Peroxisome proliferator-activated receptorγ(PPARγ)is a transcriptional coactivator that binds to a diverse range of transcription factors.PPARγcoactivator 1(PGC-1)coactivators possess an extensive range of biologic...Peroxisome proliferator-activated receptorγ(PPARγ)is a transcriptional coactivator that binds to a diverse range of transcription factors.PPARγcoactivator 1(PGC-1)coactivators possess an extensive range of biological effects in different tissues,and play a key part in the regulation of the oxidative metabolism,consequently modulating the production of reactive oxygen species,autophagy,and mitochondrial biogenesis.Owing to these findings,a large body of studies,aiming to establish the role of PGC-1 in the neuromuscular system,has shown that PGC-1 could be a promising target for therapies targeting neuromuscular diseases.Among these,some evidence has shown that various signaling pathways linked to PGC-1αare deregulated in muscular dystrophy,leading to a reduced capacity for mitochondrial oxidative phosphorylation and increased reactive oxygen species(ROS)production.In the light of these results,any intervention aimed at activating PGC-1 could contribute towards ameliorating the progression of muscular dystrophies.PGC-1αis influenced by different patho-physiological/pharmacological stimuli.Natural products have been reported to display modulatory effects on PPARγactivation with fewer side effects in comparison to synthetic drugs.Taken together,this review summarizes the current knowledge on Duchenne muscular dystrophy,focusing on the potential effects of natural compounds,acting as regulators of PGC-1α.展开更多
Esophageal cancer(ESC)is a malignant tumor that originates from the mucosal epithelium of the esophagus and is part of the digestive tract.Although the exact pathogenesis of ESC has not been fully elucidated,excessive...Esophageal cancer(ESC)is a malignant tumor that originates from the mucosal epithelium of the esophagus and is part of the digestive tract.Although the exact pathogenesis of ESC has not been fully elucidated,excessive oxidative stress is an important characteristic that leads to the development of many cancers.Abnormal expression of several proteins and transcription factors contributes to oxidative stress in ESCs,which alters the growth and proliferation of ESCs and promotes their metastasis.Natural compounds,including alkaloids,terpenes,polyphenols,and xanthine compounds,can inhibit reactive oxygen species production in ESCs.These compounds reduce oxidative stress levels and subsequently inhibit the oc-currence and progression of ESC through the regulation of targets and pathways such as the cytokine interleukins 6 and 10,superoxide dismutase,the NF-+ACY-kappa+ADs-B/MAPK pathway,and the mammalian Nrf2/ARE target pathway.Thus,targeting tumor oxidative stress has become a key focus in anti-ESC therapy.This review discusses the potential of Natural products(NPs)for treating ESCs and summarizes the application prospects of oxidative stress as a new target for ESC treatment.The findings of this review provide a reference for drug development targeting ESCs.Nonetheless,further high-quality studies will be necessary to determine the clinical efficacy of these various NPs.展开更多
Natural siderite(FeCO_(3)),simulated synthetic siderite and nZVI/FeCO_(3) composite were used as green and easily available iron-based catalysts in peroxydisulfate activation for remediating 2-chlorophenol as the targ...Natural siderite(FeCO_(3)),simulated synthetic siderite and nZVI/FeCO_(3) composite were used as green and easily available iron-based catalysts in peroxydisulfate activation for remediating 2-chlorophenol as the target contaminant and this technique can effectively degrade organic pollutants in the soil.The key reaction parameters such as catalysts dosage,oxidant concentration and pH,were investigated to evaluate the catalytic performance of different materials in catalytic systems.The buffering property of natural soil conduced satisfactory degradation performance in a wide pH range(3-10).Both the main non-radical of ^(1)O_(2) and free radicals of SO_(4)^(-) and OH·were evidenced by quenching experiment and electron paramagnetic resonance.The reduction of nZVI on FFC surface not only has the advantage for electronic transfer to promote the circulation of Fe(Ⅲ)to Fe(Ⅱ),but also can directly dechlorinate.Furthermore,the intermediates were comprehensively analyzed by GC-MS and a potential removal mechanism of three oxidant system for 2-CP soil degradation was obtained.Briefly,this research provides a new perspective for organic contaminate soil treatment using natural siderite or simulated synthetic siderite as efficient and environmental catalytic material.展开更多
