AIM To investigate the clinical significance of preoperative systemic immune-inflammation index(SII) in patients with colorectal cancer(CRC). METHODS A retrospective analysis of 1383 cases with CRC was performed follo...AIM To investigate the clinical significance of preoperative systemic immune-inflammation index(SII) in patients with colorectal cancer(CRC). METHODS A retrospective analysis of 1383 cases with CRC was performed following radical surgery. SII was calculated with the formula SII =(P × N)/L, where P, N, and L refer to peripheral platelet, neutrophil, and lymphocyte counts, respectively. The clinicopathological features and follow-up data were evaluated to compare SII with other systemic inflammation-based prognostic indices such as the neutrophil-lymphocyte ratio(NLR) and platelet-lymphocyte ratio(PLR) in patients with CRC.RESULTS The optimal cut-off point for SII was defined as 340. The overall survival(OS) and disease-free survival(DFS) were better in patients with low NLR, PLR, and SII(P < 0.05). The SII was an independent predictor of OS and DFS in multivariate analysis. The area under the receiver-operating characteristics(ROC) curve for SII(0.707) was larger than those for NLR(0.602) and PLR(0.566). In contrast to NLR and PLR, SII could effectively discriminate between the TNM subgroups. CONCLUSION SII is a more powerful tool for predicting survival outcome in patients with CRC. It might assist the identification of high-risk patients among patients with the same TNM stage.展开更多
目的探讨中性粒细胞与淋巴细胞比值(NLR)在亚特兰大新分类标准下预测急性胰腺炎严重程度的价值。方法回顾性分析118例急性胰腺炎患者的临床资料,按亚特兰大新分类标准将其分为轻度急性胰腺炎(MAP)、中度急性胰腺炎(MSAP)及重度急性胰腺...目的探讨中性粒细胞与淋巴细胞比值(NLR)在亚特兰大新分类标准下预测急性胰腺炎严重程度的价值。方法回顾性分析118例急性胰腺炎患者的临床资料,按亚特兰大新分类标准将其分为轻度急性胰腺炎(MAP)、中度急性胰腺炎(MSAP)及重度急性胰腺炎(SAP)3组,观察各组的血NLR水平在入院后第1天、第7天及出院时的动态变化以及在各个时间点上的组间差异。评估NLR与APACHEII评分、住ICU天数、住院天数的相关性,并采用受试者工作特征(ROC)曲线比较NLR、血尿素氮(BUN)、APACHEII评分及NLR联合BUN预测急性胰腺炎严重程度的有效性。结果在入院后第1天及第7天,NLR的水平依次为SAP组>MSAP组>MAP组(P=0.000)。NLR水平与APACHEII评分、住ICU天数、住院天数呈正相关(分别为r=0.577,P=0.000;r=0.527,P=0.000;r=0.597,P=0.000)。NLR在预测中度与重度急性胰腺炎时的曲线下面积与APACHEII评分无统计学差异,但优于BUN(0.876±0.032 vs 0.873±0.031,P=0.944;0.876±0.032 vs 0.660±0.050,P=0.000);预测重度急性胰腺炎时,NLR与APACHEII评分及BUN均无统计学差异(0.794±0.053 vs 0.892±0.033,P=0.118;0.794±0.053 vs 0.745±0.064,P=0.560),将NLR与BUN联合后可增加曲线下面积和诊断特异度。结论 NLR在预测急性胰腺炎严重程度上具有一定的临床意义。展开更多
