Objective： To observe the therapeutic efficacy and the mechanism of Chinese medicine eye-patch with invigorating blood circulation and detoxification on asthenopia. Methods： A total of 180 rabbits were subjected to ...Objective： To observe the therapeutic efficacy and the mechanism of Chinese medicine eye-patch with invigorating blood circulation and detoxification on asthenopia. Methods： A total of 180 rabbits were subjected to three tests, namely the skin microcircuiation, the microvascular regeneration in the skin and the skin temperature change, with 60 rabbits for each test. The rabbits in each test were randomly and equally divided into three groups： the normal control group was treated with physiological saline on naked back once per day, the low dose group was treated with the eye-patch on naked back for 15 min once per day, while the high dose group was treated for three times per day. Forty Hartley guinea pigs were randomly and equally divided into four groups for the muscle tone test： the normal control group was treated with physiological saline on naked back, the model group was treated without any medication, the low dose group was treated with the eye-patch on naked back for 10 min once per day, while the high dose group was treated for three times per day. All treatments were continued for 14 days until the termination of the test. The microcirculatory blood flow was observed by using a video-microscopy system. The histological sections were used to detect the microvascular regeneration by observing the expression of factor V$. The temperature changes on the skin surface were measured by using infrared thermometer, and the muscle tone was tested by the electromyography. Results： In compare with the normal or the model group, the improvement in the skin microcirculation and the blood vascular regeneration, and the decreasing in the muscle tone in low dose and high dose groups were statistically significant with confident level at P〈0.05. Conclusions： The eye-patch with invigorating blood circulation and detoxification has great enhancement in blood vascular regeneration and skin microcirculation, and great improvement in the indexes for muscle tone. The study explains certain therapeutic efficacy a展开更多
Objective To investigate the relationship between muscular asthenopia post photorefractive keratectomy (PRK) and eccentric ablation.Methods 16 eyes of 8 myopia cases whose muscular asthenopia was corrected by subjec...Objective To investigate the relationship between muscular asthenopia post photorefractive keratectomy (PRK) and eccentric ablation.Methods 16 eyes of 8 myopia cases whose muscular asthenopia was corrected by subjectively accepted triangular prism after PRK with vision more than 0.8 were followed up for 6-14 months. On the basis of data provided by the pre-PRK, post-PRK and their difference corneal topography, we calculated the real corrected corneal diopter (D) with the Holladay formula and measured the ablating eccentricity (h) and its direction. According to the formula δ≈Dh, the prism effective value (δ) caused by the eccentric ablation was computed and compared with objectively accepted triangular prism.Results The subjectively accepted prism was similar to values calculated from the formula. Their mean difference is 0.10±0.25. The direction of the subjectively accepted prism was in the direction of ablation deviation.Conclusions Eccentric ablation was the chief cause of post-PRK muscular visual asthenopia. The triangular prism effective value from eccentric ablation may be estimated by the formula δ≈Dh. We must pay attention to the diagnosis, treatment and prevention of post-PRK muscular asthenopia.展开更多
基金Supported by the Research Fund of Capital Medical Development(No.SF-2009-1-10)
文摘Objective： To observe the therapeutic efficacy and the mechanism of Chinese medicine eye-patch with invigorating blood circulation and detoxification on asthenopia. Methods： A total of 180 rabbits were subjected to three tests, namely the skin microcircuiation, the microvascular regeneration in the skin and the skin temperature change, with 60 rabbits for each test. The rabbits in each test were randomly and equally divided into three groups： the normal control group was treated with physiological saline on naked back once per day, the low dose group was treated with the eye-patch on naked back for 15 min once per day, while the high dose group was treated for three times per day. Forty Hartley guinea pigs were randomly and equally divided into four groups for the muscle tone test： the normal control group was treated with physiological saline on naked back, the model group was treated without any medication, the low dose group was treated with the eye-patch on naked back for 10 min once per day, while the high dose group was treated for three times per day. All treatments were continued for 14 days until the termination of the test. The microcirculatory blood flow was observed by using a video-microscopy system. The histological sections were used to detect the microvascular regeneration by observing the expression of factor V$. The temperature changes on the skin surface were measured by using infrared thermometer, and the muscle tone was tested by the electromyography. Results： In compare with the normal or the model group, the improvement in the skin microcirculation and the blood vascular regeneration, and the decreasing in the muscle tone in low dose and high dose groups were statistically significant with confident level at P〈0.05. Conclusions： The eye-patch with invigorating blood circulation and detoxification has great enhancement in blood vascular regeneration and skin microcirculation, and great improvement in the indexes for muscle tone. The study explains certain therapeutic efficacy a
文摘Objective To investigate the relationship between muscular asthenopia post photorefractive keratectomy (PRK) and eccentric ablation.Methods 16 eyes of 8 myopia cases whose muscular asthenopia was corrected by subjectively accepted triangular prism after PRK with vision more than 0.8 were followed up for 6-14 months. On the basis of data provided by the pre-PRK, post-PRK and their difference corneal topography, we calculated the real corrected corneal diopter (D) with the Holladay formula and measured the ablating eccentricity (h) and its direction. According to the formula δ≈Dh, the prism effective value (δ) caused by the eccentric ablation was computed and compared with objectively accepted triangular prism.Results The subjectively accepted prism was similar to values calculated from the formula. Their mean difference is 0.10±0.25. The direction of the subjectively accepted prism was in the direction of ablation deviation.Conclusions Eccentric ablation was the chief cause of post-PRK muscular visual asthenopia. The triangular prism effective value from eccentric ablation may be estimated by the formula δ≈Dh. We must pay attention to the diagnosis, treatment and prevention of post-PRK muscular asthenopia.
