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PTP1B抑制剂抗糖尿病作用的研究进展
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作者 吴佳敏 应宇琦 +2 位作者 杨尊华 金一 房元英 《沈阳药科大学学报》 CAS CSCD 北大核心 2023年第8期1098-1110,共13页
糖尿病是目前世界范围内严重威胁人类健康的慢性疾病之一,常伴有严重的临床并发症,如糖尿病性心肌病、肾病、视网膜病变、神经病变等。2型糖尿病(type 2 diabetes mellitus,T2DM)是最常见的糖尿病类型,其发展受到多种遗传因素和环境因... 糖尿病是目前世界范围内严重威胁人类健康的慢性疾病之一,常伴有严重的临床并发症,如糖尿病性心肌病、肾病、视网膜病变、神经病变等。2型糖尿病(type 2 diabetes mellitus,T2DM)是最常见的糖尿病类型,其发展受到多种遗传因素和环境因素影响。蛋白酪氨酸磷酸酶1B(protein tyrosine phosphatase 1B,PTP1B)在胰岛素信号转导通路负调控中发挥重要作用,已成为治疗2型糖尿病(diabetes mellitus type 2,T2DM)和肥胖症的有效靶点,探索高效安全的PTP1B抑制剂受到越来越多的关注,本文作者以PTP1B酶与T2DM和肥胖症的关系为基础,归纳整理了近年来国内外PTPIB治疗糖尿病的相关文献,综述了PTP1B抑制剂包括天然产物,天然产物衍生物,合成小分子的研究进展,旨在为设计靶向抑制PTP1B的抗糖尿病和肥胖药物的开发提供思路。 展开更多
关键词 蛋白酪氨酸磷酸酶1B抑制剂 天然产物衍生物 合成小分子 抗糖尿病药物
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Natural products:Perspectives in the pharmacological treatment of gastrointestinal anisakiasis 被引量:2
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作者 Valero A Romero MC +2 位作者 Gómez-Mateos M Hierro I Navarro MC 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2015年第8期604-609,共6页
Objective: To evaluate the activity of different natural products against L3 larvae of Anisakis type I. Methods: Information on investigations into the activity of natural products against the L3 larvae of Anisakis si... Objective: To evaluate the activity of different natural products against L3 larvae of Anisakis type I. Methods: Information on investigations into the activity of natural products against the L3 larvae of Anisakis simplex was collected from scientific journals, books, theses and reports via a library and electronic search(using Pubmed, Scopus, Medline, Web of Science and Science Direct). The search terms included: natural products, medicinal plants, essential oils, terpenic derivatives, Anisakis, antinematodal activity. Results: In the literature reviewed numerous papers were found concerning the in vitro and in vivo activity against Anisakis type I of various natural products(plant extracts, essential oils and their major components). Analysis of the results showed that in vitro tests the Melaleuca alternifolia essential oil and the ar-turmerone isolated from Curcuma longa displayed the greatest activity. In vivo, the most active compound was perillaldehyde, the main component of Perilla frutescens essential oil. Conclusions: This study shows that some natural products exhibited promising antianisakis properties. 展开更多
关键词 ANISAKIS ANISAKIASIS natural products ESSENTIAL OILS Terpenic derivatives
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