The major findings in this report are(ⅰ)development of nanocomposite photocatalyst working through Z-scheme charge transfer pathway across the heterojunction,(ⅱ)utilization of direct sunlight as the photo-source,and...The major findings in this report are(ⅰ)development of nanocomposite photocatalyst working through Z-scheme charge transfer pathway across the heterojunction,(ⅱ)utilization of direct sunlight as the photo-source,and(ⅲ)prospect of ligand-hole in photocatalysis through enhanced sub-band gap absorption,The photocatalysts,namely LaNiO_(3),g-C_(3)N_(4) and LaNiO_(3)/g-C_(3)N_(4) nanocomposites were synthesized via facile route and were characterized for their structure,morphology,microstructure,texture,elemental mapping and surface oxidation states by using several physicochemical techniques.The photocatalytic performance of the nanocomposite was tested through the degradation of hazardous azo dye pollutants,namely reactive black 5 and methylene blue as well as the colorless antibiotic-pollutant tetracycline hydrochloride in aqueous solution in presence of natural sunlight with excellent recycling activity.The 10%LaNiO_(3)/g-C_(3)N_(4) nanocomposite sample shows the best catalytic activity,degrading respectively 94%,98.6%and 88.1%of reactive black 5,methylene blue and tetracycline hydrochloride in60,180 and 120 min.The photocatalytic activity of the nanocomposite phase is several times superior to that of the pure phases.The improvements of photocatalytic activity of g-C_(3)N_(4) in the nanocomposite have been rationalized through the construction of direct Z-scheme heterojunction and suppression of electron-hole pair recombination efficiency.The enhanced photo-absorption of the nanocomposite can possibly be related to sub-bandgap absorption,which is associated to the midgap state originating from ligand-hole formation or defects in the structure.The photodegradation process is mediated through the formation of super oxide radical(O_(2))and hole(h^(+))as the main responsible species.展开更多
Nowadays, endocrine disruptor compounds in the water system have become a concern due to the risk of contamination to wild life and humans even at the nanogram level. Excess estrogens and androgens are a major contrib...Nowadays, endocrine disruptor compounds in the water system have become a concern due to the risk of contamination to wild life and humans even at the nanogram level. Excess estrogens and androgens are a major contributor group of endocrine compounds. Statistical surveys have shown that dairy farms contribute to over 90% of the total estrogens in the UK and US. Reporter gene assays (RGAs) is being developed to assess the efficiency of reactive materials to remove target hormonal contaminants from dairy farm wastewater. This study demonstrates that 2 g of reactive materials (granular activated carbon (GAC), zero-valent iron (ZVI) and organoclay) efficiently removed over 50% of 17β-estradiol and 92% Testosterone over a 24 h period from 20 ml of HPLC grade water spiked at a concentration of 1000 ng l-1. Therefore, these materials may be useful adsorbents for the advanced treatment of residual natural hormones in dairy farm wastewater.展开更多
基金supported by the crowd funding#Sport4Therapy to Giuseppe D’Antona(Italy)supported by Instituto de Salud CarlosⅢ,Grant Number:CIBEROBN CB12/03/30038
文摘Peroxisome proliferator-activated receptorγ(PPARγ)is a transcriptional coactivator that binds to a diverse range of transcription factors.PPARγcoactivator 1(PGC-1)coactivators possess an extensive range of biological effects in different tissues,and play a key part in the regulation of the oxidative metabolism,consequently modulating the production of reactive oxygen species,autophagy,and mitochondrial biogenesis.Owing to these findings,a large body of studies,aiming to establish the role of PGC-1 in the neuromuscular system,has shown that PGC-1 could be a promising target for therapies targeting neuromuscular diseases.Among these,some evidence has shown that various signaling pathways linked to PGC-1αare deregulated in muscular dystrophy,leading to a reduced capacity for mitochondrial oxidative phosphorylation and increased reactive oxygen species(ROS)production.In the light of these results,any intervention aimed at activating PGC-1 could contribute towards ameliorating the progression of muscular dystrophies.PGC-1αis influenced by different patho-physiological/pharmacological stimuli.Natural products have been reported to display modulatory effects on PPARγactivation with fewer side effects in comparison to synthetic drugs.Taken together,this review summarizes the current knowledge on Duchenne muscular dystrophy,focusing on the potential effects of natural compounds,acting as regulators of PGC-1α.
文摘Esophageal cancer(ESC)is a malignant tumor that originates from the mucosal epithelium of the esophagus and is part of the digestive tract.Although the exact pathogenesis of ESC has not been fully elucidated,excessive oxidative stress is an important characteristic that leads to the development of many cancers.Abnormal expression of several proteins and transcription factors contributes to oxidative stress in ESCs,which alters the growth and proliferation of ESCs and promotes their metastasis.Natural compounds,including alkaloids,terpenes,polyphenols,and xanthine compounds,can inhibit reactive oxygen species production in ESCs.These compounds reduce oxidative stress levels and subsequently inhibit the oc-currence and progression of ESC through the regulation of targets and pathways such as the cytokine interleukins 6 and 10,superoxide dismutase,the NF-+ACY-kappa+ADs-B/MAPK pathway,and the mammalian Nrf2/ARE target pathway.Thus,targeting tumor oxidative stress has become a key focus in anti-ESC therapy.This review discusses the potential of Natural products(NPs)for treating ESCs and summarizes the application prospects of oxidative stress as a new target for ESC treatment.The findings of this review provide a reference for drug development targeting ESCs.Nonetheless,further high-quality studies will be necessary to determine the clinical efficacy of these various NPs.
