Rationally designed multiporphyrinic architectures for boosting photodynamic therapy(PDT)have attracted significant attentions recently years due to their great potential for light-mediated generation of reactive oxyg...Rationally designed multiporphyrinic architectures for boosting photodynamic therapy(PDT)have attracted significant attentions recently years due to their great potential for light-mediated generation of reactive oxygen species.However,there is still a gap between the structure design and their PDT performance for biomedical applications.This tutorial review provides a historical overview on(i)the basic concept of PDT for deeply understanding the porphyrin-mediated PDT reactions,(ii)developing strategies for constructing porphyrinic architectures,like nanorings,boxes,metal-organic frameworks(MOFs),covalent-organic frameworks(COFs),vesicles,etc.,where we classified into the following three categories:multiporphyrin arrays,porphyrinic frameworks,and others porphyrin assemblies,(iii)the various application scenarios for clinical cancer therapy and antibacterial infection.Also,the existing challenges and future perspectives on the innovation of porphyrinic architectures for clinical PDT applications are mentioned in the end section.Moreover,the porphyrinic nanomaterials with atomically precise architectures provide an ideal platform for investigating the relationship between structures and PDT outputs,design of personalized“all-in-one”theranostic agents,and the popularization and application in wider biomedical fields.展开更多
1 Results Manganese porphyrins have attracted growing interest because of their unique physical and chemical properties,such as mimicking the role of Mn complex in photosystem Ⅱ and acting as electrocatalysts towards...1 Results Manganese porphyrins have attracted growing interest because of their unique physical and chemical properties,such as mimicking the role of Mn complex in photosystem Ⅱ and acting as electrocatalysts towards the oxidation of nitric oxide and nitrite.As one of the bottom-up techniques,we are currently investigating the design,preparation and opto-electrochemical properties of metal-mediated multiporphyrin arrays on the solid surfaces.Because the porphyrins are connected by metal ions via coordin...展开更多
基金National Key R&D Program of China,Grant/Award Number:2020YFA0908500National Natural Science Foundation of China,Grant/Award Numbers:22371062,22001054,22075065,22275046+1 种基金Zhejiang Provincial Natural Science Foundation,Grant/Award Number:LY23E030001Hangzhou Leading Innovation and Entrepreneurship Team Project,Grant/Award Number:TD2022001。
文摘Rationally designed multiporphyrinic architectures for boosting photodynamic therapy(PDT)have attracted significant attentions recently years due to their great potential for light-mediated generation of reactive oxygen species.However,there is still a gap between the structure design and their PDT performance for biomedical applications.This tutorial review provides a historical overview on(i)the basic concept of PDT for deeply understanding the porphyrin-mediated PDT reactions,(ii)developing strategies for constructing porphyrinic architectures,like nanorings,boxes,metal-organic frameworks(MOFs),covalent-organic frameworks(COFs),vesicles,etc.,where we classified into the following three categories:multiporphyrin arrays,porphyrinic frameworks,and others porphyrin assemblies,(iii)the various application scenarios for clinical cancer therapy and antibacterial infection.Also,the existing challenges and future perspectives on the innovation of porphyrinic architectures for clinical PDT applications are mentioned in the end section.Moreover,the porphyrinic nanomaterials with atomically precise architectures provide an ideal platform for investigating the relationship between structures and PDT outputs,design of personalized“all-in-one”theranostic agents,and the popularization and application in wider biomedical fields.
文摘1 Results Manganese porphyrins have attracted growing interest because of their unique physical and chemical properties,such as mimicking the role of Mn complex in photosystem Ⅱ and acting as electrocatalysts towards the oxidation of nitric oxide and nitrite.As one of the bottom-up techniques,we are currently investigating the design,preparation and opto-electrochemical properties of metal-mediated multiporphyrin arrays on the solid surfaces.Because the porphyrins are connected by metal ions via coordin...