目的:本研究探讨中性粒细胞与淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)和血小板与淋巴细胞比值(platelet to lymphocyte ratio,PLR)与接受肝动脉栓塞化疗(transarterial chemoembolization,TACE)肝癌(hepatocellular carcinom...目的:本研究探讨中性粒细胞与淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)和血小板与淋巴细胞比值(platelet to lymphocyte ratio,PLR)与接受肝动脉栓塞化疗(transarterial chemoembolization,TACE)肝癌(hepatocellular carcinoma,HCC)患者术后生存期的相关性。方法:回顾性分析2007年1月至2015年6月中山大学肿瘤防治中心肝胆胰科确诊为肝癌并行TACE治疗的216例患者。研究患者依照NLR和PLR的界值分成两组。分析并比较NLR和PLR在不同随访时间点的受试者工作曲线(ROC)下面积。单因素和多因素分析用于评价NLR和PLR与TACE术后肝癌患者预后的相关性。结果:本研究中位随访时间为431.1 d。全体研究对象1、2、3年生存率分别为61.3%、44.2%和40.5%。中位生存时间为410.5 d。术前NLR<1.77组和术前NLR≥1.77组1、2、3年生存率分别为81.6%、63.0%、45.7%和43.1%、27.0%、19.3%,差异具有统计学意义(P<0.001)。术前PLR<94.62组和术前PLR≥94.62组1、2、3年生存率分别为62.7%、47.0%、37.0%和46.8%、29.0%、18.5%,差异具有统计学意义(P=0.002)。多因素分析显示NLR≥1.77与TACE术后肝癌患者较差预后相关,是肝癌患者TACE治疗后的危险因素。结论:TACE介入术前HCC患者的NLR水平,作为系统炎症的一个反应指标,是影响其预后的危险因素。展开更多
AIM To investigated the prognostic value of the neutrophillymphocyte ratio(NLR) in patients with acute pancreatitis and determined an optimal cut-off value for the prediction of adverse outcomes in these patients.METH...AIM To investigated the prognostic value of the neutrophillymphocyte ratio(NLR) in patients with acute pancreatitis and determined an optimal cut-off value for the prediction of adverse outcomes in these patients.METHODS We retrospectively analyzed 490 patients with acute pancreatitis diagnosed between March 2007 and December 2012. NLRs were calculated at admission and 24, 48, and 72 h after admission. Patients were grouped according to acute pancreatitis severity and organ failure occurrence, and a comparative analysis was performed to compare the NLR between groups. RESULTS Among the 490 patients, 70 had severe acute pancreatitis with 31 experiencing organ failure. The severe acute pancreatitis group had a significantly higher NLR than the mild acute pancreatitis group on all 4 d(median, 6.14, 6.71, 5.70, and 4.00 vs 4.74, 4.47, 3.20, and 3.30, respectively, P < 0.05). The organ failure group had a significantly higher NLR than the group without organ failure on all 4 d(median, 7.09, 6.72, 6.27, and 6.24 vs 4.85, 4.49, 3.35, and 2.34, respectively, P < 0.05). The optimal cut-off value for baseline NLR was 4.76 in predicting severity and 4.88in predicting organ failure in acute pancreatitis. CONCLUSION Elevated baseline NLR correlates with severe acute pancreatitis and organ failure.展开更多
目的中性粒细胞与淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)是反应系统性炎症反应的定量指标之一,最近已经有一些研究探索了NLR可以作为反应急性胰腺炎(acute pancreatitis,AP)严重程度的重要指标,但是不同研究间存在不一致性...目的中性粒细胞与淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)是反应系统性炎症反应的定量指标之一,最近已经有一些研究探索了NLR可以作为反应急性胰腺炎(acute pancreatitis,AP)严重程度的重要指标,但是不同研究间存在不一致性.因此,在这项研究中,我们首次系统性地评估了不同研究中性粒细胞与淋巴细胞比值对急性胰腺炎严重程度的预测价值.方法我们在PubMed,Embase,Web of Science和Cochrane Library数据库中检索2019年4月以前关于中性粒细胞与淋巴细胞比值和胰腺炎的相关文章.三位作者分别独立审查检索到的文章.如果文章是探讨中性粒细胞与淋巴细胞比值预测急性胰腺炎严重程度的文献则纳入研究.如果是个案报道、综述、基础研究、动物实验、会议摘要则被排除.所有纳入文献的质量评分采用诊断准确性研究的质量评估-2指南(Quality Assessment of Diagnostic Accuracy Studies-2 guidelines,QUADAS-2)进行评估.双变量随机效应模型用于中性粒细胞与淋巴细胞比值预测胰腺炎严重程度的效应量的合并.结果:这项研究总共纳入10项研究(1713例患者),合并后的诊断效应量分别如下:敏感度0.76(0.68~0.82)、特异度0.72(0.61~0.81)、阳性似然比2.7(1.8~4.0)、阴性似然比0.34(0.24~0.48)、受试者工作曲线下面积0.79(0.75~0.82)和诊断比值比8(4~16).结论:NLR是一种容易检测且价格低廉的标记物,具有一定的诊断价值,能够预测急性胰腺炎患者的严重程度,从而为临床上急性胰腺炎的治疗提供新的思路.展开更多