基金supported by the National Key Research and Development Program(No.2018YFC1802605)Sichuan Province Department of Science and Technology(No.2022YFQ0081)+1 种基金International Cooperation Project of Sichuan Province(No.2019YFH1027)Sichuan University-Yibin City school and City Strategic Cooperation Project(Nos.2019CDYB-26,2020CDYB-9).
文摘Natural siderite(FeCO_(3)),simulated synthetic siderite and nZVI/FeCO_(3) composite were used as green and easily available iron-based catalysts in peroxydisulfate activation for remediating 2-chlorophenol as the target contaminant and this technique can effectively degrade organic pollutants in the soil.The key reaction parameters such as catalysts dosage,oxidant concentration and pH,were investigated to evaluate the catalytic performance of different materials in catalytic systems.The buffering property of natural soil conduced satisfactory degradation performance in a wide pH range(3-10).Both the main non-radical of ^(1)O_(2) and free radicals of SO_(4)^(-) and OH·were evidenced by quenching experiment and electron paramagnetic resonance.The reduction of nZVI on FFC surface not only has the advantage for electronic transfer to promote the circulation of Fe(Ⅲ)to Fe(Ⅱ),but also can directly dechlorinate.Furthermore,the intermediates were comprehensively analyzed by GC-MS and a potential removal mechanism of three oxidant system for 2-CP soil degradation was obtained.Briefly,this research provides a new perspective for organic contaminate soil treatment using natural siderite or simulated synthetic siderite as efficient and environmental catalytic material.
基金Project supported by the Science and Engineering Research Board(SERB),Government of India(EMR/2016/001811,EMR/2016/000083)。
文摘The major findings in this report are(ⅰ)development of nanocomposite photocatalyst working through Z-scheme charge transfer pathway across the heterojunction,(ⅱ)utilization of direct sunlight as the photo-source,and(ⅲ)prospect of ligand-hole in photocatalysis through enhanced sub-band gap absorption,The photocatalysts,namely LaNiO_(3),g-C_(3)N_(4) and LaNiO_(3)/g-C_(3)N_(4) nanocomposites were synthesized via facile route and were characterized for their structure,morphology,microstructure,texture,elemental mapping and surface oxidation states by using several physicochemical techniques.The photocatalytic performance of the nanocomposite was tested through the degradation of hazardous azo dye pollutants,namely reactive black 5 and methylene blue as well as the colorless antibiotic-pollutant tetracycline hydrochloride in aqueous solution in presence of natural sunlight with excellent recycling activity.The 10%LaNiO_(3)/g-C_(3)N_(4) nanocomposite sample shows the best catalytic activity,degrading respectively 94%,98.6%and 88.1%of reactive black 5,methylene blue and tetracycline hydrochloride in60,180 and 120 min.The photocatalytic activity of the nanocomposite phase is several times superior to that of the pure phases.The improvements of photocatalytic activity of g-C_(3)N_(4) in the nanocomposite have been rationalized through the construction of direct Z-scheme heterojunction and suppression of electron-hole pair recombination efficiency.The enhanced photo-absorption of the nanocomposite can possibly be related to sub-bandgap absorption,which is associated to the midgap state originating from ligand-hole formation or defects in the structure.The photodegradation process is mediated through the formation of super oxide radical(O_(2))and hole(h^(+))as the main responsible species.
文摘Nowadays, endocrine disruptor compounds in the water system have become a concern due to the risk of contamination to wild life and humans even at the nanogram level. Excess estrogens and androgens are a major contributor group of endocrine compounds. Statistical surveys have shown that dairy farms contribute to over 90% of the total estrogens in the UK and US. Reporter gene assays (RGAs) is being developed to assess the efficiency of reactive materials to remove target hormonal contaminants from dairy farm wastewater. This study demonstrates that 2 g of reactive materials (granular activated carbon (GAC), zero-valent iron (ZVI) and organoclay) efficiently removed over 50% of 17β-estradiol and 92% Testosterone over a 24 h period from 20 ml of HPLC grade water spiked at a concentration of 1000 ng l-1. Therefore, these materials may be useful adsorbents for the advanced treatment of residual natural hormones in dairy farm wastewater.
