protein (MAP) kinases mediate a wide variety of cellular behaviors in response to extracellular stimuli. One of the four main sub-groups, the p38 group of MAP kinases, serve as a nexus for signal transduction and play a vital role in numerous biological processes. In this review, we highlight the known characteristics and components of the p38 pathway along with the mechanism and consequences of p38 activation. We focus on the role of p38 as a signal transduction mediator and examine the evidence linking p38 to inflammation, cell cycle, cell death, development, cell differentiation, senescence and tumorigenesis in specific cell types. Upstream and downstream components of p38 are described and questions remaining to be answered are posed. Finally, we propose several directions for future research on p38.
基金This study is supported by the National Natural Science Foundation of China(Grants No.71904182,41871204,and 71961147003)P.W.acknowledges support from the CAST Young Elite Scientist Sponsorship Program.
文摘Carbon neutrality requires systematic transformations of both energy and metal systems.These transformations are not isolated but rather interlinked and interdependent,such that trade-offs between different strategies exist.Herein,we explore the critical interlinkages between energy and metal systems and further propose a circular metal-energy nexus to advance global coordinated actions towards a carbon-neutral future.
文摘This study examines the Water-Energy-Food-Ecosystems (WEFE) nexus in Lebanese agriculture, with a focus on the shift from conventional surface irrigation techniques to advanced smart irrigation systems in the Bekaa region, specifically targeting potato cultivation. The study quantitatively analyzes the interaction among water, energy, and agricultural outputs at the farm scale using the WEFE Nexus framework for scenario analysis. It evaluates variations in water productivity, environmental effects, and economic outcomes, offering a detailed view of existing practices and their sustainable improvement potential. The WEFE Nexus assessment demonstrates that smart irrigation integration significantly decreased resource usage: water consumption was reduced by 58%, diesel fuel use for irrigation dropped by 57%, and the demand for labor and fertilizers decreased by 47% and 49%, respectively. This change led to enhanced crop yields and increased resource efficiency, demonstrating the potential of smart irrigation as a transformative strategy for sustainable agriculture in Lebanon and other arid areas. Economic analysis showed that farmers could recover the costs of installing the smart irrigation system within 3 months. The findings highlight the need for further research on integrating smart irrigation with renewable energy, showing potential for sustainable agricultural development. .
文摘Given the challenges facing most humanitarian operations worldwide, a change of approach is needed to ensure greater sustainability of humanitarian settlements right from the planning stage. Some studies attribute unsustainability to inadequate provision of basic resources and highlight the apparent bottlenecks that prevent access to the meaningful data needed to plan and remedy problems. Most operations have relied on an “ad hoc ism” approach, employing parallel and disconnected data processing methods, resulting in a wide range of data being collected without subsequent prioritization to optimize interconnections that could enhance performance. There have been little efforts to study the trade-offs potentially at stake. This work proposes a new framework enabling all subsystems to operate in a single system and focusing on data processing perspective. To achieve this, this paper proposes a Triple Nexus Framework as an attempt to integrate water, energy, and housing sector data derived from a specific sub-system within the overall system in the application of Model-Based Systems Engineering. Understanding the synergies between water, energy, and housing, Systems Engineering characterizes the triple nexus framework and identifies opportunities for improved decision-making in processing operational data from these sectors. Two scenarios illustrate how an integrated platform could be a gateway to access meaningful operational data in the system and a starting point for modeling integrated human settlement systems. Upon execution, the model is tested for nexus megadata processing, and the optimization simulation yielded 67% satisfactory results, demonstrating that an integrated system could improve sustainability, and that capacity building in service delivery is more than beneficial.
文摘Understanding and predicting the impact of the global energy transition and the United Nations Sustainable Development Goals (SDGs) on global mineral demand and African supply is challenging. This study uses a resource nexus approach to investigate and analyze the impact of this transition on energy and water demand and CO2 emissions using three annual material demand scenarios. The results indicate that African mining will consume more energy by 2050, leading to an increase in cumulative demand for energy (from 98 to 14,577 TWh) and water (from 15,013 to 223,000 million m3), as well as CO2 emissions (1318 and 19,561 Gg CO2e). In contrast, only a modest increase in energy demand (207 TWh) will be required by 2050 to achieve the SDGs. Therefore, the African mining industry should reduce its energy consumption and invest more in the renewable energy sector to support the global energy transition.