目的探讨中性粒细胞与淋巴细胞的比值(NLR)在早期糖尿病肾病(DN)患者中的变化及意义。方法选取91例确诊为早期DN的患者为DN组,54例正常健康人为对照组,比较2组的中性粒细胞、淋巴细胞、NLR及生化指标水平,采用Logistic回归分析早期DN的...目的探讨中性粒细胞与淋巴细胞的比值(NLR)在早期糖尿病肾病(DN)患者中的变化及意义。方法选取91例确诊为早期DN的患者为DN组,54例正常健康人为对照组,比较2组的中性粒细胞、淋巴细胞、NLR及生化指标水平,采用Logistic回归分析早期DN的影响因素。结果 DN组的肌酐(Cr)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、中性粒细胞、C反应蛋白(CRP)高于对照组,淋巴细胞数低于对照组(均P<0.05);DN组的NLR水平高于对照组(2.52±0.57 vs 1.82±0.60,t=6.997,P<0.01)。Logistic回归分析表明,NLR、TG、TC升高均是DN的危险因素。结论 NLR升高是早期DN的高危因素,可预测早期DN的发生。展开更多
基金Supported by National Nature Science Foundation of China,No.81672343 and No.81372341Guangdong Province Natural Science Fund of China,No.2014A030310111Guangdong Science and Technology Plan Project of China,No.2013B021800131and No.201604020003
文摘AIM To investigate the clinical significance of preoperative systemic immune-inflammation index(SII) in patients with colorectal cancer(CRC). METHODS A retrospective analysis of 1383 cases with CRC was performed following radical surgery. SII was calculated with the formula SII =(P × N)/L, where P, N, and L refer to peripheral platelet, neutrophil, and lymphocyte counts, respectively. The clinicopathological features and follow-up data were evaluated to compare SII with other systemic inflammation-based prognostic indices such as the neutrophil-lymphocyte ratio(NLR) and platelet-lymphocyte ratio(PLR) in patients with CRC.RESULTS The optimal cut-off point for SII was defined as 340. The overall survival(OS) and disease-free survival(DFS) were better in patients with low NLR, PLR, and SII(P < 0.05). The SII was an independent predictor of OS and DFS in multivariate analysis. The area under the receiver-operating characteristics(ROC) curve for SII(0.707) was larger than those for NLR(0.602) and PLR(0.566). In contrast to NLR and PLR, SII could effectively discriminate between the TNM subgroups. CONCLUSION SII is a more powerful tool for predicting survival outcome in patients with CRC. It might assist the identification of high-risk patients among patients with the same TNM stage.
文摘目的探讨中性粒细胞与淋巴细胞比值(NLR)在亚特兰大新分类标准下预测急性胰腺炎严重程度的价值。方法回顾性分析118例急性胰腺炎患者的临床资料,按亚特兰大新分类标准将其分为轻度急性胰腺炎(MAP)、中度急性胰腺炎(MSAP)及重度急性胰腺炎(SAP)3组,观察各组的血NLR水平在入院后第1天、第7天及出院时的动态变化以及在各个时间点上的组间差异。评估NLR与APACHEII评分、住ICU天数、住院天数的相关性,并采用受试者工作特征(ROC)曲线比较NLR、血尿素氮(BUN)、APACHEII评分及NLR联合BUN预测急性胰腺炎严重程度的有效性。结果在入院后第1天及第7天,NLR的水平依次为SAP组>MSAP组>MAP组(P=0.000)。NLR水平与APACHEII评分、住ICU天数、住院天数呈正相关(分别为r=0.577,P=0.000;r=0.527,P=0.000;r=0.597,P=0.000)。NLR在预测中度与重度急性胰腺炎时的曲线下面积与APACHEII评分无统计学差异,但优于BUN(0.876±0.032 vs 0.873±0.031,P=0.944;0.876±0.032 vs 0.660±0.050,P=0.000);预测重度急性胰腺炎时,NLR与APACHEII评分及BUN均无统计学差异(0.794±0.053 vs 0.892±0.033,P=0.118;0.794±0.053 vs 0.745±0.064,P=0.560),将NLR与BUN联合后可增加曲线下面积和诊断特异度。结论 NLR在预测急性胰腺炎严重程度上具有一定的临床意义。
