Nanotechnology is gaining tremendous impetus due to its capability of modulating metals into their nanosize, which drastically changes the chemical, physical and optical properties of metals. Nanoparticles have been i...Nanotechnology is gaining tremendous impetus due to its capability of modulating metals into their nanosize, which drastically changes the chemical, physical and optical properties of metals. Nanoparticles have been intro- duced as materials with good potential to be extensively used in biological and medical applications. Nanoparticles are clusters of atoms in the size range of 1-100 nm. Inorganic nanoparticles and their nano-composites are applied as good antibacterial agents. Due to the outbreak of infectious diseases caused by different pathogenic bacteria and the development of antibiotic resistance, pharmaceutical companies and researchers are searching for new antibacterial agents. The metallic nanoparticles are the most promising as they show good antibacterial properties due to their large surface area to volume ratios, which draw growing interest from researchers due to increasing microbial resistance against metal ions, antibiotics and the development of resistant strains. Metallic nanoparticles can be used as effective growth inhibitors in various microorganisms and thereby are applicable to diverse medical devices. Nanotechnology discloses the use of elemental nanoparticles as active antibacterial ingredient for dental materials. In dentistry, both restorative materials and oral bacteria are believed to be responsible for restoration failure. Secondary caries is found to be the main reason to restoration failure. Secondary caries is primarily caused by invasion of plaque bacteria （acid-producing bacteria） such as Streptococcus mutans and lactobacilli in the presence of fermentable carbohydrates. To make long-lasting restorations, antibacterial materials should be made. The potential of nanoparticles to control the formation of biofilms within the oral cavity is also coming under in- creasing scrutiny. Possible uses of nanoparticles as topically applied agents within dental materials and the appli- cation of nanoparticles in the control of oral infections are also reviewed.展开更多
从废弃蚕茧及缫丝下脚料中提取纯净丝素蛋白,采用盐溶酶解法制备纳米级丝素蛋白（SFP）,按照不同配比与聚乙烯醇（PVA）采用水相混合后制备出嵌入纳米级丝素蛋白颗粒的聚乙烯醇（SFP in PVA）膜,对膜进行表征并测定其促细胞生长性能。使...从废弃蚕茧及缫丝下脚料中提取纯净丝素蛋白,采用盐溶酶解法制备纳米级丝素蛋白（SFP）,按照不同配比与聚乙烯醇（PVA）采用水相混合后制备出嵌入纳米级丝素蛋白颗粒的聚乙烯醇（SFP in PVA）膜,对膜进行表征并测定其促细胞生长性能。使用60%NaSCN溶解丝素蛋白后,采用α-糜蛋白酶、胰蛋白酶、中性蛋白酶进行酶解筛选试验,通过场发射扫描电镜观察,发现中性蛋白酶酶解得到的SFP粉末尺寸约为80~150 nm,颗粒均匀。红外光谱表征确认了SFP/PVA膜的基团间结合;扫描电镜显示SFP以微细线段状镶嵌在PVA膜中。对镶嵌膜的SFP/PVA进行了10/90、20/80、30/70、40/60四种配比的筛选试验,通过膜的表面观察、水中形态稳定性观测和促CHO细胞生长性能测试（MTT法）,结果显示,SFP/PVA配比为30/70的镶嵌膜表面光滑、水中形态稳定,促进CHO细胞快速黏附和生长性能最优。展开更多
A new kind of nano-biomaterials of nano apatite （ NA ） and polyamide8063 （ PA ） composite was prepared by direct using NA slurry. The experimental results showed that the NA content in the composite was similar to...A new kind of nano-biomaterials of nano apatite （ NA ） and polyamide8063 （ PA ） composite was prepared by direct using NA slurry. The experimental results showed that the NA content in the composite was similar to that of natural bone. Interfrace chemical bonding was formed between NA and PA. The NA keeps the original morphological structure with a crystal size of 10- 30 nm in width by 50- 90 nm in length with a ratio of - 2.5 and distributed uniformly in thepolymer. The synthetic nano-biomaterials could be one of the best bioactive materials for load-bearing bone repair or substitution materials.展开更多
文摘Nanotechnology is gaining tremendous impetus due to its capability of modulating metals into their nanosize, which drastically changes the chemical, physical and optical properties of metals. Nanoparticles have been intro- duced as materials with good potential to be extensively used in biological and medical applications. Nanoparticles are clusters of atoms in the size range of 1-100 nm. Inorganic nanoparticles and their nano-composites are applied as good antibacterial agents. Due to the outbreak of infectious diseases caused by different pathogenic bacteria and the development of antibiotic resistance, pharmaceutical companies and researchers are searching for new antibacterial agents. The metallic nanoparticles are the most promising as they show good antibacterial properties due to their large surface area to volume ratios, which draw growing interest from researchers due to increasing microbial resistance against metal ions, antibiotics and the development of resistant strains. Metallic nanoparticles can be used as effective growth inhibitors in various microorganisms and thereby are applicable to diverse medical devices. Nanotechnology discloses the use of elemental nanoparticles as active antibacterial ingredient for dental materials. In dentistry, both restorative materials and oral bacteria are believed to be responsible for restoration failure. Secondary caries is found to be the main reason to restoration failure. Secondary caries is primarily caused by invasion of plaque bacteria （acid-producing bacteria） such as Streptococcus mutans and lactobacilli in the presence of fermentable carbohydrates. To make long-lasting restorations, antibacterial materials should be made. The potential of nanoparticles to control the formation of biofilms within the oral cavity is also coming under in- creasing scrutiny. Possible uses of nanoparticles as topically applied agents within dental materials and the appli- cation of nanoparticles in the control of oral infections are also reviewed.
文摘从废弃蚕茧及缫丝下脚料中提取纯净丝素蛋白,采用盐溶酶解法制备纳米级丝素蛋白（SFP）,按照不同配比与聚乙烯醇（PVA）采用水相混合后制备出嵌入纳米级丝素蛋白颗粒的聚乙烯醇（SFP in PVA）膜,对膜进行表征并测定其促细胞生长性能。使用60%NaSCN溶解丝素蛋白后,采用α-糜蛋白酶、胰蛋白酶、中性蛋白酶进行酶解筛选试验,通过场发射扫描电镜观察,发现中性蛋白酶酶解得到的SFP粉末尺寸约为80~150 nm,颗粒均匀。红外光谱表征确认了SFP/PVA膜的基团间结合;扫描电镜显示SFP以微细线段状镶嵌在PVA膜中。对镶嵌膜的SFP/PVA进行了10/90、20/80、30/70、40/60四种配比的筛选试验,通过膜的表面观察、水中形态稳定性观测和促CHO细胞生长性能测试（MTT法）,结果显示,SFP/PVA配比为30/70的镶嵌膜表面光滑、水中形态稳定,促进CHO细胞快速黏附和生长性能最优。
文摘A new kind of nano-biomaterials of nano apatite （ NA ） and polyamide8063 （ PA ） composite was prepared by direct using NA slurry. The experimental results showed that the NA content in the composite was similar to that of natural bone. Interfrace chemical bonding was formed between NA and PA. The NA keeps the original morphological structure with a crystal size of 10- 30 nm in width by 50- 90 nm in length with a ratio of - 2.5 and distributed uniformly in thepolymer. The synthetic nano-biomaterials could be one of the best bioactive materials for load-bearing bone repair or substitution materials.