文摘AIM To investigated the prognostic value of the neutrophillymphocyte ratio(NLR) in patients with acute pancreatitis and determined an optimal cut-off value for the prediction of adverse outcomes in these patients.METHODS We retrospectively analyzed 490 patients with acute pancreatitis diagnosed between March 2007 and December 2012. NLRs were calculated at admission and 24, 48, and 72 h after admission. Patients were grouped according to acute pancreatitis severity and organ failure occurrence, and a comparative analysis was performed to compare the NLR between groups. RESULTS Among the 490 patients, 70 had severe acute pancreatitis with 31 experiencing organ failure. The severe acute pancreatitis group had a significantly higher NLR than the mild acute pancreatitis group on all 4 d(median, 6.14, 6.71, 5.70, and 4.00 vs 4.74, 4.47, 3.20, and 3.30, respectively, P < 0.05). The organ failure group had a significantly higher NLR than the group without organ failure on all 4 d(median, 7.09, 6.72, 6.27, and 6.24 vs 4.85, 4.49, 3.35, and 2.34, respectively, P < 0.05). The optimal cut-off value for baseline NLR was 4.76 in predicting severity and 4.88in predicting organ failure in acute pancreatitis. CONCLUSION Elevated baseline NLR correlates with severe acute pancreatitis and organ failure.
文摘目的中性粒细胞与淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)是反应系统性炎症反应的定量指标之一,最近已经有一些研究探索了NLR可以作为反应急性胰腺炎(acute pancreatitis,AP)严重程度的重要指标,但是不同研究间存在不一致性.因此,在这项研究中,我们首次系统性地评估了不同研究中性粒细胞与淋巴细胞比值对急性胰腺炎严重程度的预测价值.方法我们在PubMed,Embase,Web of Science和Cochrane Library数据库中检索2019年4月以前关于中性粒细胞与淋巴细胞比值和胰腺炎的相关文章.三位作者分别独立审查检索到的文章.如果文章是探讨中性粒细胞与淋巴细胞比值预测急性胰腺炎严重程度的文献则纳入研究.如果是个案报道、综述、基础研究、动物实验、会议摘要则被排除.所有纳入文献的质量评分采用诊断准确性研究的质量评估-2指南(Quality Assessment of Diagnostic Accuracy Studies-2 guidelines,QUADAS-2)进行评估.双变量随机效应模型用于中性粒细胞与淋巴细胞比值预测胰腺炎严重程度的效应量的合并.结果:这项研究总共纳入10项研究(1713例患者),合并后的诊断效应量分别如下:敏感度0.76(0.68~0.82)、特异度0.72(0.61~0.81)、阳性似然比2.7(1.8~4.0)、阴性似然比0.34(0.24~0.48)、受试者工作曲线下面积0.79(0.75~0.82)和诊断比值比8(4~16).结论:NLR是一种容易检测且价格低廉的标记物,具有一定的诊断价值,能够预测急性胰腺炎患者的严重程度,从而为临床上急性胰腺炎的治疗提供新的思路.
文摘目的探讨中性粒细胞与淋巴细胞的比值(NLR)在早期糖尿病肾病(DN)患者中的变化及意义。方法选取91例确诊为早期DN的患者为DN组,54例正常健康人为对照组,比较2组的中性粒细胞、淋巴细胞、NLR及生化指标水平,采用Logistic回归分析早期DN的影响因素。结果 DN组的肌酐(Cr)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、中性粒细胞、C反应蛋白(CRP)高于对照组,淋巴细胞数低于对照组(均P<0.05);DN组的NLR水平高于对照组(2.52±0.57 vs 1.82±0.60,t=6.997,P<0.01)。Logistic回归分析表明,NLR、TG、TC升高均是DN的危险因素。结论 NLR升高是早期DN的高危因素,可预测早期DN的发生。
